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O60825 | F262_HUMAN | "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2" (PFKFB2)

3D structures mapped by conservation among orthologs

[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // 6PF2K ]

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[ Domain: "Phosphoglycerate mutase-like" // His_Phos_1 ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3422677 OBDepict N N N O H 3 C CH 3 NH O H N H IC50 = 15.0 nM 403.49 CC(C)Cn1nc(C#N)c2cc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)ccc21 Homo sapiens CHEMBL3425139 single protein format
CHEMBL3422678 OBDepict N N N O CH 3 N H 3 C O NH O H N H IC50 = 25.0 nM 456.51 Cc1noc(C)c1Cn1nc(C#N)c2cc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)ccc21 Homo sapiens CHEMBL3425139 single protein format
CHEMBL3422674 OBDepict N N O N O CH 3 HN O H N H IC50 = 108.0 nM 491.55 CN1Cc2cc(-n3cc(C#N)c4cc(Oc5ccc(NC(=O)[C@@H]6CCCN6)cc5)ccc43)ccc2C1=O Homo sapiens CHEMBL3425139 single protein format
CHEMBL3421733 OBDepict N N N CH 3 H 3 C CH 3 N H O H NH IC50 = 141.0 nM 415.54 CC(C)Cn1cc(C#N)c2cc(N(C)c3ccc(NC(=O)[C@@H]4CCCN4)cc3)ccc21 Homo sapiens CHEMBL3425139 single protein format
CHEMBL3422676 OBDepict N N O CH 3 N H 3 C O NH O H N H IC50 = 159.0 nM 455.52 Cc1noc(C)c1Cn1cc(C#N)c2cc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)ccc21 Homo sapiens CHEMBL3425139 single protein format
CHEMBL3422675 OBDepict N N O HN O H N H IC50 = 188.0 nM 436.52 N#Cc1cn(Cc2ccccc2)c2ccc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)cc12 Homo sapiens CHEMBL3425139 single protein format
CHEMBL3421734 OBDepict N N S H 3 C CH 3 NH O H N H IC50 = 190.0 nM 418.57 CC(C)Cn1cc(C#N)c2cc(Sc3ccc(NC(=O)[C@@H]4CCCN4)cc3)ccc21 Homo sapiens CHEMBL3425139 single protein format
CHEMBL3422673 OBDepict N N O HN O H N H IC50 = 374.0 nM 422.49 N#Cc1cn(-c2ccccc2)c2ccc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)cc12 Homo sapiens CHEMBL3425139 single protein format
CHEMBL3422651 OBDepict N N O H 3 C CH 3 NH O H N H IC50 = 384.0 nM 402.5 CC(C)Cn1cc(C#N)c2cc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)ccc21 Homo sapiens CHEMBL3425139 single protein format
CHEMBL3422672 OBDepict N N O O HN O H N H IC50 = 429.0 nM 444.54 N#Cc1cn(CC2CCOCC2)c2ccc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)cc12 Homo sapiens CHEMBL3425139 single protein format
CHEMBL3421731 OBDepict O N H H N H O N H 3 C N N CH 3 IC50 = 818.0 nM 415.5 Cn1cc(-c2cn(C)c3ccc(Oc4ccc(NC(=O)[C@@H]5CCCN5)cc4)cc23)cn1 Homo sapiens CHEMBL3425139 single protein format