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O75385 | ULK1_HUMAN | Serine/threonine-protein kinase ULK1 (ULK1)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Domain: "Ubiquitin-like" // Atg8 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4860979 OBDepict F S N O O CH 3 N H 2 N O N H IC50 = -54600.0 nM 466.54 CN(C1CC1)S(=O)(=O)c1ccc(-c2cnc(N)c(-c3ccc4c(c3)CCNC4=O)c2)c(F)c1 Homo sapiens CHEMBL4804509 cell-based format
CHEMBL4855542 OBDepict NH 2 N S N O NH IC50 = -23400.0 nM 372.45 Nc1ncc(-c2cccc3ncsc23)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804509 cell-based format
CHEMBL4859660 OBDepict NH 2 N F + N O NH O _ O IC50 = -19600.0 nM 378.36 Nc1ncc(-c2cccc([N+](=O)[O-])c2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804509 cell-based format
CHEMBL4516990 OBDepict H 3 C N N H N N N H NH O IC50 = 2.9 nM 434.59 CN1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CCC4)n3)ccc2C1 Homo sapiens CHEMBL4308982 single protein format
CHEMBL4796600 OBDepict O HN N N N H F F F IC50 = 3.0 nM 362.36 O=C1CCCc2cc(Nc3ncc(C(F)(F)F)c(NC4CC4)n3)ccc21 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4746440 OBDepict F F F N HN N N H N IC50 = 5.0 nM 345.33 FC(F)(F)c1cnc(Nc2ccc3ncccc3c2)nc1NC1CC1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4741912 OBDepict H N N NH N N N H F F F IC50 = 5.0 nM 334.31 FC(F)(F)c1cnc(Nc2ccc3nc[nH]c3c2)nc1NC1CC1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL3605055 OBDepict H N N N H N N H N N N H IC50 = 5.3 nM 396.46 c1ccc2c(Nc3cc(C4CCC4)[nH]n3)nc(Nc3ccc4[nH]cnc4c3)nc2c1 Homo sapiens CHEMBL3606871 cell-based format
CHEMBL4782961 OBDepict H N N N NH N N N H F F F IC50 = 6.0 nM 335.29 FC(F)(F)c1cnc(Nc2ccc3nn[nH]c3c2)nc1NC1CC1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4758769 OBDepict F F F N NH N N H O O IC50 = 7.0 nM 366.34 FC(F)(F)c1cnc(Nc2ccc3c(c2)OCCCO3)nc1NC1CC1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 8.95 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328647 single protein format
CHEMBL4435393 OBDepict O N F F F N CH 3 H N N H N N H N N IC50 = 9.0 nM 552.61 C[C@H](c1ccnc(Nc2nc3ccc(-c4cnn(CC5CC5)c4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1 Homo sapiens CHEMBL4380527 assay format
CHEMBL4167070 OBDepict H 2 N N H O N N N H H IC50 = 11.0 nM 399.5 NC1CCCC(C(=O)Nc2ccc3[nH]nc(Nc4cccc5ccccc45)c3c2)C1 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL4778997 OBDepict O N H N H N N HN F F F IC50 = 13.0 nM 377.37 O=C(Nc1ccc(Nc2ncc(C(F)(F)F)c(NC3CC3)n2)cc1)C1CC1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4779423 OBDepict CH 3 O O N H CH 3 N N HN F F F IC50 = 13.0 nM 354.33 COc1ccc(Nc2ncc(C(F)(F)F)c(NC3CC3)n2)cc1OC Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4748400 OBDepict F F F N HN N N H N N IC50 = 13.0 nM 346.32 FC(F)(F)c1cnc(Nc2ccc3nccnc3c2)nc1NC1CC1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4794151 OBDepict H N N N H N N HN F F F IC50 = 14.0 nM 334.31 FC(F)(F)c1cnc(Nc2ccc3[nH]ncc3c2)nc1NC1CC1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4799009 OBDepict F F F N HN N N H O O IC50 = 14.0 nM 352.32 FC(F)(F)c1cnc(Nc2ccc3c(c2)OCCO3)nc1NC1CC1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4795918 OBDepict CH 3 O N N H N N HN F F F IC50 = 14.0 nM 325.29 COc1cncc(Nc2ncc(C(F)(F)F)c(NC3CC3)n2)c1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4792540 OBDepict F F F N HN N N H N IC50 = 16.0 nM 345.33 FC(F)(F)c1cnc(Nc2cnc3ccccc3c2)nc1NC1CC1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4793366 OBDepict H N N N H N N NH F F F IC50 = 17.0 nM 348.33 FC(F)(F)c1cnc(Nc2cnc3[nH]ccc3c2)nc1NC1CCC1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4800057 OBDepict F F F N HN N N H O N IC50 = 19.0 nM 335.29 FC(F)(F)c1cnc(Nc2ccc3ncoc3c2)nc1NC1CC1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4789210 OBDepict H 2 N N H N N NH F F F IC50 = 20.0 nM 309.3 Nc1ccc(Nc2ncc(C(F)(F)F)c(NC3CC3)n2)cc1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4748802 OBDepict F F F N HN N N H O O IC50 = 21.0 nM 338.29 FC(F)(F)c1cnc(Nc2ccc3c(c2)OCO3)nc1NC1CC1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4754535 OBDepict H N N H N N HN F F F IC50 = 23.0 nM 333.32 FC(F)(F)c1cnc(Nc2ccc3[nH]ccc3c2)nc1NC1CC1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4159827 OBDepict O N H H H NH 2 N N N H H IC50 = 24.0 nM 399.5 N[C@@H]1CCC[C@@H](C(=O)Nc2ccc3[nH]nc(Nc4cccc5ccccc45)c3c2)C1 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL4468020 OBDepict O N F F F N N N H N N H N N IC50 = 28.0 nM 538.58 O=C(CC(F)(F)F)N1CCN(Cc2ccnc(Nc3nc4ccc(-c5cnn(CC6CC6)c5)cc4[nH]3)c2)CC1 Homo sapiens CHEMBL4380527 assay format
CHEMBL4776497 OBDepict H N N N H N N HN F F F IC50 = 29.0 nM 334.31 FC(F)(F)c1cnc(Nc2cnc3[nH]ccc3c2)nc1NC1CC1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4786152 OBDepict O N O N H N N HN F F F IC50 = 30.0 nM 445.45 O=C(C1CC1)N(C(=O)C1CC1)c1ccc(Nc2ncc(C(F)(F)F)c(NC3CC3)n2)cc1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4750700 OBDepict CH 3 N N O HN N N N H F F F IC50 = 31.0 nM 380.37 CCN1CCOc2cc(Nc3ncc(C(F)(F)F)c(NC4CC4)n3)cnc21 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4747695 OBDepict H 3 C NH N N N H F F F N N H IC50 = 34.0 nM 308.27 CNc1nc(Nc2cnc3[nH]ccc3c2)ncc1C(F)(F)F Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4787833 OBDepict F F F N NH N N H N N IC50 = 40.0 nM 296.26 FC(F)(F)c1cnc(Nc2ccnnc2)nc1NC1CC1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4176003 OBDepict H 2 N N H O N N N H H N IC50 = 40.0 nM 400.49 NC1CCCC(C(=O)Nc2ccc3[nH]nc(Nc4cccc5ncccc45)c3c2)C1 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL4777354 OBDepict F F O O N H N N HN F F F IC50 = 42.0 nM 374.27 FC1(F)Oc2ccc(Nc3ncc(C(F)(F)F)c(NC4CC4)n3)cc2O1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4784530 OBDepict O N H HN N N N O IC50 = 45.0 nM 463.63 O=C(NCCCNc1nc(Cc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1 Homo sapiens CHEMBL4711124 single protein format
CHEMBL4170480 OBDepict O N H H H NH 2 N N N H H IC50 = 45.0 nM 399.5 N[C@H]1CCC[C@@H](C(=O)Nc2ccc3[nH]nc(Nc4cccc5ccccc45)c3c2)C1 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL4127042 OBDepict H 3 C N N H N N N H NH NH IC50 = 45.0 nM 433.6 CN1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=N)C4CCC4)n3)ccc2C1 Homo sapiens CHEMBL4121192 single protein format
CHEMBL4755602 OBDepict OH N H N N NH F F F IC50 = 50.0 nM 310.28 Oc1ccccc1Nc1ncc(C(F)(F)F)c(NC2CC2)n1 Homo sapiens CHEMBL4677633 cell-based format
CHEMBL3603853 OBDepict O N H NH N I N NH N H N O IC50 = 67.0 nM 549.42 O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1I)C1CC1 Homo sapiens CHEMBL3606871 cell-based format
CHEMBL577784 OBDepict O N N H NH N N NH I N H O S IC50 = 87.0 nM 591.48 O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1I)c1cccs1 Homo sapiens CHEMBL3606871 cell-based format
CHEMBL4128069 OBDepict CH 3 HN O O N Br N N H O O H 3 C O H 3 C CH 3 IC50 = 108.0 nM 489.33 CNC(=O)c1ccccc1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br Homo sapiens CHEMBL4121192 single protein format
CHEMBL4167729 OBDepict CH 3 O N H N N H N H O H 2 N IC50 = 110.0 nM 379.46 COc1ccccc1Nc1n[nH]c2ccc(NC(=O)C3CCCC(N)C3)cc12 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL3605056 OBDepict NH 2 HN N I N N H N H N O IC50 = 120.0 nM 481.34 NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1I Homo sapiens CHEMBL3606871 cell-based format
CHEMBL3605057 OBDepict O N H HN N N N H N O IC50 = 170.0 nM 464.61 O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1 Homo sapiens CHEMBL3606871 cell-based format
CHEMBL4168817 OBDepict CH 3 O O N H N N H N H O NH 2 IC50 = 183.0 nM 407.47 COC(=O)c1cccc(Nc2n[nH]c3ccc(NC(=O)C4CCCC(N)C4)cc23)c1 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL4794090 OBDepict NH 2 N N N H F F F O O IC50 = 230.0 nM 298.22 Nc1nc(Nc2ccc3c(c2)OCO3)ncc1C(F)(F)F Homo sapiens CHEMBL4677633 cell-based format
CHEMBL4160882 OBDepict H 2 N N H O N N N H H N IC50 = 239.0 nM 400.49 NC1CCCC(C(=O)Nc2ccc3[nH]nc(Nc4ccnc5ccccc45)c3c2)C1 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL4161514 OBDepict NH 2 N H O N N H N H O IC50 = 242.0 nM 377.45 NC1CCCC(C(=O)Nc2ccc3[nH]nc(NC(=O)c4ccccc4)c3c2)C1 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL4543618 OBDepict CH 3 O H 3 C N N N N H N H N N CH 3 H N O F F F IC50 = 263.0 nM 568.6 CC(C)Oc1cncnc1-c1ccc2nc(Nc3cc([C@@H](C)N4CCN(C(=O)CC(F)(F)F)CC4)ccn3)[nH]c2c1 Homo sapiens CHEMBL4380527 assay format
CHEMBL4164280 OBDepict NH 2 HN O N N H N H F F F IC50 = 288.0 nM 417.44 NC1CCCC(C(=O)Nc2ccc3[nH]nc(Nc4cccc(C(F)(F)F)c4)c3c2)C1 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL4163621 OBDepict O N H NH N N N H H IC50 = 315.0 nM 385.47 O=C(Nc1ccc2[nH]nc(Nc3cccc4ccccc34)c2c1)C1CCNCC1 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL4172115 OBDepict O N H H H H 2 N N NH 2 N H IC50 = 330.0 nM 273.34 Nc1n[nH]c2ccc(NC(=O)[C@H]3CCC[C@@H](N)C3)cc12 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL4177033 OBDepict H 2 N N H O N NH 2 N H IC50 = 368.0 nM 273.34 Nc1n[nH]c2ccc(NC(=O)C3CCCC(N)C3)cc12 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL4566796 OBDepict H 3 C O N N N N H N H N N CH 3 H N O F F F IC50 = 368.0 nM 554.58 COCc1cc(-c2ccc3nc(Nc4cc([C@@H](C)N5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 Homo sapiens CHEMBL4380527 assay format
CHEMBL4175598 OBDepict NH 2 N H O N N H N H Br IC50 = 416.0 nM 428.33 NC1CCCC(C(=O)Nc2ccc3[nH]nc(Nc4ccc(Br)cc4)c3c2)C1 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL4454902 OBDepict O N F F F N CH 3 H N N H N N H N N O IC50 = 416.0 nM 580.62 C[C@H](c1ccnc(Nc2nc3ccc(-c4cc(OCC5CC5)ncn4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1 Homo sapiens CHEMBL4380527 assay format
CHEMBL4160498 OBDepict CH 3 O N H N N H N H O NH 2 IC50 = 477.0 nM 393.49 COc1ccc(CNc2n[nH]c3ccc(NC(=O)C4CCCC(N)C4)cc23)cc1 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL4173259 OBDepict O N H NH N H 2 N N H IC50 = 560.0 nM 259.31 Nc1n[nH]c2ccc(NC(=O)C3CCNCC3)cc12 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL4165390 OBDepict H 2 N N H O N N N H H N IC50 = 589.0 nM 400.49 NC1CCCC(C(=O)Nc2ccc3[nH]nc(Nc4cccc5cccnc45)c3c2)C1 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL4168766 OBDepict O N H HN N NH 2 N H IC50 = 670.0 nM 259.31 Nc1n[nH]c2ccc(NC(=O)C3CCCNC3)cc12 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL4176627 OBDepict O N H N H N NH 2 N H IC50 = 840.0 nM 259.31 Nc1n[nH]c2ccc(NC(=O)C3CCCCN3)cc12 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL4172165 OBDepict NH 2 HN O N N H N H F IC50 = 840.0 nM 367.43 NC1CCCC(C(=O)Nc2ccc3[nH]nc(Nc4ccccc4F)c3c2)C1 Homo sapiens CHEMBL4136618 cell-based format
CHEMBL4538751 OBDepict O N F F F N CH 3 H N N H N N H N N CH 3 IC50 = 980.0 nM 524.55 Cc1cc(-c2ccc3nc(Nc4cc([C@@H](C)N5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 Homo sapiens CHEMBL4380527 assay format