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O95372 | LYPA2_HUMAN | Acyl-protein thioesterase 2 (LYPLA2)

3D structures mapped by conservation among orthologs

[ Domain: "alpha/beta-Hydrolases" // Hydrolase_4 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3133031 OBDepict CH 3 H O O H S O O N CH 3 H 3 C IC50 = 19.6 nM 417.66 CCCCCCCCCC[C@@H]1C(=O)O[C@H]1CCCCS(=O)(=O)CCCN(C)C Homo sapiens CHEMBL3135194 single protein format
CHEMBL1903566 OBDepict O N N N N HO H 3 C H 3 C CH 3 IC50 = 30.0 nM 418.54 CC(C)(C)C1CCN(C(=O)n2ncc(C(O)(c3ccccc3)c3ccccc3)n2)CC1 Homo sapiens CHEMBL3135191 single protein format
CHEMBL1673415 OBDepict CH 3 H O O H O O H 3 C H 3 C Ki = 34.0 nM 376.54 CCCCCCCCCC[C@@H]1C(=O)O[C@H]1CCc1ccc(OC)c(OC)c1 Homo sapiens CHEMBL3135194 single protein format
CHEMBL1673415 OBDepict CH 3 H O O H O O H 3 C H 3 C IC50 = 37.7 nM 376.54 CCCCCCCCCC[C@@H]1C(=O)O[C@H]1CCc1ccc(OC)c(OC)c1 Homo sapiens CHEMBL3135194 single protein format
CHEMBL3133033 OBDepict O N N N N HO IC50 = 200.0 nM 362.43 O=C(N1CCCCC1)n1ncc(C(O)(c2ccccc2)c2ccccc2)n1 Homo sapiens CHEMBL3135191 single protein format
CHEMBL1509398 OBDepict CH 3 O N N O S S O O Ki = 230.0 nM 454.57 COc1ccc(N2CCN(C(=O)c3cc4c(s3)-c3ccccc3S(=O)(=O)C4)CC2)cc1 Homo sapiens CHEMBL3135187 single protein format
CHEMBL3133032 OBDepict H 3 C N CH 3 O B O B O N CH 3 CH 3 Ki = 730.0 nM 548.35 CN(C)CCOB(c1ccccc1)c1ccc(COCc2ccc(B(OCCN(C)C)c3ccccc3)cc2)cc1 Homo sapiens CHEMBL3135192 single protein format