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O95267 | GRP1_HUMAN | RAS guanyl-releasing protein 1 (RASGRP1)

3D structures mapped by conservation among orthologs

[ Domain: "EF-hand" // EF-hand_7_9 ]

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[ Domain: "Ras GEF" // RasGEF ]

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[ Domain: "Cysteine-rich domain" // C1_1 ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL519741 OBDepict H 3 C O O CH 3 O HO O N CH 3 Ki = 0.25 nM 413.51 CCCC(CCC)C(=O)OCC1(CO)C/C(=Cc2cn(C)c3ccccc23)C(=O)O1 Homo sapiens CHEMBL3294522 single protein format
CHEMBL3289012 OBDepict CH 3 O O H 3 C O HO O N H 3 C Ki = 0.41 nM 413.51 CCCC(CCC)C(=O)OCC1(CO)C/C(=Cc2ccc3c(ccn3C)c2)C(=O)O1 Homo sapiens CHEMBL3294522 single protein format
CHEMBL3289014 OBDepict H 3 C O O H 3 C O HO O N CH 3 Ki = 0.69 nM 413.51 CCCC(CCC)C(=O)OCC1(CO)C/C(=Cc2cccc3ccn(C)c23)C(=O)O1 Homo sapiens CHEMBL3294522 single protein format
CHEMBL3289013 OBDepict CH 3 O O H 3 C O HO O N CH 3 Ki = 0.87 nM 413.51 CCCC(CCC)C(=O)OCC1(CO)C/C(=Cc2ccc3ccn(C)c3c2)C(=O)O1 Homo sapiens CHEMBL3294522 single protein format
CHEMBL3289011 OBDepict H 3 C O O H 3 C O HO O N H 3 C Ki = 1.55 nM 413.51 CCCC(CCC)C(=O)OCC1(CO)C/C(=Cc2cccc3c2ccn3C)C(=O)O1 Homo sapiens CHEMBL3294522 single protein format
CHEMBL4097154 OBDepict OH O O O O N H 3 C CH 3 Ki = 22.6 nM 505.57 Cc1ccc(C#Cc2ccc(C=C3CC(CO)(COC(=O)c4cn(C)c5ccccc45)OC3=O)cc2)cc1 Homo sapiens CHEMBL4020950 assay format
CHEMBL4070999 OBDepict OH O O O O N CH 3 CH 3 CH 3 H 3 C CH 3 Ki = 22.6 nM 427.54 CC(C)C(C/C=C1/CC(CO)(COC(=O)c2cn(C)c3ccccc23)OC1=O)C(C)C Homo sapiens CHEMBL4020950 assay format
CHEMBL4075373 OBDepict OH O O O O N CH 3 CH 3 CH 3 H 3 C CH 3 Ki = 31.3 nM 427.54 CC(C)C(C/C=C1CC(CO)(COC(=O)c2cn(C)c3ccccc23)OC1=O)C(C)C Homo sapiens CHEMBL4020950 assay format
CHEMBL4069954 OBDepict OH O O O O N H 3 C CH 3 Ki = 40.0 nM 505.57 Cc1ccc(C#Cc2ccc(/C=C3CC(CO)(COC(=O)c4cn(C)c5ccccc45)OC3=O)cc2)cc1 Homo sapiens CHEMBL4020950 assay format
CHEMBL4099579 OBDepict CH 3 O O HO O O N H 3 C Ki = 63.3 nM 441.57 CCCCCCCCC/C=C1CC(CO)(COC(=O)c2cn(C)c3ccccc23)OC1=O Homo sapiens CHEMBL4020950 assay format
CHEMBL4081576 OBDepict H 3 C H 3 C O O HO O O N CH 3 Ki = 133.0 nM 413.51 CCCC(/C=C1CC(CO)(COC(=O)c2cn(C)c3ccccc23)OC1=O)CCC Homo sapiens CHEMBL4020950 assay format
CHEMBL4066764 OBDepict OH O O O O H 3 C CH 3 N CH 3 Ki = 666.0 nM 343.38 CC(C)=C1CC(CO)(COC(=O)c2cn(C)c3ccccc23)OC1=O Homo sapiens CHEMBL4020950 assay format