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O14980 | XPO1_HUMAN | Exportin-1 (XPO1)

3D structures mapped by conservation among orthologs

[ Domain: "ARM repeat" // Xpo1 ]

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[ Domain: "ARM repeat" // CRM1_C ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL486133 OBDepict CH 3 CH 3 H H O H H 3 C O H 3 C CH 3 H O H 3 C H OH H CH 3 H H 3 C O HO IC50 = 1.0 nM 540.74 CCC(=C/[C@H](C)C/C=C/C(C)=C/[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C/C(C)=C/C(=O)O)/C=C/[C@@H]1OC(=O)C=C[C@@H]1C Homo sapiens CHEMBL4024845 cell-based format
CHEMBL4088268 OBDepict H 3 C H 3 C H H O O CH 3 H 3 C H O CH 3 H HO H CH 3 H H 3 C H 3 C IC50 = 10.0 nM 496.73 C/C=C(C)C[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)/C=C(C)/C=C/C[C@@H](C)/C=C(C=C[C@H]1CC=CC(=O)O1)CC Homo sapiens CHEMBL4024845 cell-based format
CHEMBL4077955 OBDepict CH 3 H 3 C CH 3 H O H H 3 C O IC50 = 25.0 nM 234.34 CCC(=C/C(C)C)/C=C/[C@@H]1OC(=O)C=C[C@@H]1C Homo sapiens CHEMBL4024845 cell-based format
CHEMBL4440028 OBDepict S N + S _ O F F F F F F IC50 = 151.0 nM 373.34 [O-][S@@+](/C=C/CCN=C=S)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 Homo sapiens CHEMBL4405709 cell-based format
CHEMBL3916670 OBDepict CH 3 O CH 3 O N N N N Cl IC50 <= 1000.0 nM 292.73 CC(C)OC(=O)/C=Cn1cnc(-c2cncc(Cl)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3926680 OBDepict CH 3 O O N N N Cl O H 3 C IC50 <= 1000.0 nM 307.74 CCOC(=O)/C=Cn1cnc(-c2cc(Cl)cc(OC)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3910886 OBDepict Cl N N N S O O CH 3 IC50 <= 1000.0 nM 283.74 CS(=O)(=O)/C=Cn1cnc(-c2cccc(Cl)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3913559 OBDepict N N N N Cl IC50 <= 1000.0 nM 230.66 N#C/C=Cn1cnc(-c2cccc(Cl)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3948709 OBDepict H 3 C O CH 3 O N N N Cl N Cl IC50 <= 1000.0 nM 327.17 CC(C)OC(=O)/C=Cn1cnc(-c2cc(Cl)nc(Cl)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3898452 OBDepict CH 3 O N N F F F N O O CH 3 CH 3 IC50 <= 1000.0 nM 355.32 COc1cc(-c2ncn(/C=CC(=O)OC(C)C)n2)cc(C(F)(F)F)c1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3983477 OBDepict CH 3 O CH 3 O N N N S Cl IC50 <= 1000.0 nM 297.77 CC(C)OC(=O)/C=Cn1cnc(-c2csc(Cl)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3938232 OBDepict Cl N N N N O IC50 <= 1000.0 nM 288.74 O=C(/C=Cn1cnc(-c2cccc(Cl)c2)n1)N1CCC1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3937152 OBDepict O O N N N Cl IC50 <= 1000.0 nM 331.8 O=C(/C=Cn1cnc(-c2cccc(Cl)c2)n1)OC1CCCCC1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3975270 OBDepict H 3 C N CH 3 O N N F F F N O O CH 3 CH 3 IC50 <= 1000.0 nM 412.41 CC(C)OC(=O)/C=Cn1cnc(-c2cc(OCCN(C)C)cc(C(F)(F)F)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3890840 OBDepict O O N O N N Cl IC50 <= 1000.0 nM 305.72 O=C(/C=Cn1cnc(-c2cccc(Cl)c2)n1)OC1COC1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3986982 OBDepict H 3 C O CH 3 O N N N H Cl IC50 <= 1000.0 nM 291.74 CC(C)OC(=O)/C=Cc1n[nH]c(-c2cccc(Cl)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3924559 OBDepict O O N N N Cl IC50 <= 1000.0 nM 325.75 O=C(/C=Cn1cnc(-c2cccc(Cl)c2)n1)Oc1ccccc1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3903633 OBDepict CH 3 O O N N N Cl IC50 <= 1000.0 nM 277.71 CCOC(=O)/C=Cn1cnc(-c2cccc(Cl)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3950319 OBDepict CH 3 O CH 3 O N N N S F F F O O CH 3 IC50 <= 1000.0 nM 403.38 CC(C)OC(=O)/C=Cn1cnc(-c2cc(C(F)(F)F)cc(S(C)(=O)=O)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3917281 OBDepict CH 3 O H 3 C O N N N NH N F F F IC50 <= 1000.0 nM 395.39 CC(C)OC(=O)/C=Cn1cnc(-c2cc(NC3CCC3)nc(C(F)(F)F)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3933280 OBDepict H 3 C O CH 3 O N N N NH N F F F H 3 C CH 3 IC50 <= 1000.0 nM 383.37 CC(C)Nc1cc(-c2ncn(/C=CC(=O)OC(C)C)n2)cc(C(F)(F)F)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3930588 OBDepict O O N N N N O F F F CH 3 CH 3 IC50 <= 1000.0 nM 432.4 CC(C)Oc1cc(-c2ncn(/C=CC(=O)OCc3ccccn3)n2)cc(C(F)(F)F)c1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3985910 OBDepict H 3 C O N N F F F N O O N H IC50 <= 1000.0 nM 368.32 COc1cc(-c2ncn(/C=CC(=O)OC3CNC3)n2)cc(C(F)(F)F)c1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3986064 OBDepict O O N N N N O N F F F CH 3 CH 3 IC50 <= 1000.0 nM 433.39 CC(C)Oc1cc(-c2ncn(/C=CC(=O)OCc3ccccn3)n2)cc(C(F)(F)F)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3942724 OBDepict CH 3 O H 3 C O N N N O N F F F H 3 C CH 3 IC50 <= 1000.0 nM 384.36 CC(C)OC(=O)/C=Cn1cnc(-c2cc(OC(C)C)nc(C(F)(F)F)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3893394 OBDepict CH 3 O O Cl N N N O O CH 3 CH 3 IC50 <= 1000.0 nM 365.82 COCCOc1cc(Cl)cc(-c2ncn(/C=CC(=O)OC(C)C)n2)c1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3909832 OBDepict H 3 C O H 3 C O N N N O F F F N IC50 <= 1000.0 nM 438.45 CC(C)OC(=O)/C=Cn1cnc(-c2cc(OCCN3CCCC3)cc(C(F)(F)F)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3967831 OBDepict N N N N O F F F CH 3 CH 3 IC50 <= 1000.0 nM 322.29 CC(C)Oc1cc(-c2ncn(/C=CC#N)n2)cc(C(F)(F)F)c1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3956065 OBDepict H 3 C O CH 3 O N N N Cl N N H CH 3 H 3 C IC50 <= 1000.0 nM 349.82 CC(C)Nc1cc(-c2ncn(/C=CC(=O)OC(C)C)n2)cc(Cl)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3928895 OBDepict O O N N H N N Cl N Cl IC50 <= 1000.0 nM 340.17 O=C(/C=Cn1cnc(-c2cc(Cl)nc(Cl)c2)n1)OC1CNC1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3926228 OBDepict N O N N CH 3 H 3 C N O O H 3 C CH 3 IC50 <= 1000.0 nM 340.38 CC(C)OC(=O)/C=Cn1cnc(-c2cc(C#N)cc(OC(C)C)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3940071 OBDepict CH 3 O N Cl N N N O O H 3 C H 3 C IC50 <= 1000.0 nM 322.75 COc1cc(-c2ncn(/C=CC(=O)OC(C)C)n2)cc(Cl)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3982070 OBDepict O O N N N Cl IC50 <= 1000.0 nM 317.78 O=C(/C=Cn1cnc(-c2cccc(Cl)c2)n1)OC1CCCC1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3941592 OBDepict O O N N H N N Cl IC50 <= 1000.0 nM 304.74 O=C(/C=Cn1cnc(-c2cccc(Cl)c2)n1)OC1CNC1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3926992 OBDepict H 3 C O CH 3 O N N N NH 2 Cl IC50 <= 1000.0 nM 306.75 CC(C)OC(=O)/C=Cn1cnc(-c2cc(Cl)ccc2N)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3928302 OBDepict CH 3 O CH 3 O N N N N S Cl IC50 = 1000.0 nM 298.75 CC(C)OC(=O)/C=Cn1cnc(-c2csc(Cl)n2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3890257 OBDepict O O N N H N N Cl IC50 = 1000.0 nM 304.74 O=C(/C=C/n1cnc(-c2cccc(Cl)c2)n1)OC1CNC1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3914451 OBDepict Cl N N N F F F IC50 = 1000.0 nM 273.64 FC(F)(F)/C=Cn1cnc(-c2cccc(Cl)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3911830 OBDepict H 3 C N CH 3 O N N F F F N O O CH 3 CH 3 IC50 = 1000.0 nM 412.41 CC(C)OC(=O)/C=C/n1cnc(-c2cc(OCCN(C)C)cc(C(F)(F)F)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3911673 OBDepict N N N N Cl IC50 = 1000.0 nM 230.66 N#C/C=C/n1cnc(-c2cccc(Cl)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3893042 OBDepict H 3 C O CH 3 O N N N Cl IC50 = 1000.0 nM 305.77 CC(C)OC(=O)/C=C/Cn1cnc(-c2cccc(Cl)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3925662 OBDepict CH 3 O CH 3 O N N N N S Br IC50 = 1000.0 nM 343.21 CC(C)OC(=O)/C=Cn1cnc(-c2csc(Br)n2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3895766 OBDepict H 3 C O CH 3 O N N N Cl IC50 = 1000.0 nM 305.77 CC(C)OC(=O)/C=CCn1cnc(-c2cccc(Cl)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3929349 OBDepict _ O + S H 3 C N N N Cl IC50 = 1000.0 nM 267.74 C[S+]([O-])/C=Cn1cnc(-c2cccc(Cl)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3929869 OBDepict O O O O N N N Cl IC50 = 1000.0 nM 333.73 O=C(/C=Cn1cnc(-c2cccc(Cl)c2)n1)OC1COC(=O)C1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3951325 OBDepict CH 3 O H 3 C O N N N Cl O Cl IC50 = 1000.0 nM 418.28 CC(C)OC(=O)/C=Cn1cnc(-c2cc(Cl)cc(Oc3ccc(Cl)cc3)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3899053 OBDepict O O N N HN N Cl IC50 = 1000.0 nM 332.79 O=C(/C=Cn1cnc(-c2cccc(Cl)c2)n1)OCC1CCCN1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3896208 OBDepict O O H 3 C H 3 C CH 3 N N N Cl IC50 = 1000.0 nM 305.76 CC(C)(C)OC(=O)/C=Cn1cnc(-c2cccc(Cl)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3964319 OBDepict CH 3 O H 3 C O N N N O Cl IC50 = 1000.0 nM 383.84 CC(C)OC(=O)/C=Cn1cnc(-c2ccc(Oc3ccc(Cl)cc3)cc2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3891836 OBDepict CH 3 O Cl N N N O O H 3 C H 3 C IC50 = 1000.0 nM 321.76 COc1ccc(-c2ncn(/C=CC(=O)OC(C)C)n2)cc1Cl Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3919410 OBDepict O O N N N N N H Cl IC50 = 1000.0 nM 329.75 O=C(/C=Cn1cnc(-c2cccc(Cl)c2)n1)OCc1cnc[nH]1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3944287 OBDepict CH 3 O O CH 3 N N N O O H 3 C H 3 C IC50 <= 1000.0 nM 317.35 COc1cc(OC)cc(-c2ncn(/C=CC(=O)OC(C)C)n2)c1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3898004 OBDepict H 3 C O CH 3 O O N N F F F N O O H 3 C CH 3 IC50 = 1000.0 nM 453.42 CC(C)OC(=O)/C=Cn1cnc(-c2cc(O/C=C/C(=O)OC(C)C)cc(C(F)(F)F)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3915859 OBDepict H 3 C O CH 3 O N N N H Cl Cl IC50 = 1000.0 nM 326.18 CC(C)OC(=O)/C=Cc1n[nH]c(-c2cc(Cl)cc(Cl)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3906262 OBDepict H 3 C NH Cl N N N O O CH 3 CH 3 IC50 <= 1000.0 nM 320.78 CNc1cc(Cl)cc(-c2ncn(/C=CC(=O)OC(C)C)n2)c1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3908937 OBDepict O O N N O N Cl IC50 <= 1000.0 nM 333.78 O=C(/C=Cn1cnc(-c2cccc(Cl)c2)n1)OC1CCOCC1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3939294 OBDepict CH 3 O CH 3 O N N N Cl IC50 <= 1000.0 nM 291.74 CC(C)OC(=O)/C=Cn1cnc(-c2cccc(Cl)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3953463 OBDepict CH 3 O CH 3 O N N N Cl IC50 <= 1000.0 nM 291.74 CC(C)OC(=O)/C=Cn1cnc(-c2ccc(Cl)cc2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3963087 OBDepict H 3 C O CH 3 O N N N F F F IC50 <= 1000.0 nM 325.29 CC(C)OC(=O)/C=Cn1cnc(-c2cccc(C(F)(F)F)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3960417 OBDepict CH 3 O CH 3 O N N N Cl Cl IC50 <= 1000.0 nM 326.18 CC(C)OC(=O)/C=Cn1cnc(-c2ccc(Cl)c(Cl)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3911272 OBDepict O O N O N N Cl IC50 <= 1000.0 nM 319.75 O=C(/C=Cn1cnc(-c2cccc(Cl)c2)n1)OC1CCOC1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3908175 OBDepict CH 3 O O N N N F Cl IC50 = 1000.0 nM 295.7 CCOC(=O)/C=C/n1cnc(-c2cc(F)cc(Cl)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3901444 OBDepict O O N N N Cl IC50 <= 1000.0 nM 303.75 O=C(/C=Cn1cnc(-c2cccc(Cl)c2)n1)OC1CCC1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3946430 OBDepict CH 3 O N N Cl N O O H 3 C H 3 C IC50 <= 1000.0 nM 321.76 COc1ccc(Cl)cc1-c1ncn(/C=CC(=O)OC(C)C)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3892114 OBDepict H 3 C O Cl N N N O O CH 3 CH 3 IC50 <= 1000.0 nM 321.76 COc1cc(Cl)cc(-c2ncn(/C=CC(=O)OC(C)C)n2)c1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3987137 OBDepict H 3 C O CH 3 O N N N Cl O H 3 C CH 3 IC50 <= 1000.0 nM 349.82 CC(C)OC(=O)/C=Cn1cnc(-c2cc(Cl)cc(OC(C)C)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3931058 OBDepict H 3 C O CH 3 O N N N Cl N O H 3 C CH 3 IC50 <= 1000.0 nM 350.81 CC(C)OC(=O)/C=Cn1cnc(-c2cc(Cl)nc(OC(C)C)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3980322 OBDepict CH 3 O O N N N Cl Cl IC50 <= 1000.0 nM 312.16 CCOC(=O)/C=Cn1cnc(-c2cc(Cl)cc(Cl)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3904126 OBDepict CH 3 O O N N N F F IC50 = 1000.0 nM 279.25 CCOC(=O)/C=Cn1cnc(-c2cc(F)cc(F)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3956187 OBDepict CH 3 O CH 3 O N N N H F IC50 = 1000.0 nM 275.28 CC(C)OC(=O)/C=Cc1nnc(-c2cccc(F)c2)[nH]1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3949109 OBDepict O O N N N N Cl IC50 <= 1000.0 nM 340.77 O=C(/C=Cn1cnc(-c2cccc(Cl)c2)n1)OCc1ccccn1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3970946 OBDepict CH 3 O O N N N Cl O H 3 C IC50 <= 1000.0 nM 293.71 COC(=O)/C=Cn1cnc(-c2cc(Cl)cc(OC)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3959872 OBDepict CH 3 O H 3 C O N N N Cl O F F F IC50 <= 1000.0 nM 375.73 CC(C)OC(=O)/C=Cn1cnc(-c2cc(Cl)cc(OC(F)(F)F)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3966051 OBDepict CH 3 O H 3 C O N N N O F F F H 3 C CH 3 IC50 <= 1000.0 nM 383.37 CC(C)OC(=O)/C=Cn1cnc(-c2cc(OC(C)C)cc(C(F)(F)F)c2)n1 Homo sapiens CHEMBL3880038 cell-based format
CHEMBL3970691 OBDepict CH 3 O H 3 C O N N N CH 3 IC50 <= 1000.0 nM 271.32 Cc1cccc(-c2ncn(/C=CC(=O)OC(C)C)n2)c1 Homo sapiens CHEMBL3880038 cell-based format