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O43293 | DAPK3_HUMAN | Death-associated protein kinase 3 (DAPK3)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 3.45 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328660 single protein format
CHEMBL3103192 OBDepict H 2 N N H 3 C HN N H O CH 3 N HN N N N IC50 = 10.0 nM 419.49 CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1N(C)CCN Homo sapiens CHEMBL3810713 single protein format
CHEMBL1230165 OBDepict Cl N H N N O HO IC50 = 17.0 nM 349.78 O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 Homo sapiens CHEMBL1663328 single protein format
CHEMBL523823 OBDepict CH 3 N N H O Cl O O OH Ki = 27.3 nM 280.67 CCn1c2cc(Cl)c(O)cc2c(=O)c2c(=O)o[nH]c21 Homo sapiens CHEMBL994193 single protein format
CHEMBL494089 OBDepict CH 3 N N N O O H 2 N N N H HN OH H 3 C H 3 C IC50 = 81.0 nM 425.49 CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21 Homo sapiens CHEMBL1028113 single protein format
CHEMBL3799389 OBDepict HO N N H O N H NH O IC50 = 140.0 nM 360.37 O=C1Nc2ccc(NC(=O)C3CC3)cc2/C1=C1/Nc2ccccc2/C1=NO Homo sapiens CHEMBL3802098 single protein format
CHEMBL1091041 OBDepict Br N O O N IC50 = 148.4 nM 329.15 O=C1OC(c2cccc(Br)c2)=N/C1=Cc1cccnc1 Homo sapiens CHEMBL1112575 single protein format
CHEMBL1091042 OBDepict H 3 C O Br O N O N IC50 = 157.0 nM 359.18 COc1ccc(C2=N/C(=Cc3cccnc3)C(=O)O2)c(Br)c1 Homo sapiens CHEMBL1112575 single protein format
CHEMBL1091784 OBDepict I Cl O N O N IC50 = 227.1 nM 410.6 O=C1OC(c2cc(I)ccc2Cl)=N/C1=Cc1ccncc1 Homo sapiens CHEMBL1112575 single protein format
CHEMBL4764610 OBDepict H 3 C O N F N O H H 3 C N H H 3 C CH 3 H 3 C N H 3 C H N IC50 = 260.0 nM 475.57 COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1N1C[C@H](C)N(C)[C@H](C)C1 Homo sapiens CHEMBL4705524 single protein format
CHEMBL1091766 OBDepict O O N N CH 3 Br IC50 = 278.5 nM 343.18 Cc1cc(C2=N/C(=Cc3cccnc3)C(=O)O2)ccc1Br Homo sapiens CHEMBL1112575 single protein format
CHEMBL1091785 OBDepict O O N N + N Cl O _ O IC50 = 278.5 nM 329.7 O=C1OC(c2ccc(Cl)c([N+](=O)[O-])c2)=N/C1=Cc1cccnc1 Homo sapiens CHEMBL1112575 single protein format
CHEMBL1092139 OBDepict O O N N + N O _ O IC50 = 291.2 nM 295.25 O=C1OC(c2ccc([N+](=O)[O-])cc2)=N/C1=Cc1cccnc1 Homo sapiens CHEMBL1112575 single protein format
CHEMBL1091764 OBDepict O O N N F F IC50 = 346.1 nM 286.24 O=C1OC(c2ccc(F)c(F)c2)=N/C1=Cc1cccnc1 Homo sapiens CHEMBL1112575 single protein format
CHEMBL1091765 OBDepict Cl N O O N IC50 = 359.6 nM 284.7 O=C1OC(c2cccc(Cl)c2)=N/C1=Cc1cccnc1 Homo sapiens CHEMBL1112575 single protein format
CHEMBL416056 OBDepict CH 3 O O HO CH 3 O N H N N H O IC50 = 360.0 nM 467.48 COC(=O)[C@]1(O)C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL911981 single protein format
CHEMBL1094004 OBDepict H 3 C O O N O N IC50 = 395.3 nM 280.28 COc1cccc(C2=N/C(=Cc3cccnc3)C(=O)O2)c1 Homo sapiens CHEMBL1112575 single protein format
CHEMBL3797466 OBDepict HO N N H O NH HN O CH 3 H 3 C IC50 = 450.0 nM 374.4 CC(C)=CC(=O)Nc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=NO)C(=O)N2 Homo sapiens CHEMBL3802098 single protein format
CHEMBL386636 OBDepict O N H O N H IC50 = 487.0 nM 338.37 O=C1NC(=O)c2c1c1c(c3[nH]c4ccccc4c23)CCc2ccccc2-1 Homo sapiens CHEMBL911981 single protein format
CHEMBL3799585 OBDepict CH 3 HN O NH O N H N HO IC50 = 510.0 nM 362.39 CCCC(=O)Nc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=NO)C(=O)N2 Homo sapiens CHEMBL3802098 single protein format
CHEMBL1091787 OBDepict Cl O N O N IC50 = 529.5 nM 284.7 O=C1OC(c2ccc(Cl)cc2)=N/C1=Cc1cccnc1 Homo sapiens CHEMBL1112575 single protein format
CHEMBL1094005 OBDepict O O N N + N H 3 C O _ O IC50 = 533.5 nM 309.28 Cc1ccc(C2=N/C(=Cc3cccnc3)C(=O)O2)cc1[N+](=O)[O-] Homo sapiens CHEMBL1112575 single protein format
CHEMBL579387 OBDepict O O N N IC50 = 583.0 nM 250.26 O=C1OC(c2ccccc2)=N/C1=Cc1cccnc1 Homo sapiens CHEMBL1112575 single protein format
CHEMBL513703 OBDepict HO N N H O NH HN O CH 3 CH 3 CH 3 IC50 = 700.0 nM 376.42 CC(C)(C)C(=O)Nc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=NO)C(=O)N2 Homo sapiens CHEMBL3802098 single protein format
CHEMBL1091786 OBDepict CH 3 N O O N IC50 = 713.7 nM 264.28 Cc1cccc(C2=N/C(=Cc3cccnc3)C(=O)O2)c1 Homo sapiens CHEMBL1112575 single protein format
CHEMBL4877302 OBDepict CH 3 O N NH N N H N N H H 3 C O H 3 C Cl IC50 = 720.0 nM 438.92 CCc1cc(Nc2nc(NCc3ccc(Cl)cc3OC)nc3cccc(OC)c23)n[nH]1 Homo sapiens CHEMBL4810429 single protein format
CHEMBL565286 OBDepict O O N N IC50 < 1000.0 nM 276.3 O=C1OC(/C=C/c2ccccc2)=N/C1=Cc1cccnc1 Homo sapiens CHEMBL1041500 single protein format