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P00750 | TPA_HUMAN | Tissue-type plasminogen activator (PLAT)

3D structures mapped by conservation among orthologs

[ Domain: "FMN-binding split barrel 2" // Trypsin_1 ]

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[ Domain: "Kringle-like" // Kringle ]

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[ Domain: "EGF/Laminin" // hEGF_3 ]

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[ Domain: "Fibronectin type I module" // fn1_1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL439678 OBDepict Cl O N N H N NH Ki = 0.29 nM 370.88 Clc1cccc(Cc2nc3c(NCCC4CCCCN4)nccc3o2)c1 Homo sapiens CHEMBL884761 single protein format
CHEMBL105819 OBDepict O NH H N O N CH 3 H H 2 N NH 2 HN O OH H 3 C + N CH 3 H O _ O IC50 = 0.7 nM 555.64 CC(O)[C@@H](C(=O)N[C@H](C)c1ccccc1)N(C)C(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)CCCN=C(N)N Homo sapiens CHEMBL847118 single protein format
CHEMBL92615 OBDepict H 3 C N H HN N O O N Cl O N H Cl Ki = 3.0 nM 558.51 CN1CCCCCOc2ccc(Cl)cc2CNC(=O)Cn2c(Cl)cnc(c2=O)N[C@@H](Cc2ccccc2)C1 Homo sapiens CHEMBL808464 single protein format
CHEMBL290376 OBDepict CH 3 NH O H N O H HN O B H HO OH N H 2 N NH 2 Ki = 5.7 nM 460.34 CC(=O)N[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)B(O)O Homo sapiens CHEMBL847428 single protein format
CHEMBL94952 OBDepict O O HN H HN O N O N Cl NH O Cl Ki = 6.0 nM 572.45 O=C1Cn2c(Cl)cnc(c2=O)N[C@@H](Cc2ccccc2)CNC(=O)OC/C=CCOc2ccc(Cl)cc2CN1 Homo sapiens CHEMBL808464 single protein format
CHEMBL418965 OBDepict Cl O N H O N Cl O N H N HN H Ki = 6.0 nM 544.48 O=C1Cn2c(Cl)cnc(c2=O)N[C@@H](Cc2ccccc2)CNCCCCCOc2ccc(Cl)cc2CN1 Homo sapiens CHEMBL808464 single protein format
CHEMBL94775 OBDepict _ O + N O OH N H HN NH 2 Ki = 19.0 nM 372.38 N=C(N)c1ccc2[nH]c(-c3cc([N+](=O)[O-])cc(-c4ccccc4)c3O)cc2c1 Homo sapiens CHEMBL847816 single protein format
CHEMBL316901 OBDepict O NH N Cl O O N HN Cl H HN Ki = 20.0 nM 530.46 O=C1Cn2c(Cl)cnc(c2=O)N[C@@H](Cc2ccccc2)CNCCCCOc2ccc(Cl)cc2CN1 Homo sapiens CHEMBL808464 single protein format
CHEMBL273196 OBDepict O NH H O H N N O NH 2 H 2 N N H H CH 3 IC50 = 34.0 nM 416.53 CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C=O)CCCN=C(N)N Homo sapiens CHEMBL815715 single protein format
CHEMBL96433 OBDepict OH N H NH NH 2 Ki = 35.0 nM 327.39 N=C(N)c1ccc2[nH]c(-c3cccc(-c4ccccc4)c3O)cc2c1 Homo sapiens CHEMBL847817 single protein format
CHEMBL59704 OBDepict OH O N H NH NH 2 Ki = 35.0 nM 343.39 N=C(N)c1ccc2[nH]c(-c3cccc(Oc4ccccc4)c3O)cc2c1 Homo sapiens CHEMBL815720 single protein format
CHEMBL357079 OBDepict O H 2 N NH 2 NH 2 NH 2 Ki = 35.0 nM 376.5 NC(N)c1ccc(/C=C2CCCC/C(=Cc3ccc(C(N)N)cc3)C2=O)cc1 Homo sapiens CHEMBL815718 single protein format
CHEMBL95940 OBDepict O NH N B H CH 3 OH OH O N NH 2 NH 2 Ki = 51.0 nM 377.25 CN(CC(=O)N[C@@H](CCCN=C(N)N)B(O)O)C(=O)CCc1ccccc1 Homo sapiens CHEMBL847428 single protein format
CHEMBL372194 OBDepict H 3 C O O N NH N N O N Cl N N Ki = 67.0 nM 524.03 CCOC(=O)CN1CCCCC1CCNc1nccc2oc(Cc3cc(Cl)ccc3-n3cncn3)nc12 Homo sapiens CHEMBL884761 single protein format
CHEMBL208140 OBDepict H N H N O H O OH HN O S HN H 2 N IC50 = 70.0 nM 461.59 N=C(N)c1ccc(CNC(=O)[C@@H]2C=CCN2C(=O)[C@@H](CC2CCCCC2)NCC(=O)O)s1 Homo sapiens CHEMBL865716 single protein format
CHEMBL27852 OBDepict H 2 N N H NH NH H O N S O H N H 2 N IC50 = 93.0 nM 547.73 N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCC2CC[C@@](N)(Cc3ccccc3)CN21)C(=O)c1nc2ccccc2s1 Homo sapiens CHEMBL815708 single protein format
CHEMBL91962 OBDepict Br OH N H HN NH 2 Ki = 94.0 nM 406.28 N=C(N)c1ccc2[nH]c(-c3cc(Br)cc(-c4ccccc4)c3O)cc2c1 Homo sapiens CHEMBL847817 single protein format
CHEMBL197843 OBDepict HO N NH N N O N Cl N N Ki = 96.0 nM 481.99 OCCN1CCCCC1CCNc1nccc2oc(Cc3cc(Cl)ccc3-n3cncn3)nc12 Homo sapiens CHEMBL884761 single protein format
CHEMBL198978 OBDepict Cl N N N O N NH N N Ki = 100.0 nM 528.06 Clc1ccc(-n2cncn2)c(Cc2nc3c(NCCC4CCCCN4Cc4ccccc4)nccc3o2)c1 Homo sapiens CHEMBL884761 single protein format
CHEMBL265315 OBDepict Cl HN H O H N N O H 2 N NH 2 NH 2 H Ki = 106.0 nM 422.96 NC(N)=NCCC[C@@H](CCl)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)Cc1ccccc1 Homo sapiens CHEMBL815713 single protein format
CHEMBL52427 OBDepict CH 3 OH N H NH H 2 N Ki = 110.0 nM 341.41 Cc1cc(-c2ccccc2)c(O)c(-c2cc3cc(C(=N)N)ccc3[nH]2)c1 Homo sapiens CHEMBL847817 single protein format
CHEMBL197593 OBDepict HO O N NH N N O N Cl N N Ki = 110.0 nM 495.97 O=C(O)CN1CCCCC1CCNc1nccc2oc(Cc3cc(Cl)ccc3-n3cncn3)nc12 Homo sapiens CHEMBL884761 single protein format
CHEMBL339902 OBDepict OH N H Cl NH H 2 N Ki = 110.0 nM 361.83 N=C(N)c1cc2cc(-c3cccc(-c4ccccc4)c3O)[nH]c2cc1Cl Homo sapiens CHEMBL847108 single protein format
CHEMBL2419745 OBDepict OH O HN H N O H NH O S NH H 2 N Ki = 113.0 nM 533.65 N=C(N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](NCC(=O)O)C(c2ccccc2)c2ccccc2)s1 Homo sapiens CHEMBL2424098 single protein format
CHEMBL135723 OBDepict I O O HN NH NH 2 Ki = 120.0 nM 385.2 N=C(N)NCc1ccc(C2CC/C(=C/I)OC2=O)cc1 Homo sapiens CHEMBL812480 single protein format
CHEMBL206205 OBDepict H N H N O H O OH HN O O HN H 2 N IC50 = 125.0 nM 445.52 N=C(N)c1coc(CNC(=O)[C@@H]2C=CCN2C(=O)[C@@H](CC2CCCCC2)NCC(=O)O)c1 Homo sapiens CHEMBL865716 single protein format
CHEMBL421214 OBDepict CH 3 O CH 3 HN O O NH H 2 N Ki = 130.0 nM 417.51 CC(C)Oc1cccc(NC(=O)c2cc(C3CCOC3)c3cc(C(=N)N)ccc3c2)c1 Homo sapiens CHEMBL815712 single protein format
CHEMBL426101 OBDepict Cl N N O N N HN N N H Ki = 140.0 nM 437.94 Clc1ccc(-n2cncn2)c(Cc2nc3c(NCCC4CCCCN4)nccc3o2)c1 Homo sapiens CHEMBL884761 single protein format
CHEMBL96354 OBDepict Cl O N H O O N Cl O N H N HN H Ki = 150.0 nM 546.46 O=C1Cn2c(Cl)cnc(c2=O)N[C@@H](Cc2ccccc2)CNCCOCCOc2ccc(Cl)cc2CN1 Homo sapiens CHEMBL808464 single protein format
CHEMBL355376 OBDepict H 2 N N H HN NH O N S O N O N S O O N IC50 = 150.0 nM 572.67 N=C(N)NCCCC(NC(=O)CN1CCN(S(=O)(=O)c2cccc3cccnc23)CC1=O)C(=O)c1nccs1 Homo sapiens CHEMBL813531 single protein format
CHEMBL92883 OBDepict Cl OH N H HN NH 2 Ki = 160.0 nM 361.83 N=C(N)c1ccc2[nH]c(-c3cc(Cl)cc(-c4ccccc4)c3O)cc2c1 Homo sapiens CHEMBL847817 single protein format
CHEMBL381709 OBDepict H N H N O H O OH HN O S N HN H 2 N IC50 = 173.0 nM 462.58 N=C(N)c1csc(CNC(=O)[C@@H]2C=CCN2C(=O)[C@@H](CC2CCCCC2)NCC(=O)O)n1 Homo sapiens CHEMBL865716 single protein format
CHEMBL319047 OBDepict O NH O NH NH 2 Ki = 180.0 nM 355.4 N=C(N)c1ccc2cc(C(=O)Nc3ccccc3)cc(-c3ccoc3)c2c1 Homo sapiens CHEMBL815712 single protein format
CHEMBL127278 OBDepict OH N H CH 3 NH NH 2 Ki = 210.0 nM 341.41 Cc1cc2[nH]c(-c3cccc(-c4ccccc4)c3O)cc2cc1C(=N)N Homo sapiens CHEMBL847108 single protein format
CHEMBL198735 OBDepict Cl N N O N N N N H F F NH Ki = 240.0 nM 473.92 FC(F)(CNc1nccc2oc(Cc3cc(Cl)ccc3-n3cncn3)nc12)C1CCCCN1 Homo sapiens CHEMBL884761 single protein format
CHEMBL64097 OBDepict CH 3 I OH NH O HN NH 2 Ki = 240.0 nM 395.2 Cc1cc(I)c(O)c(C(=O)Nc2ccc(C(=N)N)cc2)c1 Homo sapiens CHEMBL815721 single protein format
CHEMBL92251 OBDepict Cl OH N N H HN NH 2 Ki = 280.0 nM 362.82 N=C(N)c1ccc2[nH]c(-c3cc(Cl)cc(-c4ccccc4)c3O)nc2c1 Homo sapiens CHEMBL847817 single protein format
CHEMBL101759 OBDepict NH 2 B N H H HO OH O N O Ki = 280.0 nM 411.31 NCCCC[C@H](NC(=O)CN(C(=O)CCc1ccccc1)c1ccccc1)B(O)O Homo sapiens CHEMBL847428 single protein format
CHEMBL370396 OBDepict F F N NH N N O N Cl N N Ki = 290.0 nM 501.97 FC(F)CN1CCCCC1CCNc1nccc2oc(Cc3cc(Cl)ccc3-n3cncn3)nc12 Homo sapiens CHEMBL883030 single protein format
CHEMBL127909 OBDepict OH N H F NH H 2 N Ki = 350.0 nM 345.38 N=C(N)c1cc2cc(-c3cccc(-c4ccccc4)c3O)[nH]c2cc1F Homo sapiens CHEMBL847108 single protein format
CHEMBL61327 OBDepict CH 3 Br OH NH O HN NH 2 Ki = 360.0 nM 348.2 Cc1cc(Br)c(O)c(C(=O)Nc2ccc(C(=N)N)cc2)c1 Homo sapiens CHEMBL815721 single protein format
CHEMBL330572 OBDepict O N H HN S O O S N HO NH H 2 N Ki = 360.0 nM 445.53 N=C(N)c1ccc(O)c(CN2CC[C@H](NS(=O)(=O)c3cc4ncccc4s3)C2=O)c1 Homo sapiens CHEMBL812483 single protein format
CHEMBL329266 OBDepict O HN N Cl O O N NH H N H Ki = 360.0 nM 510.04 O=C1Cn2c(Cl)cnc(c2=O)N[C@@H](Cc2ccccc2)CNCCCCCOc2ccccc2CN1 Homo sapiens CHEMBL808464 single protein format
CHEMBL328772 OBDepict NH 2 NH N H OH Br Ki = 380.0 nM 330.19 N=C(N)c1ccc2[nH]c(-c3cccc(Br)c3O)cc2c1 Homo sapiens CHEMBL847817 single protein format
CHEMBL116137 OBDepict O O N N H O O F F F F F F IC50 = 390.0 nM 538.44 O=c1[nH]c(=O)n(C(CCc2ccc(OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)cc2)c2ccccc2)o1 Homo sapiens CHEMBL812494 single protein format
CHEMBL420540 OBDepict OH O HN H N O H NH O S NH H 2 N Ki = 433.0 nM 533.65 N=C(N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@H](NCC(=O)O)C(c2ccccc2)c2ccccc2)s1 Homo sapiens CHEMBL814420 single protein format
CHEMBL48608 OBDepict CH 3 Br HO N H HN NH 2 Ki = 460.0 nM 344.21 Cc1cc(Br)c(O)c(-c2cc3cc(C(=N)N)ccc3[nH]2)c1 Homo sapiens CHEMBL847816 single protein format
CHEMBL4281179 OBDepict NH 2 O CH 3 N F O F H CH 3 H 3 C CH 3 O HO IC50 = 470.0 nM 456.49 Cc1cc(Oc2nc(O[C@@H](C(=O)O)C(C)(C)C)c(F)cc2F)cc(-c2cccc(CN)c2)c1 Homo sapiens CHEMBL4267486 single protein format
CHEMBL94864 OBDepict O O HN H HN O N O N Cl NH O Cl Ki = 480.0 nM 572.45 O=C1Cn2c(Cl)cnc(c2=O)N[C@@H](Cc2ccccc2)CNC(=O)OC/C=C/COc2ccc(Cl)cc2CN1 Homo sapiens CHEMBL808464 single protein format
CHEMBL282830 OBDepict H 2 N N H NH NH H O N S O H N N H 2 N IC50 = 495.0 nM 548.72 N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCN2CC[C@@](N)(Cc3ccccc3)CN12)C(=O)c1nc2ccccc2s1 Homo sapiens CHEMBL815708 single protein format
CHEMBL377681 OBDepict OH O N H H N O H N H O N NH NH 2 IC50 = 540.0 nM 456.55 N=C(N)c1ccc(CNC(=O)[C@@H]2C=CCN2C(=O)[C@@H](CC2CCCCC2)NCC(=O)O)cn1 Homo sapiens CHEMBL865716 single protein format
CHEMBL64579 OBDepict OH O N H NH NH 2 Ki = 590.0 nM 335.41 N=C(N)c1ccc2[nH]c(-c3cccc(OC4CCCC4)c3O)cc2c1 Homo sapiens CHEMBL815720 single protein format
CHEMBL284436 OBDepict Cl N H H O H N HN N NH NH 2 H 2 N Ki = 632.0 nM 436.0 N=C(N)NCCC[C@@H](CCl)NC(=O)[C@@H]1CCN2CC[C@@](N)(Cc3ccccc3)CN12 Homo sapiens CHEMBL815714 single protein format
CHEMBL327421 OBDepict O HN N Cl O N NH N H H N H Ki = 640.0 nM 509.05 O=C1Cn2c(Cl)cnc(c2=O)N[C@@H](Cc2ccccc2)CNCCCNCCc2ccccc2CN1 Homo sapiens CHEMBL808464 single protein format
CHEMBL570867 OBDepict O N H NH N O N N H O N O H 3 C N O H 3 C H 3 C Ki = 665.0 nM 587.68 Cc1cc2cc(N/C(=NC(=O)c3ccc(C(=O)N(C)C)nc3)N[C@H]3CCCCN(CC(=O)N4CCCC4)C3=O)ccc2o1 Homo sapiens CHEMBL1038113 single protein format
CHEMBL115982 OBDepict Cl O N O O N O H IC50 = 680.0 nM 436.89 O=c1[nH]c(=O)n(C(CCc2ccc(OCc3cccc(Cl)c3)cc2)c2ccccc2)o1 Homo sapiens CHEMBL812494 single protein format
CHEMBL104166 OBDepict H 2 N NH O N H N N NH NH 2 Ki = 680.0 nM 411.47 N=C(N)c1ccc2cc(C(=O)Nc3ccc(CN)cc3)cc(Nc3ncccn3)c2c1 Homo sapiens CHEMBL815712 single protein format
CHEMBL99309 OBDepict H 2 N B HN H OH HO O N O Ki = 680.0 nM 439.37 NCCCC[C@H](NC(=O)CN(CCc1ccccc1)C(=O)CCc1ccccc1)B(O)O Homo sapiens CHEMBL847428 single protein format
CHEMBL207981 OBDepict HO O N H N O H N H O S CH 3 HN NH 2 IC50 = 687.0 nM 475.62 Cc1cc(CNC(=O)[C@@H]2C=CCN2C(=O)C(CC2CCCCC2)NCC(=O)O)sc1C(=N)N Homo sapiens CHEMBL865716 single protein format
CHEMBL303992 OBDepict OH O N N H NH NH 2 Ki = 690.0 nM 336.4 N=C(N)c1ccc2[nH]c(-c3cccc(OC4CCCC4)c3O)nc2c1 Homo sapiens CHEMBL815720 single protein format
CHEMBL330234 OBDepict Br Br OH N H NH NH 2 Ki = 690.0 nM 409.08 N=C(N)c1ccc2[nH]c(-c3cc(Br)cc(Br)c3O)cc2c1 Homo sapiens CHEMBL847817 single protein format
CHEMBL317137 OBDepict NH 2 B N H H OH OH O N O Ki = 750.0 nM 375.28 NCCCC[C@H](NC(=O)CN(C(=O)CCc1ccccc1)C1CC1)B(O)O Homo sapiens CHEMBL847428 single protein format
CHEMBL111543 OBDepict CH 3 O CH 3 NH O O CH 3 H 3 C NH H 2 N Ki = 790.0 nM 405.5 CC(C)Oc1cc(NC(=O)c2ccc3cc(C(=N)N)ccc3c2)cc(OC(C)C)c1 Homo sapiens CHEMBL814417 single protein format
CHEMBL104505 OBDepict O N H HN N N HN NH 2 Ki = 810.0 nM 382.43 N=C(N)c1ccc2cc(C(=O)Nc3ccccc3)cc(Nc3ncccn3)c2c1 Homo sapiens CHEMBL815712 single protein format
CHEMBL197984 OBDepict F F HN HN N N O N N N Ki = 840.0 nM 439.47 FC(F)(CNc1nccc2oc(Cc3ccccc3-n3cncn3)nc12)C1CCCCN1 Homo sapiens CHEMBL884761 single protein format
CHEMBL418839 OBDepict H 3 C O CH 3 O N H O NH H 2 N Ki = 844.0 nM 431.54 CC(C)Oc1cc(NC(=O)c2ccc3cc(C(=N)N)ccc3c2)cc(OC2CCCC2)c1 Homo sapiens CHEMBL814417 single protein format
CHEMBL105395 OBDepict O HN O HN NH 2 Ki = 870.0 nM 359.43 N=C(N)c1ccc2cc(C(=O)Nc3ccccc3)cc(C3CCOC3)c2c1 Homo sapiens CHEMBL815712 single protein format
CHEMBL60831 OBDepict CH 3 H 3 C O HO N H HN NH 2 Ki = 880.0 nM 323.4 CC(C)COc1cccc(-c2cc3cc(C(=N)N)ccc3[nH]2)c1O Homo sapiens CHEMBL815720 single protein format
CHEMBL141584 OBDepict O N H O H H 3 C CH 3 H 3 C N O H N H O H O HO N NH 2 H 2 N IC50 = 900.0 nM 504.59 CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O Homo sapiens CHEMBL812493 single protein format
CHEMBL266349 OBDepict OH O NH H N O H N H O NH H 2 N Ki = 900.0 nM 429.52 N=C(N)c1ccc(CNC(=O)[C@@H]2CCN2C(=O)[C@H](NCC(=O)O)C2CCCCC2)cc1 Homo sapiens CHEMBL4356327 single protein format
CHEMBL104472 OBDepict O HN H O H N N O H 2 N NH 2 N H H O O H 3 C H 3 C CH 3 IC50 = 950.0 nM 502.62 CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C=O)CCCN=C(N)N Homo sapiens CHEMBL812493 single protein format
CHEMBL327715 OBDepict OH N N H NH NH 2 Ki = 1000.0 nM 328.38 N=C(N)c1ccc2[nH]c(-c3cccc(-c4ccccc4)c3O)nc2c1 Homo sapiens CHEMBL847817 single protein format
CHEMBL62370 OBDepict OH O N N H NH NH 2 Ki = 1000.0 nM 344.37 N=C(N)c1ccc2[nH]c(-c3cccc(Oc4ccccc4)c3O)nc2c1 Homo sapiens CHEMBL815720 single protein format
CHEMBL64676 OBDepict CH 3 H 3 C O HO N N H HN NH 2 Ki = 1000.0 nM 324.38 CC(C)COc1cccc(-c2nc3cc(C(=N)N)ccc3[nH]2)c1O Homo sapiens CHEMBL815720 single protein format