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O95470 | SGPL1_HUMAN | Sphingosine-1-phosphate lyase 1 (SGPL1)

3D structures mapped by conservation among orthologs

[ Domain: "C-terminal domain in some PLP-dependent transferases" // KOG1383 ]

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[ Domain: "PLP-dependent transferases" // Aminotran_5_N ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3290335 OBDepict N N N N N H CH 3 N N IC50 = 24.0 nM 445.53 C[C@@H]1CN(c2nnc(Cc3ccccc3)c3ccc(C#N)cc23)CCN1c1ccc(C#N)cn1 Homo sapiens CHEMBL3293781 cell-based format
CHEMBL3290333 OBDepict N N N H H 3 C N N N F F F IC50 = 100.0 nM 488.52 C[C@@H]1CN(c2nnc(Cc3ccccc3)c3ccc(C(F)(F)F)cc23)CCN1c1ccc(C#N)cn1 Homo sapiens CHEMBL3293781 cell-based format
CHEMBL3798814 OBDepict CH 3 O CH 3 CH 3 N H HN O N O CH 3 IC50 = 117.0 nM 435.57 CCCCOc1cc(C)c(CNCC(NC(=O)c2cc(C)on2)c2ccccc2)cc1C Homo sapiens CHEMBL3803908 single protein format
CHEMBL3798147 OBDepict OH HN N H O N O H 3 C CH 3 CH 3 O CH 3 IC50 = 150.0 nM 447.54 COc1cc(C)c(CNCC(NC(=O)c2cc(C)on2)c2ccc(C#CCO)cc2)cc1C Homo sapiens CHEMBL3803908 single protein format
CHEMBL3799061 OBDepict CH 3 O CH 3 CH 3 NH N H O N O H 3 C O NH 2 IC50 = 150.0 nM 478.59 COc1cc(C)c(CNCC(NC(=O)c2cc(C)on2)c2ccc(CCCC(N)=O)cc2)cc1C Homo sapiens CHEMBL3803908 single protein format
CHEMBL3290331 OBDepict N N N H H 3 C N N N Cl IC50 = 210.0 nM 454.97 C[C@@H]1CN(c2nnc(Cc3ccccc3)c3ccc(Cl)cc23)CCN1c1ccc(C#N)cn1 Homo sapiens CHEMBL3293781 cell-based format
CHEMBL3799085 OBDepict CH 3 O CH 3 CH 3 N H HN O N O CH 3 IC50 = 260.0 nM 407.51 CCOc1cc(C)c(CNCC(NC(=O)c2cc(C)on2)c2ccccc2)cc1C Homo sapiens CHEMBL3803908 single protein format
CHEMBL3798254 OBDepict H 3 C O CH 3 CH 3 N H NH H O N O H 3 C IC50 = 485.0 nM 393.49 COc1cc(C)c(CNC[C@@H](NC(=O)c2cc(C)on2)c2ccccc2)cc1C Homo sapiens CHEMBL3803908 single protein format
CHEMBL3798874 OBDepict CH 3 O N NH O N H CH 3 H 3 C O F F F IC50 = 590.0 nM 461.48 Cc1cc(C(=O)NC(CNCc2cc(C)c(OCC(F)(F)F)cc2C)c2ccccc2)no1 Homo sapiens CHEMBL3803908 single protein format
CHEMBL3797779 OBDepict CH 3 O CH 3 CH 3 N H HN O N F O CH 3 IC50 = 720.0 nM 411.48 COc1cc(C)c(CNCC(NC(=O)c2cc(C)on2)c2ccc(F)cc2)cc1C Homo sapiens CHEMBL3803908 single protein format
CHEMBL3798062 OBDepict H 3 C O CH 3 H 3 C NH NH O N O IC50 = 730.0 nM 419.53 COc1cc(C)c(CNCC(NC(=O)c2cc(C3CC3)on2)c2ccccc2)cc1C Homo sapiens CHEMBL3803908 single protein format
CHEMBL3290322 OBDepict _ O + N O N N H CH 3 N N N IC50 = 740.0 nM 440.51 C[C@@H]1CN(c2nnc(Cc3ccccc3)c3ccccc23)CCN1c1ccc([N+](=O)[O-])cn1 Homo sapiens CHEMBL3293781 cell-based format
CHEMBL3799254 OBDepict H 3 C O CH 3 CH 3 N H NH O N N O H 3 C IC50 = 850.0 nM 394.48 COc1cc(C)c(CNCC(NC(=O)c2cc(C)on2)c2ccncc2)cc1C Homo sapiens CHEMBL3803908 single protein format
CHEMBL3798106 OBDepict CH 3 O N NH O N H CH 3 H 3 C O N IC50 = 1000.0 nM 470.57 Cc1cc(C(=O)NC(CNCc2cc(C)c(OCc3ccncc3)cc2C)c2ccccc2)no1 Homo sapiens CHEMBL3803908 single protein format
CHEMBL3799908 OBDepict H 3 C O CH 3 CH 3 N H NH O N O H 3 C IC50 = 1000.0 nM 393.49 COc1cc(C)c(CNCC(NC(=O)c2cc(C)on2)c2ccccc2)cc1C Homo sapiens CHEMBL3803908 single protein format