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O94804 | STK10_HUMAN | Serine/threonine-protein kinase 10 (STK10)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 9.01 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328475 single protein format
CHEMBL156277 OBDepict CH 3 O O N H NH O Cl IC50 = 12.0 nM 328.76 COc1ccccc1C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O Homo sapiens CHEMBL4839430 cell-based format
CHEMBL4875188 OBDepict H 3 C O O N H HN O N IC50 = 23.0 nM 319.32 COc1ccccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839430 cell-based format
CHEMBL4875188 OBDepict H 3 C O O N H HN O N Ki = 26.0 nM 319.32 COc1ccccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4878325 OBDepict N NH O N H O O CH 3 Br Ki = 35.0 nM 398.22 COc1cc(Br)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL156277 OBDepict CH 3 O O N H NH O Cl Ki = 46.0 nM 328.76 COc1ccccc1C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4877889 OBDepict H 3 C O O N H N H O Ki = 47.0 nM 344.37 COc1ccccc1C1=C(Nc2cccc3ccccc23)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL288441 OBDepict CH 3 O O N N H N N Cl O H 3 C Cl N CH 3 IC50 = 52.0 nM 530.46 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl Homo sapiens CHEMBL1244340 single protein format
CHEMBL4878325 OBDepict N NH O N H O O CH 3 Br IC50 = 60.0 nM 398.22 COc1cc(Br)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839430 cell-based format
CHEMBL4856751 OBDepict CH 3 O Br O N H NH O N Ki = 61.0 nM 398.22 COc1ccc(Br)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL157089 OBDepict H 3 C O O N H HN O Cl OH Ki = 73.0 nM 344.75 COc1ccccc1C1=C(Nc2ccc(O)c(Cl)c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4855513 OBDepict CH 3 O O N H NH O F Ki = 76.0 nM 312.3 COc1ccccc1C1=C(Nc2cccc(F)c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4869745 OBDepict H 3 C O O N H HN O O O Ki = 84.0 nM 338.32 COc1ccccc1C1=C(Nc2ccc3c(c2)OCO3)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4867952 OBDepict H 3 C O HN O N H HN O O CH 3 CH 3 N Ki = 88.0 nM 404.43 COc1cc(NC(=O)C(C)C)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4856751 OBDepict CH 3 O Br O N H NH O N IC50 = 99.0 nM 398.22 COc1ccc(Br)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839430 cell-based format
CHEMBL6291 OBDepict H 2 N S NH N O N H O N H 3 C IC50 = 99.0 nM 457.56 Cn1cc(C2=C(c3cn(CCCSC(=N)N)c4ccccc34)C(=O)NC2=O)c2ccccc21 Homo sapiens CHEMBL4839430 cell-based format
CHEMBL4868821 OBDepict CH 3 O O N H NH O N Ki = 110.0 nM 345.36 COc1ccccc1C1=C(Nc2ccc3ncccc3c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4877101 OBDepict N HN O N H O Ki = 110.0 nM 339.35 N#Cc1cccc(NC2=C(c3cccc4ccccc34)C(=O)NC2=O)c1 Homo sapiens CHEMBL4839427 single protein format
CHEMBL4857159 OBDepict CH 3 O O N H NH O S CH 3 Ki = 110.0 nM 340.4 COc1ccccc1C1=C(Nc2cccc(SC)c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4852101 OBDepict CH 3 O HN O N H O O H 3 C Ki = 120.0 nM 324.34 COc1ccc(NC2=C(c3ccccc3OC)C(=O)NC2=O)cc1 Homo sapiens CHEMBL4839427 single protein format
CHEMBL349540 OBDepict CH 3 O O N H NH O S H 3 C Ki = 140.0 nM 340.4 COc1ccccc1C1=C(Nc2ccc(SC)cc2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL157141 OBDepict O N H NH O Cl Cl HO Ki = 150.0 nM 349.17 O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1ccc(O)c(Cl)c1 Homo sapiens CHEMBL4839427 single protein format
CHEMBL4847820 OBDepict CH 3 O HN O N H O O H 3 C Ki = 180.0 nM 324.34 COc1cccc(NC2=C(c3ccccc3OC)C(=O)NC2=O)c1 Homo sapiens CHEMBL4839427 single protein format
CHEMBL160338 OBDepict H 3 C O O N H HN O OH Ki = 200.0 nM 310.31 COc1ccccc1C1=C(Nc2ccc(O)cc2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL347702 OBDepict OH HN O N H O Cl Ki = 300.0 nM 314.73 O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1ccc(O)cc1 Homo sapiens CHEMBL4839427 single protein format
CHEMBL156506 OBDepict Cl NH O N H O Cl Ki = 310.0 nM 333.17 O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1cccc(Cl)c1 Homo sapiens CHEMBL4839427 single protein format
CHEMBL4851482 OBDepict H 3 C O O N H HN O Ki = 320.0 nM 370.41 COc1ccccc1C1=C(Nc2ccc(-c3ccccc3)cc2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4845800 OBDepict N HN O N H O O CH 3 Cl N Cl Ki = 320.0 nM 465.3 COc1cc(-c2ccc(Cl)nc2Cl)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4869281 OBDepict CH 3 O O N H HN O N Ki = 320.0 nM 395.42 COc1ccc(-c2ccccc2)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4847807 OBDepict CH 3 O O N H NH O F F F Ki = 340.0 nM 362.31 COc1ccccc1C1=C(Nc2cccc(C(F)(F)F)c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4858023 OBDepict CH 3 S HN O N H O Cl Ki = 340.0 nM 344.82 CSc1cccc(NC2=C(c3ccccc3Cl)C(=O)NC2=O)c1 Homo sapiens CHEMBL4839427 single protein format
CHEMBL4848202 OBDepict N HN O N H O Cl Ki = 350.0 nM 323.74 N#Cc1cccc(NC2=C(c3ccccc3Cl)C(=O)NC2=O)c1 Homo sapiens CHEMBL4839427 single protein format
CHEMBL4878748 OBDepict F NH O N H O Cl Ki = 380.0 nM 316.72 O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1cccc(F)c1 Homo sapiens CHEMBL4839427 single protein format
CHEMBL4863077 OBDepict H 3 C O O N H HN O S Ki = 400.0 nM 376.44 COc1ccccc1C1=C(Nc2ccc(-c3ccsc3)cc2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4852451 OBDepict CH 3 O O N H NH N O N Ki = 440.0 nM 396.41 COc1cc(-c2cccnc2)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4854271 OBDepict H 3 C O O N H HN O N O Ki = 460.0 nM 379.42 COc1ccccc1C1=C(Nc2ccc(N3CCOCC3)cc2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4848740 OBDepict CH 3 O O NH H 3 C O N H O O CH 3 Ki = 480.0 nM 354.36 COc1cc(NC2=C(c3ccccc3OC)C(=O)NC2=O)cc(OC)c1 Homo sapiens CHEMBL4839427 single protein format
CHEMBL160231 OBDepict CH 3 O O N H NH O HO Ki = 480.0 nM 310.31 COc1ccccc1C1=C(Nc2cccc(O)c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4875006 OBDepict H 3 C O O N H HN S O N Ki = 540.0 nM 401.45 COc1cc(-c2ccsc2)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL160937 OBDepict HO NH O N H O Cl Ki = 560.0 nM 314.73 O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1cccc(O)c1 Homo sapiens CHEMBL4839427 single protein format
CHEMBL347647 OBDepict O N H NH O Cl Ki = 560.0 nM 298.73 O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1ccccc1 Homo sapiens CHEMBL4839427 single protein format
CHEMBL345800 OBDepict CH 3 O O N H NH O Cl Cl HO Ki = 590.0 nM 379.2 COc1ccccc1C1=C(Nc2cc(Cl)c(O)c(Cl)c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4876254 OBDepict H 3 C O O N H N H O O Ki = 600.0 nM 398.42 COc1ccccc1C1=C(Nc2ccc(C(=O)c3ccccc3)cc2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4851803 OBDepict O N H HN O Cl F F F OH Ki = 610.0 nM 382.73 O=C1NC(=O)C(c2ccccc2C(F)(F)F)=C1Nc1ccc(O)c(Cl)c1 Homo sapiens CHEMBL4839427 single protein format
CHEMBL4877795 OBDepict CH 3 O O NH N H O S O O CH 3 Ki = 630.0 nM 372.4 COc1ccccc1C1=C(Nc2cccc(S(C)(=O)=O)c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4855633 OBDepict H 3 C O O N H N H O S Ki = 640.0 nM 376.44 COc1ccccc1C1=C(Nc2cccc(-c3ccsc3)c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL4860051 OBDepict CH 3 S HN O N H O F F F Ki = 730.0 nM 378.38 CSc1cccc(NC2=C(c3ccccc3C(F)(F)F)C(=O)NC2=O)c1 Homo sapiens CHEMBL4839427 single protein format
CHEMBL156563 OBDepict CH 3 S HN O N H O Cl Ki = 760.0 nM 344.82 CSc1ccc(NC2=C(c3ccccc3Cl)C(=O)NC2=O)cc1 Homo sapiens CHEMBL4839427 single protein format
CHEMBL4859423 OBDepict H 3 C O O N H HN O Cl O Ki = 790.0 nM 434.88 COc1ccccc1C1=C(Nc2ccc(OCc3ccccc3)c(Cl)c2)C(=O)NC1=O Homo sapiens CHEMBL4839427 single protein format
CHEMBL346829 OBDepict CH 3 O O N H NH O Cl Ki = 950.0 nM 328.76 COc1cccc(C2=C(Nc3cccc(Cl)c3)C(=O)NC2=O)c1 Homo sapiens CHEMBL4839427 single protein format
CHEMBL4848852 OBDepict Cl HN O N H O F F F Ki = 960.0 nM 366.73 O=C1NC(=O)C(c2ccccc2C(F)(F)F)=C1Nc1cccc(Cl)c1 Homo sapiens CHEMBL4839427 single protein format
CHEMBL103667 OBDepict O HN N H N N CH 3 CH 3 CH 3 O H 3 C N O IC50 < 1000.0 nM 527.67 Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 Homo sapiens CHEMBL4602933 single protein format