O43526 | KCNQ2_HUMAN | Potassium voltage-gated channel subfamily KQT member 2 (KCNQ2)
3D structures mapped by conservation among orthologs
[ Domain: "Kv7 proximal C-terminal Domain" // KOG1419 ]
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[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
IC50 table
| molecule_chembl_id | structure | assay_type | relation | values | units | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL343822 | IC50 | = | 48.0 | nM | 412.44 | O=C1c2ccccc2C(Cc2ccnc(F)c2)(Cc2ccnc(F)c2)c2ccccc21 | Homo sapiens | CHEMBL4410389 | cell-based format | |
| CHEMBL342375 | IC50 | = | 55.0 | nM | 376.46 | O=C1c2ccccc2C(Cc2ccncc2)(Cc2ccncc2)c2ccccc21 | Homo sapiens | CHEMBL4410389 | cell-based format | |
| CHEMBL4465132 | IC50 | = | 160.0 | nM | 413.43 | O=C1c2ccccc2C(Cc2ccnnc2)(Cc2c(F)cncc2F)c2ccccc21 | Homo sapiens | CHEMBL4410389 | cell-based format | |
| CHEMBL4471453 | IC50 | = | 200.0 | nM | 448.42 | O=C1c2ccccc2C(Cc2c(F)cncc2F)(Cc2c(F)cncc2F)c2ccccc21 | Homo sapiens | CHEMBL4410389 | cell-based format | |
| CHEMBL4447214 | IC50 | = | 540.0 | nM | 404.51 | Cc1cc(CC2(Cc3ccnc(C)c3)c3ccccc3C(=O)c3ccccc32)ccn1 | Homo sapiens | CHEMBL4410389 | cell-based format |