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O15264 | MK13_HUMAN | Mitogen-activated protein kinase 13 (MAPK13)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4855542 OBDepict NH 2 N S N O NH IC50 = -43700.0 nM 372.45 Nc1ncc(-c2cccc3ncsc23)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804454 cell-based format
CHEMBL4859660 OBDepict NH 2 N F + N O NH O _ O IC50 = -11000.0 nM 378.36 Nc1ncc(-c2cccc([N+](=O)[O-])c2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804454 cell-based format
CHEMBL4868141 OBDepict H 2 N N O O HN NH S O O IC50 = -8500.0 nM 532.67 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2OC2CCCCC2)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804454 cell-based format
CHEMBL2087507 OBDepict F CH 3 NH O N N N H 3 C IC50 = 0.64 nM 364.42 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C3(C)CC3)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087515 OBDepict F CH 3 NH O N N N Cl N IC50 = 0.83 nM 421.86 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(-c3ccncc3Cl)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087513 OBDepict F CH 3 NH O N N N Cl IC50 = 1.6 nM 420.88 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(-c3ccccc3Cl)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087524 OBDepict H 3 C N CH 3 CH 3 CH 3 N N N CH 3 F N H O IC50 = 1.7 nM 395.48 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)(C)N(C)C)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087509 OBDepict F CH 3 NH O N N N IC50 = 1.9 nM 364.42 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C3CCC3)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087501 OBDepict F H 3 C HN O N N N H 3 C CH 3 H 3 C IC50 = 2.0 nM 366.44 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)(C)C)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087503 OBDepict F CH 3 NH O N N N CH 3 CH 3 IC50 = 3.0 nM 352.41 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)C)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087526 OBDepict F H 3 C HN O N N N HO H 3 C CH 3 IC50 = 3.1 nM 368.41 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)(C)O)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL561932 OBDepict F N N N H 3 C N H O Cl NH O IC50 = 4.0 nM 451.89 Cn1c(=O)cc(Nc2cc(C(=O)NC3CC3)ccc2Cl)c2cnn(-c3ccc(F)cc3)c21 Homo sapiens CHEMBL1063393 single protein format
CHEMBL2087742 OBDepict O N H F CH 3 F F N N N CH 3 CH 3 H 3 C IC50 = 6.2 nM 402.42 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1c(F)cn2c(C(C)(C)C)nnc2c1F Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087512 OBDepict H 3 C N H O N N N Cl IC50 = 6.3 nM 402.89 Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(-c3ccccc3Cl)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087505 OBDepict O HN F CH 3 N N N IC50 = 6.7 nM 350.4 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C3CC3)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087743 OBDepict O N H F CH 3 F F N N N H 3 C CH 3 IC50 = 6.7 nM 388.39 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1c(F)cn2c(C(C)C)nnc2c1F Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087522 OBDepict CH 3 O H 3 C H 3 C N N N CH 3 F N H O IC50 = 9.4 nM 382.44 COC(C)(C)c1nnc2cc(-c3cc(C(=O)NC4CC4)cc(F)c3C)ccn12 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087744 OBDepict O HN F CH 3 F F N N N IC50 = 10.0 nM 386.38 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1c(F)cn2c(C3CC3)nnc2c1F Homo sapiens CHEMBL2092446 single protein format
CHEMBL2170294 OBDepict OH H NH N N N N O F H 3 C IC50 = 11.0 nM 431.47 Cc1ccccc1-n1nc(-c2c(-c3ccc(F)cc3)nn3c2NC[C@@H](CO)C3)ccc1=O Homo sapiens CHEMBL2172908 single protein format
CHEMBL2087746 OBDepict O N H F CH 3 F F N N N H 2 N CH 3 CH 3 IC50 = 12.0 nM 403.41 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1c(F)cn2c(C(C)(C)N)nnc2c1F Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087506 OBDepict CH 3 N H O N N N H 3 C IC50 = 12.0 nM 346.43 Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(C3(C)CC3)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087499 OBDepict H 3 C N H O O N N IC50 = 14.0 nM 375.47 Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(N3CCCCC3)noc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087747 OBDepict O N H F CH 3 F F N N N N CH 3 CH 3 H 3 C H 3 C IC50 = 15.0 nM 431.46 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1c(F)cn2c(C(C)(C)N(C)C)nnc2c1F Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087521 OBDepict F H 3 C HN O N N N H 2 N H 3 C CH 3 IC50 = 15.4 nM 367.43 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)(C)N)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087500 OBDepict CH 3 N H O N N N H 3 C H 3 C CH 3 IC50 = 16.0 nM 348.45 Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)(C)C)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087525 OBDepict F H 3 C HN O N N N N H H 3 C CH 3 S O O CH 3 IC50 = 17.0 nM 445.52 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)(C)NS(C)(=O)=O)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087517 OBDepict CH 3 O H 3 C N N N CH 3 F N H O IC50 = 18.0 nM 368.41 COC(C)c1nnc2cc(-c3cc(C(=O)NC4CC4)cc(F)c3C)ccn12 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087508 OBDepict CH 3 N H O N N N IC50 = 20.0 nM 346.43 Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(C3CCC3)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087745 OBDepict O NH F H 3 C F F N N N Cl N IC50 = 23.0 nM 457.84 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1c(F)cn2c(-c3ccncc3Cl)nnc2c1F Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087504 OBDepict O HN CH 3 N N N IC50 = 26.0 nM 332.41 Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(C3CC3)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087502 OBDepict CH 3 N H O N N N CH 3 H 3 C IC50 = 27.0 nM 334.42 Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)C)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL3895054 OBDepict O N H N H N N S N CH 3 CH 3 H 3 C N H 3 C O IC50 = 27.54 nM 468.63 Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ncc(CCN3CCOCC3)s2)cc1 Homo sapiens CHEMBL3887599 single protein format
CHEMBL2087511 OBDepict F H 3 C HN O N N N O IC50 = 30.0 nM 394.45 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C3CCOCC3)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087514 OBDepict H 3 C N H O N N N Cl N IC50 = 38.0 nM 403.87 Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(-c3ccncc3Cl)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL4568087 OBDepict H 3 C N N N N N S N H O H H H 2 N IC50 = 39.0 nM 421.53 Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479745 assay format
CHEMBL2087516 OBDepict CH 3 O H 3 C N N N CH 3 N H O IC50 = 43.0 nM 350.42 COC(C)c1nnc2cc(-c3cc(C(=O)NC4CC4)ccc3C)ccn12 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087741 OBDepict O N H CH 3 F F N N N CH 3 CH 3 H 3 C IC50 = 49.0 nM 384.43 Cc1ccc(C(=O)NC2CC2)cc1-c1c(F)cn2c(C(C)(C)C)nnc2c1F Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087510 OBDepict H 3 C N H O N N N O IC50 = 56.0 nM 376.46 Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(C3CCOCC3)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL1198626 OBDepict F F S N N N CH 3 CH 3 H 3 C IC50 = 62.0 nM 319.38 CC(C)(C)c1nnc2ccc(Sc3ccc(F)cc3F)cn12 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087519 OBDepict F H 3 C HN O N N N F F F IC50 = 85.0 nM 378.33 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(F)(F)F)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL2087520 OBDepict F CH 3 NH O N N N O NH 2 IC50 = 102.0 nM 353.36 Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(N)=O)nnc2c1 Homo sapiens CHEMBL2092446 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 160.0 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328537 single protein format
CHEMBL4552628 OBDepict Cl N N N H 3 C S N H O H H H 2 N F F IC50 = 160.0 nM 425.89 Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12 Homo sapiens CHEMBL4479745 assay format
CHEMBL4793380 OBDepict O NH N H N O H 3 C H 3 C CH 3 N H N O N HN IC50 = 214.0 nM 423.48 CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 Homo sapiens CHEMBL4767015 single protein format
CHEMBL2087523 OBDepict CH 3 N H O CH 3 CH 3 N N N CH 3 F N H O IC50 = 253.0 nM 409.47 CC(=O)NC(C)(C)c1nnc2cc(-c3cc(C(=O)NC4CC4)cc(F)c3C)ccn12 Homo sapiens CHEMBL2092446 single protein format
CHEMBL3948841 OBDepict O HN N H N N CH 3 CH 3 CH 3 O H 3 C N IC50 = 280.5 nM 441.54 Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccncc3)cc2)cc1 Homo sapiens CHEMBL3887599 single protein format
CHEMBL103667 OBDepict O HN N H N N CH 3 CH 3 CH 3 O H 3 C N O IC50 = 300.0 nM 527.67 Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 Homo sapiens CHEMBL1931521 single protein format
CHEMBL4281823 OBDepict CH 3 N N N NH 2 N O O F F F IC50 = 347.0 nM 481.48 CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL4261429 single protein format
CHEMBL2380845 OBDepict O N H N H N N H O IC50 = 411.0 nM 406.45 O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccccc1 Homo sapiens CHEMBL2382832 single protein format
CHEMBL472620 OBDepict O HN N H N CH 3 N H 3 C CH 3 H 3 C O N IC50 = 619.5 nM 365.44 Cn1nc(C(C)(C)C)cc1NC(=O)Nc1ccc(Oc2ccncc2)cc1 Homo sapiens CHEMBL3887599 single protein format
CHEMBL2087518 OBDepict CH 3 N H O N N N F F F IC50 = 853.0 nM 360.34 Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(C(F)(F)F)nnc2c1 Homo sapiens CHEMBL2092446 single protein format