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O15554 | KCNN4_HUMAN | Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4744833 OBDepict H 3 C O N O H N CH 3 F F F F IC50 = 8.1 nM 374.38 COC(=O)N(C[C@H]1CCCN1C)C1(c2ccc(F)c(C(F)(F)F)c2)CC1 Homo sapiens CHEMBL4672964 cell-based format
CHEMBL4749039 OBDepict CH 3 O N O NH 2 H 3 C H 3 C F F F F IC50 = 8.6 nM 348.34 COC(=O)N(CC(C)(C)N)C1(c2ccc(F)c(C(F)(F)F)c2)CC1 Homo sapiens CHEMBL4672964 cell-based format
CHEMBL4791725 OBDepict CH 3 O N O H NH O F F F F IC50 = 8.7 nM 376.35 COC(=O)N(C[C@@H]1CCCN1)C1(c2ccc(F)c(OC(F)(F)F)c2)CC1 Homo sapiens CHEMBL4672964 cell-based format
CHEMBL42205 OBDepict F O H 2 N F IC50 = 9.0 nM 323.34 NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccccc1F Homo sapiens CHEMBL948111 single protein format
CHEMBL272039 OBDepict F O H 2 N F F IC50 = 10.0 nM 341.33 NC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccccc1F Homo sapiens CHEMBL948111 single protein format
CHEMBL405821 OBDepict F O H 2 N F IC50 = 12.0 nM 323.34 NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1 Homo sapiens CHEMBL948111 single protein format
CHEMBL260736 OBDepict F O H 2 N F F IC50 = 13.0 nM 341.33 NC(=O)C(c1cccc(F)c1)(c1cccc(F)c1)c1cccc(F)c1 Homo sapiens CHEMBL948111 single protein format
CHEMBL4788143 OBDepict F F F F N NH 2 CH 3 H 3 C IC50 = 14.0 nM 344.4 CC(C)(N)CN(CC1CC1)C1(c2ccc(F)c(C(F)(F)F)c2)CC1 Homo sapiens CHEMBL4672964 cell-based format
CHEMBL272040 OBDepict H 2 N O F F IC50 = 14.0 nM 323.34 NC(=O)C(c1ccccc1)(c1ccccc1)c1ccc(F)c(F)c1 Homo sapiens CHEMBL948111 single protein format
CHEMBL270704 OBDepict H 2 N O F F F IC50 = 14.0 nM 341.33 NC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1 Homo sapiens CHEMBL948111 single protein format
CHEMBL408700 OBDepict F O H 2 N F F IC50 = 15.0 nM 341.33 NC(=O)C(c1ccc(F)cc1)(c1cccc(F)c1)c1cccc(F)c1 Homo sapiens CHEMBL948111 single protein format
CHEMBL270071 OBDepict F O NH 2 IC50 = 15.0 nM 305.35 NC(=O)C(c1ccccc1)(c1ccccc1)c1ccccc1F Homo sapiens CHEMBL948111 single protein format
CHEMBL273092 OBDepict F O H 2 N F F IC50 = 15.0 nM 341.33 NC(=O)C(c1ccc(F)cc1)(c1ccccc1F)c1ccccc1F Homo sapiens CHEMBL948111 single protein format
CHEMBL260953 OBDepict F O H 2 N F F IC50 = 17.0 nM 341.33 NC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1cccc(F)c1 Homo sapiens CHEMBL948111 single protein format
CHEMBL4756080 OBDepict H 3 C H 2 N CH 3 N F F F IC50 = 18.0 nM 326.41 CC(C)(N)CN(C1CCC1)C1(c2cccc(C(F)(F)F)c2)CC1 Homo sapiens CHEMBL4672964 cell-based format
CHEMBL498270 OBDepict Cl N N IC50 = 20.0 nM 344.85 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1cccn1 Homo sapiens CHEMBL1032478 cell-based format
CHEMBL406683 OBDepict Cl H 2 N IC50 = 20.0 nM 293.8 NC(c1ccccc1)(c1ccccc1)c1ccccc1Cl Homo sapiens CHEMBL948111 single protein format
CHEMBL4764429 OBDepict H 3 C NH 2 CH 3 N F F F IC50 = 24.0 nM 312.38 CC(C)(N)CN(C1CC1)C1(c2cccc(C(F)(F)F)c2)CC1 Homo sapiens CHEMBL4672964 cell-based format
CHEMBL261606 OBDepict F O NH 2 F IC50 = 30.0 nM 323.34 NC(=O)C(c1ccccc1)(c1ccccc1F)c1ccccc1F Homo sapiens CHEMBL948111 single protein format
CHEMBL261828 OBDepict F O H 2 N F IC50 = 30.0 nM 323.34 NC(=O)C(c1ccccc1)(c1cccc(F)c1)c1cccc(F)c1 Homo sapiens CHEMBL948111 single protein format
CHEMBL270913 OBDepict F F O H 2 N IC50 = 34.0 nM 323.34 NC(=O)C(c1ccccc1)(c1ccccc1)c1ccc(F)cc1F Homo sapiens CHEMBL948111 single protein format
CHEMBL3287207 OBDepict O N S O O CH 3 S O F F F F IC50 = 39.0 nM 409.38 CC(c1ccc(F)c(OC(F)(F)F)c1)N1C(=O)CS(=O)(=O)c2ccsc21 Homo sapiens CHEMBL3293066 cell-based format
CHEMBL258604 OBDepict F O H 2 N IC50 = 40.0 nM 305.35 NC(=O)C(c1ccccc1)(c1ccccc1)c1ccc(F)cc1 Homo sapiens CHEMBL948111 single protein format
CHEMBL3287210 OBDepict O N S CH 3 N F F F IC50 = 41.0 nM 338.35 CC(c1cccc(C(F)(F)F)c1)N1C(=O)CSc2cccnc21 Homo sapiens CHEMBL3293066 cell-based format
CHEMBL4745327 OBDepict CH 3 O N O NH 2 H 3 C H 3 C F F F F IC50 = 47.0 nM 362.37 CCOC(=O)N(CC(C)(C)N)C1(c2ccc(F)c(C(F)(F)F)c2)CC1 Homo sapiens CHEMBL4672964 cell-based format
CHEMBL3287208 OBDepict O N S O O S O F F F F IC50 = 48.0 nM 395.36 O=C1CS(=O)(=O)c2sccc2N1Cc1ccc(F)c(OC(F)(F)F)c1 Homo sapiens CHEMBL3293066 cell-based format
CHEMBL3287205 OBDepict O N S O O N O F F F F IC50 = 49.0 nM 390.31 O=C1CS(=O)(=O)c2cccnc2N1Cc1ccc(F)c(OC(F)(F)F)c1 Homo sapiens CHEMBL3293066 cell-based format
CHEMBL4743839 OBDepict CH 3 O N O H NH F F F F IC50 = 52.0 nM 374.38 CCOC(=O)N(C[C@@H]1CCCN1)C1(c2ccc(F)c(C(F)(F)F)c2)CC1 Homo sapiens CHEMBL4672964 cell-based format
CHEMBL3287209 OBDepict O N S N O F F F IC50 = 52.0 nM 340.33 O=C1CSc2cccnc2N1Cc1cccc(OC(F)(F)F)c1 Homo sapiens CHEMBL3293066 cell-based format
CHEMBL3287212 OBDepict O N S CH 3 S N O F F F F IC50 = 60.0 nM 378.37 CC(c1ccc(F)c(OC(F)(F)F)c1)N1C(=O)CSc2ncsc21 Homo sapiens CHEMBL3293066 cell-based format
CHEMBL3287211 OBDepict OH N N S O Cl F F F IC50 = 66.0 nM 388.8 O=C1CSc2ccc(CO)nc2N1Cc1ccc(Cl)c(C(F)(F)F)c1 Homo sapiens CHEMBL3293066 cell-based format
CHEMBL272255 OBDepict NH 2 IC50 = 70.0 nM 259.35 NC(c1ccccc1)(c1ccccc1)c1ccccc1 Homo sapiens CHEMBL948111 single protein format
CHEMBL4780941 OBDepict F F F F N S O O CH 3 H 2 N CH 3 CH 3 IC50 = 75.0 nM 368.4 CC(C)(N)CN(C1(c2ccc(F)c(C(F)(F)F)c2)CC1)S(C)(=O)=O Homo sapiens CHEMBL4672964 cell-based format
CHEMBL4785936 OBDepict CH 3 O N O H 2 N CH 3 CH 3 O F F F F IC50 = 92.0 nM 364.34 COC(=O)N(CC(C)(C)N)C1(c2ccc(F)c(OC(F)(F)F)c2)CC1 Homo sapiens CHEMBL4672964 cell-based format
CHEMBL3287206 OBDepict O N S O O N S O H 3 C CH 3 F F F F IC50 = 96.0 nM 438.42 CC(C)c1nc2c(s1)S(=O)(=O)CC(=O)N2Cc1ccc(F)c(OC(F)(F)F)c1 Homo sapiens CHEMBL3293066 cell-based format
CHEMBL270495 OBDepict H 3 C O O IC50 = 330.0 nM 302.37 COC(=O)C(c1ccccc1)(c1ccccc1)c1ccccc1 Homo sapiens CHEMBL948111 single protein format
CHEMBL104 OBDepict Cl N N IC50 = 360.0 nM 344.85 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 Homo sapiens CHEMBL948111 single protein format
CHEMBL2312926 OBDepict O P N IC50 = 500.0 nM 369.4 O=P(c1ccccc1)(c1ccccc1)C(c1ccccc1)c1cccnc1 Homo sapiens CHEMBL2319030 single protein format
CHEMBL270288 OBDepict CH 3 HN IC50 = 550.0 nM 273.38 CNC(c1ccccc1)(c1ccccc1)c1ccccc1 Homo sapiens CHEMBL948111 single protein format
CHEMBL2312925 OBDepict O P N N IC50 = 1000.0 nM 370.39 O=P(c1ccccc1)(c1ccccc1)C(c1cccnc1)c1cccnc1 Homo sapiens CHEMBL2319030 single protein format