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O00311 | CDC7_HUMAN | Cell division cycle 7-related protein kinase (CDC7)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL1958408 OBDepict O N H N H N H N Ki = 0.28 nM 308.38 O=c1cc(-c2c[nH]c3ncccc23)cc(NC2CCCCC2)[nH]1 Homo sapiens CHEMBL2328973 single protein format
CHEMBL1969221 OBDepict H 3 C N CH 3 N N N N H 2 N N H Ki = 0.4 nM 409.5 CN(C)c1ccc(-c2c(-c3ccc4[nH]nc(N)c4c3)nnn2Cc2ccccc2)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL1972339 OBDepict F N N N N CH 3 N H Ki = 0.428 nM 383.43 Cc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL2003638 OBDepict F N H O N N H N N N Ki = 0.5 nM 412.43 O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3890525 OBDepict H 2 N N N H N N N S Ki = 0.5 nM 372.46 Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3cccs3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL1999931 OBDepict O N H N N H N N N Ki = 0.6 nM 394.44 O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL1969473 OBDepict H N N N N N Ki = 0.601 nM 351.41 c1ccc(Cn2nnc(-c3ccc4[nH]ncc4c3)c2-c2ccccc2)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL1986499 OBDepict F N N N N NH 2 N H Ki = 0.8 nM 384.42 Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL2322677 OBDepict Cl N N H N H N Ki = 0.9 nM 326.83 Clc1cc(-c2c[nH]c3ncccc23)cc(NC2CCCCC2)n1 Homo sapiens CHEMBL2328973 single protein format
CHEMBL3912696 OBDepict O N H N N H N N N Ki = 0.9 nM 470.54 O=C(Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12)c1ccccc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3974914 OBDepict F N N N O N N H Ki = 1.05 nM 377.42 Fc1ccc(-c2c(-c3ccc4[nH]ncc4c3)nnn2CC2CCOCC2)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3959601 OBDepict H N N NH 2 N N N Ki = 1.1 nM 380.46 Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3Cc3ccccc3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL2322674 OBDepict N N N H N H N Ki = 1.4 nM 325.38 N#Cc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 Homo sapiens CHEMBL2328973 single protein format
CHEMBL2322683 OBDepict F N N H H N H N H OH Ki = 1.7 nM 326.38 O[C@H]1CC[C@H](Nc2cc(-c3c[nH]c4ncccc34)cc(F)n2)CC1 Homo sapiens CHEMBL2328973 single protein format
CHEMBL3933471 OBDepict CH 3 N N N N N N H 2 N N H Ki = 1.9 nM 370.42 Cn1cc(-c2c(-c3ccc4[nH]nc(N)c4c3)nnn2Cc2ccccc2)cn1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL1972158 OBDepict H 2 N N N H N N N Ki = 2.1 nM 366.43 Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL1983315 OBDepict CH 3 N N N N H 3 C N H Ki = 2.25 nM 379.47 Cc1ccccc1-c1c(-c2ccc3[nH]nc(C)c3c2)nnn1Cc1ccccc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3964735 OBDepict F NH O N N H N N N Ki = 2.4 nM 452.49 O=C(Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12)c1cccc(F)c1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL2322682 OBDepict F N N H N H N Ki = 3.2 nM 310.38 Fc1cc(-c2c[nH]c3ncccc23)cc(NC2CCCCC2)n1 Homo sapiens CHEMBL2328973 single protein format
CHEMBL2322684 OBDepict F N N H H N H N H NH 2 Ki = 3.4 nM 325.39 N[C@H]1CC[C@H](Nc2cc(-c3c[nH]c4ncccc34)cc(F)n2)CC1 Homo sapiens CHEMBL2328973 single protein format
CHEMBL2000029 OBDepict CH 3 N N N N H 2 N N H Ki = 3.4 nM 380.46 Cc1ccccc1-c1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3938656 OBDepict H N N S N N N Ki = 4.92 nM 357.44 c1ccc(Cn2cc(-c3ccc4[nH]nc(-c5cccs5)c4c3)nn2)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL2322675 OBDepict N N N H H N H N H OH Ki = 5.5 nM 333.4 N#Cc1cc(-c2c[nH]c3ncccc23)cc(N[C@H]2CC[C@H](O)CC2)n1 Homo sapiens CHEMBL2328973 single protein format
CHEMBL3970165 OBDepict Cl NH O N N H N N N Ki = 6.3 nM 468.95 O=C(Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12)c1cccc(Cl)c1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL1982400 OBDepict H N N N N N Ki = 7.7 nM 351.41 c1ccc(Cn2cc(-c3ccc4[nH]nc(-c5ccccc5)c4c3)nn2)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL2322673 OBDepict N N N H N H N Ki = 7.7 nM 317.4 N#Cc1cc(-c2c[nH]c3ncccc23)cc(NC2CCCCC2)n1 Homo sapiens CHEMBL2328973 single protein format
CHEMBL3950878 OBDepict H 2 N N N H N N N Ki = 8.2 nM 386.5 Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3CC3CCCCC3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL2322678 OBDepict H N N N HN Ki = 8.7 nM 292.39 c1cnc2[nH]cc(-c3ccnc(NC4CCCCC4)c3)c2c1 Homo sapiens CHEMBL2328973 single protein format
CHEMBL1682346 OBDepict NH 2 N N H N N N Ki = 12.0 nM 290.33 Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3968307 OBDepict Cl Cl N N N N N H Ki = 12.7 nM 344.21 Clc1ccc(Cn2cc(-c3ccc4[nH]ncc4c3)nn2)c(Cl)c1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3927401 OBDepict H 3 C O N H N H O N N H N N N Ki = 13.0 nM 515.58 COc1ccc(NC(=O)Nc2n[nH]c3ccc(-c4nnn(Cc5ccccc5)c4-c4ccccc4)cc23)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL2322679 OBDepict CH 3 N N H N H N Ki = 13.0 nM 306.41 Cc1cc(-c2c[nH]c3ncccc23)cc(NC2CCCCC2)n1 Homo sapiens CHEMBL2328973 single protein format
CHEMBL2005936 OBDepict H 3 C HN O N N H N N N Ki = 13.0 nM 436.52 CCCC(=O)Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 Homo sapiens CHEMBL3887383 single protein format
CHEMBL2322680 OBDepict CH 3 N N H N H N Ki = 15.0 nM 314.39 Cc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 Homo sapiens CHEMBL2328973 single protein format
CHEMBL3907396 OBDepict H 3 C O HN O N N H N N N Ki = 15.0 nM 362.39 COCC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3891667 OBDepict Cl NH N N H N N N Ki = 15.0 nM 454.97 Clc1ccc(CNc2n[nH]c3ccc(-c4nnn(Cc5ccccc5)c4C4CC4)cc23)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3897033 OBDepict H 2 N N N H N N N Ki = 20.0 nM 372.48 Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3CC3CCCC3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3953310 OBDepict Cl N N O H 2 N N H N N N Ki = 22.0 nM 483.96 NC(=O)N(c1ccccc1Cl)c1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL1989646 OBDepict NH 2 N N H N N H 3 C N Ki = 23.0 nM 304.36 Cc1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL2322681 OBDepict CH 3 N N H H N H N H OH Ki = 27.0 nM 322.41 Cc1cc(-c2c[nH]c3ncccc23)cc(N[C@H]2CC[C@H](O)CC2)n1 Homo sapiens CHEMBL2328973 single protein format
CHEMBL3986318 OBDepict CH 3 N N N O N H 2 N N H Ki = 30.0 nM 388.48 Cc1ccccc1-c1c(-c2ccc3[nH]nc(N)c3c2)nnn1CC1CCOCC1 Homo sapiens CHEMBL3887383 single protein format
CHEMBL3914700 OBDepict H 3 C NH HN O N N H N N N Ki = 34.0 nM 361.41 CCNC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL2004631 OBDepict H 2 N N N H N N N Ki = 35.0 nM 330.4 Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL1975128 OBDepict H 2 N N N H N N I N Ki = 35.0 nM 416.23 Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3I)cc12 Homo sapiens CHEMBL3887383 single protein format
CHEMBL3968211 OBDepict H 2 N N N H N N N Ki = 37.0 nM 372.48 Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CCCCC3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3941781 OBDepict F F HN N N H N N N Ki = 37.0 nM 416.44 Fc1ccc(CNc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c(F)c1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3910678 OBDepict F HN N N H N N N Ki = 38.0 nM 398.45 Fc1cccc(CNc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3925088 OBDepict H 3 C NH N N H N N N Ki = 40.0 nM 346.44 CCCCNc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3975457 OBDepict NH 2 N O N N H N N N Ki = 41.0 nM 463.55 NC(=O)N(Cc1ccccc1)c1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3971536 OBDepict H N N NH N N N Ki = 46.0 nM 420.52 c1ccc(CNc2n[nH]c3ccc(-c4nnn(Cc5ccccc5)c4C4CC4)cc23)cc1 Homo sapiens CHEMBL3887383 single protein format
CHEMBL3980762 OBDepict CH 3 O HN N N H N N N Ki = 52.0 nM 410.48 COc1ccc(CNc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3976347 OBDepict H N N N N N Ki = 52.3 nM 275.32 c1ccc(Cn2nncc2-c2ccc3[nH]ncc3c2)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL1964288 OBDepict H N N N N N N N N Ki = 55.6 nM 432.49 c1ccc(Cn2cc(-c3ccc4[nH]nc(-c5cn(Cc6ccccc6)nn5)c4c3)nn2)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL1682352 OBDepict F N N N N N H Ki = 56.3 nM 293.31 Fc1ccc(Cn2cc(-c3ccc4[nH]ncc4c3)nn2)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL1977223 OBDepict H 3 C HN O N N H N N N Ki = 58.0 nM 360.42 CCCC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 Homo sapiens CHEMBL3887383 single protein format
CHEMBL3917330 OBDepict N HN N N H N N N Ki = 65.0 nM 405.47 N#Cc1ccc(CNc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL2322676 OBDepict H 2 N O N N H H N H N H OH Ki = 67.0 nM 351.41 NC(=O)c1cc(-c2c[nH]c3ncccc23)cc(N[C@H]2CC[C@H](O)CC2)n1 Homo sapiens CHEMBL2328973 single protein format
CHEMBL3936503 OBDepict NH 2 N N H N N N N O Ki = 68.0 nM 451.53 Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3cccc(N4CCOCC4)c3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3951439 OBDepict H 3 C N N O H 2 N N H N N N Ki = 68.0 nM 375.44 CCCN(C(N)=O)c1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3902893 OBDepict CH 3 O O N N H N N N Ki = 81.1 nM 333.35 COC(=O)c1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3960514 OBDepict Cl NH N N H N N N Ki = 93.0 nM 454.97 Clc1ccccc1CNc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3966295 OBDepict O HN N N O N N N Ki = 110.0 nM 538.61 O=C(Nc1nn(C(=O)c2ccccc2)c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12)c1ccccc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3941943 OBDepict CH 3 S N H O O N N H N N N Ki = 120.0 nM 422.51 CCS(=O)(=O)Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3985842 OBDepict H N N N H N N N Ki = 120.0 nM 380.45 c1ccc(CNc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL1969843 OBDepict H N N N N N O Ki = 127.0 nM 283.34 c1cc2[nH]ncc2cc1-c1cn(CC2CCOCC2)nn1 Homo sapiens CHEMBL3887383 single protein format
CHEMBL3919634 OBDepict Cl HN N N H N N N Ki = 140.0 nM 414.9 Clc1ccc(CNc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3937279 OBDepict O N N N H N N N Ki = 180.0 nM 358.41 O=C1CCCN1c1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3947423 OBDepict O N H N N N H NH O N N N Ki = 180.0 nM 430.47 O=C1CN(CC(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)CCN1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3928683 OBDepict H N N N N N Ki = 192.0 nM 261.29 c1ccc(-n2cc(-c3ccc4[nH]ncc4c3)nn2)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3933614 OBDepict H N N N H N N N N O Ki = 220.0 nM 403.49 c1ccc(Cn2cc(-c3ccc4[nH]nc(NCCN5CCOCC5)c4c3)nn2)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3959053 OBDepict Cl O N N N O N N H Ki = 229.0 nM 421.89 O=C(c1cccc(Cl)c1)c1c(-c2ccc3[nH]ncc3c2)nnn1CC1CCOCC1 Homo sapiens CHEMBL3887383 single protein format
CHEMBL3960629 OBDepict CH 3 N N N N H N N N Ki = 230.0 nM 373.46 CN1CCN(c2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)CC1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL1965631 OBDepict CH 3 N CH 3 NH O N N H N N N Ki = 242.0 nM 375.44 CN(C)CC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 Homo sapiens CHEMBL3887383 single protein format
CHEMBL3918627 OBDepict H N N N S N N N Ki = 258.0 nM 358.43 c1ccc(Cn2cc(-c3ccc4[nH]nc(-c5nccs5)c4c3)nn2)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3986570 OBDepict H N N N H S O O N N N Ki = 340.0 nM 506.59 O=S(=O)(Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12)c1ccccc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3956257 OBDepict H N N NH N N N Ki = 350.0 nM 386.5 c1ccc(Cn2cc(-c3ccc4[nH]nc(NCC5CCCCC5)c4c3)nn2)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3923726 OBDepict CH 3 S N H O O N N H N N N Ki = 410.0 nM 382.45 CCS(=O)(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3935067 OBDepict F N N N N NH 2 N H F F F Ki = 430.0 nM 452.42 Nc1n[nH]c2ccc(-c3nnn(Cc4ccc(C(F)(F)F)cc4)c3-c3ccc(F)cc3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL1969561 OBDepict CH 3 N H 3 C H 3 C O N N N N N H Ki = 473.0 nM 374.45 CC(C)N(C)C(=O)c1c(-c2ccc3[nH]ncc3c2)nnn1Cc1ccccc1 Homo sapiens CHEMBL3887383 single protein format
CHEMBL3964275 OBDepict H 3 C N N N N H N N N Ki = 489.0 nM 355.41 Cn1ccnc1-c1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3960171 OBDepict O N H N H N N H N N N Ki = 500.0 nM 429.53 O=C(CNC1CCCCC1)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3946172 OBDepict H N N N H N N N Ki = 570.0 nM 344.42 c1ccc(Cn2cc(-c3ccc4[nH]nc(NCC5CC5)c4c3)nn2)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3979260 OBDepict H N N N O N N N Ki = 630.0 nM 360.42 c1ccc(Cn2cc(-c3ccc4[nH]nc(N5CCOCC5)c4c3)nn2)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL1996111 OBDepict CH 3 N H 3 C O N N N N N H Ki = 640.0 nM 346.39 CN(C)C(=O)c1c(-c2ccc3[nH]ncc3c2)nnn1Cc1ccccc1 Homo sapiens CHEMBL3887383 single protein format
CHEMBL3902689 OBDepict CH 3 N CH 3 O N N H N N N Ki = 681.0 nM 346.39 CN(C)C(=O)c1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3891467 OBDepict Cl S N H O O N N H N N N Ki = 980.0 nM 505.0 O=S(=O)(Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12)c1ccc(Cl)cc1 Homo sapiens CHEMBL3887107 single protein format
CHEMBL3979653 OBDepict H N N N H S O O N N N Ki = 1000.0 nM 470.56 O=S(=O)(Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12)c1ccccc1 Homo sapiens CHEMBL3887107 single protein format