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O75582 | KS6A5_HUMAN | Ribosomal protein S6 kinase alpha-5 (RPS6KA5)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4868141 OBDepict H 2 N N O O HN NH S O O IC50 = -52500.0 nM 532.67 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2OC2CCCCC2)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804434 cell-based format
CHEMBL4867931 OBDepict H 3 C O N H S N O O H 2 N O HN IC50 = -2800.0 nM 464.55 COc1cc(NS(=O)(=O)C2CC2)ccc1-c1cnc(N)c(-c2ccc3c(c2)CCNC3=O)c1 Homo sapiens CHEMBL4804434 cell-based format
CHEMBL188434 OBDepict H 3 C N N N O H 2 N N N H N NH IC50 = 0.5 nM 342.41 CCn1c(-c2nonc2N)nc2cncc(CNC3CCNCC3)c21 Homo sapiens CHEMBL877123 single protein format
CHEMBL521823 OBDepict H 3 C N N N O O H 2 N N N NH IC50 = 1.0 nM 343.39 CCn1c(-c2nonc2N)nc2cncc(OCC3CCNCC3)c21 Homo sapiens CHEMBL1028091 single protein format
CHEMBL415770 OBDepict CH 3 N N N O H 2 N N N N HN IC50 = 1.4 nM 328.38 CCn1c(-c2nonc2N)nc2cncc(CN3CCNCC3)c21 Homo sapiens CHEMBL877123 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 1.4 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL3807898 single protein format
CHEMBL185962 OBDepict NH 2 N O N N N N IC50 = 1.8 nM 242.24 Nc1nonc1-c1nc2cnccc2n1C1CC1 Homo sapiens CHEMBL828472 single protein format
CHEMBL188806 OBDepict NH 2 N O N N N N HN IC50 = 2.0 nM 285.31 Nc1nonc1-c1nc2cnccc2n1C1CCCNC1 Homo sapiens CHEMBL877123 single protein format
CHEMBL186317 OBDepict NH 2 N N N O H 2 N N N IC50 = 2.5 nM 307.32 NCc1cccc(-n2c(-c3nonc3N)nc3cnccc32)c1 Homo sapiens CHEMBL877123 single protein format
CHEMBL426440 OBDepict H 3 C N N N O NH 2 N N N NH 2 IC50 = 3.0 nM 342.41 CCn1c(-c2nonc2N)nc2cncc(CN3CCC(N)CC3)c21 Homo sapiens CHEMBL877123 single protein format
CHEMBL189231 OBDepict NH 2 N O N N N N IC50 = 3.0 nM 284.32 Nc1nonc1-c1nc2cnccc2n1C1CCCCC1 Homo sapiens CHEMBL828472 single protein format
CHEMBL523695 OBDepict H 3 C N N N O H 2 N N N N O H H 2 N IC50 = 3.0 nM 342.36 CCn1c(-c2nonc2N)nc2cncc(C(=O)N3CC[C@@H](N)C3)c21 Homo sapiens CHEMBL1028091 single protein format
CHEMBL189657 OBDepict H 3 C N N N O NH 2 N N IC50 = 3.0 nM 230.23 CCn1c(-c2nonc2N)nc2cnccc21 Homo sapiens CHEMBL828472 single protein format
CHEMBL2347053 OBDepict H N N + N O N H O _ O IC50 = 4.0 nM 332.32 O=C1Nc2ccccc2/C1=C/c1c[nH]nc1-c1ccccc1[N+](=O)[O-] Homo sapiens CHEMBL2353278 single protein format
CHEMBL188268 OBDepict NH 2 N N N O H 2 N N N IC50 = 4.0 nM 307.32 NCc1ccc(-n2c(-c3nonc3N)nc3cnccc32)cc1 Homo sapiens CHEMBL877123 single protein format
CHEMBL187340 OBDepict CH 3 N N N O H 2 N N N Cl IC50 = 4.0 nM 264.68 CCn1c(-c2nonc2N)nc2c(Cl)nccc21 Homo sapiens CHEMBL877123 single protein format
CHEMBL360219 OBDepict CH 3 N N N O H 2 N N N N IC50 = 7.0 nM 327.39 CCn1c(-c2nonc2N)nc2cncc(CN3CCCCC3)c21 Homo sapiens CHEMBL877123 single protein format
CHEMBL6291 OBDepict H 2 N S NH N O N H O N H 3 C IC50 = 8.0 nM 457.56 Cn1cc(C2=C(c3cn(CCCSC(=N)N)c4ccccc34)C(=O)NC2=O)c2ccccc21 Homo sapiens CHEMBL1249799 cell-based format
CHEMBL364413 OBDepict CH 3 N N N O H 2 N N N CH 3 IC50 = 8.0 nM 244.26 CCn1c(-c2nonc2N)nc2c(C)nccc21 Homo sapiens CHEMBL877123 single protein format
CHEMBL365832 OBDepict H 3 C N N N Br O NH 2 N N IC50 = 9.0 nM 309.13 CCn1c(-c2nonc2N)nc2cncc(Br)c21 Homo sapiens CHEMBL877123 single protein format
CHEMBL188620 OBDepict NH 2 N CH 3 N N O H 2 N N N IC50 = 9.0 nM 259.27 CC(CN)n1c(-c2nonc2N)nc2cnccc21 Homo sapiens CHEMBL877123 single protein format
CHEMBL188433 OBDepict NH 2 N O N N N N IC50 = 11.0 nM 278.28 Nc1nonc1-c1nc2cnccc2n1-c1ccccc1 Homo sapiens CHEMBL828472 single protein format
CHEMBL493067 OBDepict CH 3 N N N O NH 2 N N NH O N H IC50 = 11.0 nM 356.39 CCn1c(-c2nonc2N)nc2cncc(C(=O)NC3CCCNC3)c21 Homo sapiens CHEMBL1028091 single protein format
CHEMBL363258 OBDepict NH 2 N N N O H 2 N N N IC50 = 13.0 nM 273.3 NCCCCn1c(-c2nonc2N)nc2cnccc21 Homo sapiens CHEMBL877123 single protein format
CHEMBL188457 OBDepict CH 3 N NH 2 N N O H 2 N N N IC50 = 13.0 nM 273.3 CCCC(N)n1c(-c2nonc2N)nc2cnccc21 Homo sapiens CHEMBL828472 single protein format
CHEMBL494662 OBDepict CH 3 N N N O NH 2 N N NH O HN IC50 = 13.0 nM 356.39 CCn1c(-c2nonc2N)nc2cncc(C(=O)NC3CCNCC3)c21 Homo sapiens CHEMBL1028091 single protein format
CHEMBL1956071 OBDepict H 3 C N N N O H 2 N N N N O H H 2 N IC50 = 14.0 nM 342.36 CCn1c(-c2nonc2N)nc2cncc(C(=O)N3CC[C@H](N)C3)c21 Homo sapiens CHEMBL1960790 single protein format
CHEMBL506153 OBDepict H 3 C NH NH O N N N H 3 C N O NH 2 N IC50 = 15.0 nM 330.35 CCn1c(-c2nonc2N)nc2cncc(C(=O)NCCNC)c21 Homo sapiens CHEMBL1028091 single protein format
CHEMBL189094 OBDepict H 3 C N N N O NH 2 N OH IC50 = 17.0 nM 245.24 CCn1c(-c2nonc2N)nc2cc(O)ccc21 Homo sapiens CHEMBL828472 single protein format
CHEMBL363054 OBDepict NH 2 N O N N N N N H IC50 = 17.0 nM 285.31 Nc1nonc1-c1nc2cnccc2n1C1CCNCC1 Homo sapiens CHEMBL828472 single protein format
CHEMBL189299 OBDepict CH 3 N N N H 2 N N N IC50 = 20.0 nM 240.27 CCn1c(-c2nccnc2N)nc2cnccc21 Homo sapiens CHEMBL828472 single protein format
CHEMBL493911 OBDepict CH 3 N N N O O H 2 N N N HN IC50 = 21.0 nM 329.36 CCn1c(-c2nonc2N)nc2cncc(OC3CCNCC3)c21 Homo sapiens CHEMBL1028091 single protein format
CHEMBL189773 OBDepict H 2 N N N N O NH 2 N N IC50 = 22.0 nM 259.27 NCCCn1c(-c2nonc2N)nc2cnccc21 Homo sapiens CHEMBL877123 single protein format
CHEMBL187339 OBDepict H 3 C N N N O NH 2 N F IC50 = 38.0 nM 247.23 CCn1c(-c2nonc2N)nc2cc(F)ccc21 Homo sapiens CHEMBL828472 single protein format
CHEMBL493066 OBDepict CH 3 N N N O H 2 N N N N O HN IC50 = 47.0 nM 342.36 CCn1c(-c2nonc2N)nc2cncc(C(=O)N3CCNCC3)c21 Homo sapiens CHEMBL1028091 single protein format
CHEMBL220241 OBDepict H 3 C N N N O NH 2 N N O N H O O N O IC50 = 49.0 nM 570.61 CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)c3)cc21 Homo sapiens CHEMBL1960790 single protein format
CHEMBL361678 OBDepict H 3 C N N CH 3 N NH 2 N N H IC50 = 55.0 nM 242.29 CCn1c(-c2c(C)n[nH]c2N)nc2cnccc21 Homo sapiens CHEMBL828472 single protein format
CHEMBL4249925 OBDepict O N H S N N H S N O O CH 3 H N Ki = 94.0 nM 427.51 CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(-c3c[nH]c4ncccc34)cs2)c1 Homo sapiens CHEMBL4235390 single protein format
CHEMBL191104 OBDepict CH 3 N N H 2 N N N IC50 = 107.0 nM 239.28 CCn1c(-c2cccnc2N)nc2cnccc21 Homo sapiens CHEMBL828472 single protein format
CHEMBL104264 OBDepict Br N H N H S O O N IC50 = 120.0 nM 446.37 O=S(=O)(NCCNC/C=C/c1ccc(Br)cc1)c1cccc2cnccc12 Homo sapiens CHEMBL1249799 cell-based format
CHEMBL188048 OBDepict H 2 N N O N N N CH 3 N IC50 = 126.0 nM 216.2 Cn1c(-c2nonc2N)nc2cnccc21 Homo sapiens CHEMBL828472 single protein format
CHEMBL365286 OBDepict H 3 C N N N O NH 2 N IC50 = 140.0 nM 229.24 CCn1c(-c2nonc2N)nc2ccccc21 Homo sapiens CHEMBL828472 single protein format
CHEMBL445180 OBDepict NH 2 O N N N H 3 C N O O H 2 N N IC50 = 162.0 nM 369.39 CCn1c(-c2nonc2N)nc2c(-c3ccoc3)ncc(OCCCN)c21 Homo sapiens CHEMBL1028091 single protein format
CHEMBL188240 OBDepict CH 3 O N N N N CH 3 O NH 2 N IC50 = 174.0 nM 274.28 CCOc1nccc2c1nc(-c1nonc1N)n2CC Homo sapiens CHEMBL877123 single protein format
CHEMBL363990 OBDepict H 3 C O N N N N H 3 C O NH 2 N IC50 = 209.0 nM 260.26 CCn1c(-c2nonc2N)nc2c(OC)nccc21 Homo sapiens CHEMBL877123 single protein format
CHEMBL365072 OBDepict H 3 C N N N N H 3 C O H 2 N N IC50 = 229.0 nM 258.29 CCc1nccc2c1nc(-c1nonc1N)n2CC Homo sapiens CHEMBL877123 single protein format
CHEMBL365902 OBDepict H 3 C N N N O NH 2 N OH IC50 = 258.0 nM 245.24 CCn1c(-c2nonc2N)nc2ccc(O)cc21 Homo sapiens CHEMBL828472 single protein format
CHEMBL1162963 OBDepict H 3 C N CH 3 N N N O N H O IC50 = 510.0 nM 515.62 CN(C)c1nc2ccc1CCCn1cc(c3ccccc31)C1=C(C(=O)NC1=O)c1cn(c3ccccc13)CC2 Homo sapiens CHEMBL885893 single protein format
CHEMBL191105 OBDepict CH 3 N CH 3 N N N O H 2 N N N IC50 = 617.0 nM 287.33 CN(C)CCCn1c(-c2nonc2N)nc2cnccc21 Homo sapiens CHEMBL877123 single protein format
CHEMBL2420911 OBDepict H N N N N N HN IC50 = 700.0 nM 272.36 c1nc(N2CCC3(CCCNC3)CC2)c2nc[nH]c2n1 Homo sapiens CHEMBL2424128 single protein format
CHEMBL583144 OBDepict Cl S N Cl N O H Ki = 728.5 nM 271.13 O=c1[nH]cnc2c1sc1c(Cl)ccc(Cl)c12 Homo sapiens CHEMBL1060313 single protein format
CHEMBL186343 OBDepict CH 3 N N N O H 2 N N N IC50 = 813.0 nM 306.33 CCn1c(-c2nonc2N)nc2c(-c3ccccc3)nccc21 Homo sapiens CHEMBL877123 single protein format
CHEMBL185731 OBDepict OH N N CH 3 N O H 2 N N IC50 = 974.0 nM 259.27 CCn1c(-c2nonc2N)nc2cc(CO)ccc21 Homo sapiens CHEMBL828472 single protein format
CHEMBL4245242 OBDepict O N H S N O N H N N H Ki = 990.0 nM 475.62 O=C(Cc1cccc(OCCCC2CCNCC2)c1)Nc1nc(-c2c[nH]c3ncccc23)cs1 Homo sapiens CHEMBL4235390 single protein format
CHEMBL493250 OBDepict NH 2 O N N N CH 3 N O H 2 N N IC50 = 1000.0 nM 379.42 CCn1c(-c2nonc2N)nc2c(-c3ccccc3)ncc(OCCCN)c21 Homo sapiens CHEMBL1028091 single protein format