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O75530 | EED_HUMAN | Polycomb protein EED (EED)

3D structures mapped by conservation among orthologs

[ Domain: "7-bladed" // ANAPC4_WD40_5 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4637096 OBDepict F HN O N N N S O O CH 3 N F F IC50 = 0.2 nM 489.48 CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccc(C(F)F)nc3)c12 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4637520 OBDepict F HN O N N N S O O CH 3 N IC50 = 0.2 nM 479.54 CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccc(C4CC4)nc3)c12 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4870920 OBDepict CH 3 N CH 3 O N N N F F F N N H F O IC50 = 0.2 nM 528.51 CC(C)N1Cc2cc(C(F)(F)F)ncc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC(C1=O)C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4060827 OBDepict CH 3 N O N H N H N CH 3 H 3 C F Ki = 0.29 nM 450.6 CC(=O)N1CCN(c2ccc([C@H]3CN(C4CCc5cccc(F)c54)C[C@@H]3N(C)C)cc2)CC1 Homo sapiens CHEMBL4007108 single protein format
CHEMBL4104741 OBDepict F N H H N H 3 C CH 3 N N S O O CH 3 Ki = 0.3 nM 486.66 CN(C)[C@H]1CN(C2CCc3cccc(F)c32)C[C@@H]1c1ccc(N2CCN(S(C)(=O)=O)CC2)cc1 Homo sapiens CHEMBL4020039 single protein format
CHEMBL4093096 OBDepict F H H N H 3 C CH 3 N N S O O CH 3 Ki = 0.3 nM 485.67 CN(C)[C@H]1CC(C2CCc3cccc(F)c32)C[C@@H]1c1ccc(N2CCN(S(C)(=O)=O)CC2)cc1 Homo sapiens CHEMBL4007108 single protein format
CHEMBL4084398 OBDepict CH 3 N O N H N H N CH 3 H 3 C H F Ki = 0.3 nM 450.6 CC(=O)N1CCN(c2ccc([C@H]3CN([C@H]4CCc5cccc(F)c54)C[C@@H]3N(C)C)cc2)CC1 Homo sapiens CHEMBL4020039 single protein format
CHEMBL4638412 OBDepict F HN O N N N S O O CH 3 N F F F IC50 = 0.3 nM 507.47 CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccc(C(F)(F)F)nc3)c12 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4644746 OBDepict CH 3 N F F F N N N S N H O O CH 3 F O IC50 = 0.4 nM 521.5 Cc1nc(C(F)(F)F)ccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnc(S(C)(=O)=O)c12 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4645310 OBDepict H 3 C N N N N S N H O O CH 3 F O IC50 = 0.4 nM 453.5 Cc1ccc(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnc(S(C)(=O)=O)c23)cn1 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4643880 OBDepict F N N N S N H O O CH 3 F O IC50 = 0.4 nM 456.47 CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccc(F)cc3)c12 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4645324 OBDepict F N H O N N N S O O CH 3 S O O CH 3 IC50 = 0.4 nM 516.58 CS(=O)(=O)c1ccc(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnc(S(C)(=O)=O)c23)cc1 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4865691 OBDepict O N H N N N CH 3 N N N H F O IC50 = 0.4 nM 421.44 Cn1ncc2c1CNC(=O)C1N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C2C13 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4076017 OBDepict NH 2 O N N H N H N CH 3 H 3 C F Ki = 0.45 nM 451.59 CN(C)[C@H]1CN(C2CCc3cccc(F)c32)C[C@@H]1C1CCN(c2ccc(C(N)=O)cn2)CC1 Homo sapiens CHEMBL4007108 single protein format
CHEMBL4642335 OBDepict H 3 C N N N N N S N H O O CH 3 F O IC50 = 0.5 nM 442.48 Cn1cc(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnc(S(C)(=O)=O)c23)cn1 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4851576 OBDepict O N H N N N HN F O IC50 = 0.5 nM 417.44 O=C1NCc2ccccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4635558 OBDepict H 3 C N CH 3 N N N S N H O O CH 3 F O IC50 = 0.5 nM 467.53 Cc1ccc(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnc(S(C)(=O)=O)c23)c(C)n1 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4877375 OBDepict H 3 C N O N N N F F F N N H F O IC50 = 0.6 nM 514.48 CCN1Cc2cc(C(F)(F)F)ncc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC(C1=O)C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4872891 OBDepict O N H N N N HN F F O IC50 = 0.6 nM 435.43 O=C1NCc2cc(F)ccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4869420 OBDepict O N CH 3 N N N N H N F F F F O IC50 = 0.6 nM 500.46 CN1Cc2cc(C(F)(F)F)ncc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC(C1=O)C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4860499 OBDepict O N N N N N H O N F F F F O IC50 = 0.6 nM 584.57 O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1CC1CCOCC1)C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4073166 OBDepict NH 2 O N N N H N H N CH 3 H 3 C CH 3 F Ki = 0.65 nM 440.57 Cc1cccc(F)c1CN1C[C@H](C2CCN(c3cnc(C(N)=O)cn3)CC2)[C@@H](N(C)C)C1 Homo sapiens CHEMBL4007108 single protein format
CHEMBL4640949 OBDepict F HN O N N N S O O CH 3 IC50 = 0.7 nM 438.48 CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccccc3)c12 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4850823 OBDepict O N N N O N N H N F F F F O IC50 = 0.7 nM 570.55 O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1C1CCOCC1)C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4873268 OBDepict O N H N N N N HN F O IC50 = 0.7 nM 418.43 O=C1NCc2ncccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4859559 OBDepict O NH N N N N H N F F F F O IC50 = 0.7 nM 486.43 O=C1NCc2cc(C(F)(F)F)ncc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4861749 OBDepict O NH N N N N N H CH 3 F O IC50 = 0.7 nM 432.46 Cc1ccc2c(n1)CNC(=O)C1N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C2C13 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4065766 OBDepict H 3 C N O N N H 3 C H N H N H 3 C CH 3 H 3 C F Ki = 0.74 nM 477.63 Cc1cccc(F)c1CN1C[C@H](c2cn(C)c3c(N4CCN(C)C(=O)C4)cccc23)[C@@H](N(C)C)C1 Homo sapiens CHEMBL4007108 single protein format
CHEMBL4640556 OBDepict F N H O N N N S O O CH 3 N S O O CH 3 IC50 = 0.8 nM 517.56 CS(=O)(=O)c1ccc(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnc(S(C)(=O)=O)c23)cn1 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4856280 OBDepict O N N N N N H N F F F F O IC50 = 0.8 nM 540.52 O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1C1CCC1)C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4878932 OBDepict O N N N F F N N H N F F F F O IC50 = 0.8 nM 576.5 O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1C1CC(F)(F)C1)C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4862163 OBDepict O N H N N F N HN F O IC50 = 0.8 nM 435.43 O=C1NCc2c(F)cccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4649099 OBDepict CH 3 S O O CH 3 N N N S N H O O CH 3 F O IC50 = 0.9 nM 530.6 Cc1cc(S(C)(=O)=O)ccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnc(S(C)(=O)=O)c12 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4856160 OBDepict CH 3 O CH 3 N O N N N F F F N N H F O IC50 = 1.0 nM 598.6 CC1CC(N2Cc3cc(C(F)(F)F)ncc3C3=CN=C(NCc4c(F)ccc5c4CCO5)N4C=NC(C2=O)C34)CC(C)O1 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4854206 OBDepict H 3 C N N O N N N F F F N NH F O IC50 = 1.0 nM 597.62 CN1CCC(CN2Cc3cc(C(F)(F)F)ncc3C3=CN=C(NCc4c(F)ccc5c4CCO5)N4C=NC(C2=O)C34)CC1 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4077363 OBDepict F N O N H 3 C H N H N H 3 C CH 3 H 3 C F Ki = 1.0 nM 466.58 Cc1cccc(F)c1CN1C[C@H](c2cn(C)c3c(C(=O)N4CC(F)C4)cccc23)[C@@H](N(C)C)C1 Homo sapiens CHEMBL4007108 single protein format
CHEMBL4850847 OBDepict O N N N HO N N H N F F F F O IC50 = 1.1 nM 556.52 O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1CC1(O)CC1)C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4847943 OBDepict O NH N N N N H F F F F O IC50 = 1.2 nM 485.44 O=C1NCc2cc(C(F)(F)F)ccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4861394 OBDepict O N N N F F CH 3 N N H N F F F F O IC50 = 1.4 nM 564.49 CC(F)(F)CN1Cc2cc(C(F)(F)F)ncc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC(C1=O)C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4871261 OBDepict O N N N N N H N F F F F O IC50 = 1.5 nM 526.49 O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1C1CC1)C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4849266 OBDepict O N N N HO CH 3 CH 3 N N H N F F F F O IC50 = 1.6 nM 558.54 CC(C)(O)CN1Cc2cc(C(F)(F)F)ncc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC(C1=O)C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4858089 OBDepict O N N N O O N N H N F F F F O IC50 = 1.6 nM 586.55 O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1CC1COCCO1)C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4854800 OBDepict F F N O N N N F F F N N H F O IC50 = 1.6 nM 550.46 O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1CC(F)F)C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4858561 OBDepict O N N N N HN CH 3 OH N F F F F O IC50 = 1.8 nM 584.57 CC1(O)CC(CN2Cc3cc(C(F)(F)F)ncc3C3=CN=C(NCc4c(F)ccc5c4CCO5)N4C=NC(C2=O)C34)C1 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4633469 OBDepict F N H O N N N S O O CH 3 CH 3 N IC50 = 1.8 nM 453.5 Cc1ncccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnc(S(C)(=O)=O)c12 Homo sapiens CHEMBL4613059 single protein format
CHEMBL3414621 OBDepict CH 3 N H 3 C O N H O N CH 3 O N H H 3 C O IC50 = 2.0 nM 572.75 CCN(c1cc(-c2ccc(CN3CCOCC3)cc2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1 Homo sapiens CHEMBL4008166 assay format
CHEMBL4059553 OBDepict H 3 C N F H H N CH 3 H 3 C N N N Ki = 2.1 nM 473.64 Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCN(c4ccccn4)CC3)cc2)[C@@H](N(C)C)C1 Homo sapiens CHEMBL4007108 single protein format
CHEMBL4068192 OBDepict H 2 N O N N H N H N CH 3 H 3 C CH 3 F Ki = 2.6 nM 435.55 Cc1cccc(F)c1CN1C[C@H](c2ccc(-c3cnn(CC(N)=O)c3)cc2)[C@@H](N(C)C)C1 Homo sapiens CHEMBL4007108 single protein format
CHEMBL4081496 OBDepict CH 3 N O N H N H N H 3 C CH 3 H 3 C F Ki = 2.6 nM 438.59 CC(=O)N1CCN(c2ccc([C@H]3CN(Cc4c(C)cccc4F)C[C@@H]3N(C)C)cc2)CC1 Homo sapiens CHEMBL4007108 single protein format
CHEMBL4639197 OBDepict H 3 C N O N N N S N H O O CH 3 F O IC50 = 2.8 nM 487.56 CC(=O)N1CCC(c2cnc(NCc3c(F)ccc4c3CCO4)n3cnc(S(C)(=O)=O)c23)CC1 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4071358 OBDepict CH 3 N O N H N H N CH 3 H 3 C H F Ki = 3.0 nM 450.6 CC(=O)N1CCN(c2ccc([C@H]3CN([C@@H]4CCc5cccc(F)c54)C[C@@H]3N(C)C)cc2)CC1 Homo sapiens CHEMBL4020039 single protein format
CHEMBL4102320 OBDepict H 3 C O O H 3 C H N H N H 3 C CH 3 F Ki = 3.0 nM 384.5 COc1ccc([C@H]2CN(C3CCc4cccc(F)c43)C[C@@H]2N(C)C)cc1OC Homo sapiens CHEMBL4020039 single protein format
CHEMBL4851414 OBDepict CH 3 N CH 3 O N N CH 3 N O N N H N H F O IC50 = 3.0 nM 463.47 CN(C)C(=O)c1cc(-c2cnc(NCc3c(F)ccc4c3CCO4)c3cn[nH]c(=O)c23)n(C)n1 Homo sapiens CHEMBL4834035 cell-based format
CHEMBL4634654 OBDepict F N H O N N N S O O CH 3 N S O O IC50 = 3.1 nM 549.65 CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(C3CCN(S(=O)(=O)C4CC4)CC3)c12 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4857414 OBDepict O N N N F F F N NH N F F F F O IC50 = 3.2 nM 568.45 O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1CC(F)(F)F)C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4648753 OBDepict F HN O N N N P O CH 3 CH 3 IC50 = 3.6 nM 436.43 CP(C)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccccc3)c12 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4855616 OBDepict O NH N N N N N H F F F F O IC50 = 3.6 nM 486.43 O=C1NCc2nc(C(F)(F)F)ccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4859723 OBDepict H 3 C N N CH 3 N O N N H N H F O IC50 = 4.0 nM 406.42 Cc1cc(-c2cnc(NCc3c(F)ccc4c3CCO4)c3cn[nH]c(=O)c23)n(C)n1 Homo sapiens CHEMBL4834035 cell-based format
CHEMBL4869720 OBDepict F N H N N N O HN F O IC50 = 4.1 nM 435.43 O=C1NCc2ccc(F)cc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4755618 OBDepict F N H O N N N N CH 3 N IC50 = 4.5 nM 376.4 Cc1ncccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 Homo sapiens CHEMBL4735359 single protein format
CHEMBL4072329 OBDepict O N S O O CH 3 N H N H N H 3 C CH 3 H 3 C F Ki = 4.6 nM 514.67 Cc1cccc(F)c1CN1C[C@H](c2ccc(C3=CCN(C(=O)CS(C)(=O)=O)CC3)nc2)[C@@H](N(C)C)C1 Homo sapiens CHEMBL4007108 single protein format
CHEMBL4077273 OBDepict H 3 C N CH 3 O N N H N H N CH 3 H 3 C CH 3 F Ki = 5.3 nM 437.56 Cc1cccc(F)c1CN1C[C@H](c2cn(CC(=O)N(C)C)c3ncccc23)[C@@H](N(C)C)C1 Homo sapiens CHEMBL4007108 single protein format
CHEMBL4855253 OBDepict F N H O N N N O N H CH 3 N IC50 = 6.0 nM 392.39 Cn1nccc1-c1cnc(NCc2c(F)ccc3c2CCO3)c2cn[nH]c(=O)c12 Homo sapiens CHEMBL4834035 cell-based format
CHEMBL4104741 OBDepict F N H H N H 3 C CH 3 N N S O O CH 3 IC50 = 7.0 nM 486.66 CN(C)[C@H]1CN(C2CCc3cccc(F)c32)C[C@@H]1c1ccc(N2CCN(S(C)(=O)=O)CC2)cc1 Homo sapiens CHEMBL4138823 single protein format
CHEMBL4103319 OBDepict N N N N N N H O IC50 = 7.0 nM 374.45 c1coc(CNc2ncc(-c3ccc(CN4CCCC4)cc3)c3nncn23)c1 Homo sapiens CHEMBL4008166 assay format
CHEMBL4642454 OBDepict F HN O N N N S O O CH 3 S O O IC50 = 7.8 nM 494.57 CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(C3CCS(=O)(=O)CC3)c12 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4649861 OBDepict F HN O N N N S O O CH 3 N S O O CH 3 IC50 = 7.9 nM 523.61 CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(C3CCN(S(C)(=O)=O)CC3)c12 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4100850 OBDepict HO F Br N H H N CH 3 H 3 C N CH 3 Ki = 8.0 nM 446.36 CN(C)[C@H]1CN(Cc2c(F)cc(O)cc2Br)C[C@@H]1c1cn(C)c2ccccc12 Homo sapiens CHEMBL4020039 single protein format
CHEMBL4847216 OBDepict H 3 C N H O N CH 3 N O N N H N H F O IC50 = 8.0 nM 460.47 CNC(=O)c1ccc(-c2cnc(NCc3c(F)ccc4c3CCO4)c3cn[nH]c(=O)c23)c(C)n1 Homo sapiens CHEMBL4834035 cell-based format
CHEMBL4088683 OBDepict N N H N N N O N CH 3 CH 3 IC50 = 9.0 nM 372.43 CN(C)Cc1ccc(-c2cc(C#N)c(NCc3ccco3)n3cnnc23)cc1 Homo sapiens CHEMBL4008166 assay format
CHEMBL4079806 OBDepict N N H N N N O N CH 3 CH 3 IC50 = 9.0 nM 372.43 CN(C)Cc1ccc(-c2cc(C#N)c(NCc3ccoc3)n3cnnc23)cc1 Homo sapiens CHEMBL4008166 assay format
CHEMBL4850478 OBDepict H 3 C N H O N N H 3 C N O N N H N H F O IC50 = 9.0 nM 449.45 CNC(=O)c1ncc(-c2cnc(NCc3c(F)ccc4c3CCO4)c3cn[nH]c(=O)c23)n1C Homo sapiens CHEMBL4834035 cell-based format
CHEMBL4869748 OBDepict O NH N N N N H F F F F O IC50 = 9.2 nM 485.44 O=C1NCc2ccc(C(F)(F)F)cc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4072980 OBDepict H 3 C N F H H N CH 3 H 3 C S O O CH 3 Ki = 10.0 nM 390.52 Cc1cccc(F)c1CN1C[C@H](c2ccc(S(C)(=O)=O)cc2)[C@@H](N(C)C)C1 Homo sapiens CHEMBL4020039 single protein format
CHEMBL4079307 OBDepict H 3 C N F H H N CH 3 H 3 C N N N IC50 = 10.0 nM 473.64 Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCN(c4ccncc4)CC3)cc2)[C@@H](N(C)C)C1 Homo sapiens CHEMBL3994543 single protein format
CHEMBL4795893 OBDepict F N H H N H 3 C CH 3 N H 3 C Ki = 11.0 nM 377.51 CN(C)[C@H]1CN(C2CCc3cccc(F)c32)C[C@@H]1c1cn(C)c2ccccc12 Homo sapiens CHEMBL4735354 single protein format
CHEMBL4080018 OBDepict F H N H H N H 3 C CH 3 N H 3 C Ki = 11.0 nM 377.51 CN(C)[C@H]1CN([C@H]2CCc3cccc(F)c32)C[C@@H]1c1cn(C)c2ccccc12 Homo sapiens CHEMBL4007108 single protein format
CHEMBL4877695 OBDepict O N H N N S N NH F O IC50 = 11.3 nM 423.47 O=C1NCc2sccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4085428 OBDepict CH 3 N F H H N H 3 C CH 3 N CH 3 Ki = 12.0 nM 365.5 Cc1cccc(F)c1CN1C[C@H](c2cn(C)c3ccccc23)[C@@H](N(C)C)C1 Homo sapiens CHEMBL4007108 single protein format
CHEMBL4078052 OBDepict CH 3 O O CH 3 H N H N CH 3 H 3 C CH 3 F Ki = 12.0 nM 372.48 COc1ccc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)cc1OC Homo sapiens CHEMBL4020039 single protein format
CHEMBL4647900 OBDepict F HN O N N N S O O CH 3 O IC50 = 12.0 nM 446.5 CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(C3CCOCC3)c12 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4075197 OBDepict F N Br H H N H 3 C CH 3 N H 3 C Ki = 13.0 nM 430.37 CN(C)[C@H]1CN(Cc2c(F)cccc2Br)C[C@@H]1c1cn(C)c2ccccc12 Homo sapiens CHEMBL4007108 single protein format
CHEMBL4081748 OBDepict H 3 C N CH 3 N N N N N H O IC50 = 13.0 nM 348.41 CN(C)Cc1ccc(-c2cnc(NCc3ccco3)n3cnnc23)cc1 Homo sapiens CHEMBL4008166 assay format
CHEMBL4855124 OBDepict F N H O N N N O N H N CH 3 CH 3 IC50 = 13.0 nM 406.42 Cc1ncc(-c2cnc(NCc3c(F)ccc4c3CCO4)c3cn[nH]c(=O)c23)n1C Homo sapiens CHEMBL4834035 cell-based format
CHEMBL4847397 OBDepict O N H N N S N NH F O IC50 = 13.2 nM 423.47 O=C1NCc2ccsc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4858622 OBDepict O N H N N N NH F O IC50 = 13.8 nM 431.47 O=C1NCCc2ccccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4871456 OBDepict HO N CH 3 N O N N H N H F O IC50 = 14.0 nM 433.44 Cc1nc(CO)ccc1-c1cnc(NCc2c(F)ccc3c2CCO3)c2cn[nH]c(=O)c12 Homo sapiens CHEMBL4834035 cell-based format
CHEMBL4850269 OBDepict CH 3 N H 3 C O N CH 3 N O N N H N H F O IC50 = 15.0 nM 474.5 Cc1nc(C(=O)N(C)C)ccc1-c1cnc(NCc2c(F)ccc3c2CCO3)c2cn[nH]c(=O)c12 Homo sapiens CHEMBL4834035 cell-based format
CHEMBL4870866 OBDepict CH 3 N N CH 3 N O N N H N H F O IC50 = 17.0 nM 406.42 Cc1nn(C)cc1-c1cnc(NCc2c(F)ccc3c2CCO3)c2cn[nH]c(=O)c12 Homo sapiens CHEMBL4834035 cell-based format
CHEMBL4089371 OBDepict O N H 3 C CH 3 H N H N H 3 C CH 3 H 3 C F Ki = 18.0 nM 383.51 Cc1cccc(F)c1CN1C[C@H](c2ccc(C(=O)N(C)C)cc2)[C@@H](N(C)C)C1 Homo sapiens CHEMBL4007108 single protein format
CHEMBL4079004 OBDepict CH 3 O O CH 3 H N H N CH 3 H 3 C F Br Ki = 18.0 nM 437.35 COc1ccc([C@H]2CN(Cc3c(F)cccc3Br)C[C@@H]2N(C)C)cc1OC Homo sapiens CHEMBL4020039 single protein format
CHEMBL4077899 OBDepict CH 3 N O N H N H N CH 3 H 3 C H F Ki = 18.0 nM 450.6 CC(=O)N1CCN(c2ccc([C@@H]3CN([C@@H]4CCc5cccc(F)c54)C[C@H]3N(C)C)cc2)CC1 Homo sapiens CHEMBL4020039 single protein format
CHEMBL4645381 OBDepict CH 3 O O N N N N H F O IC50 = 18.0 nM 432.46 CCOC(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccccc3)c12 Homo sapiens CHEMBL4613059 single protein format
CHEMBL4869208 OBDepict NH 2 O N N N N H F O IC50 = 18.8 nM 403.42 NC(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccccc3)c12 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4105572 OBDepict H 3 C N CH 3 N N N N N H O IC50 = 19.0 nM 348.41 CN(C)Cc1ccc(-c2cnc(NCc3ccoc3)n3cnnc23)cc1 Homo sapiens CHEMBL4008166 assay format
CHEMBL4850017 OBDepict F N H O N N N N O H CH 3 N IC50 = 19.0 nM 392.39 Cc1nccn1-c1cnc(NCc2c(F)ccc3c2CCO3)c2cn[nH]c(=O)c12 Homo sapiens CHEMBL4834035 cell-based format
CHEMBL4861770 OBDepict O N H N N N N H F O IC50 = 19.5 nM 403.42 O=C1Nc2ccccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 Homo sapiens CHEMBL4828520 single protein format
CHEMBL4099766 OBDepict N N H N N N S N CH 3 CH 3 IC50 = 20.0 nM 388.5 CN(C)Cc1ccc(-c2cc(C#N)c(NCc3cccs3)n3cnnc23)cc1 Homo sapiens CHEMBL4008166 assay format
CHEMBL4856933 OBDepict O N N N N N N H F O IC50 = 20.0 nM 394.41 O=C1CC2(CC2)CN1c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 Homo sapiens CHEMBL4834035 cell-based format
CHEMBL4093911 OBDepict Cl N O N H N H N H 3 C CH 3 H 3 C F IC50 = 20.0 nM 535.11 Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCN(C(=O)c4ccc(Cl)cc4)CC3)cc2)[C@@H](N(C)C)C1 Homo sapiens CHEMBL3994543 single protein format