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O15496 | PA2GX_HUMAN | Group 10 secretory phospholipase A2 (PLA2G10)

3D structures mapped by conservation among orthologs

[ Domain: "Phospholipase A2, PLA2" // Phospholip_A2_1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL477548 OBDepict CH 3 CH 3 N O O H 2 N O N H O S O O CH 3 IC50 = 7.0 nM 485.56 CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(C)(=O)=O)cccc2n1Cc1ccccc1 Homo sapiens CHEMBL990836 single protein format
CHEMBL514705 OBDepict H 3 C H 3 C N O O NH 2 O O OH IC50 = 10.0 nM 458.51 CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cc3ccccc3c2n1Cc1ccccc1 Homo sapiens CHEMBL990836 single protein format
CHEMBL514656 OBDepict CH 3 CH 3 N O O H 2 N O HN O S O O CH 3 IC50 = 11.0 nM 561.66 Cc1ccccc1S(=O)(=O)NC(=O)COc1cccc2c1c(C(=O)C(N)=O)c(CC(C)C)n2Cc1ccccc1 Homo sapiens CHEMBL990836 single protein format
CHEMBL4215835 OBDepict OH O CH 3 N N O H 2 N O F F F IC50 = 14.0 nM 407.35 CC(CC(=O)O)c1cccc(-n2c(C(N)=O)cc3ccc(OC(F)(F)F)cc32)n1 Homo sapiens CHEMBL4199509 single protein format
CHEMBL474874 OBDepict CH 3 H 3 C N O O NH 2 O N H O S O O Cl IC50 = 14.0 nM 582.08 CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3Cl)cccc2n1Cc1ccccc1 Homo sapiens CHEMBL990836 single protein format
CHEMBL4210991 OBDepict OH O CH 3 H N O H 2 N O F F F IC50 = 15.0 nM 406.36 C[C@@H](CC(=O)O)c1cccc(-n2c(C(N)=O)cc3ccc(OC(F)(F)F)cc32)c1 Homo sapiens CHEMBL4199509 single protein format
CHEMBL514692 OBDepict H 3 C N O O H 2 N O N H O S O O IC50 = 15.0 nM 519.58 CCc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cccc2n1Cc1ccccc1 Homo sapiens CHEMBL990836 single protein format
CHEMBL515637 OBDepict H 3 C N O O H 2 N O O OH IC50 = 20.0 nM 430.46 CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cc3ccccc3c2n1Cc1ccccc1 Homo sapiens CHEMBL990836 single protein format
CHEMBL148649 OBDepict H 3 C N O O H 2 N O H 3 C O HO IC50 = 22.0 nM 394.43 CCc1c(C(=O)C(N)=O)c2c(OC(C)C(=O)O)cccc2n1Cc1ccccc1 Homo sapiens CHEMBL990836 single protein format
CHEMBL4171084 OBDepict OH O N O H 2 N O F F F IC50 = 26.0 nM 392.33 NC(=O)c1cc2ccc(OC(F)(F)F)cc2n1-c1cccc(CCC(=O)O)c1 Homo sapiens CHEMBL4151113 assay format
CHEMBL4217510 OBDepict OH O N N O H 2 N O F F F IC50 = 29.0 nM 393.32 NC(=O)c1cc2ccc(OC(F)(F)F)cc2n1-c1cccc(CCC(=O)O)n1 Homo sapiens CHEMBL4199509 single protein format
CHEMBL506485 OBDepict CH 3 H 3 C N O O NH 2 O N H O S O O IC50 = 30.0 nM 597.69 CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cc3ccccc3c2n1Cc1ccccc1 Homo sapiens CHEMBL990836 single protein format
CHEMBL477549 OBDepict CH 3 H 3 C N O O NH 2 O N H O S O O F F F IC50 = 30.0 nM 539.53 CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)C(F)(F)F)cccc2n1Cc1ccccc1 Homo sapiens CHEMBL990836 single protein format
CHEMBL4214052 OBDepict OH O CH 3 N O NH 2 O F F F IC50 = 32.0 nM 406.36 CC(Cc1cccc(-n2c(C(N)=O)cc3ccc(OC(F)(F)F)cc32)c1)C(=O)O Homo sapiens CHEMBL4199509 single protein format
CHEMBL4204172 OBDepict CH 3 O O OH N O H 2 N O F F F IC50 = 39.0 nM 422.36 COC(Cc1cccc(-n2c(C(N)=O)cc3ccc(OC(F)(F)F)cc32)c1)C(=O)O Homo sapiens CHEMBL4199509 single protein format
CHEMBL4176544 OBDepict OH O N O H 2 N F F F IC50 = 43.0 nM 376.33 NC(=O)c1cc2ccc(C(F)(F)F)cc2n1-c1cccc(CCC(=O)O)c1 Homo sapiens CHEMBL4151113 assay format
CHEMBL504813 OBDepict H 3 C H 3 C N O O NH 2 O O OH IC50 = 50.0 nM 408.45 CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1ccccc1 Homo sapiens CHEMBL990836 single protein format
CHEMBL4205511 OBDepict OH O CH 3 N N O NH 2 O F F F IC50 = 65.0 nM 407.35 CC(Cc1cccc(-n2c(C(N)=O)cc3ccc(OC(F)(F)F)cc32)n1)C(=O)O Homo sapiens CHEMBL4199509 single protein format
CHEMBL4160483 OBDepict OH O N O H 2 N O F F IC50 = 68.0 nM 374.34 NC(=O)c1cc2ccc(OC(F)F)cc2n1-c1cccc(CCC(=O)O)c1 Homo sapiens CHEMBL4151113 assay format
CHEMBL148674 OBDepict H 3 C N O O H 2 N O O OH IC50 = 75.0 nM 380.4 CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1ccccc1 Homo sapiens CHEMBL860950 single protein format
CHEMBL208315 OBDepict H 3 C N O O H 2 N O CH 3 O OH IC50 = 75.0 nM 394.43 CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cc(C)cc2n1Cc1ccccc1 Homo sapiens CHEMBL860950 single protein format
CHEMBL477156 OBDepict CH 3 H 3 C N O O NH 2 O H 3 C N H O S O O IC50 = 80.0 nM 561.66 CC(C)Cc1c(C(=O)C(N)=O)c2c(OC(C)C(=O)NS(=O)(=O)c3ccccc3)cccc2n1Cc1ccccc1 Homo sapiens CHEMBL990836 single protein format
CHEMBL4172222 OBDepict HO O N O NH 2 Cl IC50 = 90.0 nM 342.78 NC(=O)c1cc2ccc(Cl)cc2n1-c1cccc(CCC(=O)O)c1 Homo sapiens CHEMBL4151113 assay format
CHEMBL446349 OBDepict CH 3 N O O NH 2 O HN O S O O IC50 = 90.0 nM 569.64 CCc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cc3ccccc3c2n1Cc1ccccc1 Homo sapiens CHEMBL990836 single protein format
CHEMBL4175583 OBDepict OH O N O H 2 N O F F F IC50 = 93.0 nM 406.36 NC(=O)c1cc2ccc(OCC(F)(F)F)cc2n1-c1cccc(CCC(=O)O)c1 Homo sapiens CHEMBL4151113 assay format
CHEMBL4174522 OBDepict N N O H 2 N O OH IC50 = 110.0 nM 333.35 N#Cc1ccc2cc(C(N)=O)n(-c3cccc(CCC(=O)O)c3)c2c1 Homo sapiens CHEMBL4151113 assay format
CHEMBL4213094 OBDepict OH O N N O H 2 N O F F F IC50 = 110.0 nM 393.32 NC(=O)c1cc2ccc(OC(F)(F)F)cc2n1-c1cc(CCC(=O)O)ccn1 Homo sapiens CHEMBL4199509 single protein format
CHEMBL152921 OBDepict H 3 C NH O H S O HO IC50 = 120.0 nM 453.65 CCCCCC/C=C/CC(=O)N[C@H](CSc1ccc(Cc2ccccc2)cc1)CC(=O)O Homo sapiens CHEMBL759984 single protein format
CHEMBL477157 OBDepict CH 3 H 3 C N O O NH 2 O N H O S O O Cl IC50 = 140.0 nM 582.08 CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3cccc(Cl)c3)cccc2n1Cc1ccccc1 Homo sapiens CHEMBL990836 single protein format
CHEMBL4205008 OBDepict OH O CH 3 N N O NH 2 O F F F IC50 = 140.0 nM 407.35 CC(Cc1ccnc(-n2c(C(N)=O)cc3ccc(OC(F)(F)F)cc32)c1)C(=O)O Homo sapiens CHEMBL4199509 single protein format
CHEMBL4173359 OBDepict OH O N O NH 2 IC50 = 160.0 nM 348.4 NC(=O)c1cc2ccc(C3CC3)cc2n1-c1cccc(CCC(=O)O)c1 Homo sapiens CHEMBL4151113 assay format
CHEMBL4175643 OBDepict CH 3 N O NH 2 O HO IC50 = 170.0 nM 336.39 CCc1ccc2cc(C(N)=O)n(-c3cccc(CCC(=O)O)c3)c2c1 Homo sapiens CHEMBL4151113 assay format
CHEMBL4203027 OBDepict CH 3 O OH N N O H 2 N O F F F IC50 = 170.0 nM 421.38 CCC(Cc1cccc(-n2c(C(N)=O)cc3ccc(OC(F)(F)F)cc32)n1)C(=O)O Homo sapiens CHEMBL4199509 single protein format
CHEMBL4207266 OBDepict OH O CH 3 H N O H 2 N O F F F IC50 = 200.0 nM 406.36 C[C@H](CC(=O)O)c1cccc(-n2c(C(N)=O)cc3ccc(OC(F)(F)F)cc32)c1 Homo sapiens CHEMBL4199509 single protein format
CHEMBL4171797 OBDepict OH O N O H 2 N CH 3 IC50 = 230.0 nM 322.36 Cc1ccc2cc(C(N)=O)n(-c3cccc(CCC(=O)O)c3)c2c1 Homo sapiens CHEMBL4151113 assay format
CHEMBL4206163 OBDepict OH O N N O H 2 N O F F F IC50 = 240.0 nM 393.32 NC(=O)c1cc2ccc(OC(F)(F)F)cc2n1-c1ccnc(CCC(=O)O)c1 Homo sapiens CHEMBL4199509 single protein format
CHEMBL4161605 OBDepict HO O N O NH 2 F IC50 = 260.0 nM 326.33 NC(=O)c1cc2ccc(F)cc2n1-c1cccc(CCC(=O)O)c1 Homo sapiens CHEMBL4151113 assay format
CHEMBL4457557 OBDepict HO O O NH 2 IC50 = 280.0 nM 359.43 NC(=O)c1ccc(Cc2ccccc2)cc1-c1cccc(CCC(=O)O)c1 Homo sapiens CHEMBL4431157 single protein format
CHEMBL475071 OBDepict CH 3 CH 3 N O O H 2 N O HN O S O O H 3 C IC50 = 320.0 nM 561.66 Cc1ccc(S(=O)(=O)NC(=O)COc2cccc3c2c(C(=O)C(N)=O)c(CC(C)C)n3Cc2ccccc2)cc1 Homo sapiens CHEMBL990836 single protein format
CHEMBL4204160 OBDepict OH O H 3 C CH 3 N N O H 2 N O F F F IC50 = 320.0 nM 421.38 CC(C)(Cc1cccc(-n2c(C(N)=O)cc3ccc(OC(F)(F)F)cc32)n1)C(=O)O Homo sapiens CHEMBL4199509 single protein format
CHEMBL152402 OBDepict CH 3 HN O H S O OH IC50 = 380.0 nM 427.61 CCCCCC/C=C/CC(=O)N[C@@H](CCC(=O)O)CSc1ccc2ccccc2c1 Homo sapiens CHEMBL759984 single protein format
CHEMBL4593409 OBDepict NH 2 O CH 3 H O OH IC50 = 400.0 nM 373.45 C[C@H](Cc1cccc(-c2cc(Cc3ccccc3)ccc2C(N)=O)c1)C(=O)O Homo sapiens CHEMBL4431157 single protein format
CHEMBL4207065 OBDepict OH O O N O NH 2 O F F F IC50 = 430.0 nM 382.29 NC(=O)c1cc2ccc(OC(F)(F)F)cc2n1-c1ccc(CCC(=O)O)o1 Homo sapiens CHEMBL4199509 single protein format
CHEMBL4533403 OBDepict H 3 C O OH O NH 2 IC50 = 430.0 nM 387.48 CCC(Cc1cccc(-c2cc(Cc3ccccc3)ccc2C(N)=O)c1)C(=O)O Homo sapiens CHEMBL4431157 single protein format
CHEMBL514846 OBDepict CH 3 H 3 C N O O NH 2 O N H O S O O Cl IC50 = 540.0 nM 582.08 CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccc(Cl)cc3)cccc2n1Cc1ccccc1 Homo sapiens CHEMBL990836 single protein format
CHEMBL4453126 OBDepict OH O O NH 2 IC50 = 580.0 nM 399.49 NC(=O)c1ccc(Cc2ccccc2)cc1-c1cccc(CC(C(=O)O)C2CC2)c1 Homo sapiens CHEMBL4431157 single protein format
CHEMBL4160502 OBDepict CH 3 O N O NH 2 O HO IC50 = 620.0 nM 338.36 COc1ccc2cc(C(N)=O)n(-c3cccc(CCC(=O)O)c3)c2c1 Homo sapiens CHEMBL4151113 assay format
CHEMBL4451830 OBDepict CH 3 O OH O NH 2 IC50 = 750.0 nM 373.45 CC(Cc1cccc(-c2cc(Cc3ccccc3)ccc2C(N)=O)c1)C(=O)O Homo sapiens CHEMBL4431157 single protein format
CHEMBL152031 OBDepict H 3 C NH O H S O HO IC50 = 790.0 nM 413.58 CCCCCC/C=C/CC(=O)N[C@H](CSc1ccc2ccccc2c1)CC(=O)O Homo sapiens CHEMBL759984 single protein format
CHEMBL4159939 OBDepict OH O N O NH 2 CH 3 IC50 = 830.0 nM 322.36 Cc1cccc2c1cc(C(N)=O)n2-c1cccc(CCC(=O)O)c1 Homo sapiens CHEMBL4151113 assay format
CHEMBL4176269 OBDepict OH O N O H 2 N IC50 = 990.0 nM 308.34 NC(=O)c1cc2ccccc2n1-c1cccc(CCC(=O)O)c1 Homo sapiens CHEMBL4151113 assay format
CHEMBL220842 OBDepict CH 3 O O O N N O H O CH 3 IC50 = 1000.0 nM 588.87 CCCCCCCCCCCCCCOC(COCCCCCCCCCC)COc1ccc(-c2noc(=O)[nH]2)cc1 Homo sapiens CHEMBL917132 assay format
CHEMBL43502 OBDepict CH 3 O N O O H 2 N IC50 = 1000.0 nM 308.34 COc1ccc2nc(Oc3ccccc3)cc(CC(N)=O)c2c1 Homo sapiens CHEMBL769605 single protein format