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O15075 | DCLK1_HUMAN | Serine/threonine-protein kinase DCLK1 (DCLK1)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Domain: "Ubiquitin-like" // DCX ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL1673048 OBDepict H 3 C O N H NH O N N N N H 3 C N H 3 C H 3 C O IC50 = 1.0 nM 501.59 COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL4612962 assay format
CHEMBL4646447 OBDepict H 3 C N N N O N N H CH 3 N H S O O CH 3 IC50 = 2.0 nM 424.49 CN1C(=O)c2ccccc2N(C)c2nc(Nc3ccc(NS(C)(=O)=O)cc3)ncc21 Homo sapiens CHEMBL4612962 assay format
CHEMBL4643632 OBDepict CH 3 O NH N H O N N N N CH 3 N CH 3 H 3 C O IC50 = 2.0 nM 515.62 CCN1C(=O)c2ccccc2N(C)c2nc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)ncc21 Homo sapiens CHEMBL4612962 assay format
CHEMBL4634326 OBDepict CH 3 O N H N N N N N H 3 C N H 3 C CH 3 O IC50 = 3.0 nM 473.58 CCN1C(=O)c2ccccc2N(C)c2nc(Nc3ccc(N4CCN(C)CC4)cc3OC)ncc21 Homo sapiens CHEMBL4612962 assay format
CHEMBL4636475 OBDepict H 3 C O N H HN S N N O O H 3 C N N H 3 C H 3 C O IC50 = 3.0 nM 454.51 COc1cc(NS(C)(=O)=O)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL4612962 assay format
CHEMBL4645267 OBDepict H 3 C O N H N N N N N H 3 C N H 3 C O IC50 = 4.0 nM 535.65 COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(Cc1ccccc1)c1ccccc1C(=O)N2C Homo sapiens CHEMBL4612962 assay format
CHEMBL4640016 OBDepict H 3 C O N H NH O N N N N H 3 C N H 3 C O F F F IC50 = 10.0 nM 569.59 COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2CC(F)(F)F Homo sapiens CHEMBL4612962 assay format
CHEMBL1673041 OBDepict H 3 C O N H N N N O N N H 3 C H 3 C O IC50 = 11.0 nM 446.51 COc1cc(N2CCOCC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL4612962 assay format
CHEMBL1673039 OBDepict H 3 C O N H N N N N N H 3 C N H 3 C H 3 C O IC50 = 11.0 nM 459.55 COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL4612962 assay format
CHEMBL4636072 OBDepict H 3 C O N H N N N N N H 3 C N CH 3 O IC50 = 14.0 nM 499.62 COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C1CCC1)c1ccccc1C(=O)N2C Homo sapiens CHEMBL4612962 assay format
CHEMBL4639395 OBDepict H 3 C O N H N N N N N H 3 C N H 3 C O F F F IC50 = 17.0 nM 527.55 COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2CC(F)(F)F Homo sapiens CHEMBL4612962 assay format
CHEMBL1673053 OBDepict H 3 C O N H N N N N N H 3 C N CH 3 O IC50 = 26.0 nM 513.65 COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)c1ccccc1C(=O)N2C Homo sapiens CHEMBL4612962 assay format
CHEMBL4648947 OBDepict CH 3 N H 3 C N N O N N H H 3 C O CH 3 N N H 3 C IC50 = 32.0 nM 501.64 CCC(C)N1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3OC)nc21 Homo sapiens CHEMBL4612962 assay format
CHEMBL4644273 OBDepict CH 3 O N H N H S N N O O CH 3 N N H 3 C CH 3 O IC50 = 36.0 nM 468.54 CCN1C(=O)c2ccccc2N(C)c2nc(Nc3ccc(NS(C)(=O)=O)cc3OC)ncc21 Homo sapiens CHEMBL4612962 assay format
CHEMBL4634025 OBDepict HO N CH 3 N H N N N N H 3 C H 3 C O IC50 = 37.0 nM 444.54 Cc1cc(N2CCC(O)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL4612962 assay format
CHEMBL1673042 OBDepict H 3 C O N H N N N HN N N H 3 C H 3 C O IC50 = 52.0 nM 445.53 COc1cc(N2CCNCC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL4612962 assay format
CHEMBL4647792 OBDepict CH 3 O HN N O N N N N N H 3 C CH 3 O N CH 3 IC50 = 58.0 nM 570.7 COc1cc(C(=O)N2CCN(C3CCN(C)CC3)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL4612962 assay format
CHEMBL1673052 OBDepict H 3 C O N H N N N N N H 3 C N H 3 C H 3 C CH 3 O IC50 = 71.0 nM 487.61 COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C(C)C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL4612962 assay format
CHEMBL4641263 OBDepict H 3 C O N H HN S N N O O H 3 C N N H 3 C O F F F IC50 = 80.0 nM 522.51 COc1cc(NS(C)(=O)=O)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2CC(F)(F)F Homo sapiens CHEMBL4612962 assay format
CHEMBL1673040 OBDepict H 3 C O N H N N N N HO N H 3 C H 3 C O IC50 = 97.0 nM 460.54 COc1cc(N2CCC(O)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL4612962 assay format
CHEMBL4648454 OBDepict H 3 C O N H N N N N N N H 3 C H 3 C O N H 3 C IC50 = 104.0 nM 542.69 COc1cc(N2CCN(C3CCN(C)CC3)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL4612962 assay format
CHEMBL4649424 OBDepict HO N N H N N N N H 3 C H 3 C O IC50 = 109.0 nM 430.51 CN1C(=O)c2ccccc2N(C)c2nc(Nc3ccc(N4CCC(O)CC4)cc3)ncc21 Homo sapiens CHEMBL4612962 assay format
CHEMBL3904942 OBDepict H 3 C N N N O N N H H 3 C S O O H 2 N IC50 = 111.0 nM 410.46 CN1C(=O)c2ccccc2N(C)c2nc(Nc3cccc(S(N)(=O)=O)c3)ncc21 Homo sapiens CHEMBL4612962 assay format
CHEMBL4646882 OBDepict H 3 C O N H NH O N N N N H 3 C N H 3 C CH 3 H 3 C O IC50 = 126.0 nM 529.65 COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C(C)C Homo sapiens CHEMBL4612962 assay format
CHEMBL1673051 OBDepict CH 3 O N H N N N N N H 3 C N CH 3 H 3 C O IC50 = 154.0 nM 473.58 CCN1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3OC)nc21 Homo sapiens CHEMBL4612962 assay format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 173.0 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328382 single protein format
CHEMBL1673047 OBDepict CH 3 N N N O N N H H 3 C S O O NH 2 IC50 = 187.0 nM 410.46 CN1C(=O)c2ccccc2N(C)c2nc(Nc3ccc(S(N)(=O)=O)cc3)ncc21 Homo sapiens CHEMBL4612962 assay format
CHEMBL4645722 OBDepict H 3 C N N O N H CH 3 H 3 C N N N N H 3 C O F F F IC50 = 214.0 nM 555.61 CC(C)Oc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2CC(F)(F)F Homo sapiens CHEMBL4612962 assay format
CHEMBL4649318 OBDepict H 3 C O N H N N N N N H 3 C N H 3 C CH 3 H 3 C O IC50 = 411.0 nM 487.61 COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C(C)C Homo sapiens CHEMBL4612962 assay format
CHEMBL4632948 OBDepict HO N O N H CH 3 H 3 C N N N N H 3 C H 3 C O IC50 = 510.0 nM 488.59 CC(C)Oc1cc(N2CCC(O)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL4612962 assay format
CHEMBL1673046 OBDepict CH 3 O N H N N N N HO N H 3 C H 3 C O IC50 = 716.0 nM 474.57 CCOc1cc(N2CCC(O)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL4612962 assay format