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P00746 | CFAD_HUMAN | Complement factor D (CFD)

3D structures mapped by conservation among orthologs

[ Domain: "FMN-binding split barrel 2" // Trypsin_1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL2180765 OBDepict N O N N H O H 2 N N O H H HN O H F Cl IC50 = 1.0 nM 524.94 N#CCOc1ccc2c(c1)c(NC(=O)N1[C@H](C(=O)NCc3cccc(Cl)c3F)C[C@H]3C[C@H]31)cn2C(N)=O Homo sapiens CHEMBL2188699 single protein format
CHEMBL4114217 OBDepict H 3 C NH H N O N N N N H 2 N F O O CH 3 CH 3 IC50 = 1.0 nM 507.57 CCN[C@H](CC(=O)N1CCN(c2nc(N)c3cc(OC)c(OC)c(F)c3n2)CC1)c1ccc(C#N)cc1 Homo sapiens CHEMBL3889157 cell-based format
CHEMBL4106993 OBDepict CH 3 O O F CH 3 N NH 2 N N N O NH H CH 3 O N IC50 = 1.0 nM 563.63 COc1cc2c(N)nc(N3CCN(C(=O)C[C@@H](NCC4(C)COC4)c4ccc(C#N)cc4)CC3)nc2c(F)c1OC Homo sapiens CHEMBL3889157 cell-based format
CHEMBL2180764 OBDepict H N O N H CH 3 F O N H N F Cl O NH 2 O O OH IC50 = 2.0 nM 563.95 C[C@@]1(F)C[C@@H](C(=O)NCc2cccc(Cl)c2F)N(C(=O)Nc2cn(C(N)=O)c3ccc(OCC(=O)O)cc23)C1 Homo sapiens CHEMBL2188699 single protein format
CHEMBL3109655 OBDepict F N N N O NH 2 N O H H NH O H N Br IC50 = 2.0 nM 516.33 NC(=O)c1nn(CC(=O)N2[C@H](C(=O)Nc3cccc(Br)n3)C[C@H]3C[C@H]32)c2cnc(CF)cc12 Homo sapiens CHEMBL3111918 assay format
CHEMBL3678945 OBDepict H 3 C N N N O H 2 N N O H H HN O H N Br IC50 = 3.0 nM 512.37 CCc1cc2c(C(N)=O)nn(CC(=O)N3[C@H](C(=O)Nc4cccc(Br)n4)C[C@H]4C[C@H]43)c2cn1 Homo sapiens CHEMBL3705899 assay format
CHEMBL4535197 OBDepict OH H 2 N H Br O O OH IC50 = 3.0 nM 456.34 N[C@H](CO)c1cccc(-c2cc(Br)cc(COc3ccccc3CC(=O)O)c2)c1 Homo sapiens CHEMBL4394736 assay format
CHEMBL3673724 OBDepict CH 3 O N HN O NH 2 N O H H F NH O F Cl IC50 = 3.0 nM 505.91 COc1ccc2c(c1)c(NC(=O)N1C[C@H](F)C[C@H]1C(=O)NCc1cccc(Cl)c1F)cn2C(N)=O Homo sapiens CHEMBL3705899 assay format
CHEMBL3673802 OBDepict HO N N H O NH 2 N O H H NH O H F Cl IC50 = 3.0 nM 485.9 NC(=O)n1cc(NC(=O)N2[C@H](C(=O)NCc3cccc(Cl)c3F)C[C@H]3C[C@H]32)c2cc(O)ccc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL3673804 OBDepict OH O O N N H O NH 2 N O H H NH O H F Cl IC50 = 3.0 nM 543.94 NC(=O)n1cc(NC(=O)N2[C@H](C(=O)NCc3cccc(Cl)c3F)C[C@H]3C[C@H]32)c2cc(OCC(=O)O)ccc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL3678905 OBDepict O N N H H N HN O H O H 2 N F Cl IC50 = 3.0 nM 469.9 NC(=O)c1nn(CC(=O)N2[C@H](C(=O)NCc3cccc(Cl)c3F)C[C@H]3C[C@H]32)c2ccccc12 Homo sapiens CHEMBL3705899 assay format
CHEMBL4115620 OBDepict H 3 C N N N O N N O CH 3 N O H H HN O H CH 3 H H Cl Cl IC50 = 3.0 nM 574.47 CC(=O)c1nn(CC(=O)N2[C@H](C(=O)N[C@H](C)[C@H]3CC3(Cl)Cl)C[C@H]3C[C@H]32)c2ccc(OCc3ncn(C)n3)cc12 Homo sapiens CHEMBL3889242 assay format
CHEMBL3109654 OBDepict I N N H O H N H O H N N O NH 2 IC50 = 3.0 nM 530.33 NC(=O)c1nn(CC(=O)N2[C@H](C(=O)Nc3cccc(I)n3)C[C@H]3C[C@H]32)c2ccccc12 Homo sapiens CHEMBL3111918 assay format
CHEMBL4111856 OBDepict O N N H H N NH O H O CH 3 H O CH 3 Cl Cl N N IC50 = 3.0 nM 571.47 CC(=O)c1nn(CC(=O)N2[C@H](C(=O)NC[C@@H]3C(C)C3(Cl)Cl)C[C@H]3C[C@H]32)c2ccc(OCc3ncccn3)cc12 Homo sapiens CHEMBL3889242 assay format
CHEMBL2180766 OBDepict O O CH 3 CH 3 H 3 C N N H O H 2 N N O H H NH O H F Cl IC50 = 3.0 nM 584.05 CC(C)(C)OC(=O)Cc1ccc2c(NC(=O)N3[C@H](C(=O)NCc4cccc(Cl)c4F)C[C@H]4C[C@H]43)cn(C(N)=O)c2c1 Homo sapiens CHEMBL2188699 single protein format
CHEMBL3678910 OBDepict H 3 C N N N O H 2 N N O H H F HN O H O CH 3 F Cl IC50 = 3.0 nM 534.95 CCc1cc2c(C(N)=O)nn(CC(=O)N3C[C@H](F)[C@@H](OC)[C@H]3C(=O)NCc3cccc(Cl)c3F)c2cn1 Homo sapiens CHEMBL3705899 assay format
CHEMBL4106731 OBDepict O N N H H N HN O H CH 3 H O H 3 C H O Cl Cl N N CH 3 H IC50 = 3.0 nM 573.48 CC(=O)c1nn(CC(=O)N2[C@H](C(=O)N[C@H](C)[C@H]3CC3(Cl)Cl)C[C@H]3C[C@H]32)c2ccc(OCc3cc(C)[nH]n3)cc12 Homo sapiens CHEMBL3889242 assay format
CHEMBL3673750 OBDepict H N O N H H 3 C F O N H N F Cl O NH 2 O O O CH 3 IC50 = 3.0 nM 577.97 COC(=O)COc1ccc2c(c1)c(NC(=O)N1C[C@](C)(F)C[C@H]1C(=O)NCc1cccc(Cl)c1F)cn2C(N)=O Homo sapiens CHEMBL3705899 assay format
CHEMBL4107243 OBDepict CH 3 O O F CH 3 N NH 2 N N N O HN H H 3 C CH 3 N IC50 = 3.0 nM 521.6 COc1cc2c(N)nc(N3CCN(C(=O)C[C@@H](NC(C)C)c4ccc(C#N)cc4)CC3)nc2c(F)c1OC Homo sapiens CHEMBL3889157 cell-based format
CHEMBL4113469 OBDepict CH 3 N H O H N O F N N N NH 2 F O O H 3 C CH 3 IC50 = 3.0 nM 528.56 CCNC(=O)[C@H](CC(=O)N1CCN(c2nc(N)c3cc(OC)c(OC)c(F)c3n2)CC1)c1ccc(F)cc1 Homo sapiens CHEMBL3889157 cell-based format
CHEMBL3668673 OBDepict O N HN H NH O N O NH 2 F Cl IC50 = 3.0 nM 469.9 NC(=O)n1cc(NC(=O)N2C3CC3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccccc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL4250860 OBDepict O N H H N N H F O N Br N O H 3 C N N CH 3 IC50 = 4.0 nM 580.42 CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccc(-c3cnc(C)nc3)cc12 Homo sapiens CHEMBL4229693 assay format
CHEMBL4112203 OBDepict Cl N N O NH 2 N O H H N H O H CH 3 H H Cl Cl IC50 = 4.0 nM 498.8 C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccc(Cl)cc21)[C@H]1CC1(Cl)Cl Homo sapiens CHEMBL3889242 assay format
CHEMBL3668636 OBDepict OH N H H F O Cl H N H HN O H N O CH 3 IC50 = 4.0 nM 498.94 CC(=O)n1cc(NC(=O)N2[C@H](C(=O)N[C@H](CO)c3cccc(Cl)c3F)C[C@H]3C[C@H]32)c2ccccc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL4111681 OBDepict CH 3 O O F CH 3 N NH 2 N N N O NH H S IC50 = 4.0 nM 514.63 COc1cc2c(N)nc(N3CCN(C(=O)C[C@@H](NCC4CC4)c4ccsc4)CC3)nc2c(F)c1OC Homo sapiens CHEMBL3889157 cell-based format
CHEMBL4108959 OBDepict CH 3 HN H N O N N N N NH 2 F O O H 3 C CH 3 IC50 = 4.0 nM 493.54 CN[C@H](CC(=O)N1CCN(c2nc(N)c3cc(OC)c(OC)c(F)c3n2)CC1)c1ccc(C#N)cc1 Homo sapiens CHEMBL3889157 cell-based format
CHEMBL3683739 OBDepict Br N N H O H N H F N H O N O H 2 N IC50 = 4.0 nM 489.31 NC(=O)n1cc(NC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccccc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL4114056 OBDepict O N N H H N N H O H H 3 C H O H 3 C CH 3 H O Cl Cl N N IC50 = 4.0 nM 585.49 CC(=O)c1nn(CC(=O)N2[C@H](C(=O)N[C@H](C)[C@H]3CC3(Cl)Cl)C[C@H]3C[C@H]32)c2cc(C)c(OCc3ncccn3)cc12 Homo sapiens CHEMBL3889242 assay format
CHEMBL4111206 OBDepict H 3 C N N O N N O CH 3 N O H H HN O H CH 3 H H Cl Cl IC50 = 4.0 nM 573.48 CC(=O)c1nn(CC(=O)N2[C@H](C(=O)N[C@H](C)[C@H]3CC3(Cl)Cl)C[C@H]3C[C@H]32)c2ccc(OCc3ccn(C)n3)cc12 Homo sapiens CHEMBL3889242 assay format
CHEMBL3673732 OBDepict CH 3 O N N H O NH 2 N O H NH O F Cl IC50 = 4.0 nM 499.93 COc1ccc2c(c1)c(NC(=O)N1C3CC3C[C@H]1C(=O)NCc1cccc(Cl)c1F)cn2C(N)=O Homo sapiens CHEMBL3705899 assay format
CHEMBL4246585 OBDepict OH H 2 N H O HO O OH IC50 = 4.0 nM 407.47 N[C@H](CO)c1cccc(-c2cc(CO)cc(COc3ccccc3CC(=O)O)c2)c1 Homo sapiens CHEMBL4229719 assay format
CHEMBL3673738 OBDepict H 3 C O O N N H O H 2 N N O H H HN O H F Cl IC50 = 4.0 nM 555.99 CCOC(=O)Cc1ccc2c(c1)c(NC(=O)N1[C@H](C(=O)NCc3cccc(Cl)c3F)C[C@H]3C[C@H]31)cn2C(N)=O Homo sapiens CHEMBL3705899 assay format
CHEMBL3683725 OBDepict Br N N H O H N H O H N N O NH 2 Cl IC50 = 4.0 nM 517.77 NC(=O)c1nn(CC(=O)N2[C@H](C(=O)Nc3cccc(Br)n3)C[C@H]3C[C@H]32)c2cc(Cl)ccc12 Homo sapiens CHEMBL3705899 assay format
CHEMBL3683724 OBDepict Br N NH O H N H O H N N O CH 3 O N N IC50 = 4.0 nM 590.44 CC(=O)c1nn(CC(=O)N2[C@H](C(=O)Nc3cccc(Br)n3)C[C@H]3C[C@H]32)c2ccc(OCc3ncccn3)cc12 Homo sapiens CHEMBL3705899 assay format
CHEMBL3673812 OBDepict H N O N H CH 3 F O N H N F Cl O NH 2 O HO IC50 = 4.0 nM 549.96 C[C@@]1(F)C[C@@H](C(=O)NCc2cccc(Cl)c2F)N(C(=O)Nc2cn(C(N)=O)c3ccc(OCCO)cc23)C1 Homo sapiens CHEMBL3705899 assay format
CHEMBL3683720 OBDepict Br N HN O H N H 3 C O H N N O H 2 N IC50 = 4.0 nM 497.35 C[C@@]12C[C@@H](C(=O)Nc3cccc(Br)n3)N(C(=O)Cn3nc(C(N)=O)c4ccccc43)[C@@H]1C2 Homo sapiens CHEMBL3705899 assay format
CHEMBL3678944 OBDepict Br N N H O H N H O H N N N O NH 2 CH 3 IC50 = 4.0 nM 498.34 Cc1cc2c(C(N)=O)nn(CC(=O)N3[C@H](C(=O)Nc4cccc(Br)n4)C[C@H]4C[C@H]43)c2cn1 Homo sapiens CHEMBL3705899 assay format
CHEMBL3678898 OBDepict O N N H H N N H O H N O H 2 N F Cl IC50 = 5.0 nM 532.96 NC(=O)c1nn(CC(=O)N2[C@H](C(=O)Nc3cccc(-c4ccccc4Cl)c3F)C[C@H]3C[C@H]32)c2cnccc12 Homo sapiens CHEMBL3705899 assay format
CHEMBL3673808 OBDepict OH O N N H O NH 2 N O H H NH O H F Cl IC50 = 5.0 nM 529.96 NC(=O)n1cc(NC(=O)N2[C@H](C(=O)NCc3cccc(Cl)c3F)C[C@H]3C[C@H]32)c2cc(OCCO)ccc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL3673793 OBDepict O N N H N H HN O N O H 2 N F Cl IC50 = 5.0 nM 456.87 NC(=O)n1cc(NC(=O)N2N=CC[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccccc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL3683719 OBDepict Br N N H O H N H O H N N H 3 C N O NH 2 CH 3 IC50 = 5.0 nM 512.37 Cc1cc2c(C(N)=O)nn(CC(=O)N3[C@H](C(=O)Nc4cccc(Br)n4)C[C@H]4C[C@H]43)c2c(C)n1 Homo sapiens CHEMBL3705899 assay format
CHEMBL3683717 OBDepict Br N N N H O H N H O H N N O CH 3 IC50 = 5.0 nM 483.33 CC(=O)c1nn(CC(=O)N2[C@H](C(=O)Nc3cncc(Br)n3)C[C@H]3C[C@H]32)c2ccccc12 Homo sapiens CHEMBL3705899 assay format
CHEMBL3673726 OBDepict F N N H O NH 2 N O H NH O F Cl IC50 = 5.0 nM 487.89 NC(=O)n1cc(NC(=O)N2C3CC3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cc(F)ccc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL3965664 OBDepict Br N N H O H N H 3 C O H N N N O NH 2 CH 3 IC50 = 5.0 nM 512.37 Cc1cc2c(C(N)=O)nn(CC(=O)N3[C@H](C(=O)Nc4cccc(Br)n4)C[C@@]4(C)C[C@@H]34)c2cn1 Homo sapiens CHEMBL3705899 assay format
CHEMBL4114574 OBDepict N N H N O N H N N NH 2 F O O CH 3 CH 3 IC50 = 5.0 nM 551.58 COc1cc2c(N)nc(N3CCN(C(=O)c4cc5cc(C#N)ccc5[nH]4)C[C@@H]3c3ccccc3)nc2c(F)c1OC Homo sapiens CHEMBL3889157 cell-based format
CHEMBL3668669 OBDepict CH 3 O O N HN O NH 2 N O H N H O F Cl IC50 = 5.0 nM 543.98 COCCOc1ccc2c(c1)c(NC(=O)N1C3CC3C[C@H]1C(=O)NCc1cccc(Cl)c1F)cn2C(N)=O Homo sapiens CHEMBL3705899 assay format
CHEMBL3683730 OBDepict H 3 C O H H F H N HN O O N N N Br O H 2 N IC50 = 5.0 nM 519.33 CO[C@@H]1[C@@H](F)CN(C(=O)Cn2nc(C(N)=O)c3ccccc32)[C@@H]1C(=O)Nc1cccc(Br)n1 Homo sapiens CHEMBL3705899 assay format
CHEMBL3683737 OBDepict Br N N H O H N H HN O H N O NH 2 IC50 = 5.0 nM 483.33 NC(=O)n1cc(NC(=O)N2[C@H](C(=O)Nc3cccc(Br)n3)C[C@H]3C[C@H]32)c2ccccc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL4108241 OBDepict O N N H H N NH O H O CH 3 H O Cl Cl N S IC50 = 5.0 nM 562.48 CC(=O)c1nn(CC(=O)N2[C@H](C(=O)NC[C@H]3CC3(Cl)Cl)C[C@H]3C[C@H]32)c2ccc(OCc3nccs3)cc12 Homo sapiens CHEMBL3889242 assay format
CHEMBL3109653 OBDepict CH 3 N CH 3 N N O H 2 N N O H H HN O H N F F F IC50 = 6.0 nM 501.47 Cc1cc2c(C(N)=O)nn(CC(=O)N3[C@H](C(=O)Nc4cccc(C(F)(F)F)n4)C[C@H]4C[C@H]43)c2c(C)n1 Homo sapiens CHEMBL3111918 assay format
CHEMBL3668710 OBDepict OH N H H F O Cl H N H HN O H N O NH 2 IC50 = 6.0 nM 499.93 NC(=O)n1cc(NC(=O)N2[C@H](C(=O)N[C@H](CO)c3cccc(Cl)c3F)C[C@H]3C[C@H]32)c2ccccc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL3678879 OBDepict O N N H H NH O H O CH 3 O F Cl N N IC50 = 6.0 nM 576.03 CC(=O)c1cn(CC(=O)N2[C@H](C(=O)NCc3cccc(Cl)c3F)C[C@H]3C[C@H]32)c2ccc(OCc3ncccn3)cc12 Homo sapiens CHEMBL3705899 assay format
CHEMBL4114680 OBDepict O N N H H N N H O H H 3 C H O NH 2 F CH 3 CH 3 IC50 = 6.0 nM 427.48 CC(C)=C(F)[C@@H](C)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc21 Homo sapiens CHEMBL3889128 assay format
CHEMBL4114991 OBDepict CH 3 O O H 3 C F NH 2 N N N N O HN H CH 3 F IC50 = 6.0 nM 486.52 CN[C@H](CC(=O)N1CCN(c2nc(N)c3cc(OC)c(OC)c(F)c3n2)CC1)c1ccc(F)cc1 Homo sapiens CHEMBL3889157 cell-based format
CHEMBL4115570 OBDepict CH 3 O O H 3 C F NH 2 N N N N O N H F IC50 = 6.0 nM 540.62 COc1cc2c(N)nc(N3CCN(C(=O)C[C@H](c4ccc(F)cc4)N4CCCCC4)CC3)nc2c(F)c1OC Homo sapiens CHEMBL3889157 cell-based format
CHEMBL4107659 OBDepict CH 3 O N H H N O F N N N NH 2 F O O CH 3 CH 3 IC50 = 6.0 nM 544.6 COCCCN[C@H](CC(=O)N1CCN(c2nc(N)c3cc(OC)c(OC)c(F)c3n2)CC1)c1ccc(F)cc1 Homo sapiens CHEMBL3889157 cell-based format
CHEMBL3928150 OBDepict N N H N O N H H 3 C N N H 2 N F O O H 3 C H 3 C IC50 = 6.0 nM 503.54 CC[C@H]1CN(C(=O)c2cc3cc(C#N)ccc3[nH]2)CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1 Homo sapiens CHEMBL3889157 cell-based format
CHEMBL4109971 OBDepict F N H H N O F N N N NH 2 F O O CH 3 CH 3 IC50 = 6.0 nM 518.54 COc1cc2c(N)nc(N3CCN(C(=O)C[C@@H](NCCF)c4ccc(F)cc4)CC3)nc2c(F)c1OC Homo sapiens CHEMBL3889157 cell-based format
CHEMBL3668640 OBDepict CH 3 O O O N HN O NH 2 N O H N H O F Cl IC50 = 6.0 nM 557.97 COC(=O)COc1ccc2c(c1)c(NC(=O)N1C3CC3C[C@H]1C(=O)NCc1cccc(Cl)c1F)cn2C(N)=O Homo sapiens CHEMBL3705899 assay format
CHEMBL4114221 OBDepict H 3 C NH H N O F N N N H 2 N F O O CH 3 CH 3 IC50 = 6.0 nM 500.55 CCN[C@H](CC(=O)N1CCN(c2nc(N)c3cc(OC)c(OC)c(F)c3n2)CC1)c1ccc(F)cc1 Homo sapiens CHEMBL3889157 cell-based format
CHEMBL3668685 OBDepict O N N H H S HN O N O H 2 N F Cl IC50 = 6.0 nM 475.93 NC(=O)n1cc(NC(=O)N2CCS[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccccc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL4113412 OBDepict O N N H H N HN O H CH 3 H O H 3 C H O Cl Cl N N CH 3 H 3 C IC50 = 6.0 nM 587.51 CC(=O)c1nn(CC(=O)N2[C@H](C(=O)N[C@H](C)[C@H]3CC3(Cl)Cl)C[C@H]3C[C@H]32)c2ccc(OCc3cc(C)n(C)n3)cc12 Homo sapiens CHEMBL3889242 assay format
CHEMBL3678906 OBDepict O N N H H N N H O H CH 3 N H 3 C H O H 2 N F Cl IC50 = 6.0 nM 498.95 Cc1nccc2c(C(N)=O)nn(CC(=O)N3[C@H](C(=O)N[C@H](C)c4cccc(Cl)c4F)C[C@H]4C[C@H]43)c12 Homo sapiens CHEMBL3705899 assay format
CHEMBL3678913 OBDepict O N N H H N NH O H N O NH 2 F Cl IC50 = 6.0 nM 510.96 NC(=O)c1nn(CC(=O)N2[C@H](C(=O)NCc3cccc(Cl)c3F)C[C@H]3C[C@H]32)c2cnc(C3CC3)cc12 Homo sapiens CHEMBL3705899 assay format
CHEMBL4107774 OBDepict CH 3 O O F CH 3 N NH 2 N N H N O N IC50 = 6.0 nM 538.58 COc1cc2c(N)nc(N3CCN(C(=O)/C=C/c4ccc(C#N)cc4)C[C@@H]3c3ccccc3)nc2c(F)c1OC Homo sapiens CHEMBL3889157 cell-based format
CHEMBL4113964 OBDepict O N N H H N HN O H CH 3 H O H 3 C O Cl Cl N N IC50 = 6.0 nM 571.47 CC(=O)c1nn(CC(=O)N2[C@H](C(=O)N[C@H](C)C3CC3(Cl)Cl)C[C@H]3C[C@H]32)c2ccc(OCc3ncccn3)cc12 Homo sapiens CHEMBL3889242 assay format
CHEMBL3673814 OBDepict OH N N H O NH 2 N O H H NH O H F Cl IC50 = 7.0 nM 513.96 NC(=O)n1cc(NC(=O)N2[C@H](C(=O)NCc3cccc(Cl)c3F)C[C@H]3C[C@H]32)c2cc(CCO)ccc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL3673821 OBDepict OH N N H O NH 2 N O H NH O F Cl IC50 = 7.0 nM 485.9 NC(=O)n1cc(NC(=O)N2C3CC3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccc(O)cc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL4111845 OBDepict O N N H H N NH O H O NH 2 H O Cl Cl N S IC50 = 7.0 nM 563.47 NC(=O)c1nn(CC(=O)N2[C@H](C(=O)NC[C@H]3CC3(Cl)Cl)C[C@H]3C[C@H]32)c2ccc(OCc3nccs3)cc12 Homo sapiens CHEMBL3889242 assay format
CHEMBL3673822 OBDepict O N H H N H F N H O F Cl N O NH 2 HO IC50 = 7.0 nM 491.88 NC(=O)n1cc(NC(=O)N2C[C@H](F)C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccc(O)cc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL3943926 OBDepict H 3 C H N N N N O NH 2 H 2 N H F O O H 3 C CH 3 N IC50 = 7.0 nM 507.57 CC[C@H]1CN(C(=O)C[C@@H](N)c2ccc(C#N)cc2)CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1 Homo sapiens CHEMBL3889157 cell-based format
CHEMBL3673752 OBDepict HO N H H O Cl H N H HN O H N O NH 2 IC50 = 7.0 nM 481.94 NC(=O)n1cc(NC(=O)N2[C@H](C(=O)N[C@H](CO)c3cccc(Cl)c3)C[C@H]3C[C@H]32)c2ccccc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL4110511 OBDepict CH 3 O O H 3 C F NH 2 N N N H N O NH 2 H F IC50 = 7.0 nM 548.59 COc1cc2c(N)nc(N3CCN(C(=O)C[C@@H](N)c4ccc(F)cc4)C[C@@H]3c3ccccc3)nc2c(F)c1OC Homo sapiens CHEMBL3889157 cell-based format
CHEMBL3663978 OBDepict Cl S N H O H N H F N H O N O NH 2 IC50 = 7.0 nM 463.92 NC(=O)n1cc(NC(=O)N2C[C@H](F)C[C@H]2C(=O)NCc2ccc(Cl)s2)c2ccccc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL3668711 OBDepict CH 3 O H H F H N N H O NH O F N Cl O H 2 N IC50 = 7.0 nM 505.91 CO[C@@H]1[C@@H](F)CN(C(=O)Nc2cn(C(N)=O)c3ccccc23)[C@@H]1C(=O)NCc1cccc(Cl)c1F Homo sapiens CHEMBL3705899 assay format
CHEMBL3683722 OBDepict Br N N H O H N H O H N N O NH 2 IC50 = 7.0 nM 483.33 NC(=O)c1nn(CC(=O)N2C[C@H]3C[C@H]3[C@H]2C(=O)Nc2cccc(Br)n2)c2ccccc12 Homo sapiens CHEMBL3705899 assay format
CHEMBL3673730 OBDepict CH 3 O N NH O H 2 N N O H H F HN O F O F F F IC50 = 7.0 nM 541.43 COc1ccc2c(c1)c(NC(=O)N1C[C@H](F)C[C@H]1C(=O)Nc1cccc(OC(F)(F)F)c1F)cn2C(N)=O Homo sapiens CHEMBL3705899 assay format
CHEMBL3673860 OBDepict O N N H NH H HN O N O H 2 N F Cl IC50 = 7.0 nM 458.88 NC(=O)n1cc(NC(=O)N2NCC[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccccc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL4115683 OBDepict O N N H H N HN O H O H 3 C F O H 3 C CH 3 N N IC50 = 7.0 nM 520.57 CC(=O)c1nn(CC(=O)N2[C@H](C(=O)NCC(F)=C(C)C)C[C@H]3C[C@H]32)c2ccc(OCc3ncccn3)cc12 Homo sapiens CHEMBL3889128 assay format
CHEMBL3683732 OBDepict H 3 C O H H F H N HN O O N N N Br O H 3 C IC50 = 7.0 nM 518.34 CO[C@@H]1[C@@H](F)CN(C(=O)Cn2nc(C(C)=O)c3ccccc32)[C@@H]1C(=O)Nc1cccc(Br)n1 Homo sapiens CHEMBL3705899 assay format
CHEMBL4115682 OBDepict O N N H H N N H O H CH 3 O H 2 N F H 3 C CH 3 IC50 = 7.0 nM 427.48 CC(C)=C(F)C(C)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc21 Homo sapiens CHEMBL3889128 assay format
CHEMBL4108542 OBDepict O N N H H N NH O H O CH 3 H O CH 3 Cl Cl N N IC50 = 7.0 nM 571.47 CC(=O)c1nn(CC(=O)N2[C@H](C(=O)NC[C@H]3C(C)C3(Cl)Cl)C[C@H]3C[C@H]32)c2ccc(OCc3ncccn3)cc12 Homo sapiens CHEMBL3889242 assay format
CHEMBL3663968 OBDepict O N N H H H F NH O N O NH 2 F Cl IC50 = 7.0 nM 475.88 NC(=O)n1cc(NC(=O)N2C[C@H](F)C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccccc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL4111301 OBDepict CH 3 N H H S N O Cl N N N H 2 N F O O H 3 C CH 3 IC50 = 8.0 nM 537.06 CCCN[C@H](CC(=O)N1CCN(c2nc(N)c3cc(OC)c(OC)c(F)c3n2)CC1)c1ccc(Cl)s1 Homo sapiens CHEMBL3889157 cell-based format
CHEMBL3678938 OBDepict Br N N H O H N H O H N N N O NH 2 IC50 = 8.0 nM 484.31 NC(=O)c1nn(CC(=O)N2[C@H](C(=O)Nc3cccc(Br)n3)C[C@H]3C[C@H]32)c2cnccc12 Homo sapiens CHEMBL3705899 assay format
CHEMBL3919985 OBDepict OH H N H N H O HN O N F Cl O NH 2 IC50 = 8.0 nM 499.93 NC(=O)n1cc(NC(=O)N2[C@H](C(=O)NCc3cccc(Cl)c3F)C[C@@]3(CO)C[C@@H]23)c2ccccc21 Homo sapiens CHEMBL3705899 assay format
CHEMBL3673735 OBDepict H N O N H H F O N H N F Cl O H 2 N O O H 3 C IC50 = 8.0 nM 549.96 COCCOc1ccc2c(c1)c(NC(=O)N1C[C@H](F)C[C@H]1C(=O)NCc1cccc(Cl)c1F)cn2C(N)=O Homo sapiens CHEMBL3705899 assay format
CHEMBL3678734 OBDepict O N N H H F NH O O CH 3 F Br IC50 = 8.0 nM 518.36 CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NCc2cccc(Br)c2F)c2ccccc12 Homo sapiens CHEMBL3705899 assay format
CHEMBL4468000 OBDepict H 2 N O O OH IC50 = 8.0 nM 347.41 NCc1cccc(-c2cccc(COc3ccccc3CC(=O)O)c2)c1 Homo sapiens CHEMBL4394736 assay format
CHEMBL3683745 OBDepict N O CH 3 N N O H 3 C N O H H HN O H F O F F F IC50 = 8.0 nM 573.5 CC(=O)c1nn(CC(=O)N2[C@H](C(=O)Nc3cccc(OC(F)(F)F)c3F)C[C@H]3C[C@H]32)c2ccc(OC(C)C#N)cc12 Homo sapiens CHEMBL3705899 assay format
CHEMBL3668774 OBDepict H 2 C O N N H O H 2 N N O H H HN O H F Cl IC50 = 8.0 nM 525.97 C=CCOc1ccc2c(c1)c(NC(=O)N1[C@H](C(=O)NCc3cccc(Cl)c3F)C[C@H]3C[C@H]31)cn2C(N)=O Homo sapiens CHEMBL3705899 assay format
CHEMBL4584532 OBDepict OH NH 2 H O OH CH 3 H 3 C O OH IC50 = 8.0 nM 435.52 CC(C)(O)c1cc(COc2ccccc2CC(=O)O)cc(-c2cccc([C@H](N)CO)c2)c1 Homo sapiens CHEMBL4394736 assay format
CHEMBL4115177 OBDepict CH 3 N N O N N O H 3 C N O H H N H O H H Cl Cl IC50 = 8.0 nM 571.47 CC(=O)c1nn(CC(=O)N2[C@H](C(=O)NC[C@H]3CC3(Cl)Cl)C[C@H]3C[C@H]32)c2ccc(OCc3nccc(C)n3)cc12 Homo sapiens CHEMBL3889242 assay format
CHEMBL3678854 OBDepict CH 3 O H H F H N NH O O N N F Cl O CH 3 O HO IC50 = 8.0 nM 548.93 CO[C@@H]1[C@@H](F)CN(C(=O)Cn2nc(C(C)=O)c3ccc(C(=O)O)cc32)[C@@H]1C(=O)NCc1cccc(Cl)c1F Homo sapiens CHEMBL3705899 assay format
CHEMBL3673815 OBDepict O N HN H NH O N O NH 2 O F Cl OH CH 3 H 3 C IC50 = 8.0 nM 558.01 CC(C)(O)COc1ccc2c(c1)c(NC(=O)N1C3CC3C[C@H]1C(=O)NCc1cccc(Cl)c1F)cn2C(N)=O Homo sapiens CHEMBL3705899 assay format
CHEMBL3668742 OBDepict CH 3 O N H H F O Cl H N H NH O H N O H 2 N IC50 = 8.0 nM 513.96 COC[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Nc1cn(C(N)=O)c2ccccc12)c1cccc(Cl)c1F Homo sapiens CHEMBL3705899 assay format
CHEMBL3668691 OBDepict CH 3 O H N H NH O N H O N F Cl O NH 2 IC50 = 9.0 nM 513.96 COC[C@@]12C[C@@H](C(=O)NCc3cccc(Cl)c3F)N(C(=O)Nc3cn(C(N)=O)c4ccccc34)[C@@H]1C2 Homo sapiens CHEMBL3705899 assay format
CHEMBL3683754 OBDepict CH 3 O O N N O H 3 C N O H H NH O H F O F F F IC50 = 9.0 nM 578.52 COCCOc1ccc2c(c1)c(C(C)=O)nn2CC(=O)N1[C@H](C(=O)Nc2cccc(OC(F)(F)F)c2F)C[C@H]2C[C@H]21 Homo sapiens CHEMBL3705899 assay format
CHEMBL3950448 OBDepict OH H N H NH O O N N F Br O NH 2 IC50 = 9.0 nM 530.35 NC(=O)c1nn(CC(=O)N2[C@H](C(=O)Nc3cccc(Br)c3F)C[C@@]3(CO)C[C@@H]23)c2ccccc12 Homo sapiens CHEMBL3705899 assay format
CHEMBL3678851 OBDepict H 3 C N N N O H 2 N N O H H F HN O H O CH 3 F O F F F IC50 = 9.0 nM 570.48 CCc1cc2c(C(N)=O)nn(CC(=O)N3C[C@H](F)[C@@H](OC)[C@H]3C(=O)Nc3cccc(OC(F)(F)F)c3F)c2cn1 Homo sapiens CHEMBL3705899 assay format