HOME LIGAND hPROTEOME OTHERS DOCUMENT

P00492 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)

3D structures mapped by conservation among orthologs

[ Domain: "PRTase-like" // Pribosyltran ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4282830 OBDepict O N P H N H O O OH OH N N P OH H N HO O HO OH Ki = 1.0 nM 481.3 O=C(CCP(=O)(O)O)N1C[C@@H](OC[C@@H](O)P(=O)(O)O)[C@H](n2cnc3c(O)ncnc32)C1 Homo sapiens CHEMBL4268771 single protein format
CHEMBL4290716 OBDepict O N P H N H O O OH OH N N P HO H NH 2 N O O OH HO H Ki = 3.0 nM 496.31 Nc1nc2c(ncn2[C@@H]2CN(C(=O)CCP(=O)(O)O)C[C@H]2OC[C@@H](O)P(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL4268777 single protein format
CHEMBL4086362 OBDepict NH 2 N N H N O N O O P O _ O _ O P O _ O _ O + Na + Na + Na + Na Ki = 6.0 nM 529.2 Nc1nc2c(ncn2CC(COCCP(=O)([O-])[O-])COCP(=O)([O-])[O-])c(=O)[nH]1.[Na+].[Na+].[Na+].[Na+] Homo sapiens CHEMBL4041378 single protein format
CHEMBL4285691 OBDepict O N P H N H O O OH OH N N P OH H N HO O HO OH Ki = 8.0 nM 481.3 O=C(CCP(=O)(O)O)N1C[C@@H](OC[C@H](O)P(=O)(O)O)[C@H](n2cnc3c(O)ncnc32)C1 Homo sapiens CHEMBL4268771 single protein format
CHEMBL4277753 OBDepict O N P H N H O O OH OH N N P HO H NH 2 N O O OH HO H Ki = 8.0 nM 496.31 Nc1nc2c(ncn2[C@@H]2CN(C(=O)CCP(=O)(O)O)C[C@H]2OC[C@H](O)P(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL4268777 single protein format
CHEMBL3578115 OBDepict H N N O N N N P N O OH HO P P O OH HO O OH HO Ki = 10.0 nM 546.35 O=c1[nH]cnc2c1ncn2CCN(CCN(CCP(=O)(O)O)CCP(=O)(O)O)CCP(=O)(O)O Homo sapiens CHEMBL3579427 single protein format
CHEMBL3578110 OBDepict OH N P N O OH OH P N O OH OH N N H 2 N N O H Ki = 30.0 nM 497.39 Nc1nc2c(ncn2CCN(CCN(CCO)CCP(=O)(O)O)CCP(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL3579427 single protein format
CHEMBL3394315 OBDepict NH 2 N N H N O N N O P O HO OH P O OH OH Ki = 30.0 nM 440.29 Nc1nc2c(ncn2CCN(CCP(=O)(O)O)COCCP(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL3396536 single protein format
CHEMBL3578114 OBDepict H N H 2 N N O N N N P N O OH HO P P O OH HO O OH HO Ki = 30.0 nM 561.37 Nc1nc2c(ncn2CCN(CCN(CCP(=O)(O)O)CCP(=O)(O)O)CCP(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL3579427 single protein format
CHEMBL4280490 OBDepict O N P H N H O O OH OH N N P NH 2 N O O HO HO H Ki = 30.0 nM 480.31 Nc1nc2c(ncn2[C@@H]2CN(C(=O)CCP(=O)(O)O)C[C@@H]2OCCP(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL4268771 single protein format
CHEMBL2325752 OBDepict NH 2 N N H N O N O O P P O OH HO O OH HO Ki = 30.0 nM 427.25 Nc1nc2c(ncn2CC(COCP(=O)(O)O)COCP(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL2329985 single protein format
CHEMBL3394327 OBDepict Br N N N O N N H H 2 N P O O OH HO P O OH HO Ki = 40.0 nM 533.21 Nc1nc2c(nc(Br)n2CCN(CCOCCP(=O)(O)O)CCP(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL3396536 single protein format
CHEMBL3578112 OBDepict OH N P N O OH OH P N O OH OH N N H 2 N N O H Ki = 40.0 nM 511.41 Nc1nc2c(ncn2CCN(CCN(CCCO)CCP(=O)(O)O)CCP(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL3579427 single protein format
CHEMBL1233603 OBDepict H N NH 2 N O N H H NH H HO H H OH O P O OH OH Ki = 56.0 nM 361.25 Nc1nc2c([C@@H]3N[C@H](COP(=O)(O)O)[C@@H](O)[C@H]3O)c[nH]c2c(=O)[nH]1 Homo sapiens CHEMBL4377151 single protein format
CHEMBL2153497 OBDepict HO N P N O OH OH N N H 2 N N O H Ki = 70.0 nM 346.28 Nc1nc2c(ncn2CCN(CCO)CCP(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL2157773 single protein format
CHEMBL2153480 OBDepict N N P N O OH HO N N H 2 N N O H Ki = 70.0 nM 355.3 N#CCCN(CCn1cnc2c(=O)[nH]c(N)nc21)CCP(=O)(O)O Homo sapiens CHEMBL2157773 single protein format
CHEMBL3394316 OBDepict H N H 2 N N O N N N P O O OH HO P O OH HO Ki = 80.0 nM 454.32 Nc1nc2c(ncn2CCN(CCOCCP(=O)(O)O)CCP(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL3396536 single protein format
CHEMBL594335 OBDepict CH 3 O P O OH HO N N N H 2 N N O H Ki = 100.0 nM 317.24 CC(CP(=O)(O)O)OCCn1cnc2c(=O)[nH]c(N)nc21 Homo sapiens CHEMBL1041579 assay format
CHEMBL2420072 OBDepict F O H N N N P O OH OH NH 2 N O H Ki = 100.0 nM 335.23 Nc1nc2c(ncn2C[C@@H](CF)OCCP(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL2423189 cell-based format
CHEMBL4546337 OBDepict OH N H N N N P N N O OH OH H 2 N N O H Ki = 100.0 nM 356.24 Nc1nc2c(ncn2C[C@H](CO)n2cc(P(=O)(O)O)nn2)c(=O)[nH]1 Homo sapiens CHEMBL4377127 single protein format
CHEMBL2153484 OBDepict OH O N P N O OH HO N N NH 2 N O H Ki = 100.0 nM 388.32 Nc1nc2c(ncn2CCN(CCCC(=O)O)CCP(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL2157773 single protein format
CHEMBL2153476 OBDepict CH 3 O O N P N O HO OH N N NH 2 N O H Ki = 100.0 nM 388.32 CCOC(=O)CN(CCn1cnc2c(=O)[nH]c(N)nc21)CCP(=O)(O)O Homo sapiens CHEMBL2157773 single protein format
CHEMBL4067618 OBDepict NH 2 N N H N O O O P O _ O _ O P O _ O _ O + Na + Na + Na + Na Ki = 100.0 nM 528.21 Nc1nc2c(ccn2CC(COCCP(=O)([O-])[O-])COCP(=O)([O-])[O-])c(=O)[nH]1.[Na+].[Na+].[Na+].[Na+] Homo sapiens CHEMBL4041378 single protein format
CHEMBL2153478 OBDepict H 3 C O O N P N O OH HO N N NH 2 N O H Ki = 100.0 nM 402.35 COC(=O)CCCN(CCn1cnc2c(=O)[nH]c(N)nc21)CCP(=O)(O)O Homo sapiens CHEMBL2157773 single protein format
CHEMBL4098313 OBDepict NH 2 N N H N O N O O P P O _ O _ O O _ O _ O + Na + Na + Na + Na Ki = 100.0 nM 543.23 Nc1nc2c(ncn2CC(COCCP(=O)([O-])[O-])COCCP(=O)([O-])[O-])c(=O)[nH]1.[Na+].[Na+].[Na+].[Na+] Homo sapiens CHEMBL4055717 single protein format
CHEMBL2153483 OBDepict OH O N P N O OH HO N N NH 2 N O H Ki = 150.0 nM 374.29 Nc1nc2c(ncn2CCN(CCC(=O)O)CCP(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL2157773 single protein format
CHEMBL3394312 OBDepict O N H N N N N O P O OH HO P O OH HO Ki = 190.0 nM 425.28 O=c1[nH]cnc2c1ncn2CCN(CCP(=O)(O)O)COCCP(=O)(O)O Homo sapiens CHEMBL3396536 single protein format
CHEMBL2153485 OBDepict NH 2 N N H N O N N P P O OH HO O OH HO Ki = 200.0 nM 410.26 Nc1nc2c(ncn2CCN(CCP(=O)(O)O)CCP(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL2157773 single protein format
CHEMBL4454497 OBDepict _ O + S P N O _ O _ O N N H 2 N N O H + Na + Na Ki = 200.0 nM 379.25 Nc1nc2c(ncn2CC[S+]([O-])CCP(=O)([O-])[O-])c(=O)[nH]1.[Na+].[Na+] Homo sapiens CHEMBL4313640 single protein format
CHEMBL1233663 OBDepict H N N O N H H NH H HO H H OH O P O OH OH Ki = 250.0 nM 346.24 O=c1[nH]cnc2c([C@@H]3N[C@H](COP(=O)(O)O)[C@@H](O)[C@H]3O)c[nH]c12 Homo sapiens CHEMBL4377151 single protein format
CHEMBL4090466 OBDepict NH 2 N N H N O N O O P P O _ O _ O O _ O _ O + Na + Na + Na + Na Ki = 300.0 nM 529.2 Nc1nc2c(ncn2C(COCCP(=O)([O-])[O-])COCCP(=O)([O-])[O-])c(=O)[nH]1.[Na+].[Na+].[Na+].[Na+] Homo sapiens CHEMBL4055717 single protein format
CHEMBL3394314 OBDepict H N H 2 N N O N N N P O OH HO P O OH HO Ki = 300.0 nM 438.32 Nc1nc2c(ncn2CCN(CCCCP(=O)(O)O)CCP(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL3396536 single protein format
CHEMBL610201 OBDepict H 3 C O P O OH OH N N N H 2 N N O H Ki = 300.0 nM 331.27 CCC(CP(=O)(O)O)OCCn1cnc2c(=O)[nH]c(N)nc21 Homo sapiens CHEMBL1041579 assay format
CHEMBL2414636 OBDepict OH NH H P O OH HO N N H N O H Ki = 380.0 nM 316.25 O=c1[nH]cnc2c(CN[C@H](CO)CCP(=O)(O)O)c[nH]c12 Homo sapiens CHEMBL2415854 single protein format
CHEMBL4437088 OBDepict NH 2 N N H N O N S P O _ O _ O + Na + Na Ki = 400.0 nM 363.25 Nc1nc2c(ncn2CCSCCP(=O)([O-])[O-])c(=O)[nH]1.[Na+].[Na+] Homo sapiens CHEMBL4313640 single protein format
CHEMBL4561412 OBDepict OH N H N N N P N N O OH OH H 2 N N O H Ki = 400.0 nM 356.24 Nc1nc2c(ncn2C[C@@H](CO)n2cc(P(=O)(O)O)nn2)c(=O)[nH]1 Homo sapiens CHEMBL4377127 single protein format
CHEMBL177948 OBDepict NH 2 N N HO N N O P O OH OH Ki = 400.0 nM 317.24 Nc1nc(O)c2ncn(COCCCCP(=O)(O)O)c2n1 Homo sapiens CHEMBL1932721 single protein format
CHEMBL2414638 OBDepict HO HN H P F O OH HO N N H N O H Ki = 420.0 nM 334.24 O=c1[nH]cnc2c(CN[C@H](CO)CC(F)P(=O)(O)O)c[nH]c12 Homo sapiens CHEMBL2415854 single protein format
CHEMBL2153477 OBDepict CH 3 O O N P N O HO OH N N NH 2 N O H Ki = 500.0 nM 388.32 COC(=O)CCN(CCn1cnc2c(=O)[nH]c(N)nc21)CCP(=O)(O)O Homo sapiens CHEMBL2157773 single protein format
CHEMBL1928784 OBDepict NH 2 N N H N O N P O HO OH Ki = 500.0 nM 315.27 Nc1nc2c(ncn2CCCCCCP(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL1932721 single protein format
CHEMBL267803 OBDepict NH 2 N N HO N N P O OH OH Ki = 500.0 nM 301.24 Nc1nc(O)c2ncn(CCCCCP(=O)(O)O)c2n1 Homo sapiens CHEMBL1932721 single protein format
CHEMBL88057 OBDepict Cl Cl HN O Ki = 500.0 nM 354.24 O=C(Nc1cc2c3ccccc3ccc2c2ccccc12)C(Cl)Cl Homo sapiens CHEMBL697044 single protein format
CHEMBL3578111 OBDepict OH N P N O OH OH P N O OH OH N N N O H Ki = 500.0 nM 482.37 O=c1[nH]cnc2c1ncn2CCN(CCN(CCO)CCP(=O)(O)O)CCP(=O)(O)O Homo sapiens CHEMBL3579427 single protein format
CHEMBL4291117 OBDepict O N P H N H O O OH OH N N P N HO O OH HO Ki = 600.0 nM 465.3 O=C(CCP(=O)(O)O)N1C[C@H](OCCP(=O)(O)O)[C@H](n2cnc3c(O)ncnc32)C1 Homo sapiens CHEMBL4268771 single protein format
CHEMBL313154 OBDepict NH 2 Ki = 600.0 nM 243.31 Nc1cc2c3ccccc3ccc2c2ccccc12 Homo sapiens CHEMBL697044 single protein format
CHEMBL3604955 OBDepict OH OH N P N O OH HO N N NH 2 N O H Ki = 600.0 nM 376.31 Nc1nc2c(ncn2CCN(CCP(=O)(O)O)CC(O)CO)c(=O)[nH]1 Homo sapiens CHEMBL3606787 single protein format
CHEMBL2325754 OBDepict NH 2 N N H N O N O O P O OH HO P O HO HO Ki = 600.0 nM 441.27 Nc1nc2c(ncn2CC(COCCP(=O)(O)O)OCCP(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL2329985 single protein format
CHEMBL2153481 OBDepict N N P N O OH HO N N NH 2 N O H Ki = 600.0 nM 369.32 N#CCCCN(CCn1cnc2c(=O)[nH]c(N)nc21)CCP(=O)(O)O Homo sapiens CHEMBL2157773 single protein format
CHEMBL4583093 OBDepict OH O H N N N P O OH OH NH 2 N O H Ki = 600.0 nM 333.24 Nc1nc2c(ncn2C[C@@H](CO)OCCP(=O)(O)O)c(=O)[nH]1 Homo sapiens CHEMBL4377155 single protein format
CHEMBL3578109 OBDepict O N H N N N O O P O OH HO P O HO OH Ki = 700.0 nM 426.26 O=c1[nH]cnc2c1ncn2CC(COCCP(=O)(O)O)OCCP(=O)(O)O Homo sapiens CHEMBL4041378 single protein format
CHEMBL3394313 OBDepict H N N O N N N P O O OH HO P O OH HO Ki = 1000.0 nM 439.3 O=c1[nH]cnc2c1ncn2CCN(CCOCCP(=O)(O)O)CCP(=O)(O)O Homo sapiens CHEMBL3396536 single protein format
CHEMBL2325753 OBDepict O N H N N N O O P P O HO OH O OH OH Ki = 1000.0 nM 412.23 O=c1[nH]cnc2c1ncn2CC(COCP(=O)(O)O)COCP(=O)(O)O Homo sapiens CHEMBL2329985 single protein format
CHEMBL552299 OBDepict NH 2 N N H N O N H O P O OH HO Ki = 1000.0 nM 305.23 Nc1nc2c(c(=O)[nH]1)NCN2CCOCCP(=O)(O)O Homo sapiens CHEMBL1035272 single protein format
CHEMBL4066860 OBDepict NH 2 N N H N O O O P P O _ O _ O O _ O _ O + Na + Na + Na + Na Ki = 1000.0 nM 542.24 Nc1nc2c(ccn2CC(COCCP(=O)([O-])[O-])COCCP(=O)([O-])[O-])c(=O)[nH]1.[Na+].[Na+].[Na+].[Na+] Homo sapiens CHEMBL4055717 single protein format