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P00533 | EGFR_HUMAN | Epidermal growth factor receptor (EGFR)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Domain: "Leucine-rich repeats" // GF_recep_IV,Recep_L_domain ]

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[ Domain: "Leucine-rich repeats" // Recep_L_domain ]

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[ Domain: "Epidermal growth factor receptor transmembrane-juxtamembrane segment" // TM_ErbB1 ]

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[ Domain: "Epidermal growth factor receptor transmembrane-juxtamembrane segment" // KOG1025 ]

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[ Domain: "Growth factor receptor domain" // Furin-like_4 ]

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[ Domain: "Growth factor receptor domain" // Furin-like ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL63786 OBDepict Br NH N N IC50 = 0.003 nM 350.22 Brc1cccc(Nc2ncnc3cc4ccccc4cc23)c1 Homo sapiens CHEMBL683040 cell-based format
CHEMBL29197 OBDepict CH 3 O O CH 3 N N H N Br Ki = 0.006 nM 360.21 COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC Homo sapiens CHEMBL940057 single protein format
CHEMBL35820 OBDepict CH 3 O O N N H N CH 3 Br IC50 = 0.006 nM 388.26 CCOc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OCC Homo sapiens CHEMBL677389 cell-based format
CHEMBL53711 OBDepict Br N H N N N N CH 3 H 3 C IC50 = 0.006 nM 344.22 CN(C)c1cc2c(Nc3cccc(Br)c3)ncnc2cn1 Homo sapiens CHEMBL674648 single protein format
CHEMBL66031 OBDepict Br N H N N N N H IC50 = 0.008 nM 340.18 Brc1cccc(Nc2ncnc3cc4[nH]cnc4cc23)c1 Homo sapiens CHEMBL679944 single protein format
CHEMBL53753 OBDepict H 3 C NH N N N N H Br IC50 = 0.008 nM 330.19 CNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1 Homo sapiens CHEMBL679944 single protein format
CHEMBL176582 OBDepict Br N H N N N N H 3 C IC50 = 0.01 nM 354.21 Cn1cnc2cc3ncnc(Nc4cccc(Br)c4)c3cc21 Homo sapiens CHEMBL683040 cell-based format
CHEMBL174426 OBDepict Br N H N N N N H 3 C IC50 = 0.025 nM 354.21 Cn1cnc2cc3c(Nc4cccc(Br)c4)ncnc3cc21 Homo sapiens CHEMBL683040 cell-based format
CHEMBL29197 OBDepict CH 3 O O CH 3 N N H N Br IC50 = 0.025 nM 360.21 COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC Homo sapiens CHEMBL677389 cell-based format
CHEMBL4100860 OBDepict HO N N H N N H F O N H CH 3 O CH 2 Ki = 0.03 nM 487.54 C=CC(=O)Nc1ccc(OC)c(Nc2cc(-c3[nH]c(CCCO)nc3-c3ccc(F)cc3)ccn2)c1 Homo sapiens CHEMBL4013167 assay format
CHEMBL1243316 OBDepict H 3 C O NH N O N H N NH Cl F HC IC50 = 0.03 nM 477.93 C#CCNC/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)c(C#N)cnc2cc1OCC Homo sapiens CHEMBL1249168 single protein format
CHEMBL3613702 OBDepict CH 2 HN O N N N H F Cl Cl IC50 = 0.037 nM 377.21 C=CC(=O)Nc1ccc2ncnc(Nc3cc(F)c(Cl)c(Cl)c3)c2c1 Homo sapiens CHEMBL3616083 single protein format
CHEMBL363815 OBDepict CH 2 HN O N N N H F Cl Cl IC50 = 0.037 nM 377.21 C=CC(=O)Nc1ccc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2c1 Homo sapiens CHEMBL832761 cell-based format
CHEMBL275762 OBDepict Cl HN O N N N H F Cl Cl IC50 = 0.07 nM 399.64 O=C(CCl)Nc1ccc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2c1 Homo sapiens CHEMBL832761 cell-based format
CHEMBL327307 OBDepict CH 3 O O CH 3 N N H N Br Br IC50 = 0.072 nM 439.11 COc1cc2ncnc(Nc3ccc(Br)c(Br)c3)c2cc1OC Homo sapiens CHEMBL680017 cell-based format
CHEMBL180022 OBDepict CH 3 O NH N O N H N N CH 3 H 3 C Cl O N IC50 = 0.08 nM 557.05 CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C Homo sapiens CHEMBL892951 single protein format
CHEMBL53428 OBDepict Br N H N N N N H 3 C CH 3 IC50 = 0.09 nM 344.22 CN(C)c1cc2ncnc(Nc3cccc(Br)c3)c2cn1 Homo sapiens CHEMBL677387 single protein format
CHEMBL4778248 OBDepict HO N H H N N N H O CH 3 N H N IC50 = 0.1 nM 500.65 COc1cc(CNCCN2CCCCC2)ccc1-c1cc2c(N[C@H](CO)c3ccccc3)ncnc2[nH]1 Homo sapiens CHEMBL4718820 single protein format
CHEMBL4742081 OBDepict HO N H H N N N H O CH 3 N H N NH IC50 = 0.1 nM 501.64 COc1cc(CNCCN2CCNCC2)ccc1-c1cc2c(N[C@H](CO)c3ccccc3)ncnc2[nH]1 Homo sapiens CHEMBL4718820 single protein format
CHEMBL55729 OBDepict NH 2 N N IC50 = 0.1 nM 145.17 Nc1ccc2cncnc2c1 Homo sapiens CHEMBL680021 cell-based format
CHEMBL420624 OBDepict NH 2 N N N H Br IC50 = 0.1 nM 315.17 Nc1ccc2c(Nc3cccc(Br)c3)ncnc2c1 Homo sapiens CHEMBL677387 single protein format
CHEMBL4748367 OBDepict HO NH H N N N H F N H N CH 3 CH 3 IC50 = 0.1 nM 448.55 CN(C)CCNCc1ccc(-c2cc3c(N[C@H](CO)c4ccccc4)ncnc3[nH]2)cc1F Homo sapiens CHEMBL4718820 single protein format
CHEMBL4784258 OBDepict HO NH H N N N H O CH 3 N CH 3 N CH 3 CH 3 IC50 = 0.1 nM 474.61 COc1cc(CN(C)CCN(C)C)ccc1-c1cc2c(N[C@H](CO)c3ccccc3)ncnc2[nH]1 Homo sapiens CHEMBL4718820 single protein format
CHEMBL4760328 OBDepict OH NH H N N N H O CH 3 IC50 = 0.1 nM 388.47 CCOc1ccccc1-c1cc2c(N[C@H](CCO)c3ccccc3)ncnc2[nH]1 Homo sapiens CHEMBL4718820 single protein format
CHEMBL4787951 OBDepict HO N H H N N N H O CH 3 N H N O IC50 = 0.1 nM 502.62 COc1cc(CNCCN2CCOCC2)ccc1-c1cc2c(N[C@H](CO)c3ccccc3)ncnc2[nH]1 Homo sapiens CHEMBL4718820 single protein format
CHEMBL4759003 OBDepict H 3 C O N N H H N N HN N H 3 C H 3 C H 3 C H IC50 = 0.1 nM 444.58 COc1cc(CNCCN(C)C)ccc1-c1cc2c(N[C@H](C)c3ccccc3)ncnc2[nH]1 Homo sapiens CHEMBL4718820 single protein format
CHEMBL553 OBDepict CH 3 O O O N N H N O CH 3 CH Ki = 0.1 nM 393.44 C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 Homo sapiens CHEMBL3375799 protein format
CHEMBL4098072 OBDepict CH 2 HN O N H O CH 3 N N N H S H 3 C F Ki = 0.1 nM 475.55 C=CC(=O)Nc1ccc(OC)c(Nc2cc(-c3[nH]c(SC)nc3-c3ccc(F)cc3)ccn2)c1 Homo sapiens CHEMBL4013167 assay format
CHEMBL190094 OBDepict CH 3 N CH 3 NH O N N N H F Cl Cl IC50 = 0.11 nM 434.3 CN(C)C/C=C/C(=O)Nc1ccc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2c1 Homo sapiens CHEMBL832761 cell-based format
CHEMBL31965 OBDepict H 2 C NH O O N N H N N Cl F O Ki = 0.11 nM 485.95 C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1 Homo sapiens CHEMBL3790712 assay format
CHEMBL328216 OBDepict Br N H N N H 2 N NH 2 IC50 = 0.12 nM 330.19 Nc1cc2ncnc(Nc3cccc(Br)c3)c2cc1N Homo sapiens CHEMBL677204 cell-based format
CHEMBL193160 OBDepict Cl HN O N N N H I IC50 = 0.12 nM 438.66 O=C(CCl)Nc1ccc2ncnc(Nc3cccc(I)c3)c2c1 Homo sapiens CHEMBL832761 cell-based format
CHEMBL3930620 OBDepict HO NH O N N N N N NH F Cl IC50 = 0.12 nM 483.94 O=C(CCCCCCn1cc(-c2ccc3ncnc(Nc4cccc(Cl)c4F)c3c2)nn1)NO Homo sapiens CHEMBL3870704 single protein format
CHEMBL54400 OBDepict CH 3 N H N N N N H Br IC50 = 0.13 nM 330.19 CNc1cc2ncnc(Nc3cccc(Br)c3)c2cn1 Homo sapiens CHEMBL677387 single protein format
CHEMBL3892310 OBDepict CH 3 N CH 3 HN O O N N H N O Cl F IC50 = 0.13 nM 511.99 CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCC1C2COCC21 Homo sapiens CHEMBL3887593 single protein format
CHEMBL51853 OBDepict Br N H N N NH 2 N IC50 = 0.13 nM 316.16 Nc1cc2c(Nc3cccc(Br)c3)ncnc2cn1 Homo sapiens CHEMBL674648 single protein format
CHEMBL3883534 OBDepict H 2 C NH O O CH 3 N N H N Cl F Ki = 0.14 nM 372.79 C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OC Homo sapiens CHEMBL3877213 cell-based format
CHEMBL417478 OBDepict H 2 C NH O N N N H N N Cl F O IC50 = 0.16 nM 482.95 C=CC(=O)Nc1nc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1/C=C/CCN1CCOCC1 Homo sapiens CHEMBL674020 single protein format
CHEMBL592617 OBDepict N HN O N N N H Br IC50 = 0.17 nM 382.22 N#CCC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 Homo sapiens CHEMBL1072157 cell-based format
CHEMBL418967 OBDepict CH 3 O O N N H N CH 3 Br IC50 = 0.17 nM 416.32 CCCOc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OCCC Homo sapiens CHEMBL680017 cell-based format
CHEMBL93032 OBDepict Br N H N N HO OH IC50 = 0.17 nM 332.16 Oc1cc2ncnc(Nc3cccc(Br)c3)c2cc1O Homo sapiens CHEMBL677205 cell-based format
CHEMBL4761468 OBDepict CH 2 NH O N N H CH 3 O N N CH 3 N CH 3 CH 3 N IC50 = 0.18 nM 525.66 C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C4CC4)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C Homo sapiens CHEMBL4714437 single protein format
CHEMBL2031302 OBDepict H 3 C O NH N O N N H CH 2 Cl F IC50 = 0.18 nM 386.81 C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCC Homo sapiens CHEMBL2033041 single protein format
CHEMBL166093 OBDepict HO OH NH N N N N H Br IC50 = 0.18 nM 390.24 OCC(O)CNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1 Homo sapiens CHEMBL674648 single protein format
CHEMBL166154 OBDepict H 3 C NH N N N N H Cl IC50 = 0.19 nM 285.74 CNc1cc2c(Nc3cccc(Cl)c3)ncnc2cn1 Homo sapiens CHEMBL674648 single protein format
CHEMBL165864 OBDepict OH NH N N N N H Br IC50 = 0.19 nM 360.22 OCCNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1 Homo sapiens CHEMBL674648 single protein format
CHEMBL4747958 OBDepict H 2 C HN O N N H CH 3 O N N CH 3 N H 3 C H 3 C N S N O O H 3 C CH 3 IC50 = 0.2 nM 592.73 C=CC(=O)Nc1cc(Nc2nccc(-c3cn(S(=O)(=O)N(C)C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C Homo sapiens CHEMBL4714437 single protein format
CHEMBL4164805 OBDepict HO NH H N N N H O CH 3 OH IC50 = 0.2 nM 390.44 COc1cc(CO)ccc1-c1cc2c(N[C@H](CO)c3ccccc3)ncnc2[nH]1 Homo sapiens CHEMBL4718840 single protein format
CHEMBL4776396 OBDepict CH 3 O N H N N N H H HO IC50 = 0.2 nM 374.44 CCOc1ccccc1-c1cc2c(N[C@H](CO)c3ccccc3)ncnc2[nH]1 Homo sapiens CHEMBL4718820 single protein format
CHEMBL4175024 OBDepict HO NH H N N N H OH IC50 = 0.2 nM 360.42 OCc1ccc(-c2cc3c(N[C@H](CO)c4ccccc4)ncnc3[nH]2)cc1 Homo sapiens CHEMBL4718840 single protein format
CHEMBL3753235 OBDepict CH 2 NH O N N O N N H O CH 3 N N CH 3 IC50 = 0.2 nM 587.68 C=CC(=O)Nc1cccc(-n2c(=O)c(-c3ccccc3)cc3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1 Homo sapiens CHEMBL3755797 protein format
CHEMBL437879 OBDepict CH 3 O O CH 3 N N H N F Cl Cl IC50 = 0.208 nM 368.2 COc1cc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2cc1OC Homo sapiens CHEMBL832761 cell-based format
CHEMBL161956 OBDepict OH N CH 3 N N N N H Br IC50 = 0.22 nM 374.24 CN(CCO)c1cc2c(Nc3cccc(Br)c3)ncnc2cn1 Homo sapiens CHEMBL674648 single protein format
CHEMBL4851176 OBDepict N N NH N H N O O H 3 C N NH N HC IC50 = 0.23 nM 520.6 C#Cc1cccc(Nc2ncnc3cc(OC)c(OCCCCCN/C(=NC#N)Nc4ccncc4)cc23)c1 Homo sapiens CHEMBL4819610 assay format
CHEMBL2031300 OBDepict CH 3 N N N H O N N HN Br IC50 = 0.23 nM 469.39 CN1CCN(CCC(=O)Nc2ccc3ncnc(Nc4cccc(Br)c4)c3c2)CC1 Homo sapiens CHEMBL2033041 single protein format
CHEMBL316064 OBDepict CH 3 O O CH 3 N N H N F F F IC50 = 0.24 nM 349.31 COc1cc2ncnc(Nc3cccc(C(F)(F)F)c3)c2cc1OC Homo sapiens CHEMBL680017 cell-based format
CHEMBL127041 OBDepict OH NH N N N N H Br IC50 = 0.24 nM 360.22 OCCNc1cc2ncnc(Nc3cccc(Br)c3)c2cn1 Homo sapiens CHEMBL677387 single protein format
CHEMBL4862351 OBDepict CH 3 O O NH N Cl N N H O N O O IC50 = 0.2446 nM 511.97 CCOC(=O)c1ccccc1Nc1nc(Nc2ccc(OCC(=O)N3CCOCC3)cc2)ncc1Cl Homo sapiens CHEMBL4832125 single protein format
CHEMBL328955 OBDepict NH 2 N N N H Cl IC50 = 0.25 nM 270.72 Nc1ccc2c(Nc3cccc(Cl)c3)ncnc2c1 Homo sapiens CHEMBL680017 cell-based format
CHEMBL52913 OBDepict CH 2 NH O N N N H Cl IC50 = 0.25 nM 324.77 C=CC(=O)Nc1ccc2c(Nc3cccc(Cl)c3)ncnc2c1 Homo sapiens CHEMBL856168 single protein format
CHEMBL3360608 OBDepict H 3 C O O N N H N N CH N + N O _ O IC50 = 0.26 nM 458.48 C#Cc1cccc(Nc2ncnc3cc(OCCCCn4ccnc4[N+](=O)[O-])c(OC)cc23)c1 Homo sapiens CHEMBL3375345 single protein format
CHEMBL4796010 OBDepict CH 2 NH O + S N H _ O O N N CH 3 N CH 3 CH 3 N IC50 = 0.26 nM 544.68 C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C4CC4)c4ccccc34)n2)c(OC)cc1[S+]([O-])CCN(C)C Homo sapiens CHEMBL4713360 assay format
CHEMBL2031303 OBDepict CH 3 O NH N O N N H N H 3 C CH 3 Cl F IC50 = 0.27 nM 431.9 CCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)CCN(C)C Homo sapiens CHEMBL2033041 single protein format
CHEMBL3929484 OBDepict OH N H O N N N N N NH F Cl IC50 = 0.27 nM 469.91 O=C(CCCCCn1cc(-c2ccc3ncnc(Nc4cccc(Cl)c4F)c3c2)nn1)NO Homo sapiens CHEMBL3870704 single protein format
CHEMBL152905 OBDepict NH 2 S N N NH Br IC50 = 0.27 nM 371.26 Nc1ccc2sc3c(Nc4cccc(Br)c4)ncnc3c2c1 Homo sapiens CHEMBL679944 single protein format
CHEMBL2031298 OBDepict O HN N N N N H Br IC50 = 0.27 nM 454.37 O=C(CCN1CCCCC1)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 Homo sapiens CHEMBL2033041 single protein format
CHEMBL355816 OBDepict HO O NH N N N N H Br IC50 = 0.28 nM 374.2 O=C(O)CNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1 Homo sapiens CHEMBL674648 single protein format
CHEMBL128468 OBDepict OH O NH N N N N H Br IC50 = 0.28 nM 402.25 O=C(O)CCCNc1cc2ncnc(Nc3cccc(Br)c3)c2cn1 Homo sapiens CHEMBL677387 single protein format
CHEMBL2031297 OBDepict CH 3 N CH 3 HN O N N N H Br IC50 = 0.28 nM 414.31 CN(C)CCC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 Homo sapiens CHEMBL2033041 single protein format
CHEMBL2031305 OBDepict CH 3 O NH N O N NH N Cl O F IC50 = 0.29 nM 473.94 CCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)CCN1CCOCC1 Homo sapiens CHEMBL2033041 single protein format
CHEMBL426580 OBDepict Br N H N N N N CH 3 H IC50 = 0.29 nM 354.21 Cc1nc2cc3c(Nc4cccc(Br)c4)ncnc3cc2[nH]1 Homo sapiens CHEMBL683040 cell-based format
CHEMBL2029436 OBDepict CH 2 NH O N N O N N N H O CH 3 N N CH 3 IC50 = 0.3 nM 590.69 C=CC(=O)Nc1cccc(N2C(=O)N(c3ccccc3)Cc3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1 Homo sapiens CHEMBL2033651 single protein format
CHEMBL3544983 OBDepict H 3 C O O N N N H H F H H Cl N Cl CH 3 IC50 = 0.3 nM 491.39 COc1cc2c(Nc3ccc(Cl)c(Cl)c3F)ncnc2cc1OC[C@@H]1C[C@@H]2CN(C)C[C@@H]2C1 Homo sapiens CHEMBL4394508 cell-based format
CHEMBL4785569 OBDepict CH 3 O N H N N NH CH 3 H IC50 = 0.3 nM 358.45 CCOc1ccccc1-c1cc2c(N[C@H](C)c3ccccc3)ncnc2[nH]1 Homo sapiens CHEMBL4718820 single protein format
CHEMBL4740573 OBDepict OH N H H N N N H O CH 3 N H S O O CH 3 IC50 = 0.3 nM 453.52 COc1cc(NS(C)(=O)=O)ccc1-c1cc2c(N[C@H](CO)c3ccccc3)ncnc2[nH]1 Homo sapiens CHEMBL4718820 single protein format
CHEMBL4127317 OBDepict H 2 C NH O N N O N N HN O CH 3 H 3 C O CH 3 N N CH 3 IC50 = 0.3 nM 570.65 C=CC(=O)Nc1cccc(-n2c(=O)n(C(C)C)c(=O)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1 Homo sapiens CHEMBL4125335 assay format
CHEMBL3357644 OBDepict CH 3 O HN N O N HN F N Cl F O IC50 = 0.3 nM 489.91 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C(F)=CCN1CCOCC1 Homo sapiens CHEMBL3385194 single protein format
CHEMBL4748320 OBDepict HO NH H N N N H N H N CH 3 CH 3 IC50 = 0.3 nM 430.56 CN(C)CCNCc1ccc(-c2cc3c(N[C@H](CO)c4ccccc4)ncnc3[nH]2)cc1 Homo sapiens CHEMBL4718820 single protein format
CHEMBL4743998 OBDepict H N N N N H NH H 3 C H S O O H 3 C IC50 = 0.3 nM 407.5 C[C@@H](Nc1ncnc2[nH]c(-c3ccc(NS(C)(=O)=O)cc3)cc12)c1ccccc1 Homo sapiens CHEMBL4718820 single protein format
CHEMBL203644 OBDepict CH 3 HN O N N N N H Cl F IC50 = 0.3 nM 355.76 CC#CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1 Homo sapiens CHEMBL862512 assay format
CHEMBL4787816 OBDepict HO NH H N N N H O CH 3 N H N CH 3 CH 3 IC50 = 0.3 nM 460.58 COc1cc(CNCCN(C)C)ccc1-c1cc2c(N[C@H](CO)c3ccccc3)ncnc2[nH]1 Homo sapiens CHEMBL4718820 single protein format
CHEMBL4439338 OBDepict CH 3 O O N N NH N Cl N H NH O F IC50 = 0.3 nM 595.12 COc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1OCCCN1CCNCCNCC1 Homo sapiens CHEMBL4329616 assay format
CHEMBL4290812 OBDepict CH 2 NH O N N H O N N CH 3 N CH 3 N H 3 C IC50 = 0.3 nM 509.61 C=C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N1CCN(C)CC1 Homo sapiens CHEMBL4258550 single protein format
CHEMBL3360603 OBDepict CH 3 O O N NH N N Cl F N + N O _ O IC50 = 0.31 nM 486.89 COc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCCn1ccnc1[N+](=O)[O-] Homo sapiens CHEMBL3375345 single protein format
CHEMBL4873506 OBDepict N N HN N H N O O CH 3 N HN N CH IC50 = 0.32 nM 534.62 C#Cc1cccc(Nc2ncnc3cc(OC)c(OCCCCCCN/C(=NC#N)Nc4cccnc4)cc23)c1 Homo sapiens CHEMBL4819610 assay format
CHEMBL3355877 OBDepict CH 3 O O N N NH Cl N F N + N O _ O IC50 = 0.32 nM 514.95 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCCCCn1ccnc1[N+](=O)[O-] Homo sapiens CHEMBL3372999 single protein format
CHEMBL3360606 OBDepict H 3 C O O N N H N O Cl N F N + N O _ O IC50 = 0.32 nM 502.89 COc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCOCCn1ccnc1[N+](=O)[O-] Homo sapiens CHEMBL3375345 single protein format
CHEMBL3360619 OBDepict H 3 C O O N N H N Br N N + N O _ O IC50 = 0.33 nM 527.38 COc1cc2c(Nc3cccc(Br)c3)ncnc2cc1OCCCCCn1ccnc1[N+](=O)[O-] Homo sapiens CHEMBL3375345 single protein format
CHEMBL366580 OBDepict Br N H N N N N H IC50 = 0.34 nM 340.18 Brc1cccc(Nc2ncnc3cc4c[nH]nc4cc23)c1 Homo sapiens CHEMBL679548 cell-based format
CHEMBL91980 OBDepict NH 2 N N N H I IC50 = 0.35 nM 362.17 Nc1ccc2c(Nc3cccc(I)c3)ncnc2c1 Homo sapiens CHEMBL680017 cell-based format
CHEMBL4860398 OBDepict N N HN N H N O O CH 3 N HN N CH IC50 = 0.35 nM 534.62 C#Cc1cccc(Nc2ncnc3cc(OC)c(OCCCCCCN/C(=NC#N)Nc4ccncc4)cc23)c1 Homo sapiens CHEMBL4819610 assay format
CHEMBL163369 OBDepict OH N OH NH N N N N H Br IC50 = 0.35 nM 461.36 OCCN(CCO)CCCNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1 Homo sapiens CHEMBL674648 single protein format
CHEMBL603266 OBDepict O N H N S O N N NH Br IC50 = 0.36 nM 456.33 O=C(Cn1sccc1=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 Homo sapiens CHEMBL1072157 cell-based format
CHEMBL39320 OBDepict Br N H N N N N H 3 C IC50 = 0.37 nM 354.21 Cn1ncc2cc3c(Nc4cccc(Br)c4)ncnc3cc21 Homo sapiens CHEMBL677389 cell-based format
CHEMBL3895468 OBDepict H 3 C N CH 3 NH O O N N H N O Cl F IC50 = 0.37 nM 511.99 CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCC12COCC1C2 Homo sapiens CHEMBL3887593 single protein format
CHEMBL599863 OBDepict O HN N H O O N N N H Br IC50 = 0.37 nM 492.33 O=C(CNC(=O)Oc1ccccc1)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 Homo sapiens CHEMBL1072157 cell-based format
CHEMBL3360618 OBDepict CH 3 O O N NH N N Br N + N O _ O IC50 = 0.37 nM 513.35 COc1cc2c(Nc3cccc(Br)c3)ncnc2cc1OCCCCn1ccnc1[N+](=O)[O-] Homo sapiens CHEMBL3375345 single protein format
CHEMBL4071012 OBDepict CH 2 N H O S N N H N N H F Ki = 0.38 nM 459.55 C=CC(=O)NCCSc1nc(-c2ccc(F)cc2)c(-c2ccnc(Nc3ccccc3)c2)[nH]1 Homo sapiens CHEMBL4013167 assay format
CHEMBL2029434 OBDepict H 2 C NH O N O N N CH 3 H 3 C N HN O CH 3 N N CH 3 IC50 = 0.38 nM 556.67 C=CC(=O)Nc1cccc(N2C(=O)N(C(C)C)Cc3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1 Homo sapiens CHEMBL2033651 single protein format
CHEMBL2447950 OBDepict CH 3 O O N N H N CH 3 Cl ClH IC50 = 0.38 nM 380.28 CCOc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OCC.Cl Homo sapiens CHEMBL916319 cell-based format