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O15164 | TIF1A_HUMAN | Transcription intermediary factor 1-alpha (TRIM24)

3D structures mapped by conservation among orthologs

[ Domain: "FYVE/PHD zinc finger" // PHD_1 ]

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[ Domain: "Bromodomain" // Bromodomain ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3775251 OBDepict NH 2 O O O CH 3 HN N S N CH 3 O O N N H 3 C H 3 C O IC50 = 7.9 nM 558.66 CCCOc1cc(OCCCCN)cc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)cn2)n(C)c(=O)n3C)c1 Homo sapiens CHEMBL3779310 cell-based format
CHEMBL3775901 OBDepict NH 2 O O O CH 3 HN N S CH 3 N O O N N H 3 C O H 3 C IC50 = 10.0 nM 586.72 CCCOc1cc(OCCCCCCN)cc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)cn2)n(C)c(=O)n3C)c1 Homo sapiens CHEMBL3779310 cell-based format
CHEMBL3775348 OBDepict NH 2 O O O CH 3 HN N S N CH 3 O O N N H 3 C H 3 C O IC50 = 11.0 nM 572.69 CCCOc1cc(OCCCCCN)cc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)cn2)n(C)c(=O)n3C)c1 Homo sapiens CHEMBL3779310 cell-based format
CHEMBL3775853 OBDepict CH 3 O O HN N S N CH 3 O O O O H 3 C H 3 C H 3 C O IC50 = 43.0 nM 527.6 CCCOc1cccc(Oc2cc3c(cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)n(C)c(=O)n3C)c1 Homo sapiens CHEMBL3779310 cell-based format
CHEMBL3775073 OBDepict CH 3 O O HN N S N CH 3 O O N N H 3 C H 3 C H 3 C O IC50 = 53.0 nM 485.57 CCCOc1cccc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)c(C)n2)n(C)c(=O)n3C)c1 Homo sapiens CHEMBL3779310 cell-based format
CHEMBL3774507 OBDepict CH 3 H 3 C O O NH N S N H 3 C O O N N CH 3 CH 3 H 3 C O IC50 = 57.0 nM 499.59 Cc1nc(S(=O)(=O)Nc2cc3c(cc2Oc2cccc(OCC(C)C)c2)n(C)c(=O)n3C)cn1C Homo sapiens CHEMBL3779310 cell-based format
CHEMBL3774770 OBDepict OH O O O CH 3 HN N S CH 3 N O O N N H 3 C O H 3 C IC50 = 60.0 nM 587.7 CCCOc1cc(OCCCCCCO)cc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)cn2)n(C)c(=O)n3C)c1 Homo sapiens CHEMBL3779310 cell-based format
CHEMBL3775689 OBDepict H 3 C N N S N H O O O N N H 3 C CH 3 O O O IC50 = 100.0 nM 513.58 Cn1cnc(S(=O)(=O)Nc2cc3c(cc2Oc2cccc(OCC4CCOC4)c2)n(C)c(=O)n3C)c1 Homo sapiens CHEMBL3779310 cell-based format
CHEMBL3775132 OBDepict CH 3 H 3 C O O NH N S N H 3 C O O H 3 C O IC50 = 110.0 nM 445.54 CC(C)COc1cccc(Oc2cc3c(cc2NS(=O)(=O)C2CC2)n(C)c(=O)n3C)c1 Homo sapiens CHEMBL3779310 cell-based format
CHEMBL3774529 OBDepict CH 3 O O O HN N S N CH 3 O O N N H 3 C H 3 C H 3 C O IC50 = 130.0 nM 515.59 COCCCOc1cccc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)c(C)n2)n(C)c(=O)n3C)c1 Homo sapiens CHEMBL3779310 cell-based format
CHEMBL4572394 OBDepict O N IC50 = 133.4 nM 175.23 O=Cc1ccc(N2CCCC2)cc1 Homo sapiens CHEMBL4418856 single protein format
CHEMBL18620 OBDepict O IC50 = 135.8 nM 84.12 O=C1CCCC1 Homo sapiens CHEMBL4418856 single protein format
CHEMBL3775263 OBDepict H 3 C O O S H 3 C HN O O O N N CH 3 CH 3 O O IC50 = 140.0 nM 575.64 COc1ccc(S(=O)(=O)Nc2cc3c(cc2Oc2cccc(OCc4ccccc4)c2)n(C)c(=O)n3C)cc1OC Homo sapiens CHEMBL3779310 cell-based format
CHEMBL4467793 OBDepict O N H CH 3 IC50 = 156.6 nM 159.19 Cc1cccc2c(C=O)c[nH]c12 Homo sapiens CHEMBL4418856 single protein format
CHEMBL3774452 OBDepict CH 3 O O HN N S N CH 3 O O N N H 3 C H 3 C H 3 C O IC50 = 160.0 nM 499.59 CCCCOc1cccc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)c(C)n2)n(C)c(=O)n3C)c1 Homo sapiens CHEMBL3779310 cell-based format
CHEMBL13883 OBDepict CH 3 O HO O IC50 = 162.0 nM 152.15 COc1cc(C=O)ccc1O Homo sapiens CHEMBL4418856 single protein format
CHEMBL4592980 OBDepict O O OH IC50 = 164.8 nM 226.23 O=Cc1cccc(-c2ccc(C(=O)O)cc2)c1 Homo sapiens CHEMBL4418856 single protein format
CHEMBL18737 OBDepict O IC50 = 166.3 nM 126.2 O=C1CCCCCCC1 Homo sapiens CHEMBL4418856 single protein format
CHEMBL3774653 OBDepict CH 3 O O HN N S N CH 3 O O N N H 3 C H 3 C H 3 C O IC50 = 180.0 nM 471.54 CCOc1cccc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)c(C)n2)n(C)c(=O)n3C)c1 Homo sapiens CHEMBL3779310 cell-based format
CHEMBL2229659 OBDepict O N CH 3 IC50 = 180.2 nM 109.13 Cn1cccc1C=O Homo sapiens CHEMBL4418856 single protein format
CHEMBL350966 OBDepict CH 3 O HO O IC50 = 219.7 nM 152.15 COc1ccc(C=O)c(O)c1 Homo sapiens CHEMBL4418856 single protein format
CHEMBL3775286 OBDepict H 3 C N N S N H O O O N N H 3 C CH 3 O O IC50 = 220.0 nM 519.58 Cn1cnc(S(=O)(=O)Nc2cc3c(cc2Oc2cccc(OCc4ccccc4)c2)n(C)c(=O)n3C)c1 Homo sapiens CHEMBL3779310 cell-based format
CHEMBL108925 OBDepict O OH IC50 = 221.3 nM 122.12 O=Cc1ccccc1O Homo sapiens CHEMBL4418856 single protein format
CHEMBL543846 OBDepict O OH HO N CH 3 ClH IC50 = 225.2 nM 203.62 Cc1ncc(CO)c(C=O)c1O.Cl Homo sapiens CHEMBL4418856 single protein format
CHEMBL3775640 OBDepict H 3 C N CH 3 N S N H O O O N N H 3 C CH 3 O O IC50 = 270.0 nM 533.61 Cc1nc(S(=O)(=O)Nc2cc3c(cc2Oc2cccc(OCc4ccccc4)c2)n(C)c(=O)n3C)cn1C Homo sapiens CHEMBL3779310 cell-based format
CHEMBL3774883 OBDepict H 3 C O O S H 3 C HN O O O N N CH 3 CH 3 O O N CH 3 H 3 C IC50 = 270.0 nM 584.7 COc1ccc(S(=O)(=O)Nc2cc3c(cc2Oc2cccc(OCCCCN(C)C)c2)n(C)c(=O)n3C)cc1OC Homo sapiens CHEMBL3779310 cell-based format
CHEMBL4580867 OBDepict NH 2 HN O N N N H N N CH 3 N H O IC50 = 303.5 nM 384.44 Cc1nc[nH]c1-c1nc2ccc(C(=O)NN)cn2c1NCCN1CCOCC1 Homo sapiens CHEMBL4418856 single protein format
CHEMBL4470369 OBDepict CH 3 O O N N N H N N H 3 C N H O IC50 = 308.2 nM 384.44 COC(=O)c1ccc2nc(-c3nc[nH]c3C)c(NCCN3CCOCC3)n2c1 Homo sapiens CHEMBL4418856 single protein format
CHEMBL4446283 OBDepict CH 3 O N H N N N H 3 C N H IC50 = 356.0 nM 319.37 COc1ccc(Nc2c(-c3nc[nH]c3C)nc3ccccn23)cc1 Homo sapiens CHEMBL4418856 single protein format
CHEMBL4451080 OBDepict CH 3 O O N N N H N S O O CH 3 IC50 = 415.3 nM 550.64 COC(=O)c1ccc2nc(-c3cn(S(=O)(=O)c4ccc(C)cc4)c4ccccc34)c(NCc3ccccc3)n2c1 Homo sapiens CHEMBL4418856 single protein format
CHEMBL3769965 OBDepict H 3 C O O N H N S N H 3 C O O O O CH 3 CH 3 CH 3 O IC50 = 430.0 nM 499.55 COc1ccc(Oc2cc3c(cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)n(C)c(=O)n3C)cc1 Homo sapiens CHEMBL3771488 cell-based format
CHEMBL3769887 OBDepict H 3 C O O S H 3 C HN O O O N N CH 3 CH 3 O IC50 = 480.0 nM 469.52 COc1ccc(S(=O)(=O)Nc2cc3c(cc2Oc2ccccc2)n(C)c(=O)n3C)cc1OC Homo sapiens CHEMBL3771488 cell-based format
CHEMBL4452179 OBDepict CH 3 O O CH 3 N H N N N S O O H 3 C IC50 = 584.2 nM 566.68 COc1ccc(CCNc2c(-c3cn(S(=O)(=O)c4ccc(C)cc4)c4ccccc34)nc3ccccn23)cc1OC Homo sapiens CHEMBL4418856 single protein format
CHEMBL3770259 OBDepict CH 3 O O HN N S CH 3 N O O O H 3 C IC50 = 730.0 nM 439.49 COc1ccc(Oc2cc3c(cc2NS(=O)(=O)c2ccccc2)n(C)c(=O)n3C)cc1 Homo sapiens CHEMBL3771488 cell-based format
CHEMBL3771002 OBDepict H 3 C O S HN O O O N N CH 3 CH 3 O IC50 = 740.0 nM 439.49 COc1ccc(S(=O)(=O)Nc2cc3c(cc2Oc2ccccc2)n(C)c(=O)n3C)cc1 Homo sapiens CHEMBL3771488 cell-based format
CHEMBL4461534 OBDepict H N N H 3 C N N H N N O IC50 = 746.4 nM 326.4 Cc1[nH]cnc1-c1nc2ccccn2c1NCCN1CCOCC1 Homo sapiens CHEMBL4418856 single protein format
CHEMBL3770456 OBDepict H 3 C O O HN N S CH 3 N O O O H 3 C O CH 3 IC50 = 770.0 nM 469.52 COc1ccc(Oc2cc3c(cc2NS(=O)(=O)c2ccc(OC)cc2)n(C)c(=O)n3C)cc1 Homo sapiens CHEMBL3771488 cell-based format
CHEMBL4448530 OBDepict CH 3 O N H N N N N Br H H 3 C IC50 = 818.3 nM 398.26 COc1ccc(Nc2c(-c3c[nH]c(C)n3)nc3ccc(Br)cn23)cc1 Homo sapiens CHEMBL4418856 single protein format
CHEMBL4436408 OBDepict H 3 C N CH 3 O N CH 3 N O H IC50 = 910.0 nM 295.34 CN(C)C(=O)c1cccc(-c2cn(C)c(=O)c3[nH]ccc23)c1 Homo sapiens CHEMBL4425870 assay format