P02766 | TTHY_HUMAN | Transthyretin (TTR)
3D structures mapped by conservation among orthologs
[ Domain: "Prealbumin-like" // Transthyretin ]
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[ Domain: pdbs with more than 2 multi-domains ]
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[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
IC50 table
| molecule_chembl_id | structure | assay_type | relation | values | units | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3695459 | IC50 | = | 277.0 | nM | 318.28 | COc1ccc(/C=N/n2c(S)nnc2C(F)(F)F)cc1O | Homo sapiens | CHEMBL3705442 | single protein format | |
| CHEMBL63323 | IC50 | = | 289.0 | nM | 282.22 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL3705442 | single protein format | |
| CHEMBL3695460 | IC50 | = | 296.0 | nM | 248.3 | Cc1n[nH]c(C)c1CCCOc1ccccc1F | Homo sapiens | CHEMBL3705442 | single protein format | |
| CHEMBL591504 | IC50 | = | 301.0 | nM | 393.06 | COc1c(Br)cc(/C=C2SC(=O)NC2=O)cc1Br | Homo sapiens | CHEMBL3705442 | single protein format | |
| CHEMBL1581319 | IC50 | = | 329.1 | nM | 267.29 | CCOc1ccccc1-c1nc(-c2ccncc2)no1 | Homo sapiens | CHEMBL3705442 | single protein format | |
| CHEMBL1835582 | IC50 | = | 433.0 | nM | 290.41 | CC1(C)NC(=O)C(C#N)=C(SCc2ccccc2)S1 | Homo sapiens | CHEMBL3705442 | single protein format | |
| CHEMBL3695461 | IC50 | = | 504.0 | nM | 277.71 | Cc1ccc(O)c(Nc2ccccc2C(=O)O)c1Cl | Homo sapiens | CHEMBL3705442 | single protein format | |
| CHEMBL3695462 | IC50 | = | 586.0 | nM | 325.33 | N#CC1(C#N)c2c([nH]c3ccccc23)OC2c3ccccc3C(=O)C21 | Homo sapiens | CHEMBL3705442 | single protein format | |
| CHEMBL28 | IC50 | = | 653.0 | nM | 270.24 | O=c1cc(-c2ccc(O)cc2)oc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL3705442 | single protein format | |
| CHEMBL168276 | IC50 | = | 741.0 | nM | 200.11 | O=[N+]([O-])c1cc(O)c(O)c([N+](=O)[O-])c1 | Homo sapiens | CHEMBL3705442 | single protein format | |
| CHEMBL1256291 | IC50 | = | 755.0 | nM | 277.21 | O=C(c1cc(O)c(O)c([N+](=O)[O-])c1)c1ccccc1F | Homo sapiens | CHEMBL3705442 | single protein format | |
| CHEMBL183906 | IC50 | = | 815.0 | nM | 273.24 | O=C1NC(=O)/C(=C/c2cccc(C(F)(F)F)c2)S1 | Homo sapiens | CHEMBL3705442 | single protein format | |
| CHEMBL1348329 | IC50 | = | 842.0 | nM | 255.3 | O=C1NC(=O)/C(=C/c2cccc3ccccc23)S1 | Homo sapiens | CHEMBL3705442 | single protein format |