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P01375 | TNFA_HUMAN | Tumor necrosis factor (TNF)

3D structures mapped by conservation among orthologs

[ Domain: "TNF-like" // TNF ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3642435 OBDepict H 3 C O O N HN O N H O N N N H Ki = 0.03 nM 442.44 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3cncc(-c4cn[nH]c4)c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640299 OBDepict H 3 C O F O N HN O N H O F N H N O H Ki = 0.03 nM 467.39 COc1ccc2c(c1F)C(=O)N(C[C@@]1(C#Cc3cc(F)c4c(=O)[nH][nH]c4c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640298 OBDepict H 3 C O O N HN O N H O F N H N O H Ki = 0.0521 nM 449.4 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3cc(F)c4c(=O)[nH][nH]c4c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640339 OBDepict H 3 C O O N N H O NH O N OH N N H 3 C Ki = 0.0524 nM 548.56 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(-c4nc(-c5cnn(C)c5)ccc4O)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640336 OBDepict H 3 C O O N N H O NH O N OH N Ki = 0.0556 nM 545.56 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(-c4nc(-c5ccncc5)ccc4O)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642459 OBDepict H 3 C O O N HN O N H O N N N H Ki = 0.06 nM 442.44 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3cncc(-c4cc[nH]n4)c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640352 OBDepict H 3 C O F O N N H O NH O F N OH N N H 3 C Ki = 0.0627 nM 584.54 COc1ccc2c(c1F)C(=O)N(C[C@@]1(C#Cc3ccc(-c4nc(-c5cnn(C)c5)ccc4O)c(F)c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642501 OBDepict O N N N N H N O NH O O O H 3 C Ki = 0.063 nM 598.7 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C(N=O)N4CCN(C5CCCCCC5)CC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640337 OBDepict H 3 C O O N N H O NH O N OH N Ki = 0.0651 nM 545.56 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(-c4nc(-c5cccnc5)ccc4O)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642496 OBDepict O N N N N H N O N H O O O CH 3 Ki = 0.072 nM 542.6 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C(N=O)N4CCN(C5CC5)CC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL1288000 OBDepict H 3 C O O N N H O NH O N OH Ki = 0.074 nM 468.47 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(-c4ncccc4O)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640370 OBDepict H 3 C O O N N H O NH O N O O CH 3 H 3 C CH 3 Ki = 0.0762 nM 552.59 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(-c4ncccc4OC(=O)C(C)(C)C)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640367 OBDepict H 3 C O F O N N H O NH O F N OH N Ki = 0.077 nM 581.54 COc1ccc2c(c1F)C(=O)N(C[C@@]1(C#Cc3ccc(-c4nc(-c5cccnc5)ccc4O)c(F)c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640366 OBDepict H 3 C O F O N N H O NH O N OH N Ki = 0.0781 nM 563.55 COc1ccc2c(c1F)C(=O)N(C[C@@]1(C#Cc3ccc(-c4nc(-c5cccnc5)ccc4O)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640368 OBDepict H 3 C O F O N N H O NH O N OH N O Ki = 0.0826 nM 583.58 COc1ccc2c(c1F)C(=O)N(C[C@@]1(C#Cc3ccc(-c4nc(N5CCC(=O)CC5)ccc4O)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642511 OBDepict O N N N H 3 C N H N O NH O O O H 3 C Ki = 0.083 nM 516.56 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C(N=O)N4CCN(C)CC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642508 OBDepict CH 3 N N N HO N H N O HN O O O CH 3 Ki = 0.093 nM 580.65 CCN1CCN(c2ccc(O)c(-c3ccc(C#C[C@]4(CN5Cc6ccc(OC)cc6C5=O)NC(=O)NC4=O)cc3)n2)CC1 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642499 OBDepict CH 3 N N N OH NH N O N H O O O CH 3 Ki = 0.093 nM 558.64 CCCCN1CCN(/C(=N/O)c2ccc(C#C[C@]3(CN4Cc5ccc(OC)cc5C4=O)NC(=O)NC3=O)cc2)CC1 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640351 OBDepict H 3 C O F O N N H O NH O N OH N N H 3 C Ki = 0.0973 nM 566.55 COc1ccc2c(c1F)C(=O)N(C[C@@]1(C#Cc3ccc(-c4nc(-c5cnn(C)c5)ccc4O)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL1288726 OBDepict H 3 C N N N OH F N H N O NH O O O H 3 C Ki = 0.0988 nM 598.64 CCN1CCN(c2ccc(O)c(-c3ccc(C#C[C@]4(CN5Cc6ccc(OC)cc6C5=O)NC(=O)NC4=O)cc3F)n2)CC1 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642518 OBDepict H 3 C O O N HN O N H O CH 3 CH 3 N H O N H O Ki = 0.1 nM 501.5 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C4(C)NC(=O)NC4=O)cc3C)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642528 OBDepict CH 3 O F O N N H O HN O N Ki = 0.11 nM 394.36 COc1ccc2c(c1F)C(=O)N(C[C@@]1(C#Cc3cccnc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640417 OBDepict CH 3 O O N N H O HN O O Ki = 0.11 nM 403.39 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccccc3C=O)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642500 OBDepict O N N N N H N O NH O O O H 3 C Ki = 0.11 nM 584.68 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C(N=O)N4CCN(C5CCCCC5)CC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642514 OBDepict O N N S N H 3 C N H N O NH O O O CH 3 Ki = 0.12 nM 522.59 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C(N=O)N4CCN(C)CC4)s3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642527 OBDepict H 3 C O O N N H O N H O N N N H Ki = 0.12 nM 442.44 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3cccnc3-c3cn[nH]c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642513 OBDepict O N N N H N O NH O O O H 3 C Ki = 0.12 nM 501.54 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C(N=O)N4CCCCC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640402 OBDepict H 3 C O O N N H O N H O N O NH O Ki = 0.12 nM 541.56 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(N4C(=O)CCC4C(=O)NC4CC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642509 OBDepict O N N O N H N O NH O O O H 3 C Ki = 0.13 nM 503.52 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C(N=O)N4CCOCC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640401 OBDepict CH 3 N N O N O HN N O N H O O O CH 3 Ki = 0.13 nM 598.66 CCN1CCN(C(=O)C2CCC(=O)N2c2ccc(C#C[C@]3(CN4Cc5ccc(OC)cc5C4=O)NC(=O)NC3=O)cc2)CC1 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642457 OBDepict H 3 C O O N HN O N H O N N S H 2 N Ki = 0.15 nM 474.5 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3cncc(-c4csc(N)n4)c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642447 OBDepict CH 3 O O N N H O HN O H 3 C O NH 2 Ki = 0.15 nM 432.44 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3cc(C(N)=O)ccc3C)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642502 OBDepict O N N N N H N O NH O O O H 3 C Ki = 0.15 nM 578.63 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C(N=O)N4CCN(c5ccccc5)CC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642476 OBDepict CH 3 O O N N H O HN O OH OH F F F Ki = 0.16 nM 489.41 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C(O)(O)C(F)(F)F)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642442 OBDepict H 2 N N H O N H O HN N O N H O O O H 3 C Ki = 0.16 nM 502.49 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C4(CN)NC(=O)NC4=O)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642490 OBDepict O N N N CH 3 N H N O HN O O O CH 3 Ki = 0.16 nM 530.59 CCN1CCN(C(N=O)c2ccc(C#C[C@]3(CN4Cc5ccc(OC)cc5C4=O)NC(=O)NC3=O)cc2)CC1 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642491 OBDepict O N N S N H N O NH O O O H 3 C Ki = 0.16 nM 519.58 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C(N=O)N4CCSCC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640408 OBDepict H 3 C O O N HN O N H O N H O N CH 3 Ki = 0.17 nM 515.57 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(NC(=O)C4CCN(C)CC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642485 OBDepict CH 3 O O N NH O HN O N H O HN O Ki = 0.17 nM 527.54 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C4(C5CCC5)NC(=O)NC4=O)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642512 OBDepict O N N O N H N O NH O O O H 3 C Ki = 0.17 nM 515.53 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C(N=O)N4CCC(=O)CC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642463 OBDepict CH 3 N N N N H HN N O N H O O O H 3 C Ki = 0.17 nM 527.59 CCN1CCN(c2n[nH]c3cc(C#C[C@]4(CN5Cc6ccc(OC)cc6C5=O)NC(=O)NC4=O)ccc23)CC1 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642517 OBDepict O N N N N CH 3 N H N O HN O O O CH 3 Ki = 0.18 nM 531.57 CCN1CCN(C(N=O)c2ccc(C#C[C@]3(CN4Cc5ccc(OC)cc5C4=O)NC(=O)NC3=O)cn2)CC1 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640406 OBDepict H 3 C O F O N HN O N H O N N H O N H 3 C Ki = 0.18 nM 534.55 COc1ccc2c(c1F)C(=O)N(C[C@@]1(C#Cc3cncc(NC(=O)C4CCN(C)CC4)c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642495 OBDepict O N N O HN N O N H O O O H 3 C Ki = 0.18 nM 503.52 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3cccc(C(N=O)N4CCOCC4)c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642488 OBDepict H 3 C O O N HN O N H O O H 3 C N H O N H O Ki = 0.18 nM 527.49 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc4oc(C5(C)NC(=O)NC5=O)cc4c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640391 OBDepict O N N H CH 3 F N CH 3 N H N O HN O O F O CH 3 Ki = 0.18 nM 580.59 CCN1CCN(C(N=O)c2ccc(C#C[C@]3(CN4Cc5ccc(OC)c(F)c5C4=O)NC(=O)NC3=O)cc2F)[C@@H](C)C1 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642535 OBDepict CH 3 O F O N N H O HN O H 3 C N Ki = 0.19 nM 408.39 COc1ccc2c(c1F)C(=O)N(C[C@@]1(C#Cc3cccnc3C)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640389 OBDepict O N N H H 3 C F HN N H N O NH O O F O H 3 C Ki = 0.19 nM 552.54 COc1ccc2c(c1F)C(=O)N(C[C@@]1(C#Cc3ccc(C(N=O)N4CCNC[C@@H]4C)c(F)c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640388 OBDepict CH 3 O O N N H O N H O N H H 2 N O O Ki = 0.19 nM 485.46 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(Nc4c(N)c(=O)c4=O)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640386 OBDepict CH 3 O O N N H O N H O N H O NH O N O Ki = 0.19 nM 598.62 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(Nc4c(NCCN5CCOCC5)c(=O)c4=O)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642548 OBDepict CH 3 O O N N H O N H O N N O Ki = 0.19 nM 461.48 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3cccnc3N3CCOCC3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640431 OBDepict H 3 C O O N N H O NH O N N Ki = 0.19 nM 459.51 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(N4CCCCC4)nc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642552 OBDepict H 3 C O O N N H O NH O N N N H Ki = 0.19 nM 442.44 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(-c4cn[nH]c4)nc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642505 OBDepict H 3 C O O N HN O N H O N N HO N CH 3 H 3 C Ki = 0.19 nM 558.64 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(/C(=N/O)N4CCCN(C(C)C)CC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642510 OBDepict O N N N H N O NH O O O H 3 C Ki = 0.19 nM 487.52 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C(N=O)N4CCCC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640341 OBDepict H 3 C O O N N H O NH O N O O H 3 C N Ki = 0.195 nM 587.59 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(-c4nc(-c5cccnc5)ccc4OC(C)=O)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642524 OBDepict H 3 C O O N N H O N H O N N N CH 3 Ki = 0.2 nM 456.46 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3cccnc3-c3cnn(C)c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642450 OBDepict CH 3 O N N N H N H N O NH O O O H 3 C Ki = 0.2 nM 472.46 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(-c4nnc[nH]4)cc3OC)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640392 OBDepict CH 3 O F O N N H O HN O Cl N F Ki = 0.2 nM 446.8 COc1ccc2c(c1F)C(=O)N(C[C@@]1(C#Cc3cc(F)cnc3Cl)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642537 OBDepict N HN N NH 2 N H N O HN O O O CH 3 Ki = 0.21 nM 457.45 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(/N=C(N)NC#N)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642446 OBDepict HO N HN N O N H O O O H 3 C Ki = 0.21 nM 456.46 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3cnc4ccccc4c3CO)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642519 OBDepict H 3 C O O N HN O N H O CH 3 N H S N H O Ki = 0.21 nM 503.54 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C4(C)NC(=O)NC4=S)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642516 OBDepict O N N N N H 3 C N H N O NH O O O H 3 C Ki = 0.21 nM 517.55 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C(N=O)N4CCN(C)CC4)nc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642515 OBDepict O N N S O N H N O HN O O O CH 3 Ki = 0.21 nM 509.54 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C(N=O)N4CCOCC4)s3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642529 OBDepict H 3 C O O N N H O NH O N H 3 C N CH 3 N H 3 C Ki = 0.21 nM 484.52 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(-c4c(C)nn(C)c4C)nc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640387 OBDepict CH 3 O O N N H O N H O N H O HN O N H 3 C H 3 C Ki = 0.22 nM 556.58 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(Nc4c(NCCN(C)C)c(=O)c4=O)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642489 OBDepict H 3 C O O N HN O N H O O H 3 C H 3 C N H O N H O Ki = 0.22 nM 541.52 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc4oc(C5(C)NC(=O)NC5=O)c(C)c4c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642525 OBDepict H 3 C O O N N H O N H O N CH 3 N H 3 C N CH 3 Ki = 0.22 nM 484.52 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3cccnc3-c3c(C)nn(C)c3C)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642441 OBDepict CH 3 O F O N N H O HN O N H O NH O Ki = 0.22 nM 517.47 COc1ccc2c(c1F)C(=O)N(C[C@@]1(C#Cc3ccc4c(c3)CCC43NC(=O)NC3=O)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642437 OBDepict CH 3 O O N N H O HN O N H 2 N N NH 2 Ki = 0.22 nM 407.39 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3cnc(N)nc3N)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640312 OBDepict H 3 C O O N HN O N H O N H N O H Ki = 0.237 nM 431.41 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc4c(=O)[nH][nH]c4c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642562 OBDepict CH 3 O O N N H O HN O N H O NH O Ki = 0.24 nM 499.48 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc4c(c3)CC[C@@]43NC(=O)NC3=O)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642523 OBDepict CH 3 O O N N H O HN O CH 3 CH 3 O NH 2 Ki = 0.24 nM 460.49 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C(C)(C)C(N)=O)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642494 OBDepict O N N N H 3 C HN N O N H O O O H 3 C Ki = 0.24 nM 516.56 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3cccc(C(N=O)N4CCN(C)CC4)c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642492 OBDepict H 3 C O O N HN O N H O N N HO N H 3 C Ki = 0.24 nM 530.59 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(/C(=N/O)N4CCCN(C)CC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640404 OBDepict H 3 C O O N HN O NH O N O N O N H 3 C Ki = 0.24 nM 584.63 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(N4C(=O)CCC4C(=O)N4CCN(C)CC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642434 OBDepict H 3 C O O N HN O N H O N N H 2 N Ki = 0.24 nM 468.47 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3cncc(-c4ccc(N)nc4)c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642461 OBDepict H 3 C O O N HN O N H O N H 2 N N H Ki = 0.25 nM 430.42 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc4[nH]nc(N)c4c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642448 OBDepict CH 3 O O N N H O HN O S HN O F F F Ki = 0.25 nM 520.49 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(CCNC(=O)C(F)(F)F)s3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642533 OBDepict H 3 C O O N HN O N H O N O NH 2 N H Ki = 0.25 nM 530.59 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C(C(N)=O)N4CCCNCC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642467 OBDepict CH 3 O N H O N N H N O NH O O O H 3 C Ki = 0.25 nM 463.45 CCOC(=O)Nc1cncc(C#C[C@]2(CN3Cc4ccc(OC)cc4C3=O)NC(=O)NC2=O)c1 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640310 OBDepict H 3 C O O N HN O N H O N O N H 3 C H Ki = 0.253 nM 445.44 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc4c(c3)c(=O)[nH]n4C)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640340 OBDepict CH 3 N N NH N O N H O O F O CH 3 Ki = 0.259 nM 519.58 CCN1CCN(Cc2ccc(C#C[C@]3(CN4Cc5ccc(OC)c(F)c5C4=O)NC(=O)NC3=O)cc2)CC1 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640311 OBDepict H 3 C O O N HN O N H O N H 3 C N O H Ki = 0.259 nM 445.44 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc4c(=O)[nH]n(C)c4c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642561 OBDepict CH 3 O O N N H O HN O N H O NH O Ki = 0.26 nM 499.48 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc4c(c3)CC[C@]43NC(=O)NC3=O)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642460 OBDepict H 3 C O O N HN O N H O N H N H 2 N Ki = 0.26 nM 430.42 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc4c(N)n[nH]c4c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642469 OBDepict H 3 C O O N HN O N H O N O F Ki = 0.26 nM 512.5 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C(N=O)c4ccc(F)cc4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642559 OBDepict H 3 C O O N N H O NH O N N N H O N H O Ki = 0.26 nM 543.54 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(N4CCC5(CC4)NC(=O)NC5=O)nc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642564 OBDepict O N N N CH 3 N H N O HN O O O CH 3 Ki = 0.27 nM 544.61 CCN1CCN(C(N=O)c2ccc(C#C[C@]3(CN4CCc5cc(OC)ccc5C4=O)NC(=O)NC3=O)cc2)CC1 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640382 OBDepict H 3 C O O N N H O NH O N O N H H 3 C Ki = 0.27 nM 483.48 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(-c4ccc(C)[nH]c4=O)nc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642477 OBDepict H 3 C O O N N H O NH O N N O H 3 C Ki = 0.27 nM 457.45 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(-c4noc(C)n4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640422 OBDepict CH 3 N N N OH N O H 3 C NH N O N H O O O CH 3 Ki = 0.27 nM 561.6 CCN1CCN(/C(=N/O)c2cnc(C#C[C@]3(CN4Cc5ccc(OC)cc5C4=O)NC(=O)NC3=O)c(OC)c2)CC1 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642563 OBDepict CH 3 O O N N H O HN O N H O NH O Ki = 0.27 nM 499.48 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc4c(c3)CCC43NC(=O)NC3=O)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642493 OBDepict HO N N N H N O N H O O O CH 3 Ki = 0.27 nM 473.49 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(/C(=N/O)N4CCC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640308 OBDepict CH 3 O O N N H O HN O N N CH 3 NH 2 Ki = 0.271 nM 470.49 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(-c4cc(N)n(C)n4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642470 OBDepict O N N H 3 C N H N O NH O O O H 3 C Ki = 0.28 nM 515.57 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C(N=O)C4CCN(C)CC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640393 OBDepict N N H 3 C HN N O NH O O F O H 3 C Ki = 0.28 nM 515.55 COc1ccc2c(c1F)C(=O)N(C[C@@]1(C#Cc3ccc(C4(C#N)CCN(C)CC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640383 OBDepict H 3 C O F O N N H O NH O F CH 3 N H O N H O Ki = 0.28 nM 523.45 COc1ccc2c(c1F)C(=O)N(C[C@@]1(C#Cc3ccc(C4(C)NC(=O)NC4=O)c(F)c3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3642521 OBDepict CH 3 O O N N H O N H O O NH 2 Ki = 0.28 nM 458.47 COc1ccc2c(c1)C(=O)N(C[C@@]1(C#Cc3ccc(C4(C(N)=O)CC4)cc3)NC(=O)NC1=O)C2 Homo sapiens CHEMBL3705047 single protein format
CHEMBL3640356 OBDepict CH 3 N N N N H N O HN O O F O CH 3 Ki = 0.28 nM 582.64 CCN1CCN(c2cccc(-c3ccc(C#C[C@]4(CN5Cc6ccc(OC)c(F)c6C5=O)NC(=O)NC4=O)cc3)n2)CC1 Homo sapiens CHEMBL3705047 single protein format