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O00750 | P3C2B_HUMAN | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4869265 OBDepict CH 3 N CH 3 O N CH 3 H N O N S O NH CH 3 CH 3 IC50 = 9.57 nM 481.62 CN(C)C(=O)c1ccc2c(c1)c(C[C@H]1COCCN1c1nc3c(s1)C(=O)NC(C)(C)C3)cn2C Homo sapiens CHEMBL4807566 single protein format
CHEMBL538346 OBDepict OH N N N O N O ClH IC50 = 10.0 nM 384.82 Cl.Oc1cccc(-c2nc(N3CCOCC3)c3oc4ncccc4c3n2)c1 Homo sapiens CHEMBL906677 cell-based format
CHEMBL1765602 OBDepict NH 2 N N N O F F F IC50 = 24.5 nM 432.41 Nc1ccc(-c2ccc3ncc4ccc(=O)n(-c5cccc(C(F)(F)F)c5)c4c3c2)cn1 Homo sapiens CHEMBL1768557 single protein format
CHEMBL3913354 OBDepict OH N N O N O IC50 = 26.0 nM 347.37 Oc1cccc(-c2cc3c(oc4ncccc43)c(N3CCOCC3)n2)c1 Homo sapiens CHEMBL3861261 cell-based format
CHEMBL573339 OBDepict OH N N N O N O IC50 = 26.0 nM 348.36 Oc1cccc(-c2nc(N3CCOCC3)c3oc4ncccc4c3n2)c1 Homo sapiens CHEMBL3376670 single protein format
CHEMBL2165017 OBDepict CH 3 O N N H N N N N H 3 C N NH 2 N S O O CH 3 IC50 = 29.0 nM 485.57 COc1ccc(Nc2ncc(CN3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 Homo sapiens CHEMBL2169658 single protein format
CHEMBL1879463 OBDepict N H 3 C CH 3 N O N H 3 C N N IC50 = 44.0 nM 469.55 Cn1c(=O)n(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21 Homo sapiens CHEMBL3861268 single protein format
CHEMBL3354566 OBDepict N N O N CH 3 N N IC50 = 44.0 nM 467.53 Cn1c(=O)n(-c2ccc(C3(C#N)CC3)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21 Homo sapiens CHEMBL3376670 single protein format
CHEMBL1241857 OBDepict CH 3 O O N CH 3 HN N N O N IC50 = 64.0 nM 351.37 COc1ccc2c(c1OC)N=C(NC(=O)c1cccnc1)N1CCN=C21 Homo sapiens CHEMBL3376670 single protein format
CHEMBL556399 OBDepict Br N N N N S H 3 C O O CH 3 + N O _ O ClH IC50 = 100.0 nM 488.75 Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnc2ccc(Br)cn12.Cl Homo sapiens CHEMBL906677 cell-based format
CHEMBL541133 OBDepict Cl N N N S S O O CH 3 + N O _ O ClH IC50 = 100.0 nM 471.35 Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)c1nc(-c2cnc3ccc(Cl)cn23)cs1.Cl Homo sapiens CHEMBL919698 single protein format
CHEMBL4749655 OBDepict OH N H O N N N N N O HO IC50 = 103.0 nM 454.53 O=C(CCCCCCn1cnc2c(N3CCOCC3)nc(-c3cccc(CO)c3)nc21)NO Homo sapiens CHEMBL4707203 single protein format
CHEMBL1229535 OBDepict HO N H S O O Cl S CH 3 N N H O CH 3 IC50 = 140.0 nM 389.89 CC(=O)/N=c1/[nH]c(C)c(-c2ccc(Cl)c(S(=O)(=O)NCCO)c2)s1 Homo sapiens CHEMBL3376670 single protein format
CHEMBL586702 OBDepict F F N N N N N N N O O IC50 = 180.0 nM 417.42 FC(F)c1nc2ccccc2n1-c1nc(N2CCOCC2)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3376670 single protein format
CHEMBL541643 OBDepict OH N N N S O ClH IC50 = 220.0 nM 349.84 Cl.Oc1cccc(-c2nc(N3CCOCC3)c3sccc3n2)c1 Homo sapiens CHEMBL906677 cell-based format
CHEMBL4164334 OBDepict CH 3 H 3 C H 2 N H N H O N S CH 3 N N H Cl S O O CH 3 IC50 = 247.9 nM 494.04 Cc1ccc(S(=O)(=O)Nc2cc(-c3sc(NC(=O)[C@@H](N)C(C)C)nc3C)cnc2Cl)cc1 Homo sapiens CHEMBL4156829 assay format
CHEMBL2387080 OBDepict CH 3 N N N CH 3 H 3 C N N O N N H 3 C H 3 C O H 2 N IC50 = 292.0 nM 460.54 Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C(C)(C)C(N)=O)c4)cc2OCC3)n(C(C)C)n1 Homo sapiens CHEMBL2388256 single protein format
CHEMBL3922359 OBDepict S N H S O N O O Cl F IC50 = 370.0 nM 434.9 O=C1NC(=S)S/C1=Cc1ccc2c(c1)N(Cc1ccc(F)c(Cl)c1)C(=O)CO2 Homo sapiens CHEMBL3861261 cell-based format
CHEMBL3218571 OBDepict S N H S O N O O Cl F IC50 = 370.0 nM 434.9 O=C1NC(=S)S/C1=C/c1ccc2c(c1)N(Cc1ccc(F)c(Cl)c1)C(=O)CO2 Homo sapiens CHEMBL3376670 single protein format
CHEMBL3218581 OBDepict NH 2 O H N N H O N S CH 3 N S CH 3 CH 3 H 3 C IC50 = 462.0 nM 393.54 Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1csc(C(C)(C)C)n1 Homo sapiens CHEMBL3376670 single protein format
CHEMBL3354564 OBDepict CH 3 N H O N N N O N H S O O IC50 = 530.0 nM 553.64 CC(=O)Nc1ccc2nc(-c3cccc(NS(=O)(=O)c4cccc5ccccc45)c3)nc(N3CCOCC3)c2c1 Homo sapiens CHEMBL3376670 single protein format
CHEMBL3903959 OBDepict H 3 C N H O N N N O N H S O O IC50 = 530.0 nM 553.64 CC(=O)Nc1ccc2nc(-c3cccc(NS(=O)(=O)c4ccc5ccccc5c4)c3)nc(N3CCOCC3)c2c1 Homo sapiens CHEMBL3861247 cell-based format
CHEMBL3354565 OBDepict CH 3 N H O N N N O HN S O O IC50 = 630.0 nM 503.58 CC(=O)Nc1ccc2nc(-c3cccc(NS(=O)(=O)c4ccccc4)c3)nc(N3CCOCC3)c2c1 Homo sapiens CHEMBL3376670 single protein format
CHEMBL521851 OBDepict H N N N N N S N O N S O O CH 3 IC50 = 670.0 nM 513.65 CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1 Homo sapiens CHEMBL980854 single protein format
CHEMBL1922094 OBDepict O N OH CH 3 H N S CH 3 N N N O N N H 2 N IC50 = 794.0 nM 498.61 Cc1c(CN2CCN(C(=O)[C@H](C)O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 Homo sapiens CHEMBL1925488 single protein format
CHEMBL4174988 OBDepict CH 3 H 3 C H 2 N H N H O N S CH 3 N N H Cl S O O CH 3 IC50 = 882.3 nM 494.04 Cc1cccc(S(=O)(=O)Nc2cc(-c3sc(NC(=O)[C@@H](N)C(C)C)nc3C)cnc2Cl)c1 Homo sapiens CHEMBL4156829 assay format