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O15151 | MDM4_HUMAN | Protein Mdm4 (MDM4)

3D structures mapped by conservation among orthologs

[ Domain: "SWIB/MDM2 domain" // SWIB ]

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[ Domain: "Rubredoxin-related" // zf-RanBP ]

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[ Domain: "RING/U-box" // zf-C3HC4_3 ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4068667 OBDepict O NH H CH 3 O OH O N H N IC50 = 3.3 nM 461.56 CC(CC(=O)N[C@@H](Cc1ccc(OCCCNc2ccccn2)cc1)C(=O)O)c1ccccc1 Homo sapiens CHEMBL4019947 cell-based format
CHEMBL4065471 OBDepict O NH H O HO O N H N IC50 = 4.6 nM 599.73 O=C(CC(c1ccccc1)(c1ccccc1)c1ccccc1)N[C@@H](Cc1ccc(OCCCNc2ccccn2)cc1)C(=O)O Homo sapiens CHEMBL4019947 cell-based format
CHEMBL4095983 OBDepict O NH H O HO O HN N IC50 = 6.1 nM 523.63 O=C(CC(c1ccccc1)c1ccccc1)N[C@@H](Cc1ccc(OCCCNc2ccccn2)cc1)C(=O)O Homo sapiens CHEMBL4019947 cell-based format
CHEMBL4105199 OBDepict H 3 C O O N H H O OH IC50 = 10.4 nM 479.58 COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1 Homo sapiens CHEMBL4019947 cell-based format
CHEMBL4095042 OBDepict O N H H O OH Cl IC50 = 10.7 nM 407.9 O=C(CC(c1ccccc1)c1ccccc1)N[C@@H](Cc1ccc(Cl)cc1)C(=O)O Homo sapiens CHEMBL4019947 cell-based format
CHEMBL4165669 OBDepict O NH N H H N H O O O HO CH 3 H NH HN NH 2 IC50 = 12.1 nM 454.49 C[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)c1cccc(NC(=N)N)c1)c1ccccc1 Homo sapiens CHEMBL4145047 cell-based format
CHEMBL4080951 OBDepict CH 3 O O NH H O OH IC50 = 22.8 nM 403.48 COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CC(c1ccccc1)c1ccccc1 Homo sapiens CHEMBL4019947 cell-based format
CHEMBL3220312 OBDepict HO NH HO O N O N H O F F N H CH 3 Cl IC50 = 25.0 nM 518.9 Cc1c(Cl)ccc2c(/C=C3NC(=O)N(C(C(=O)NC(CO)CO)c4ccc(F)c(F)c4)C3=O)c[nH]c12 Homo sapiens CHEMBL3223533 single protein format
CHEMBL4064911 OBDepict O NH H O HO O IC50 = 55.8 nM 479.58 O=C(CC(c1ccccc1)c1ccccc1)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)O Homo sapiens CHEMBL4019947 cell-based format
CHEMBL4170132 OBDepict O HN N H H N H O O O OH N H NH H 2 N IC50 = 57.5 nM 504.55 N=C(N)Nc1cccc(C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)NCCc2ccc3ccccc3c2)c1 Homo sapiens CHEMBL4145047 cell-based format
CHEMBL4169540 OBDepict O HN N H H N H O O O OH N H NH H 2 N IC50 = 77.4 nM 516.56 N=C(N)Nc1cccc(C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)NC(c2ccccc2)c2ccccc2)c1 Homo sapiens CHEMBL4145047 cell-based format
CHEMBL4162220 OBDepict O NH N H H N H O O O HO N H HN NH 2 IC50 = 81.9 nM 476.49 N=C(N)Nc1cccc(C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)Nc2cccc3ccccc23)c1 Homo sapiens CHEMBL4145047 cell-based format
CHEMBL4100348 OBDepict O N H H O OH + N O _ O IC50 = 87.9 nM 418.45 O=C(CC(c1ccccc1)c1ccccc1)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O Homo sapiens CHEMBL4019947 cell-based format
CHEMBL4102803 OBDepict O N H H O OH OH IC50 = 136.4 nM 389.45 O=C(CC(c1ccccc1)c1ccccc1)N[C@H](Cc1ccc(O)cc1)C(=O)O Homo sapiens CHEMBL4019947 cell-based format
CHEMBL4074577 OBDepict O N H H O OH IC50 = 140.0 nM 373.45 O=C(CC(c1ccccc1)c1ccccc1)N[C@@H](Cc1ccccc1)C(=O)O Homo sapiens CHEMBL4019947 cell-based format
CHEMBL3691722 OBDepict H 2 N N O N H 3 C H 3 C CH 3 O N H 3 C CH 3 Cl Cl IC50 = 150.2 nM 549.5 COc1ccc(CN)cc1-n1nc2c(c1C(C)C)C(c1ccc(Cl)cc1C)N(c1cc(Cl)ccc1C)C2=O Homo sapiens CHEMBL3707531 single protein format
CHEMBL3653161 OBDepict N O N N H 3 C H 3 C CH 3 O N H 3 C CH 3 Cl Cl IC50 = 175.0 nM 545.47 COc1ccc(C#N)cc1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1C)N(c1cc(Cl)ccc1C)C2=O Homo sapiens CHEMBL3707750 single protein format
CHEMBL3653167 OBDepict CH 3 O N N N H O H 3 C CH 3 H 3 C O N H 3 C CH 3 Cl Cl IC50 = 179.0 nM 577.51 CNC(=O)c1ccc(OC)c(-c2nc3c(n2C(C)C)C(c2ccc(Cl)cc2C)N(c2cc(Cl)ccc2C)C3=O)c1 Homo sapiens CHEMBL3707750 single protein format
CHEMBL3735996 OBDepict Cl N N O HO H Cl Ki = 200.0 nM 511.41 O=C(O)c1[nH]c2cc(Cl)ccc2c1-c1c(-c2ccccc2)c2ccccc2n1Cc1ccc(Cl)cc1 Homo sapiens CHEMBL3737264 single protein format
CHEMBL4073512 OBDepict O N H H O OH NH 2 IC50 = 207.4 nM 388.47 Nc1ccc(C[C@H](NC(=O)CC(c2ccccc2)c2ccccc2)C(=O)O)cc1 Homo sapiens CHEMBL4019947 cell-based format
CHEMBL4084848 OBDepict O N H H O OH OH IC50 = 214.5 nM 389.45 O=C(CC(c1ccccc1)c1ccccc1)N[C@@H](Cc1ccc(O)cc1)C(=O)O Homo sapiens CHEMBL4019947 cell-based format
CHEMBL4164619 OBDepict O NH N H H N H O O O HO N H HN NH 2 IC50 = 219.0 nM 454.49 N=C(N)Nc1cccc(C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)NCCc2ccccc2)c1 Homo sapiens CHEMBL4145047 cell-based format
CHEMBL3653166 OBDepict CH 3 O N N N O H 3 C CH 3 CH 3 H 3 C O N H 3 C CH 3 Cl Cl IC50 = 229.0 nM 591.54 COc1ccc(C(=O)N(C)C)cc1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1C)N(c1cc(Cl)ccc1C)C2=O Homo sapiens CHEMBL3707750 single protein format
CHEMBL4173995 OBDepict O NH N H H N H O O O HO N H HN NH 2 Cl IC50 = 302.0 nM 474.91 N=C(N)Nc1cccc(C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)NCc2ccc(Cl)cc2)c1 Homo sapiens CHEMBL4145047 cell-based format
CHEMBL3653174 OBDepict HO O N N H 3 C H 3 C CH 3 O N H 3 C CH 3 Cl Cl IC50 = 340.0 nM 550.49 COc1ccc(CO)cc1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1C)N(c1cc(Cl)ccc1C)C2=O Homo sapiens CHEMBL3707750 single protein format
CHEMBL4092607 OBDepict O N H H O OH O H 3 C H 3 C CH 3 IC50 = 401.0 nM 445.56 CC(C)(C)Oc1ccc(C[C@H](NC(=O)CC(c2ccccc2)c2ccccc2)C(=O)O)cc1 Homo sapiens CHEMBL4019947 cell-based format
CHEMBL3653159 OBDepict CH 3 O F N N H 3 C CH 3 O N H 3 C CH 3 Cl Cl IC50 = 411.0 nM 538.45 COc1cccc(F)c1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1C)N(c1cc(Cl)ccc1C)C2=O Homo sapiens CHEMBL3707750 single protein format
CHEMBL3691721 OBDepict N N O N H 3 C H 3 C CH 3 O N H 3 C CH 3 Cl Cl IC50 = 452.0 nM 545.47 COc1ccc(C#N)cc1-n1nc2c(c1C(C)C)C(c1ccc(Cl)cc1C)N(c1cc(Cl)ccc1C)C2=O Homo sapiens CHEMBL3707531 single protein format
CHEMBL3653158 OBDepict CH 3 O N N F H 3 C CH 3 O N H 3 C CH 3 Cl Cl IC50 = 468.0 nM 538.45 COc1ccc(F)cc1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1C)N(c1cc(Cl)ccc1C)C2=O Homo sapiens CHEMBL3707750 single protein format
CHEMBL3691739 OBDepict CH 3 O N N H 3 C CH 3 O N H CH 3 O Cl Cl N H 3 C CH 3 IC50 = 489.1 nM 593.55 COc1ccccc1-n1nc2c(c1C(C)C)[C@H](c1ccc(Cl)cc1C)N(c1cc(Cl)ccc1OCCN(C)C)C2=O Homo sapiens CHEMBL3707531 single protein format
CHEMBL3691702 OBDepict CH 3 O N N N O H 3 C CH 3 CH 3 H 3 C O N H 3 C CH 3 Cl Cl IC50 = 500.6 nM 591.54 COc1ccc(C(=O)N(C)C)cc1-n1nc2c(c1C(C)C)C(c1ccc(Cl)cc1C)N(c1cc(Cl)ccc1C)C2=O Homo sapiens CHEMBL3707531 single protein format
CHEMBL3691710 OBDepict CH 3 O N N N H O H 3 C CH 3 H 3 C O N H 3 C N Cl CH 3 Cl O IC50 = 505.1 nM 594.5 CNC(=O)c1ccc(OC)c(-n2nc3c(c2C(C)C)C(c2ccc(Cl)cc2C)N(c2cc(Cl)c(=O)n(C)c2)C3=O)c1 Homo sapiens CHEMBL3707531 single protein format
CHEMBL3653164 OBDepict CH 3 O N N O CH 3 N N H 3 C CH 3 O N H 3 C CH 3 Cl Cl IC50 = 530.0 nM 552.46 COc1ncc(-c2nc3c(n2C(C)C)C(c2ccc(Cl)cc2C)N(c2cc(Cl)ccc2C)C3=O)c(OC)n1 Homo sapiens CHEMBL3707750 single protein format
CHEMBL3653162 OBDepict CH 3 O N N H 3 C CH 3 O N CH 3 CH 3 Cl Cl IC50 = 534.0 nM 520.46 COc1ccccc1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1C)N(c1cc(Cl)ccc1C)C2=O Homo sapiens CHEMBL3707750 single protein format
CHEMBL3687290 OBDepict H 3 C O N N CH 3 H 3 C O N F F Cl F IC50 = 585.3 nM 511.93 COc1ccccc1-n1nc2c(c1C(C)C)C(c1ccc(F)c(F)c1)N(c1cccc(Cl)c1F)C2=O Homo sapiens CHEMBL3707531 single protein format
CHEMBL3691709 OBDepict H 3 C O N N CH 3 CH 3 O N CH 3 N Cl Cl O H 3 C IC50 = 625.4 nM 551.47 CCn1cc(N2C(=O)c3nn(-c4ccccc4OC)c(C(C)C)c3C2c2ccc(Cl)cc2C)cc(Cl)c1=O Homo sapiens CHEMBL3707531 single protein format
CHEMBL3217780 OBDepict S N H HN O O N + N O _ O IC50 = 630.0 nM 494.53 O=C1NC(=S)NC(=O)C1=Cc1cc(-c2ccccc2)n(-c2ccc([N+](=O)[O-])cc2)c1-c1ccccc1 Homo sapiens CHEMBL3227585 single protein format
CHEMBL3691697 OBDepict CH 3 O N N N H O H 3 C CH 3 H 3 C O N H 3 C CH 3 Cl Cl IC50 = 649.8 nM 577.51 CNC(=O)c1ccc(OC)c(-n2nc3c(c2C(C)C)C(c2ccc(Cl)cc2C)N(c2cc(Cl)ccc2C)C3=O)c1 Homo sapiens CHEMBL3707531 single protein format
CHEMBL3220103 OBDepict O N H HN O O N + N O _ O IC50 = 680.0 nM 478.46 O=C1NC(=O)C(=Cc2cc(-c3ccccc3)n(-c3ccc([N+](=O)[O-])cc3)c2-c2ccccc2)C(=O)N1 Homo sapiens CHEMBL3227585 single protein format
CHEMBL3691737 OBDepict CH 3 O N N H 3 C CH 3 O N H H 3 C CH 3 Cl Cl IC50 = 699.9 nM 520.46 COc1ccccc1-n1nc2c(c1C(C)C)[C@H](c1ccc(Cl)cc1C)N(c1cc(Cl)ccc1C)C2=O Homo sapiens CHEMBL3707531 single protein format
CHEMBL3653160 OBDepict Cl CH 3 N N O N CH 3 H 3 C H 3 C Cl O F F F IC50 = 703.0 nM 574.43 Cc1cc(Cl)ccc1C1c2c(nc(-c3ccccc3OC(F)(F)F)n2C(C)C)C(=O)N1c1cc(Cl)ccc1C Homo sapiens CHEMBL3707750 single protein format
CHEMBL3653220 OBDepict CH 3 O N N H 3 C CH 3 O N CH 3 F Cl Cl IC50 = 710.0 nM 524.42 COc1ccccc1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1C)N(c1cccc(Cl)c1F)C2=O Homo sapiens CHEMBL3707750 single protein format
CHEMBL3653176 OBDepict HO O N N H 3 C H 3 C CH 3 O N F Cl Cl IC50 = 760.0 nM 540.42 COc1ccc(CO)cc1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1)N(c1cccc(Cl)c1F)C2=O Homo sapiens CHEMBL3707750 single protein format
CHEMBL3653172 OBDepict CH 3 O N N N H 3 C CH 3 O N CH 3 CH 3 Cl Cl IC50 = 790.0 nM 521.45 COc1cnccc1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1C)N(c1cc(Cl)ccc1C)C2=O Homo sapiens CHEMBL3707750 single protein format
CHEMBL4177354 OBDepict O NH N H H N H O O O HO N H HN NH 2 IC50 = 812.0 nM 530.59 N=C(N)Nc1cccc(C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)NCC(c2ccccc2)c2ccccc2)c1 Homo sapiens CHEMBL4145047 cell-based format
CHEMBL4163249 OBDepict O NH N H H N H O O O HO N H HN NH 2 IC50 = 836.0 nM 440.46 N=C(N)Nc1cccc(C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)NCc2ccccc2)c1 Homo sapiens CHEMBL4145047 cell-based format
CHEMBL3691708 OBDepict CH 3 O N O N Cl O N N CH 3 H 3 C CH 3 Cl O CH 3 IC50 = 838.1 nM 581.5 COCCn1cc(N2C(=O)c3nn(-c4ccccc4OC)c(C(C)C)c3C2c2ccc(Cl)cc2C)cc(Cl)c1=O Homo sapiens CHEMBL3707531 single protein format
CHEMBL3347643 OBDepict CH 3 O O Cl O O CH 3 N O N CH 3 IC50 = 847.4 nM 428.87 CCOc1cc(/C=C2C(=O)N(c3ccccc3)N=C2C)cc(Cl)c1OCC(=O)OC Homo sapiens CHEMBL4019947 cell-based format
CHEMBL3220102 OBDepict N N O HN O N H S IC50 = 900.0 nM 474.55 N#Cc1ccc(-n2c(-c3ccccc3)cc(C=C3C(=O)NC(=S)NC3=O)c2-c2ccccc2)cc1 Homo sapiens CHEMBL3227585 single protein format
CHEMBL3657117 OBDepict H 3 C O N CH 3 H N H N N O N O H 3 C O H 3 C Cl Cl F IC50 = 950.0 nM 572.42 COC[C@@H](C)n1c(-c2cnc(OC)nc2OC)nc2c1[C@H](c1ccc(Cl)cc1)N(c1ccc(F)c(Cl)c1)C2=O Homo sapiens CHEMBL3707750 single protein format