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O60725 | ICMT_HUMAN | Protein-S-isoprenylcysteine O-methyltransferase (ICMT)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4443354 OBDepict N F O CH 3 H O N N IC50 = 0.002 nM 377.42 C[C@H](COc1cccc(-n2ccnc2C2CC2)c1)Oc1ccc(C#N)cc1F Homo sapiens CHEMBL4307065 cell-based format
CHEMBL4558383 OBDepict CH 3 O O N H 3 C H O N N IC50 = 0.003 nM 389.46 COc1cc(C#N)ccc1O[C@@H](C)COc1cccc(-n2ccnc2C2CC2)c1 Homo sapiens CHEMBL4307065 cell-based format
CHEMBL4583704 OBDepict N O O H 3 C H 3 C H O N CH 3 N IC50 = 0.08 nM 363.42 COc1cc(C#N)ccc1O[C@@H](C)COc1cccc(-n2ccnc2C)c1 Homo sapiens CHEMBL4307065 cell-based format
CHEMBL4446351 OBDepict N Cl O O N N IC50 = 0.1 nM 379.85 N#Cc1ccc(OCCOc2cccc(-n3ccnc3C3CC3)c2)c(Cl)c1 Homo sapiens CHEMBL4307065 cell-based format
CHEMBL4449942 OBDepict N O O N N IC50 = 0.16 nM 345.4 N#Cc1ccc(OCCOc2cccc(-n3ccnc3C3CC3)c2)cc1 Homo sapiens CHEMBL4307065 cell-based format
CHEMBL4446048 OBDepict N O O H 3 C O N CH 3 N IC50 = 0.2 nM 349.39 COc1cc(C#N)ccc1OCCOc1cccc(-n2ccnc2C)c1 Homo sapiens CHEMBL4307065 cell-based format
CHEMBL4468997 OBDepict N Cl O O N CH 3 N IC50 = 0.2 nM 353.81 Cc1nccn1-c1cccc(OCCOc2ccc(C#N)cc2Cl)c1 Homo sapiens CHEMBL4307065 cell-based format
CHEMBL4464629 OBDepict N F O CH 3 H O N CH 3 N IC50 = 0.7 nM 351.38 C[C@@H](COc1cccc(-c2ccnn2C)c1)Oc1ccc(C#N)cc1F Homo sapiens CHEMBL4307065 cell-based format
CHEMBL4473893 OBDepict N O O H 3 C O N CH 3 N IC50 = 0.9 nM 349.39 COc1cc(C#N)ccc1OCCOc1cccc(-c2ccnn2C)c1 Homo sapiens CHEMBL4307065 cell-based format
CHEMBL1800705 OBDepict H 3 C O N H CH 3 CH 3 O H 3 C CH 3 IC50 = 1.0 nM 367.53 COc1cccc(NCCC2(c3ccccc3)CC(C)(C)OC(C)(C)C2)c1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL4445788 OBDepict N CH 3 O H 3 C H O N CH 3 N IC50 = 1.6 nM 347.42 Cc1cc(C#N)ccc1O[C@@H](C)COc1cccc(-c2ccnn2C)c1 Homo sapiens CHEMBL4307065 cell-based format
CHEMBL1800516 OBDepict Cl HN S O H 3 C CH 3 IC50 = 3.8 nM 349.93 CC1(C)CC(CCNc2cccc(Cl)c2)(c2cccs2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800513 OBDepict H 3 C O N H O H 3 C CH 3 F IC50 = 8.0 nM 357.47 COc1cccc(NCCC2(c3cccc(F)c3)CCOC(C)(C)C2)c1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800715 OBDepict H 3 C O N H O H 3 C CH 3 IC50 = 10.0 nM 339.48 COc1cccc(NCC[C@@]2(c3ccccc3)CCOC(C)(C)C2)c1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800522 OBDepict CH 3 H 3 C O CH 3 CH 3 N H IC50 = 15.0 nM 337.51 CC1(C)CC(CCNc2ccccc2)(c2ccccc2)CC(C)(C)O1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800426 OBDepict H 3 C O N H O H 3 C CH 3 IC50 = 15.0 nM 339.48 COc1cccc(NCCC2(c3ccccc3)CCOC(C)(C)C2)c1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800514 OBDepict H 3 C O HN S O H 3 C H 3 C IC50 = 19.0 nM 345.51 COc1cccc(NCCC2(c3cccs3)CCOC(C)(C)C2)c1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800485 OBDepict Cl N H O CH 3 CH 3 IC50 = 25.0 nM 343.9 CC1(C)CC(CCNc2cccc(Cl)c2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800498 OBDepict F Cl N H O CH 3 CH 3 IC50 = 25.0 nM 361.89 CC1(C)CC(CCNc2ccc(F)c(Cl)c2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800501 OBDepict _ O + N O N H O CH 3 CH 3 IC50 = 26.0 nM 354.45 CC1(C)CC(CCNc2cccc([N+](=O)[O-])c2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800417 OBDepict H 3 C N H O H 3 C CH 3 IC50 = 31.0 nM 323.48 Cc1cccc(NCCC2(c3ccccc3)CCOC(C)(C)C2)c1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800418 OBDepict CH 3 N H O CH 3 H 3 C IC50 = 31.0 nM 323.48 Cc1ccc(NCCC2(c3ccccc3)CCOC(C)(C)C2)cc1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800496 OBDepict CH 3 O F F N H O CH 3 H 3 C IC50 = 31.0 nM 375.46 COc1c(F)cc(NCCC2(c3ccccc3)CCOC(C)(C)C2)cc1F Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800499 OBDepict Cl N H F O CH 3 CH 3 IC50 = 32.0 nM 361.89 CC1(C)CC(CCNc2cc(Cl)ccc2F)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800421 OBDepict H 3 C N H O H 3 C CH 3 IC50 = 40.0 nM 337.51 CCc1cccc(NCCC2(c3ccccc3)CCOC(C)(C)C2)c1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800490 OBDepict H 3 C Cl N H O H 3 C CH 3 IC50 = 49.0 nM 357.93 Cc1ccc(NCCC2(c3ccccc3)CCOC(C)(C)C2)cc1Cl Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800492 OBDepict F N H O CH 3 CH 3 IC50 = 52.0 nM 327.44 CC1(C)CC(CCNc2cccc(F)c2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800420 OBDepict H 3 C N H CH 3 O H 3 C CH 3 IC50 = 54.0 nM 337.51 Cc1cc(C)cc(NCCC2(c3ccccc3)CCOC(C)(C)C2)c1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800483 OBDepict N N H O H 3 C H 3 C IC50 = 66.0 nM 334.46 CC1(C)CC(CCNc2cccc(C#N)c2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800419 OBDepict H 3 C H 3 C N H O H 3 C CH 3 IC50 = 69.0 nM 337.51 Cc1ccc(NCCC2(c3ccccc3)CCOC(C)(C)C2)cc1C Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800477 OBDepict CH 3 O H 3 C N H O H 3 C H 3 C IC50 = 90.0 nM 353.51 COc1cc(NCCC2(c3ccccc3)CCOC(C)(C)C2)ccc1C Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800479 OBDepict F O F F N H O CH 3 CH 3 IC50 = 90.0 nM 393.45 CC1(C)CC(CCNc2cccc(OC(F)(F)F)c2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800512 OBDepict H 3 C O N H O H 3 C CH 3 F IC50 = 100.0 nM 357.47 COc1cccc(NCCC2(c3ccc(F)cc3)CCOC(C)(C)C2)c1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1484316 OBDepict O N O O CH 3 CH 3 IC50 = 120.0 nM 417.55 CC1(C)CC(CCN(Cc2ccccc2)C(=O)c2ccco2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800484 OBDepict N N H O CH 3 CH 3 IC50 = 123.0 nM 334.46 CC1(C)CC(CCNc2ccc(C#N)cc2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800481 OBDepict CH 3 N H 3 C N H O H 3 C H 3 C IC50 = 131.0 nM 352.52 CN(C)c1cccc(NCCC2(c3ccccc3)CCOC(C)(C)C2)c1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800423 OBDepict H 3 C H 3 C N H O H 3 C H 3 C IC50 = 132.0 nM 351.53 CC(C)c1ccc(NCCC2(c3ccccc3)CCOC(C)(C)C2)cc1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800495 OBDepict CH 3 O F N H O H 3 C CH 3 IC50 = 160.0 nM 357.47 COc1ccc(NCCC2(c3ccccc3)CCOC(C)(C)C2)cc1F Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800422 OBDepict CH 3 H 3 C N H O H 3 C H 3 C IC50 = 167.0 nM 351.53 CC(C)c1cccc(NCCC2(c3ccccc3)CCOC(C)(C)C2)c1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800493 OBDepict F N H O CH 3 CH 3 IC50 = 168.0 nM 327.44 CC1(C)CC(CCNc2ccc(F)cc2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800487 OBDepict Cl N H Cl O CH 3 CH 3 IC50 = 170.0 nM 378.34 CC1(C)CC(CCNc2cc(Cl)cc(Cl)c2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800488 OBDepict Cl Cl N H O CH 3 CH 3 IC50 = 181.0 nM 378.34 CC1(C)CC(CCNc2ccc(Cl)c(Cl)c2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800480 OBDepict F O F F NH O CH 3 CH 3 IC50 = 184.0 nM 393.45 CC1(C)CC(CCNc2ccc(OC(F)(F)F)cc2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800511 OBDepict H 3 C O N H O H 3 C CH 3 Cl IC50 = 190.0 nM 373.92 COc1cccc(NCCC2(c3cccc(Cl)c3)CCOC(C)(C)C2)c1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800714 OBDepict H 3 C O N H O H 3 C CH 3 IC50 = 230.0 nM 339.48 COc1cccc(NCC[C@]2(c3ccccc3)CCOC(C)(C)C2)c1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800515 OBDepict CH 3 CH 3 O S N H IC50 = 270.0 nM 315.48 CC1(C)CC(CCNc2ccccc2)(c2cccs2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800476 OBDepict CH 3 O N H O CH 3 H 3 C IC50 = 270.0 nM 339.48 COc1ccc(NCCC2(c3ccccc3)CCOC(C)(C)C2)cc1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800494 OBDepict H 3 C F N H O H 3 C CH 3 IC50 = 300.0 nM 341.47 Cc1ccc(NCCC2(c3ccccc3)CCOC(C)(C)C2)c(F)c1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800489 OBDepict Cl CH 3 N H O H 3 C CH 3 IC50 = 308.0 nM 357.93 Cc1cc(NCCC2(c3ccccc3)CCOC(C)(C)C2)ccc1Cl Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800360 OBDepict O O N O H 3 C H 3 C IC50 = 310.0 nM 417.55 CC1(C)CC(CCN(CC(=O)c2ccco2)c2ccccc2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800486 OBDepict Cl N H O CH 3 CH 3 IC50 = 360.0 nM 343.9 CC1(C)CC(CCNc2ccc(Cl)cc2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800500 OBDepict H 3 C CH 3 O N H F F F IC50 = 380.0 nM 377.45 CC1(C)CC(CCNc2cccc(C(F)(F)F)c2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800708 OBDepict H 3 C O N H CH 3 CH 3 S H 3 C CH 3 IC50 = 420.0 nM 383.6 COc1cccc(NCCC2(c3ccccc3)CC(C)(C)SC(C)(C)C2)c1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800521 OBDepict H 3 C Cl N H O IC50 = 460.0 nM 329.87 Cc1ccc(NCCC2(c3ccccc3)CCOCC2)cc1Cl Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800497 OBDepict Cl F N H O CH 3 CH 3 IC50 = 470.0 nM 361.89 CC1(C)CC(CCNc2ccc(Cl)c(F)c2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1258894 OBDepict CH 3 N N H 3 C IC50 = 500.0 nM 402.63 CCCCCCCCn1cc(CN2CCCC2)c2cc(-c3cccc(C)c3)ccc21 Homo sapiens CHEMBL1259548 cell-based format
CHEMBL1800361 OBDepict CH 3 S N H H O O O H 3 C NH N N H IC50 = 500.0 nM 542.71 CSCC[C@@H](NC(=O)c1ccc(CNCc2c[nH]cn2)cc1-c1ccccc1C)C(=O)OCc1ccccc1 Homo sapiens CHEMBL1803640 cell-based format
CHEMBL1800491 OBDepict F N H O H 3 C H 3 C IC50 = 550.0 nM 327.44 CC1(C)CC(CCNc2ccccc2F)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800424 OBDepict H 3 C CH 3 O N H H 3 C H 3 C CH 3 IC50 = 556.0 nM 365.56 CC1(C)CC(CCNc2cccc(C(C)(C)C)c2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1257625 OBDepict CH 3 N N H 3 C H 3 C H 3 C IC50 = 600.0 nM 404.64 CCCCCCCCn1cc(CN(CC)CC)c2cc(-c3ccc(C)cc3)ccc21 Homo sapiens CHEMBL1259548 cell-based format
CHEMBL1257624 OBDepict CH 3 N N H 3 C H 3 C CH 3 IC50 = 600.0 nM 404.64 CCCCCCCCn1cc(CN(CC)CC)c2cc(-c3ccccc3C)ccc21 Homo sapiens CHEMBL1259548 cell-based format
CHEMBL1800510 OBDepict H 3 C O N H O H 3 C CH 3 Cl IC50 = 630.0 nM 373.92 COc1cccc(NCCC2(c3ccc(Cl)cc3)CCOC(C)(C)C2)c1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800478 OBDepict H 3 C O O N H CH 3 O H 3 C CH 3 IC50 = 652.0 nM 369.51 COc1ccc(NCCC2(c3ccccc3)CCOC(C)(C)C2)cc1OC Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800502 OBDepict _ O + N O N H O H 3 C H 3 C IC50 = 682.0 nM 354.45 CC1(C)CC(CCNc2ccc([N+](=O)[O-])cc2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1258547 OBDepict CH 3 N H 2 N H 3 C IC50 = 700.0 nM 348.53 CCCCCCCCn1cc(CN)c2cc(-c3cccc(C)c3)ccc21 Homo sapiens CHEMBL1259548 cell-based format
CHEMBL1258659 OBDepict CH 3 N N H 3 C H 3 C H 3 C IC50 = 700.0 nM 404.64 CCCCCCCCn1cc(CN(CC)CC)c2cc(-c3cccc(C)c3)ccc21 Homo sapiens CHEMBL1259548 cell-based format
CHEMBL1258895 OBDepict CH 3 N N H 3 C IC50 = 700.0 nM 416.65 CCCCCCCCn1cc(CN2CCCCC2)c2cc(-c3cccc(C)c3)ccc21 Homo sapiens CHEMBL1259548 cell-based format
CHEMBL1800425 OBDepict H 3 C CH 3 O N H H 3 C H 3 C CH 3 IC50 = 760.0 nM 365.56 CC1(C)CC(CCNc2ccc(C(C)(C)C)cc2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1800518 OBDepict H 3 C O N H O IC50 = 777.0 nM 311.43 COc1cccc(NCCC2(c3ccccc3)CCOCC2)c1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1258097 OBDepict CH 3 N N O CH 3 CH 3 O H 3 C IC50 = 800.0 nM 448.65 CCCCCCCCn1cc(CC(=O)N(CC)CC)c2cc(-c3cccc(OC)c3)ccc21 Homo sapiens CHEMBL1259548 cell-based format
CHEMBL1258775 OBDepict H 3 C N CH 3 N CH 3 CH 3 IC50 = 800.0 nM 432.7 CCCCCCCCn1cc(CN(CCC)CCC)c2cc(-c3cccc(C)c3)ccc21 Homo sapiens CHEMBL1259548 cell-based format
CHEMBL2035530 OBDepict CH 3 O O S H 3 C N N N IC50 = 800.0 nM 449.62 COC(=O)CCSC/C=C(C)CCn1cc(CCc2ccc(-c3ccccc3)cc2)nn1 Homo sapiens CHEMBL2039061 single protein format
CHEMBL3219960 OBDepict HO S CH 3 CH 3 CH 3 CH 3 IC50 = 860.0 nM 282.49 CC(C)=CCC/C(C)=C/CC/C(C)=C/CSCCO Homo sapiens CHEMBL3226402 single protein format
CHEMBL2376504 OBDepict CH 3 N N H 3 C H 3 C N N H 2 N IC50 = 860.0 nM 407.61 CCCCCCCCn1cc(CN(CC)CC)c2cc(-c3cnc(N)nc3)ccc21 Homo sapiens CHEMBL2380129 cell-based format
CHEMBL1258776 OBDepict CH 3 N N CH 3 H 3 C CH 3 H 3 C IC50 = 900.0 nM 404.64 CCCCCCCCn1cc(CN(C)C(C)C)c2cc(-c3cccc(C)c3)ccc21 Homo sapiens CHEMBL1259548 cell-based format
CHEMBL1257159 OBDepict CH 3 N N N H 3 C H 3 C IC50 = 900.0 nM 431.67 CCCCCCCCn1cc(CN2CCN(C)CC2)c2cc(-c3cccc(C)c3)ccc21 Homo sapiens CHEMBL1259548 cell-based format
CHEMBL2376433 OBDepict CH 3 N N H 3 C H 3 C F N IC50 = 960.0 nM 409.59 CCCCCCCCn1cc(CN(CC)CC)c2cc(-c3ccncc3F)ccc21 Homo sapiens CHEMBL2380129 cell-based format
CHEMBL1800415 OBDepict H 3 C CH 3 O N H IC50 = 1000.0 nM 309.45 CC1(C)CC(CCNc2ccccc2)(c2ccccc2)CCO1 Homo sapiens CHEMBL1803626 single protein format
CHEMBL1258098 OBDepict CH 3 N N O CH 3 CH 3 O CH 3 IC50 = 1000.0 nM 462.68 CCCCCCCCn1cc(CC(=O)N(CC)CC)c2cc(-c3cccc(OCC)c3)ccc21 Homo sapiens CHEMBL1259548 cell-based format
CHEMBL1258096 OBDepict NH 2 O N H 3 C CH 3 H 3 C CH 3 IC50 = 1000.0 nM 400.57 CC(C)=CCC/C(C)=C/Cn1cc(CC(N)=O)c2cc(-c3cccc(C)c3)ccc21 Homo sapiens CHEMBL1259548 cell-based format
CHEMBL392347 OBDepict CH 3 N O NH 2 H 3 C IC50 = 1000.0 nM 376.54 CCCCCCCCn1cc(CC(N)=O)c2cc(-c3ccc(C)cc3)ccc21 Homo sapiens CHEMBL1259548 cell-based format
CHEMBL1257623 OBDepict CH 3 N O NH 2 CH 3 IC50 = 1000.0 nM 376.54 CCCCCCCCn1cc(CC(N)=O)c2cc(-c3ccccc3C)ccc21 Homo sapiens CHEMBL1259548 cell-based format