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O15054 | KDM6B_HUMAN | Lysine-specific demethylase 6B (KDM6B)

3D structures mapped by conservation among orthologs

[ Domain: "Double-stranded beta-helix" // JmjC_1 ]

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[ Domain: "LIM domain-like" // KOG1246_3rd ]

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[ Domain: "C-terminal helical domain in Jumonji domain-containing histone demethylases" // KOG1246_2nd ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL1230640 OBDepict OH O N OH IC50 = 140.0 nM 189.17 O=C(O)c1ccc(O)c2ncccc12 Homo sapiens CHEMBL3112251 single protein format
CHEMBL3188597 OBDepict OH O HN N N N N IC50 = 150.0 nM 389.46 O=C(O)CCNc1cc(N2CCc3ccccc3CC2)nc(-c2ccccn2)n1 Homo sapiens CHEMBL3757620 single protein format
CHEMBL3753391 OBDepict HO O NH N N N N N IC50 = 150.0 nM 378.44 O=C(O)CCNc1nc(N2CCc3ccccc3CC2)cc(-n2cccn2)n1 Homo sapiens CHEMBL3757620 single protein format
CHEMBL3752893 OBDepict HO O NH N N N N S IC50 = 200.0 nM 395.49 O=C(O)CCNc1nc(-c2nccs2)cc(N2CCc3ccccc3CC2)n1 Homo sapiens CHEMBL3757620 single protein format
CHEMBL3752179 OBDepict HO O NH N N N N N N IC50 = 210.0 nM 379.42 O=C(O)CCNc1nc(N2CCc3ccccc3CC2)cc(-n2ccnn2)n1 Homo sapiens CHEMBL3757620 single protein format
CHEMBL3753740 OBDepict HO O NH N N N N N N IC50 = 270.0 nM 379.42 O=C(O)CCNc1nc(N2CCc3ccccc3CC2)cc(-n2nccn2)n1 Homo sapiens CHEMBL3757620 single protein format
CHEMBL3752769 OBDepict HO O NH N N N N N IC50 = 490.0 nM 364.41 O=C(O)CCNc1nc(N2CCc3ccccc3C2)cc(-n2cccn2)n1 Homo sapiens CHEMBL3757620 single protein format
CHEMBL3752835 OBDepict HO O NH N N N N N N F IC50 = 550.0 nM 411.44 O=C(O)CCNc1nc(N2CCN(c3ccc(F)cc3)CC2)cc(-n2cccn2)n1 Homo sapiens CHEMBL3757620 single protein format
CHEMBL3752143 OBDepict OH O HN N N N N S N F IC50 = 600.0 nM 428.49 O=C(O)CCNc1nc(-c2nccs2)cc(N2CCN(c3ccc(F)cc3)CC2)n1 Homo sapiens CHEMBL3757620 single protein format
CHEMBL3752551 OBDepict HO O NH N N N N N N Cl Cl IC50 = 740.0 nM 462.34 O=C(O)CCNc1nc(N2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc(-n2cccn2)n1 Homo sapiens CHEMBL3757620 single protein format
CHEMBL3753449 OBDepict HO O NH N N N N N IC50 = 750.0 nM 392.46 O=C(O)CCNc1nc(N2CCC(c3ccccc3)CC2)cc(-n2cccn2)n1 Homo sapiens CHEMBL3757620 single protein format
CHEMBL3752294 OBDepict OH O HN N N N N S N N IC50 = 900.0 nM 411.49 O=C(O)CCNc1nc(-c2nccs2)cc(N2CCN(c3ccccn3)CC2)n1 Homo sapiens CHEMBL3757620 single protein format
CHEMBL3752343 OBDepict HO O NH N N N N S N Cl Cl IC50 = 940.0 nM 479.39 O=C(O)CCNc1nc(-c2nccs2)cc(N2CCN(c3ccc(Cl)c(Cl)c3)CC2)n1 Homo sapiens CHEMBL3757620 single protein format
CHEMBL3753199 OBDepict HO O NH N N N N S IC50 = 990.0 nM 381.46 O=C(O)CCNc1nc(-c2nccs2)cc(N2CCc3ccccc3C2)n1 Homo sapiens CHEMBL3757620 single protein format
CHEMBL4280291 OBDepict F N N N N N N H F F F IC50 = 1000.0 nM 402.36 Fc1ccc(CCn2cnc(-c3cc(-c4nn[nH]c4C(F)(F)F)ccn3)c2)cc1 Homo sapiens CHEMBL4257004 cell-based format
CHEMBL3774692 OBDepict NH 2 S N N O OH IC50 = 1000.0 nM 221.24 Nc1nc(-c2cc(C(=O)O)ccn2)cs1 Homo sapiens CHEMBL3776391 single protein format
CHEMBL3753326 OBDepict HO O NH N N N N N N N IC50 = 1000.0 nM 394.44 O=C(O)CCNc1nc(N2CCN(c3ccccn3)CC2)cc(-n2cccn2)n1 Homo sapiens CHEMBL3757620 single protein format
CHEMBL4293697 OBDepict F N N N N N N H F F F IC50 = 1000.0 nM 402.36 Fc1cccc(CCn2cnc(-c3cc(-c4nn[nH]c4C(F)(F)F)ccn3)c2)c1 Homo sapiens CHEMBL4257004 cell-based format