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O60658 | PDE8A_HUMAN | "High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A" (PDE8A)

3D structures mapped by conservation among orthologs

[ Domain: "HD-domain/PDEase-like" // PDEase_I ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL1779976 OBDepict CH 3 N NH O N N H 3 C O IC50 = 1.8 nM 452.56 Cc1cccc(CNC(=O)C2CN(Cc3nc(-c4ccccc4)oc3C)Cc3ccccc32)n1 Homo sapiens CHEMBL1780333 single protein format
CHEMBL1779978 OBDepict CH 3 N N H O N N H 3 C O IC50 = 1.8 nM 404.51 Cc1cccc(CNC(=O)C2CCCN(Cc3nc(-c4ccccc4)oc3C)C2)n1 Homo sapiens CHEMBL1780333 single protein format
CHEMBL1779984 OBDepict CH 3 H N H N H O N CH 3 O N H 3 C IC50 = 1.8 nM 432.57 CC[C@@H]1C[C@@H](C(=O)NCc2cccc(C)n2)CN(Cc2nc(-c3ccccc3)oc2C)C1 Homo sapiens CHEMBL1780333 single protein format
CHEMBL2070735 OBDepict CH 3 N N NH 2 N N N H O N N S IC50 = 1.9 nM 346.42 Cc1nc(N)c2nnn(C[C@H]3CN(Cc4nccs4)CCO3)c2n1 Homo sapiens CHEMBL2073624 single protein format
CHEMBL4762103 OBDepict F F O N N CH 3 H N N Cl N H 2 N IC50 = 10.0 nM 354.75 C[C@@H](c1cc(OCC(F)F)ccn1)n1cnc2c(N)nc(Cl)nc21 Homo sapiens CHEMBL4706222 assay format
CHEMBL3646900 OBDepict F O F N O N O N O N IC50 = 15.0 nM 558.59 N#Cc1cc(Cn2c(=O)c3cc(OC(CF)CF)ccc3n(C3CCN(C=O)CC3)c2=O)ccc1-c1ccccc1 Homo sapiens CHEMBL3706022 single protein format
CHEMBL4753446 OBDepict F F O N N CH 3 N N Cl N H 2 N IC50 = 26.0 nM 354.75 CC(c1cc(OCC(F)F)ccn1)n1cnc2c(N)nc(Cl)nc21 Homo sapiens CHEMBL4706222 assay format
CHEMBL4790482 OBDepict Cl N N NH 2 N N N IC50 = 46.0 nM 328.81 Nc1nc(Cl)nc2c1ncn2Cc1cccc(C2CCCC2)n1 Homo sapiens CHEMBL4706222 assay format
CHEMBL4800434 OBDepict Cl N N NH 2 N N N F IC50 = 130.0 nM 354.78 Nc1nc(Cl)nc2c1ncn2Cc1cccc(-c2ccccc2F)n1 Homo sapiens CHEMBL4706222 assay format
CHEMBL3646893 OBDepict F O F N O N O N O O O H 3 C H 3 C IC50 = 140.0 nM 517.53 COc1ccc(Cn2c(=O)c3cc(OC(CF)CF)ccc3n(C3CCN(C=O)CC3)c2=O)cc1OC Homo sapiens CHEMBL3706022 single protein format
CHEMBL4789101 OBDepict Cl N N NH 2 N N N O IC50 = 220.0 nM 344.81 Nc1nc(Cl)nc2c1ncn2Cc1cccc(C2CCOCC2)n1 Homo sapiens CHEMBL4706222 assay format
CHEMBL4778928 OBDepict Cl N N NH 2 N N N O IC50 = 240.0 nM 326.75 Nc1nc(Cl)nc2c1ncn2Cc1cccc(-c2ccco2)n1 Homo sapiens CHEMBL4706222 assay format
CHEMBL4745958 OBDepict Cl N N NH 2 N N N O IC50 = 250.0 nM 342.79 Nc1nc(Cl)nc2c1ncn2Cc1cccc(C2=CCOCC2)n1 Homo sapiens CHEMBL4706222 assay format
CHEMBL4798107 OBDepict Cl N N NH 2 N N N IC50 = 250.0 nM 326.79 Nc1nc(Cl)nc2c1ncn2Cc1cccc(C2=CCCC2)n1 Homo sapiens CHEMBL4706222 assay format
CHEMBL4757863 OBDepict F F O N N N N Cl N NH 2 IC50 = 360.0 nM 340.72 Nc1nc(Cl)nc2c1ncn2Cc1cc(OCC(F)F)ccn1 Homo sapiens CHEMBL4706222 assay format
CHEMBL4747327 OBDepict Cl N N N N Cl N NH 2 IC50 = 410.0 nM 295.13 Nc1nc(Cl)nc2c1ncn2Cc1cc(Cl)ccn1 Homo sapiens CHEMBL4706222 assay format
CHEMBL4750412 OBDepict CH 3 O N N N N Cl N H 2 N IC50 = 660.0 nM 290.71 COc1ccnc(Cn2cnc3c(N)nc(Cl)nc32)c1 Homo sapiens CHEMBL4706222 assay format
CHEMBL4786234 OBDepict F F O N N N N Cl N NH 2 IC50 = 920.0 nM 340.72 Nc1nc(Cl)nc2c1ncn2Cc1cccc(OCC(F)F)n1 Homo sapiens CHEMBL4706222 assay format