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O43781 | DYRK3_HUMAN | Dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4546504 OBDepict CH 3 N CH 3 O O N H CH 3 H N N F F F O N H H Cl H 3 C HO IC50 = 0.104 nM 555.99 C[C@@H](Oc1cc(C(=O)N(C)C)ccc1Nc1nc(O[C@H]2CC[C@@](C)(O)CC2)c2c(Cl)c[nH]c2n1)C(F)(F)F Homo sapiens CHEMBL4349105 assay format
CHEMBL3894571 OBDepict CH 3 O F N H N N S N O NH CH 3 IC50 = 21.1 nM 383.41 COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4F)c3c2s1 Homo sapiens CHEMBL4719514 single protein format
CHEMBL3589674 OBDepict CH 3 O N N H O HO Cl IC50 = 30.0 nM 402.84 COc1cccc(-c2ccc3nc(C(=O)O)c4c5cccc(Cl)c5[nH]c4c3c2)c1 Homo sapiens CHEMBL3591330 assay format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 34.8 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328393 single protein format
CHEMBL3103192 OBDepict H 2 N N H 3 C HN N H O CH 3 N HN N N N IC50 = 40.0 nM 419.49 CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1N(C)CCN Homo sapiens CHEMBL3810707 single protein format
CHEMBL4228654 OBDepict CH 3 HN H 3 C N N N N O HO IC50 = 54.0 nM 373.42 CC(C)Nc1ccc2cnn(-c3cncc(-c4ccc(C(=O)O)cc4)n3)c2c1 Homo sapiens CHEMBL4222682 single protein format
CHEMBL2409175 OBDepict N N N N N H NH N H CH 3 O CH 3 IC50 = 70.0 nM 361.41 CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1C Homo sapiens CHEMBL2410929 single protein format
CHEMBL4105084 OBDepict H 3 C N H H HO N N N Cl IC50 = 81.0 nM 316.79 CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 Homo sapiens CHEMBL4041966 assay format
CHEMBL2386747 OBDepict CH 3 O HN N S N N H N Cl Cl IC50 = 93.2 nM 404.28 COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1 Homo sapiens CHEMBL4719514 single protein format
CHEMBL4062218 OBDepict CH 3 N H O O N H CH 3 N N O N H O N H 3 C IC50 = 99.0 nM 512.57 CNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(-c4ccc5nc(C)oc5c4)c[nH]c3n2)c(OC)c1 Homo sapiens CHEMBL4031757 assay format
CHEMBL4071322 OBDepict H 3 C O O N N N N H H HO CH 3 IC50 = 110.0 nM 354.41 CCOC(=O)c1cccc(-c2cnc3ccc(N[C@@H](CC)CO)nn23)c1 Homo sapiens CHEMBL4041966 assay format
CHEMBL4061526 OBDepict CH 3 N H H OH N N N NH O H 3 C IC50 = 110.0 nM 339.4 CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(NC(C)=O)c3)n2n1 Homo sapiens CHEMBL4041966 assay format
CHEMBL4062820 OBDepict H 3 C NH H OH N N N N H IC50 = 120.0 nM 321.38 CC[C@@H](CO)Nc1ccc2ncc(-c3cc4ccccc4[nH]3)n2n1 Homo sapiens CHEMBL4041966 assay format
CHEMBL4072506 OBDepict HO N N N N O CH 3 IC50 = 140.0 nM 268.28 COc1ccc2ncc(-c3cccc(/C=N/O)c3)n2n1 Homo sapiens CHEMBL4041966 assay format
CHEMBL3092863 OBDepict NH 2 O O O O N H NH N O O O IC50 = 180.0 nM 498.54 NCCOCCOCCOCCOc1ccc(NC2=N/C(=Cc3ccc4c(c3)OCO4)C(=O)N2)cc1 Homo sapiens CHEMBL3097747 assay format
CHEMBL3092862 OBDepict NH 2 O O O N H N NH O O O IC50 = 200.0 nM 454.48 NCCOCCOCCOc1ccc(NC2=N/C(=Cc3ccc4c(c3)OCO4)C(=O)N2)cc1 Homo sapiens CHEMBL3097747 assay format
CHEMBL4074132 OBDepict HO N H H H 3 C H 3 C N N N N IC50 = 320.0 nM 297.36 CC(C)[C@@H](CO)Nc1ccc2ncc(-c3cccnc3)n2n1 Homo sapiens CHEMBL4041966 assay format
CHEMBL4084364 OBDepict H 3 C N H H HO N N N N N NH 2 IC50 = 320.0 nM 299.34 CC[C@@H](CO)Nc1ccc2ncc(-c3ccnc(N)n3)n2n1 Homo sapiens CHEMBL4041966 assay format
CHEMBL1802358 OBDepict O N H N N H O O IC50 = 320.0 nM 307.31 O=C1NC(Nc2ccccc2)=N/C1=Cc1ccc2c(c1)OCO2 Homo sapiens CHEMBL2187131 assay format
CHEMBL4284209 OBDepict CH 3 H 3 C N N N N N H N H H H NH 2 N IC50 = 380.0 nM 456.6 CC(C)c1cnn2c(NCc3ccc(-c4ccccn4)cc3)nc(N[C@H]3CC[C@H](N)CC3)nc12 Homo sapiens CHEMBL4275866 assay format
CHEMBL4071013 OBDepict OH N N N N N Cl IC50 = 430.0 nM 357.85 OCCN1CCN(c2ccc3ncc(-c4cccc(Cl)c4)n3n2)CC1 Homo sapiens CHEMBL4041966 assay format
CHEMBL4093104 OBDepict CH 3 N H H OH N N N O IC50 = 460.0 nM 310.36 CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(C=O)c3)n2n1 Homo sapiens CHEMBL4041966 assay format
CHEMBL4077159 OBDepict OH N N N N Cl IC50 = 510.0 nM 272.7 O/N=C/c1cccc(-c2cnc3ccc(Cl)nn23)c1 Homo sapiens CHEMBL4041966 assay format
CHEMBL4102871 OBDepict CH 3 N H O HN N N N HN O CH 3 IC50 = 520.0 nM 400.44 CC(=O)Nc1cccc(Nc2ccc3ncc(-c4cccc(NC(C)=O)c4)n3n2)c1 Homo sapiens CHEMBL4041966 assay format
CHEMBL4082981 OBDepict CH 3 HN H HO N N N N H Br IC50 = 610.0 nM 400.28 CC[C@@H](CO)Nc1ccc2ncc(-c3cc4cc(Br)ccc4[nH]3)n2n1 Homo sapiens CHEMBL4041966 assay format
CHEMBL269538 OBDepict H 3 C O N H CH 3 N IC50 = 800.0 nM 212.25 COc1ccc2c(c1)[nH]c1c(C)nccc12 Homo sapiens CHEMBL1051268 single protein format
CHEMBL4079347 OBDepict H 3 C O N N N N H IC50 = 910.0 nM 264.29 COc1ccc2ncc(-c3ccc4[nH]ccc4c3)n2n1 Homo sapiens CHEMBL4041966 assay format
CHEMBL4065432 OBDepict HO N N N N N H H OH CH 3 IC50 = 920.0 nM 325.37 CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(/C=N/O)c3)n2n1 Homo sapiens CHEMBL4041966 assay format
CHEMBL4092673 OBDepict CH 3 N H OH N O H 3 C N N NH O H 3 C IC50 = 930.0 nM 381.44 CC[C@@H](CO)N(C(C)=O)c1ccc2ncc(-c3cccc(NC(C)=O)c3)n2n1 Homo sapiens CHEMBL4041966 assay format
CHEMBL4100956 OBDepict CH 3 N H H OH N N N N IC50 = 950.0 nM 283.34 CC[C@@H](CO)Nc1ccc2ncc(-c3cccnc3)n2n1 Homo sapiens CHEMBL4041966 assay format