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O60911 | CATL2_HUMAN | Cathepsin L2 (CTSV)

3D structures mapped by conservation among orthologs

[ Domain: "Cysteine proteinases" // Peptidase_C1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL1289645 OBDepict CH 3 N H O NH O O N Cl N H 3 C O F F F N IC50 = 16.6 nM 523.9 CCC(NC(=O)c1ccc(OCc2ccccn2)c(C(F)(F)F)c1Cl)C(=O)C(=O)Nc1ccn(C)n1 Homo sapiens CHEMBL1292096 single protein format
CHEMBL194068 OBDepict CH 3 N H H O HN O O O H 3 C H H O N H CH 3 H 3 C IC50 = 29.0 nM 417.51 CCCC[C@H](NC(=O)O[C@@H]1C(=O)NCC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 Homo sapiens CHEMBL829137 single protein format
CHEMBL1289305 OBDepict CH 3 N H O N H O O N Cl N H F F F IC50 = 29.5 nM 402.76 CCC(NC(=O)c1cccc(C(F)(F)F)c1Cl)C(=O)C(=O)Nc1cc[nH]n1 Homo sapiens CHEMBL1292096 single protein format
CHEMBL1289644 OBDepict H 3 C N N HN O O N H CH 3 O Cl O F F F N IC50 = 36.3 nM 509.87 CC(NC(=O)c1ccc(OCc2ccccn2)c(C(F)(F)F)c1Cl)C(=O)C(=O)Nc1ccn(C)n1 Homo sapiens CHEMBL1292096 single protein format
CHEMBL218394 OBDepict O NH N H H H 3 C H 3 C CH 3 H 3 C CH 3 H 3 C N O H H N H O H H 3 C CH 3 O O NH 2 IC50 = 75.0 nM 519.69 CC(C)(C)NC(=O)N[C@H](C(=O)N1C[C@H]2[C@@H]([C@H]1C(=O)NC(CC1CCC1)C(=O)C(N)=O)C2(C)C)C(C)(C)C Homo sapiens CHEMBL1245051 single protein format
CHEMBL196896 OBDepict CH 3 N H H O HN O O O H 3 C H H O O CH 3 H 3 C IC50 = 79.0 nM 418.49 CCCC[C@H](NC(=O)O[C@@H]1C(=O)OCC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 Homo sapiens CHEMBL829137 single protein format
CHEMBL3648398 OBDepict O N H H N O H H Cl O H O Ki = 100.0 nM 404.89 O=C(N[C@H](C(=O)N1C[C@H](Cl)[C@H]2OCC(=O)[C@H]21)C1CCCCC1)c1ccccc1 Homo sapiens CHEMBL3707692 single protein format
CHEMBL191584 OBDepict CH 3 N H H O HN O O O N H H N H 3 C H 3 C H 3 C N N F F F IC50 = 130.0 nM 562.59 CCCC[C@H](NC(=O)O[C@H](Cn1cnc(-c2ccc(C(F)(F)F)cc2)c1)C(C)(C)C)C(=O)C(=O)Nc1ccn[nH]1 Homo sapiens CHEMBL827829 single protein format
CHEMBL390474 OBDepict O O N H H O H 3 C H 3 C IC50 = 131.0 nM 247.29 Cc1cccc(O[C@H]2CCN3C[C@H]2OC3=O)c1C Homo sapiens CHEMBL907578 single protein format
CHEMBL541700 OBDepict CH 3 CH 3 H N H O O CH 3 H 3 C H HN O H 3 C CH 3 H NH O CH 3 CH 3 CH 3 H N O O H H 3 C O H 3 C IC50 = 140.0 nM 592.78 CC[C@H](C)[C@@H](C(=O)O[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)/C=C/C(=O)N1C(=O)C=C(OC)[C@@H]1C)N(C)C Homo sapiens CHEMBL3108103 single protein format
CHEMBL230474 OBDepict O O N H H O IC50 = 158.0 nM 219.24 O=C1O[C@@H]2CN1CC[C@@H]2Oc1ccccc1 Homo sapiens CHEMBL907578 single protein format
CHEMBL234367 OBDepict CH 3 N H H O HN O O O N H H N H 3 C H 3 C H 3 C N N F F F IC50 = 170.0 nM 562.59 CCCC[C@H](NC(=O)O[C@H](Cn1ccc(-c2ccc(C(F)(F)F)cc2)n1)C(C)(C)C)C(=O)C(=O)Nc1ccn[nH]1 Homo sapiens CHEMBL827829 single protein format
CHEMBL3648411 OBDepict O N H H N N O N H H Cl O H O Ki = 170.0 nM 470.96 O=C(N[C@H](C(=O)N1C[C@H](Cl)[C@H]2OCC(=O)[C@H]21)C1CCCCC1)c1cccc(-n2ccnc2)c1 Homo sapiens CHEMBL3707692 single protein format
CHEMBL193582 OBDepict H 3 C NH H O NH O O O H 3 C H CH 3 H 3 C H 3 C IC50 = 180.0 nM 442.6 CCCC[C@H](NC(=O)OC1C2(C)CCC(C2)C1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 Homo sapiens CHEMBL829137 single protein format
CHEMBL196298 OBDepict CH 3 N H H O HN O O O CH 3 H IC50 = 190.0 nM 400.52 CCCC[C@H](NC(=O)OC1CC2CCC1C2)C(=O)C(=O)N[C@H](C)c1ccccc1 Homo sapiens CHEMBL829137 single protein format
CHEMBL1668599 OBDepict CH 3 O O OH CH 3 O H 3 C N O CH 3 OH Ki = 200.0 nM 331.32 COc1c(OC)c(OC)c2c(c1O)c(=O)c1cccc(O)c1n2C Homo sapiens CHEMBL1670880 assay format
CHEMBL3648405 OBDepict O N H H N N O N N N H H Cl O H O Ki = 240.0 nM 472.93 O=C(N[C@H](C(=O)N1C[C@H](Cl)[C@H]2OCC(=O)[C@H]21)C1CCCCC1)c1cccc(-n2cnnn2)c1 Homo sapiens CHEMBL3707692 single protein format
CHEMBL196240 OBDepict CH 3 N H H O HN O O O H 3 C H H IC50 = 290.0 nM 422.53 CCCC[C@H](NC(=O)O[C@H]1CCc2ccccc21)C(=O)C(=O)N[C@H](C)c1ccccc1 Homo sapiens CHEMBL829137 single protein format
CHEMBL195963 OBDepict H 3 C N H H O N H O O O CH 3 H H IC50 = 340.0 nM 436.55 CCCC[C@H](NC(=O)O[C@H]1CCCc2ccccc21)C(=O)C(=O)N[C@H](C)c1ccccc1 Homo sapiens CHEMBL829137 single protein format
CHEMBL197509 OBDepict H 3 C N H H O NH O O O CH 3 H IC50 = 390.0 nM 440.58 CCCC[C@H](NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)C(=O)N[C@H](C)c1ccccc1 Homo sapiens CHEMBL829137 single protein format
CHEMBL2042470 OBDepict _ O + N O N O H O Ki = 400.0 nM 346.34 O=c1c2cc(OCc3ccccc3)ccc2[nH]c2ccc([N+](=O)[O-])cc12 Homo sapiens CHEMBL2043897 assay format
CHEMBL4438688 OBDepict OH O HO H OH H O H OH OH HO HO HO IC50 = 420.0 nM 544.51 O=C(c1ccc(O)cc1O)[C@H]1[C@H](c2ccc(O)cc2)c2cc(O)c(O)cc2[C@H](O)[C@]1(O)C(=O)c1ccc(O)cc1 Homo sapiens CHEMBL4376337 single protein format
CHEMBL190053 OBDepict CH 3 N H H O N H O O O N H H N H 3 C H 3 C CH 3 N N F F F IC50 = 430.0 nM 562.59 CCCC[C@H](NC(=O)O[C@H](Cn1cc(-c2ccc(C(F)(F)F)cc2)cn1)C(C)(C)C)C(=O)C(=O)Nc1ccn[nH]1 Homo sapiens CHEMBL827829 single protein format
CHEMBL1668597 OBDepict CH 3 O OH N CH 3 OH O OH CH 3 CH 3 CH 3 H 3 C Ki = 500.0 nM 423.51 COc1c(O)c(CC=C(C)C)c(O)c2c(=O)c3c(CC=C(C)C)ccc(O)c3n(C)c12 Homo sapiens CHEMBL1670880 assay format
CHEMBL4462944 OBDepict HO H H O OH O O OH HO OH OH IC50 = 700.0 nM 526.5 O=C1c2ccc(O)cc2OC2c3cc(O)c(O)cc3[C@@H](c3ccc(O)cc3)[C@@H](C(=O)c3ccc(O)cc3O)C12 Homo sapiens CHEMBL4376337 single protein format
CHEMBL3648397 OBDepict O N H H N O H H F O H O Ki = 700.0 nM 388.44 O=C(N[C@H](C(=O)N1C[C@H](F)[C@H]2OCC(=O)[C@H]21)C1CCCCC1)c1ccccc1 Homo sapiens CHEMBL3707692 single protein format
CHEMBL481611 OBDepict H HN F F F H N H O F CH 3 CH 3 N S O O CH 3 IC50 = 762.0 nM 525.57 CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 Homo sapiens CHEMBL945084 single protein format
CHEMBL2042446 OBDepict CH 3 N H O Ki = 800.0 nM 277.37 CCCCc1ccc(-c2cc(=O)c3ccccc3[nH]2)cc1 Homo sapiens CHEMBL2043893 assay format
CHEMBL2042454 OBDepict OH O N H + N O O _ O Ki = 800.0 nM 414.42 O=C(O)c1cc2ccccc2cc1Nc1ccc(OCc2ccccc2)c([N+](=O)[O-])c1 Homo sapiens CHEMBL2043895 assay format
CHEMBL230478 OBDepict H 3 C CH 3 O H H O N O IC50 = 894.0 nM 199.25 CC(C)CO[C@H]1CCN2C[C@H]1OC2=O Homo sapiens CHEMBL907578 single protein format
CHEMBL2042454 OBDepict OH O N H + N O O _ O IC50 = 1000.0 nM 414.42 O=C(O)c1cc2ccccc2cc1Nc1ccc(OCc2ccccc2)c([N+](=O)[O-])c1 Homo sapiens CHEMBL2043890 assay format
CHEMBL451705 OBDepict CH 3 O O N CH 3 CH 3 OH O OH Ki = 1000.0 nM 301.3 COc1cc(O)c2c(=O)c3cccc(O)c3n(C)c2c1OC Homo sapiens CHEMBL1670880 assay format