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O95180 | CAC1H_HUMAN | Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4205005 OBDepict O N H N N N CH 3 CH 3 F F IC50 = 3.4 nM 370.4 CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)c(F)c3)n2)cc1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4203101 OBDepict O N H N N N H 3 C CH 3 H 3 C O F F IC50 = 3.8 nM 424.45 CN1C(=O)C(C)(C)c2cc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)ccc21 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL1210565 OBDepict F HN F N O O N N Cl F IC50 = 4.0 nM 500.91 O=C(Nc1cc(F)cc(F)c1)N1CCC2(CC1)C(=O)N(c1ccc(F)c(Cl)c1)C2c1ccccn1 Homo sapiens CHEMBL1212315 cell-based format
CHEMBL4204077 OBDepict O N H N N N CH 3 CH 3 Cl IC50 = 4.1 nM 368.87 CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(Cl)cc3)n2)cc1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4215974 OBDepict O N H N N H 3 C O F F IC50 = 4.3 nM 397.43 CC1(c2ccc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)cc2)COC1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4204507 OBDepict O N H N N N CH 3 CH 3 O F F F IC50 = 5.1 nM 418.42 CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(OC(F)(F)F)cc3)n2)cc1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4212039 OBDepict O N H N N N H F F IC50 = 5.3 nM 366.37 O=C(Cc1ccc2cc[nH]c2c1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4207031 OBDepict O N H N N CH 3 CH 3 F F IC50 = 6.0 nM 369.42 CC(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)c(F)c3)n2)cc1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL3906825 OBDepict F N N H CH 3 N H H 3 C N H O IC50 = 6.0 nM 418.52 C[C@H]1c2ccc(F)nc2N(Cc2ccccc2)C[C@@H](C)N1C(=O)NCc1ccccc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL4206509 OBDepict O HN N N F F F F IC50 = 6.1 nM 417.41 O=C(Cc1ccc(C2CC(F)(F)C2)cc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4202587 OBDepict CH 3 O CH 3 HN O N CH 3 Cl H 3 C H 3 C IC50 = 6.6 nM 402.97 CC(C)OCc1ccccc1CNC(=O)c1c2c(c(Cl)n1C)CC(C)(C)CC2 Homo sapiens CHEMBL4180613 cell-based format
CHEMBL4214862 OBDepict O N H N N N N F F F F IC50 = 6.7 nM 433.41 O=C(Cc1ccc(N2CCC(F)(F)C2)nc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4208907 OBDepict N N N N N H O CH 3 O F F F IC50 = 7.0 nM 429.4 Cc1cc(CC(=O)Nc2ccn(Cc3ccc(C#N)cn3)n2)ccc1OCC(F)(F)F Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4218608 OBDepict N N N N N H O H 3 C H 3 C CH 3 IC50 = 7.5 nM 373.46 CC(C)(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(C#N)cn3)n2)cc1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4207291 OBDepict H 3 C O N H O F F F N N N N IC50 = 7.8 nM 443.43 CCc1cc(CC(=O)Nc2ccn(Cc3ccc(C#N)cn3)n2)ccc1OCC(F)(F)F Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4216687 OBDepict H 3 C O F F N N N H O N H 3 C CH 3 IC50 = 7.8 nM 400.43 COc1c(F)cc(Cn2ccc(NC(=O)Cc3ccc(N(C)C)cc3)n2)cc1F Homo sapiens CHEMBL4181720 cell-based format
CHEMBL1684950 OBDepict O N H CH 3 H N O CH 3 CH 3 F F F IC50 = 8.2 nM 380.41 CC(C)c1ccc(CC(=O)N[C@H](C)c2ccc(OCC(F)(F)F)cn2)cc1 Homo sapiens CHEMBL3855324 cell-based format
CHEMBL4203847 OBDepict O N H N N N N H 3 C F F IC50 = 8.4 nM 381.39 Cn1ncc2cc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)ccc21 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4209481 OBDepict O N H N N N N N H 3 C F F IC50 = 8.6 nM 382.37 Cn1ncc2cc(CC(=O)Nc3cnn(Cc4ccc(F)c(F)c4)n3)ccc21 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL3906199 OBDepict O N HN H H 3 C H H 3 C N F F IC50 = 9.0 nM 435.52 C[C@H]1c2ccccc2N(Cc2cccc(F)c2F)C[C@@H](C)N1C(=O)NCc1ccccc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL4209376 OBDepict O N H N N N CH 3 H 3 C O F F IC50 = 10.0 nM 400.43 CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(OC(F)F)cc3)n2)cc1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4213335 OBDepict O N H N N N H 3 C CH 3 CH 3 IC50 = 10.0 nM 348.45 Cc1ccc(Cn2ccc(NC(=O)Cc3ccc(N(C)C)cc3)n2)cc1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4203748 OBDepict O N H N N O O F CH 3 CH 3 F IC50 = 10.0 nM 427.45 CC1(C)OCC(c2ccc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)cc2)O1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL3924174 OBDepict O N N H H CH 3 H CH 3 N N F IC50 = 11.0 nM 404.49 C[C@H]1c2ccccc2N(Cc2ccccc2F)C[C@@H](C)N1C(=O)Nc1cccnc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL4211105 OBDepict O HN N N O F F F F IC50 = 11.0 nM 433.41 O=C(Cc1ccc(OC2CC(F)(F)C2)cc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4205453 OBDepict O N H N CH 3 Cl H 3 C H 3 C N N IC50 = 12.0 nM 410.95 Cn1c(Cl)c2c(c1C(=O)NCc1ccccc1Cn1cccn1)CCC(C)(C)C2 Homo sapiens CHEMBL4180613 cell-based format
CHEMBL4208950 OBDepict O N H N N N CH 3 CH 3 F IC50 = 12.0 nM 352.41 CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)cc3)n2)cc1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL3936835 OBDepict F N H H 3 C N H H 3 C N H O N IC50 = 12.0 nM 404.49 C[C@H]1c2ccc(F)cc2N(Cc2ccccc2)C[C@@H](C)N1C(=O)Nc1cccnc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL4208626 OBDepict O N H N N F O F F IC50 = 13.0 nM 401.39 O=C(Cc1ccc(C2(F)COC2)cc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL3969822 OBDepict O N NH H CH 3 H H 3 C N O F F F IC50 = 13.0 nM 457.5 C[C@H]1c2ccccc2N(Cc2ccc(C(F)(F)F)o2)C[C@@H](C)N1C(=O)NCc1ccccc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL3931239 OBDepict O N N H H CH 3 H CH 3 N N O F F F IC50 = 14.0 nM 444.46 C[C@H]1c2ccccc2N(Cc2ccc(C(F)(F)F)o2)C[C@@H](C)N1C(=O)Nc1cccnc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL3896161 OBDepict F N H CH 3 N H H 3 C N H O N IC50 = 14.0 nM 404.49 C[C@H]1c2ccccc2N(Cc2cccc(F)c2)C[C@@H](C)N1C(=O)Nc1cccnc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL4218161 OBDepict N F N N N H O N CH 3 CH 3 IC50 = 14.0 nM 377.42 CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(C#N)c(F)c3)n2)cc1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4205399 OBDepict O N H N N O CH 3 CH 3 F F IC50 = 14.0 nM 377.44 CC(C)c1ccc(CC(=O)Nc2ccn(CC3CCC(F)(F)CO3)n2)cc1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4207159 OBDepict O HN N N N H F F IC50 = 14.0 nM 366.37 O=C(Cc1ccc2[nH]ccc2c1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL3934860 OBDepict CH 3 O NH N O H CH 3 H CH 3 N IC50 = 14.0 nM 429.56 COc1ccc(CNC(=O)N2[C@@H](C)c3ccccc3N(Cc3ccccc3)C[C@H]2C)cc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL4207979 OBDepict O N H N N O N CH 3 O F F IC50 = 15.0 nM 398.37 Cn1c(=O)oc2cc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)ccc21 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL3918060 OBDepict O N NH H CH 3 H H 3 C N S N F F F IC50 = 15.0 nM 474.55 C[C@H]1c2ccccc2N(Cc2cnc(C(F)(F)F)s2)C[C@@H](C)N1C(=O)NCc1ccccc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL3894794 OBDepict F N N N H O Br F IC50 = 16.0 nM 456.29 O=C(Nc1ccc(F)cc1)N1N=C(c2ccc(Br)cc2)CC1c1ccc(F)cc1 Homo sapiens CHEMBL3855324 cell-based format
CHEMBL1210629 OBDepict O N N H O N F F F N F F IC50 = 17.0 nM 516.47 O=C(Nc1cccc(C(F)(F)F)c1)N1CCC2(CC1)C(=O)N(c1ccc(F)c(F)c1)C2c1ccccn1 Homo sapiens CHEMBL1212315 cell-based format
CHEMBL4204573 OBDepict N N N N N H O CH 3 O F F F IC50 = 18.0 nM 443.43 Cc1cc(CC(=O)Nc2ccn(Cc3ccc(C#N)cn3)n2)ccc1OCCC(F)(F)F Homo sapiens CHEMBL4181720 cell-based format
CHEMBL3968363 OBDepict O N N H H H 3 C H H 3 C N N F F IC50 = 18.0 nM 422.48 C[C@H]1c2ccccc2N(Cc2ccc(F)c(F)c2)C[C@@H](C)N1C(=O)Nc1cccnc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL4217292 OBDepict N N N N HN O F F F IC50 = 18.0 nM 425.41 N#Cc1ccc(Cn2ccc(NC(=O)Cc3ccc(C4(C(F)(F)F)CC4)cc3)n2)nc1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL1210766 OBDepict Cl N O N N N H O F F IC50 = 18.0 nM 482.92 O=C(Nc1cc(F)cc(F)c1)N1CCC2(CC1)C(=O)N(c1cccc(Cl)c1)C2c1ccccn1 Homo sapiens CHEMBL1212315 cell-based format
CHEMBL4214109 OBDepict CH 3 H 3 C O NH O N H 3 C Cl H H 3 C H CH 3 IC50 = 20.0 nM 402.97 CC(C)COc1ccccc1CNC(=O)c1c2c(c(Cl)n1C)C[C@H](C)[C@@H](C)C2 Homo sapiens CHEMBL4180613 cell-based format
CHEMBL4204611 OBDepict N N N N H O N CH 3 CH 3 IC50 = 20.0 nM 359.43 CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(C#N)cc3)n2)cc1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4212744 OBDepict O N H N H 3 C Cl O CH 3 CH 3 F F F IC50 = 21.0 nM 428.88 Cn1c(Cl)c2c(c1C(=O)NCc1ccccc1OCC(F)(F)F)CCC(C)(C)C2 Homo sapiens CHEMBL4180613 cell-based format
CHEMBL4202418 OBDepict CH 3 CH 3 O HN O N CH 3 Cl F F F IC50 = 21.0 nM 442.91 CC(C)COc1ccccc1CNC(=O)c1c2c(c(Cl)n1C)CC(C(F)(F)F)CC2 Homo sapiens CHEMBL4180613 cell-based format
CHEMBL4213830 OBDepict H 3 C O N H O N CH 3 Cl CH 3 H 3 C IC50 = 21.0 nM 374.91 CCOc1ccccc1CNC(=O)c1c2c(c(Cl)n1C)CC(C)(C)CC2 Homo sapiens CHEMBL4180613 cell-based format
CHEMBL4213589 OBDepict H 3 C Cl N H 3 C CH 3 N H O O CH 3 CH 3 IC50 = 21.0 nM 362.9 CCc1c(C)c(C(=O)NCc2ccccc2OCC(C)C)n(C)c1Cl Homo sapiens CHEMBL4180613 cell-based format
CHEMBL4215213 OBDepict CH 3 O N H O N CH 3 Cl CH 3 H 3 C IC50 = 21.0 nM 388.94 CCOCc1ccccc1CNC(=O)c1c2c(c(Cl)n1C)CC(C)(C)CC2 Homo sapiens CHEMBL4180613 cell-based format
CHEMBL4205068 OBDepict N N N H N O F F N N H 3 C IC50 = 21.0 nM 406.4 Cn1ncc2cc(CC(=O)Nc3nn(Cc4ccc(F)c(F)c4)cc3C#N)ccc21 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL3962647 OBDepict F N H N O N H N F IC50 = 21.0 nM 378.38 O=C(Nc1ccc(F)cc1)N1N=C(c2ccncc2)C[C@H]1c1ccc(F)cc1 Homo sapiens CHEMBL3855324 cell-based format
CHEMBL4209946 OBDepict O N H N N N N F H F F IC50 = 21.0 nM 415.42 O=C(Cc1ccc(N2CC[C@H](F)C2)nc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4216756 OBDepict O N H S N CH 3 CH 3 F F IC50 = 22.0 nM 386.47 CC(C)c1ccc(CC(=O)Nc2nc(Cc3ccc(F)c(F)c3)cs2)cc1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL3945715 OBDepict F F N H CH 3 N H CH 3 N H O N IC50 = 22.0 nM 422.48 C[C@H]1c2c(F)cc(F)cc2N(Cc2ccccc2)C[C@@H](C)N1C(=O)Nc1cccnc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL4211734 OBDepict O N H N H 3 C Cl N O CH 3 CH 3 F F F IC50 = 23.0 nM 429.87 Cn1c(Cl)c2c(c1C(=O)NCc1ncccc1OCC(F)(F)F)CCC(C)(C)C2 Homo sapiens CHEMBL4180613 cell-based format
CHEMBL4218617 OBDepict CH 3 H 3 C N H O N N IC50 = 23.0 nM 333.44 CC(C)c1ccc(CC(=O)Nc2ccn(Cc3ccccc3)n2)cc1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL3938021 OBDepict H 3 C O N H N O H CH 3 H H 3 C N N O F F F IC50 = 24.0 nM 488.51 COc1ccc(CNC(=O)N2[C@@H](C)c3ccncc3N(Cc3ccc(C(F)(F)F)o3)C[C@H]2C)cc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL4212176 OBDepict N N N N N H O H 3 C O F F F IC50 = 25.0 nM 415.38 Cc1cc(CC(=O)Nc2ccn(Cc3ccc(C#N)cn3)n2)ccc1OC(F)(F)F Homo sapiens CHEMBL4181720 cell-based format
CHEMBL3981633 OBDepict F N H N O N F IC50 = 25.0 nM 377.39 O=C(Nc1ccc(F)cc1)N1N=C(c2ccccc2)CC1c1ccc(F)cc1 Homo sapiens CHEMBL3855324 cell-based format
CHEMBL4216691 OBDepict O N H N H 3 C Cl N O CH 3 CH 3 N CH 3 N IC50 = 25.0 nM 415.93 Cc1onc(CNC(=O)c2c3c(c(Cl)n2C)CC(C)(C)CC3)c1Cn1cccn1 Homo sapiens CHEMBL4180613 cell-based format
CHEMBL3921765 OBDepict O N N H H H 3 C H H 3 C N N D D IC50 = 25.0 nM 388.51 [2H]C([2H])(c1ccccc1)N1C[C@@H](C)N(C(=O)Nc2cccnc2)[C@@H](C)c2ccccc21 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL4204934 OBDepict CH 3 O N H O S Br H 3 C H 3 C IC50 = 25.0 nM 422.39 COCc1ccccc1CNC(=O)c1sc(Br)c2c1CCC(C)(C)C2 Homo sapiens CHEMBL4180613 cell-based format
CHEMBL4210232 OBDepict H 3 C N H 3 C N H O H 3 C Cl O CH 3 CH 3 IC50 = 27.0 nM 362.9 CCc1c(C)c(Cl)n(C)c1C(=O)NCc1ccccc1OCC(C)C Homo sapiens CHEMBL4180613 cell-based format
CHEMBL4218528 OBDepict CH 3 CH 3 O NH O N CH 3 Cl IC50 = 27.0 nM 360.89 CC(C)COc1ccccc1CNC(=O)c1c2c(c(Cl)n1C)CCC2 Homo sapiens CHEMBL4180613 cell-based format
CHEMBL3897825 OBDepict CH 3 N N H CH 3 N H H 3 C N H O IC50 = 28.0 nM 414.55 Cc1ccc2c(n1)N(Cc1ccccc1)C[C@@H](C)N(C(=O)NCc1ccccc1)[C@H]2C Homo sapiens CHEMBL3865204 cell-based format
CHEMBL3902886 OBDepict O N H CH 3 H H 3 C N N S N F F F IC50 = 30.0 nM 474.55 C[C@H]1c2ccccc2N(Cc2cnc(C(F)(F)F)s2)C[C@@H](C)N1C(=O)CCc1cccnc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL4205975 OBDepict O N H N O N N O F F F IC50 = 30.0 nM 446.43 O=C(NCc1ccc(N2CCCC2)nc1)c1coc(Cc2ccc(OC(F)(F)F)cc2)n1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4218220 OBDepict O N H N N N N F F F F IC50 = 30.0 nM 433.41 O=C(NCc1ccc(N2CCC(F)(F)C2)nc1)c1ccn(Cc2ccc(F)c(F)c2)n1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL3897240 OBDepict F N H H 3 C N H CH 3 N H O N IC50 = 31.0 nM 404.49 C[C@H]1c2ccccc2N(Cc2ccc(F)cc2)C[C@@H](C)N1C(=O)Nc1cccnc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL4205754 OBDepict O N H N N N CH 3 CH 3 CH 3 F F IC50 = 31.0 nM 384.43 CC(C)(C)c1ccc(CC(=O)Nc2ncn(Cc3ccc(F)c(F)c3)n2)cc1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL1210902 OBDepict Cl F N O N N N N H F F F F IC50 = 31.0 nM 547.92 O=C1N(c2ccc(F)c(Cl)c2)C(c2ccccn2)C12CCN(c1nc3cc(F)c(C(F)(F)F)cc3[nH]1)CC2 Homo sapiens CHEMBL1212315 cell-based format
CHEMBL3943761 OBDepict O N HN H H 3 C H H 3 C N N IC50 = 31.0 nM 400.53 C[C@H]1c2cccnc2N(Cc2ccccc2)C[C@@H](C)N1C(=O)NCc1ccccc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL4204873 OBDepict O N H N N O F O F IC50 = 32.0 nM 399.4 O=C(Cc1ccc(OC2COC2)cc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4210625 OBDepict N N CH 3 CH 3 H 3 C N H O N O F F F IC50 = 33.0 nM 420.44 Cn1c(C#N)c2c(c1C(=O)NCc1ncccc1OCC(F)(F)F)CCC(C)(C)C2 Homo sapiens CHEMBL4180613 cell-based format
CHEMBL3940280 OBDepict H 3 C O N N H CH 3 N H H 3 C N H O IC50 = 33.0 nM 430.55 COc1ccc(CN2C[C@@H](C)N(C(=O)NCc3ccccc3)[C@@H](C)c3ccccc32)cn1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL3928071 OBDepict HO N N N H O N O CH 3 Br IC50 = 33.0 nM 495.38 COc1ccc([C@]2(CCO)CC(c3cccnc3)=NN2C(=O)Nc2ccc(Br)cc2)cc1 Homo sapiens CHEMBL3855324 cell-based format
CHEMBL3892579 OBDepict F N H N O N N F IC50 = 33.0 nM 378.38 O=C(Nc1ccc(F)cc1)N1N=C(c2ccncc2)CC1c1ccc(F)cc1 Homo sapiens CHEMBL3855324 cell-based format
CHEMBL4206219 OBDepict O HN N N O F H 3 C F O IC50 = 34.0 nM 427.45 CC1(COc2ccc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)cc2)COC1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL3913893 OBDepict O N HN H H 3 C H H 3 C N IC50 = 35.0 nM 399.54 C[C@H]1c2ccccc2N(Cc2ccccc2)C[C@@H](C)N1C(=O)NCc1ccccc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL4204295 OBDepict O N H N N N N H 3 C F F IC50 = 35.0 nM 381.39 Cn1ccc2cc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)cnc21 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL1210983 OBDepict H 3 C CH 3 H N H H O O N O N O N F Cl IC50 = 35.0 nM 527.0 CC[C@H](C)[C@H](NC(=O)N1CCC2(CC1)C(=O)N(c1cccc(F)c1)C2c1ccc(Cl)cc1)C(=O)OC#N Homo sapiens CHEMBL1212315 cell-based format
CHEMBL3915799 OBDepict Cl N N H CH 3 N H H 3 C N H O IC50 = 36.0 nM 434.97 C[C@H]1c2ccc(Cl)nc2N(Cc2ccccc2)C[C@@H](C)N1C(=O)NCc1ccccc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL4208413 OBDepict O N H N N N H 3 C CH 3 CH 3 IC50 = 36.0 nM 348.45 Cc1cccc(Cn2ccc(NC(=O)Cc3ccc(N(C)C)cc3)n2)c1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL3941448 OBDepict O N H H 3 C H H 3 C N N IC50 = 38.0 nM 399.54 C[C@H]1c2ccccc2N(Cc2ccccc2)C[C@@H](C)N1C(=O)CCc1cccnc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL4217227 OBDepict CH 3 N H 3 C N H O N N IC50 = 38.0 nM 334.42 CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccccc3)n2)cc1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL4217174 OBDepict O N H N CH 3 Cl H 3 C H 3 C N N N IC50 = 38.0 nM 411.94 Cn1c(Cl)c2c(c1C(=O)NCc1ccccc1Cn1cncn1)CCC(C)(C)C2 Homo sapiens CHEMBL4180613 cell-based format
CHEMBL4210633 OBDepict CH 3 O N H O S Br CH 3 CH 3 IC50 = 39.0 nM 436.42 CCOCc1ccccc1CNC(=O)c1sc(Br)c2c1CCC(C)(C)C2 Homo sapiens CHEMBL4180613 cell-based format
CHEMBL4213286 OBDepict O N H N H 3 C Cl N O CH 3 CH 3 F F F IC50 = 39.0 nM 429.87 Cn1c(Cl)c2c(c1C(=O)NCc1cccnc1OCC(F)(F)F)CCC(C)(C)C2 Homo sapiens CHEMBL4180613 cell-based format
CHEMBL3964030 OBDepict F N H N O N S O O CH 3 IC50 = 40.0 nM 437.5 CS(=O)(=O)c1ccc(C2CC(c3ccccc3)=NN2C(=O)Nc2ccc(F)cc2)cc1 Homo sapiens CHEMBL3855324 cell-based format
CHEMBL1210628 OBDepict O N N H F O N F N Cl F IC50 = 41.0 nM 500.91 O=C(Nc1ccc(F)c(F)c1)N1CCC2(CC1)C(=O)N(c1ccc(F)c(Cl)c1)C2c1ccccn1 Homo sapiens CHEMBL1212315 cell-based format
CHEMBL3949063 OBDepict O N N H H CH 3 H H 3 C N N F F F IC50 = 42.0 nM 468.52 C[C@H]1c2ccccc2N(Cc2cccc(C(F)(F)F)n2)C[C@@H](C)N1C(=O)NCc1ccccc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL3972616 OBDepict O N N H H CH 3 H CH 3 N N S N F F F IC50 = 42.0 nM 461.51 C[C@H]1c2ccccc2N(Cc2cnc(C(F)(F)F)s2)C[C@@H](C)N1C(=O)Nc1cccnc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL4216897 OBDepict O N H N H 3 C Cl O CH 3 CH 3 F F F IC50 = 42.0 nM 442.91 Cn1c(Cl)c2c(c1C(=O)NCc1ccccc1OCCC(F)(F)F)CCC(C)(C)C2 Homo sapiens CHEMBL4180613 cell-based format
CHEMBL3939715 OBDepict O N N H H CH 3 H CH 3 N O CH 3 H 3 C CH 3 IC50 = 44.0 nM 409.57 C[C@H]1c2ccccc2N(CCOC(C)(C)C)C[C@@H](C)N1C(=O)NCc1ccccc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL1210899 OBDepict Cl N O N N N N H F F F F IC50 = 44.0 nM 529.93 O=C1N(c2cccc(Cl)c2)C(c2ccccn2)C12CCN(c1nc3cc(F)c(C(F)(F)F)cc3[nH]1)CC2 Homo sapiens CHEMBL1212315 cell-based format
CHEMBL3926060 OBDepict O N NH H CH 3 H H 3 C N N O F F F IC50 = 44.0 nM 458.48 C[C@H]1c2ccncc2N(Cc2ccc(C(F)(F)F)o2)C[C@@H](C)N1C(=O)NCc1ccccc1 Homo sapiens CHEMBL3865204 cell-based format
CHEMBL4209751 OBDepict O N H CH 3 N N N CH 3 H 3 C F IC50 = 44.0 nM 366.44 CC(C(=O)Nc1ccn(Cc2ccc(F)cc2)n1)c1ccc(N(C)C)cc1 Homo sapiens CHEMBL4181720 cell-based format
CHEMBL1210267 OBDepict H 3 C CH 3 H N H H O O H 3 C N O O N F Cl IC50 = 45.0 nM 516.01 CC[C@H](C)[C@H](NC(=O)N1CCC2(CC1)C(=O)N(c1cccc(F)c1)C2c1ccc(Cl)cc1)C(=O)OC Homo sapiens CHEMBL1212315 cell-based format