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O60678 | ANM3_HUMAN | Protein arginine N-methyltransferase 3 (PRMT3)

3D structures mapped by conservation among orthologs

[ Domain: "S-adenosyl-L-methionine-dependent methyltransferases" // PrmA ]

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[ Domain: "Arginine methyltransferase oligomerization subdomain" // PRMT5_C_1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3901808 OBDepict NH 2 N CH 3 N H O H 3 C CH 3 IC50 = 4.0 nM 287.41 CC(C)Oc1ccc(-c2c[nH]cc2CN(C)CCN)cc1 Homo sapiens CHEMBL3859038 single protein format
CHEMBL4079503 OBDepict O HN N H N O N F IC50 = 10.0 nM 316.34 O=C(NCC(=O)N1CCCC1)Nc1ccc2cnc(F)cc2c1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4076640 OBDepict O N H N H N O N IC50 = 17.0 nM 326.4 O=C(NCC(=O)N1CCCCCC1)Nc1ccc2cnccc2c1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4061429 OBDepict O HN N H N O Cl N IC50 = 19.0 nM 332.79 O=C(NCC(=O)N1CCCC1)Nc1cc(Cl)c2cnccc2c1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4094513 OBDepict NH 2 N CH 3 S Cl IC50 = 22.0 nM 306.86 CN(CCN)Cc1ccccc1Sc1ccccc1Cl Homo sapiens CHEMBL4026501 single protein format
CHEMBL4061085 OBDepict O N H NH N O N IC50 = 22.0 nM 338.41 O=C(NCC(=O)N1C2CCCC1CC2)Nc1ccc2cnccc2c1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4086964 OBDepict O NH N H N O N F F IC50 = 35.0 nM 348.35 O=C(NCC(=O)N1CCC(F)(F)CC1)Nc1ccc2cnccc2c1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4095787 OBDepict O NH N H CH 3 N O N IC50 = 36.0 nM 312.37 Cc1cc2cnccc2cc1NC(=O)NCC(=O)N1CCCC1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4082966 OBDepict O NH N H N O N IC50 = 46.0 nM 324.38 O=C(NCC(=O)N1C2CCC1CC2)Nc1ccc2cnccc2c1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4105488 OBDepict O N H HN N O N IC50 = 55.0 nM 338.41 O=C(NCC(=O)N1CC2CCCC2C1)Nc1ccc2cnccc2c1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4097428 OBDepict O N H NH N O N IC50 = 61.0 nM 284.32 O=C(NCC(=O)N1CCC1)Nc1ccc2cnccc2c1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4087094 OBDepict O HN N H N O N IC50 = 84.0 nM 312.37 O=C(NCC(=O)N1CCCCC1)Nc1ccc2cnccc2c1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4082359 OBDepict O HN N H N O CH 3 N IC50 = 87.0 nM 326.4 CN(C(=O)CNC(=O)Nc1ccc2cnccc2c1)C1CCCC1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4072005 OBDepict O HN N H N O N IC50 = 91.0 nM 298.35 O=C(NCC(=O)N1CCCC1)Nc1ccc2cnccc2c1 Homo sapiens CHEMBL4027816 cell-based format
CHEMBL4065941 OBDepict CH 3 N O H 3 C N H N H O N IC50 = 114.0 nM 300.36 CCN(CC)C(=O)CNC(=O)Nc1ccc2cnccc2c1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4077534 OBDepict O NH N H F N O N IC50 = 134.0 nM 316.34 O=C(NCC(=O)N1CCCC1)Nc1cc2ccncc2cc1F Homo sapiens CHEMBL4027816 cell-based format
CHEMBL4071410 OBDepict O NH N H N O H 3 C CH 3 N IC50 = 134.0 nM 326.4 CC1CCC(C)N1C(=O)CNC(=O)Nc1ccc2cnccc2c1 Homo sapiens CHEMBL4027816 cell-based format
CHEMBL4090733 OBDepict O N H HN N O H 3 C CH 3 N IC50 = 150.0 nM 272.31 CN(C)C(=O)CNC(=O)Nc1ccc2cnccc2c1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4074611 OBDepict O HN NH N H O N IC50 = 158.0 nM 284.32 O=C(CNC(=O)Nc1ccc2cnccc2c1)NC1CC1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4097411 OBDepict H 3 C O O H N O NH NH O N IC50 = 166.0 nM 356.38 COC(=O)[C@@H]1CCCN1C(=O)CNC(=O)Nc1ccc2cnccc2c1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4059940 OBDepict O N H NH N O CH 3 N IC50 = 194.0 nM 312.37 Cc1nccc2cc(NC(=O)NCC(=O)N3CCCC3)ccc12 Homo sapiens CHEMBL4027812 single protein format
CHEMBL2325198 OBDepict O NH HN N O S N N IC50 = 230.0 nM 319.39 O=C(NCC(=O)N1CCCCC1)Nc1ccc2nnsc2c1 Homo sapiens CHEMBL2330282 single protein format
CHEMBL4062783 OBDepict O HN N H N O N F F F F IC50 = 240.0 nM 370.31 O=C(NCC(=O)N1CC(F)(F)C(F)(F)C1)Nc1ccc2cnccc2c1 Homo sapiens CHEMBL4027816 cell-based format
CHEMBL4101037 OBDepict H 2 N N H NH O N IC50 = 291.0 nM 326.44 NCC1(CCNC(=O)Nc2ccc3cnccc3c2)CCCCC1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4063230 OBDepict O N H NH NH O N IC50 = 292.0 nM 312.37 O=C(CNC(=O)Nc1ccc2cnccc2c1)NC1CCCC1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4081032 OBDepict O N H HN N IC50 = 295.0 nM 283.38 O=C(NCCC1CCCC1)Nc1ccc2cnccc2c1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL2325177 OBDepict O NH HN S N N + N O _ O IC50 = 300.0 nM 329.34 O=C(NCc1ccc([N+](=O)[O-])cc1)Nc1ccc2nnsc2c1 Homo sapiens CHEMBL2330282 single protein format
CHEMBL2325197 OBDepict O HN NH O S N N F IC50 = 360.0 nM 330.34 O=C(NCC(=O)c1ccc(F)cc1)Nc1ccc2nnsc2c1 Homo sapiens CHEMBL2330282 single protein format
CHEMBL4104833 OBDepict O N H NH N IC50 = 421.0 nM 295.39 O=C(NCCC1=CCCCC1)Nc1ccc2cnccc2c1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4100373 OBDepict CH 3 O N CH 3 O N H N H O N IC50 = 476.0 nM 288.31 CON(C)C(=O)CNC(=O)Nc1ccc2cnccc2c1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4084879 OBDepict O HN N H HN O N IC50 = 477.0 nM 326.4 O=C(CNC(=O)Nc1ccc2cnccc2c1)NC1CCCCC1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL2325183 OBDepict O NH HN O S N N IC50 = 480.0 nM 312.35 O=C(NCC(=O)c1ccccc1)Nc1ccc2nnsc2c1 Homo sapiens CHEMBL2330282 single protein format
CHEMBL2325195 OBDepict O NH HN OH S N N IC50 = 490.0 nM 320.42 O=C(NCC(O)C1CCCCC1)Nc1ccc2nnsc2c1 Homo sapiens CHEMBL2330282 single protein format
CHEMBL4099065 OBDepict O N H NH N IC50 = 540.0 nM 297.4 O=C(NCCC1CCCCC1)Nc1ccc2cnccc2c1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL4090682 OBDepict O N H NH N O O O IC50 = 757.0 nM 317.35 O=C(NCC(=O)N1CCCCC1)Nc1ccc2c(c1)COC2=O Homo sapiens CHEMBL4027812 single protein format
CHEMBL418052 OBDepict NH 2 N N N N H O H OH H H HO S NH 2 H O HO IC50 = 760.0 nM 384.42 Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O Homo sapiens CHEMBL4684519 single protein format
CHEMBL4067331 OBDepict O N H NH N IC50 = 833.0 nM 291.35 O=C(NCCc1ccccc1)Nc1ccc2cnccc2c1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL2325196 OBDepict O NH HN O S N N IC50 = 840.0 nM 318.4 O=C(NCC(=O)C1CCCCC1)Nc1ccc2nnsc2c1 Homo sapiens CHEMBL2330282 single protein format
CHEMBL2325178 OBDepict O HN N H S N N S O O CH 3 IC50 = 850.0 nM 362.44 CS(=O)(=O)c1ccc(CNC(=O)Nc2ccc3nnsc3c2)cc1 Homo sapiens CHEMBL2330282 single protein format
CHEMBL4588797 OBDepict N N H 2 N N N H O H HO H H OH S H 2 N H O OH IC50 = 870.0 nM 408.44 N#Cc1cn([C@@H]2O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]2O)c2ncnc(N)c12 Homo sapiens CHEMBL4479554 single protein format
CHEMBL4068520 OBDepict O HN N H N O N N IC50 = 967.0 nM 313.36 O=C(NCC(=O)N1CCCCC1)Nc1ccc2cncnc2c1 Homo sapiens CHEMBL4027812 single protein format
CHEMBL2325442 OBDepict O N H NH S N N IC50 = 1000.0 nM 304.42 O=C(NCCC1CCCCC1)Nc1ccc2nnsc2c1 Homo sapiens CHEMBL2330282 single protein format