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P00751 | CFAB_HUMAN | Complement factor B (CFB)

3D structures mapped by conservation among orthologs

[ Domain: "FMN-binding split barrel 2" // Trypsin_1 ]

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[ Domain: "vWA-like" // VWA ]

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[ Domain: "Complement control module/SCR domain" // Sushi ]

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[ Domain: "Complement control module/SCR domain" // Sushi_3 ]

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[ Domain: "Complement control module/SCR domain" // Sushi_1 ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4114217 OBDepict H 3 C NH H N O N N N N H 2 N F O O CH 3 CH 3 IC50 = 1.0 nM 507.57 CCN[C@H](CC(=O)N1CCN(c2nc(N)c3cc(OC)c(OC)c(F)c3n2)CC1)c1ccc(C#N)cc1 Homo sapiens CHEMBL4229714 cell-based format
CHEMBL4639592 OBDepict CH 3 O H N H N O HO H 3 C H IC50 = 6.0 nM 432.56 CCO[C@H]1CCN(Cc2c(C3CC3)cc(C)c3[nH]ccc23)[C@H](c2ccc(C(=O)O)cc2)C1 Homo sapiens CHEMBL4614752 single protein format
CHEMBL4594448 OBDepict CH 3 O H N H O CH 3 N O OH CH 3 H IC50 = 12.0 nM 422.53 CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@H](c2ccc(C(=O)O)cc2)C1 Homo sapiens CHEMBL4614752 single protein format
CHEMBL4644208 OBDepict H 3 C O H N H CH 3 N O HO H 3 C H IC50 = 18.0 nM 406.53 CCO[C@H]1CCN(Cc2c(C)cc(C)c3[nH]ccc23)[C@H](c2ccc(C(=O)O)cc2)C1 Homo sapiens CHEMBL4614752 single protein format
CHEMBL4632794 OBDepict H 3 C O H N H O CH 3 N O HO H 3 C H IC50 = 18.0 nM 408.5 COc1cc(C)c2[nH]ccc2c1CN1CC[C@H](OC)C[C@H]1c1ccc(C(=O)O)cc1 Homo sapiens CHEMBL4614752 single protein format
CHEMBL4641109 OBDepict H 3 C O H N H N O HO H 3 C H IC50 = 18.0 nM 418.54 CO[C@H]1CCN(Cc2c(C3CC3)cc(C)c3[nH]ccc23)[C@H](c2ccc(C(=O)O)cc2)C1 Homo sapiens CHEMBL4614752 single protein format
CHEMBL4247942 OBDepict N N N H NH F F F H 3 C H 3 C O CH 3 CH 3 IC50 = 23.0 nM 388.39 CNC(c1nc2ccc(C#N)cc2[nH]1)(c1c(C)cc(C)cc1OC)C(F)(F)F Homo sapiens CHEMBL4229713 cell-based format
CHEMBL4646504 OBDepict H 3 C O H N H CH 3 N O HO H 3 C H IC50 = 24.0 nM 392.5 CO[C@H]1CCN(Cc2c(C)cc(C)c3[nH]ccc23)[C@H](c2ccc(C(=O)O)cc2)C1 Homo sapiens CHEMBL4614752 single protein format
CHEMBL3894205 OBDepict CH 3 HN F F F N N O H CH 3 N N CH 3 H N IC50 = 30.0 nM 414.39 CNC(c1nc2cc(C#N)cnc2[nH]1)(c1c(OC)cc(C)c2[nH]ccc12)C(F)(F)F Homo sapiens CHEMBL3889177 cell-based format
CHEMBL3927308 OBDepict H 3 C O CH 3 CH 3 CH 3 N N H N N N H IC50 = 40.0 nM 345.41 COc1cc(C)c2[nH]ccc2c1C(C)(C)c1nc2cc(C#N)cnc2[nH]1 Homo sapiens CHEMBL3889177 cell-based format
CHEMBL3954424 OBDepict H 3 C O CH 3 NH 2 CH 3 N N N H H N N IC50 = 40.0 nM 346.39 COc1cc(C)c2[nH]ccc2c1C(C)(N)c1nc2cc(C#N)cnc2[nH]1 Homo sapiens CHEMBL3889177 cell-based format
CHEMBL3908792 OBDepict H 3 C O CH 3 OH CH 3 N N N H H N N IC50 = 50.0 nM 347.38 COc1cc(C)c2[nH]ccc2c1C(C)(O)c1nc2cc(C#N)cnc2[nH]1 Homo sapiens CHEMBL3889177 cell-based format
CHEMBL3913748 OBDepict N N N N H HO CH 3 N H 3 C H IC50 = 60.0 nM 357.42 Cc1cc(C2CC2)c(C(C)(O)c2nc3cc(C#N)cnc3[nH]2)c2cc[nH]c12 Homo sapiens CHEMBL3889177 cell-based format
CHEMBL4644994 OBDepict OH O N CH 3 N CH 3 H IC50 = 62.0 nM 362.47 Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(C(=O)O)cc1 Homo sapiens CHEMBL4614752 single protein format
CHEMBL3945639 OBDepict H 3 C O CH 3 OH N N N H H N N IC50 = 90.0 nM 333.35 COc1cc(C)c2[nH]ccc2c1C(O)c1nc2ncc(C#N)cc2[nH]1 Homo sapiens CHEMBL3889177 cell-based format
CHEMBL3958120 OBDepict N N N N H NH 2 F F F N CH 3 H IC50 = 90.0 nM 410.4 Cc1cc(C2CC2)c(C(N)(c2nc3cc(C#N)cnc3[nH]2)C(F)(F)F)c2cc[nH]c12 Homo sapiens CHEMBL3889177 cell-based format
CHEMBL3899277 OBDepict CH 3 CH 3 HO N F F F N N H H N N IC50 = 100.0 nM 399.38 CCc1cc(C)c2[nH]ccc2c1C(O)(c1nc2cc(C#N)cnc2[nH]1)C(F)(F)F Homo sapiens CHEMBL3889177 cell-based format
CHEMBL3949381 OBDepict CH 3 O CH 3 H 2 N N F F F N N H H N N IC50 = 290.0 nM 400.36 COc1cc(C)c2[nH]ccc2c1C(N)(c1nc2cc(C#N)cnc2[nH]1)C(F)(F)F Homo sapiens CHEMBL3889177 cell-based format
CHEMBL3904754 OBDepict H 3 C N H CH 3 N N O H H 3 C N N CH 3 H N IC50 = 295.0 nM 360.42 CNC(C)(c1nc2cc(C#N)cnc2[nH]1)c1c(OC)cc(C)c2[nH]ccc12 Homo sapiens CHEMBL3889177 cell-based format
CHEMBL3910541 OBDepict N N N N H HO N H 3 C H IC50 = 460.0 nM 343.39 Cc1cc(C2CC2)c(C(O)c2nc3cc(C#N)cnc3[nH]2)c2cc[nH]c12 Homo sapiens CHEMBL3889177 cell-based format
CHEMBL3926271 OBDepict CH 3 HN CH 3 N N H CH 3 N N H 3 C H N IC50 = 540.0 nM 358.45 CCc1cc(C)c2[nH]ccc2c1C(C)(NC)c1nc2cc(C#N)cnc2[nH]1 Homo sapiens CHEMBL3889177 cell-based format
CHEMBL4647418 OBDepict NH 2 O N CH 3 N CH 3 H IC50 = 710.0 nM 361.49 Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(C(N)=O)cc1 Homo sapiens CHEMBL4614752 single protein format
CHEMBL4633437 OBDepict CH 3 O N H 3 C N CH 3 H IC50 = 720.0 nM 348.49 COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(c2ccccc2)C1 Homo sapiens CHEMBL4614752 single protein format
CHEMBL3931270 OBDepict CH 3 O CH 3 N N O H CH 3 N N H 3 C H N IC50 = 720.0 nM 361.41 COc1cc(C)c2[nH]ccc2c1C(C)(OC)c1nc2cc(C#N)cnc2[nH]1 Homo sapiens CHEMBL3889177 cell-based format