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P04049 | RAF1_HUMAN | RAF proto-oncogene serine/threonine-protein kinase (RAF1)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Domain: "Ubiquitin-like" // RBD ]

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[ Domain: "Cysteine-rich domain" // C1_1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3924812 OBDepict OH P O O OH HO N N CH 3 N H O O N F F F IC50 = 0.024 nM 596.5 Cc1ccc(NC(=O)c2cc(C(F)(F)F)ccn2)cc1-c1cc(OCC(O)CP(=O)(O)O)nc(N2CCOCC2)c1 Homo sapiens CHEMBL3865244 cell-based format
CHEMBL3961999 OBDepict O N H N F F F CH 3 N N O O O P O OH OH IC50 = 0.03 nM 582.47 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cnc(OCCOP(=O)(O)O)c(N2CCOCC2)c1 Homo sapiens CHEMBL3865244 cell-based format
CHEMBL3933272 OBDepict CH 3 N N N H N O S O F F F IC50 = 0.039 nM 498.53 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1nc(N2CCOCC2)c2sccc2n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL4775998 OBDepict O NH N H F H 3 C CH 3 H 3 C CH 3 N NH 2 Ki < 0.05 nM 394.49 Cc1cc(F)c(NC(=O)NCCC(C)(C)C)cc1-c1ccc2cc(N)ncc2c1 Homo sapiens CHEMBL4715073 single protein format
CHEMBL4778772 OBDepict O HN N H F CH 3 H 3 C CH 3 CH 3 N O N H 3 C Ki < 0.05 nM 410.49 Cc1cc(F)c(NC(=O)NCCC(C)(C)C)cc1-c1ccc2c(=O)n(C)ncc2c1 Homo sapiens CHEMBL4715073 single protein format
CHEMBL4758903 OBDepict N CH 3 H 3 C NH O F CH 3 N O N H 3 C Ki < 0.05 nM 454.51 Cc1cc(F)c(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-c1ccc2c(=O)n(C)ncc2c1 Homo sapiens CHEMBL4715073 single protein format
CHEMBL3951474 OBDepict CH 3 N H N N O O F F IC50 = 0.056 nM 423.46 Cc1ccc(NC(=O)c2cccc(C(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL4776565 OBDepict O NH F CH 3 CH 3 H 3 C CH 3 N O N H 3 C Ki = 0.06 nM 409.51 Cc1cc(F)c(C(=O)NCCCC(C)(C)C)cc1-c1ccc2c(=O)n(C)ncc2c1 Homo sapiens CHEMBL4715073 single protein format
CHEMBL4780060 OBDepict O HN N H F N H CH 3 H 3 C CH 3 CH 3 F N O N CH 3 Ki = 0.061 nM 443.5 Cc1cc(F)c(NC(=O)NCCC(C)(C)C)cc1Nc1ccc2ncn(C)c(=O)c2c1F Homo sapiens CHEMBL4715073 single protein format
CHEMBL3577124 OBDepict CH 3 N H N N N H 3 C CH 3 NH F N H O H 3 C CH 3 H 3 C Ki = 0.061 nM 424.52 CNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)c(C)nc2n1 Homo sapiens CHEMBL4715073 single protein format
CHEMBL4778419 OBDepict N CH 3 H 3 C NH O F CH 3 N N O N H 3 C Ki = 0.062 nM 455.49 Cc1cc(F)c(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-c1cnc2c(=O)n(C)ncc2c1 Homo sapiens CHEMBL4715073 single protein format
CHEMBL3905257 OBDepict CH 3 N N H N N O N O F F F IC50 = 0.065 nM 481.48 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cn2ccnc2c(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL4740241 OBDepict CH 3 N H N N N CH 3 O CH 3 NH F N H O H 3 C CH 3 H 3 C Ki = 0.081 nM 440.52 CNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)c(=O)n(C)c2n1 Homo sapiens CHEMBL4715073 single protein format
CHEMBL3959581 OBDepict CH 3 N NH N N O CH 2 H 3 C O F F F IC50 = 0.09 nM 482.51 C=C(C)c1cc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3929689 OBDepict O N H N F F F CH 3 O N N O O P O OH OH IC50 = 0.1 nM 582.47 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(OCCOP(=O)(O)O)nc(N2CCOCC2)c1 Homo sapiens CHEMBL3865244 cell-based format
CHEMBL3952506 OBDepict O N H N F F H 3 C CH 3 O N N H H 3 C O O P O OH OH IC50 = 0.1 nM 592.54 Cc1ccc(NC(=O)c2ccnc(C(C)(F)F)c2)cc1-c1cc(OCCOP(=O)(O)O)nc(N2CCOC[C@H]2C)c1 Homo sapiens CHEMBL3865244 cell-based format
CHEMBL3966766 OBDepict N N O N H 3 C N H O O F F F IC50 = 0.103 nM 496.49 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(CC#N)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3967893 OBDepict H 3 C N N H N N N O O O F F F IC50 = 0.103 nM 527.55 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3972141 OBDepict H 3 C N N H N N S O O O CH 3 O F F F IC50 = 0.11 nM 520.53 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(S(C)(=O)=O)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3919205 OBDepict NH 2 N N CH 3 N H O O F F F IC50 = 0.117 nM 456.47 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N)nc(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3962812 OBDepict H 3 C N N H N N O O O F F F O IC50 = 0.119 nM 542.56 Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(OC2CCOCC2)c(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3914464 OBDepict H 3 C N H N H 3 C N O O O F F CH 3 IC50 = 0.122 nM 467.52 Cc1ccc(NC(=O)c2cccc(C(C)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3907015 OBDepict CH 3 N H N N O O S O O H 3 C IC50 = 0.124 nM 451.55 Cc1ccc(NC(=O)c2cccc(S(C)(=O)=O)c2)cc1-c1ccnc(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3942721 OBDepict H 3 C N N H N N N O O O F F F IC50 = 0.13 nM 527.55 Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3987177 OBDepict OH O N N N CH 3 O N H O F F F IC50 = 0.132 nM 502.49 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(OCCO)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3928030 OBDepict CH 3 N N H N N N O N O F F F IC50 = 0.134 nM 508.5 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(-n2ccnc2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3976881 OBDepict CH 3 N N H N N N O N O O N CH 3 H 3 C IC50 = 0.137 nM 503.61 Cc1ccc(NC(=O)c2cncc(N(C)C)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3956654 OBDepict H 3 C N N H N N O O F F F IC50 = 0.145 nM 442.44 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)ncn1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3984282 OBDepict O N O N N N CH 3 O HN O F F F IC50 = 0.148 nM 541.53 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2=O)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3927963 OBDepict H 3 C N N H N N N O O F F F IC50 = 0.155 nM 481.48 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc2nccn2c(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3889721 OBDepict H 3 C N N H N N O O F F F IC50 = 0.156 nM 442.44 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cncc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3960515 OBDepict CH 3 N N H N N O O F F IC50 = 0.16 nM 424.45 Cc1ncc(NC(=O)c2cccc(C(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3909119 OBDepict H 3 C N H N H 3 C N O O O N F F F IC50 = 0.16 nM 472.47 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3912148 OBDepict H 3 C N H N N O O F F F IC50 = 0.161 nM 441.45 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3924576 OBDepict H 3 C N N H N N O N H O F F F IC50 = 0.171 nM 481.48 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc2[nH]cnc2c(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3945935 OBDepict H 3 C N H N H 3 C N O O O N F F CH 3 IC50 = 0.172 nM 468.5 Cc1ccc(NC(=O)c2ccnc(C(C)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3903274 OBDepict CH 3 N N H CH 3 N N N O O O F F F IC50 = 0.179 nM 541.57 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1nc(N2CCOCC2)nc(N2CCOCC2)c1C Homo sapiens CHEMBL3887884 single protein format
CHEMBL3930929 OBDepict H 3 C N O N N CH 3 N H O O F F F IC50 = 0.18 nM 486.49 CCn1cc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)nc(N2CCOCC2)c1=O Homo sapiens CHEMBL3887884 single protein format
CHEMBL3928581 OBDepict H 3 C N N H N N O O F F F IC50 = 0.182 nM 442.44 Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL4108504 OBDepict H 3 C N N H N N O N H CH 3 O F F F IC50 = 0.185 nM 495.51 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cn2ccnc2c(N2CCOC[C@H]2C)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3971301 OBDepict H 3 C N N H N H N O O O F F F IC50 = 0.187 nM 458.44 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1c[nH]c(=O)c(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3960436 OBDepict H 3 C N H N N N O O O F F F IC50 = 0.187 nM 526.56 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3906652 OBDepict CH 3 N N H O N N O O O F F F IC50 = 0.191 nM 542.56 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(OC2CCOCC2)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL4111816 OBDepict N O H 3 C H N N O CH 3 NH O F F F IC50 = 0.196 nM 510.52 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(O[C@H](C)C#N)c(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3966243 OBDepict CH 3 N N H N N N O N N O OH CH 3 H 3 C F F F IC50 = 0.198 nM 567.57 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(-n2cc(C(C)(C)O)nn2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3980394 OBDepict HO H O N N CH 3 N H O F F F IC50 = 0.199 nM 471.48 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1ccnc(N2CCO[C@H](CO)C2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL4583691 OBDepict OH O N N CH 3 N H O O N F F F IC50 = 0.2 nM 502.49 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(OCCO)nc(N2CCOCC2)c1 Homo sapiens CHEMBL4342919 single protein format
CHEMBL3960775 OBDepict H 3 C N N H N N N O O O O F F F IC50 = 0.202 nM 543.55 Cc1ccc(NC(=O)c2cccc(OC(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3936964 OBDepict CH 3 N N H N N O N O F F F IC50 = 0.205 nM 481.48 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c2nccn2n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3955743 OBDepict OH N H N N N CH 3 O N H O F F F IC50 = 0.21 nM 501.51 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(NCCO)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3894542 OBDepict CH 3 N H N CH 3 N O O O F F IC50 = 0.213 nM 453.49 Cc1ccc(NC(=O)c2cccc(C(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3946003 OBDepict CH 3 HN N N N H 3 C O N H O F F F IC50 = 0.214 nM 485.51 CCNc1nc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)cc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3918750 OBDepict H 3 C N H O N N O H 3 C O F F F IC50 = 0.215 nM 471.48 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)n(C)c(=O)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3924392 OBDepict H 3 C N H N H N O O O F F F IC50 = 0.219 nM 457.45 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1c[nH]c(=O)c(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3947696 OBDepict H 3 C N H N N O O H O O F F F IC50 = 0.225 nM 497.47 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c2oc(=O)[nH]c2c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3904667 OBDepict CH 3 N H N CH 3 N O O N O N CH 3 H 3 C IC50 = 0.23 nM 447.54 Cc1ccc(NC(=O)c2cncc(N(C)C)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3940726 OBDepict H 3 C N N H N N H 3 C O O O N F F F IC50 = 0.245 nM 473.46 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3959652 OBDepict H 3 C N N H N N N O O O F F F IC50 = 0.25 nM 541.57 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCCOCC2)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3929949 OBDepict O NH N O O N N H Cl IC50 < 0.25 nM 444.88 O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4cccc(Cl)c4[nH]3)ccnc2N1 Homo sapiens CHEMBL3888086 assay format
CHEMBL3949277 OBDepict CH 3 N H N N O O N S O O H 3 C IC50 = 0.25 nM 452.54 Cc1ccc(NC(=O)c2ccnc(S(C)(=O)=O)c2)cc1-c1ccnc(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3954132 OBDepict O NH N O O N N H HO IC50 < 0.25 nM 426.43 O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4ccc(O)cc4[nH]3)ccnc2N1 Homo sapiens CHEMBL3888086 assay format
CHEMBL3946213 OBDepict O NH N O O O N N IC50 < 0.25 nM 438.44 O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc(-c4ccccc4)no3)ccnc2N1 Homo sapiens CHEMBL3888086 assay format
CHEMBL3970406 OBDepict O NH N O O N N H IC50 < 0.25 nM 436.47 O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc(-c4ccccc4)c[nH]3)ccnc2N1 Homo sapiens CHEMBL3888086 assay format
CHEMBL3951813 OBDepict H 3 C N N H N N O O F F CH 3 IC50 = 0.253 nM 438.48 Cc1ncc(NC(=O)c2cccc(C(C)(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3927672 OBDepict H 3 C N N H N N H 3 C O O O F F F IC50 = 0.255 nM 472.47 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3946071 OBDepict F F N O N N CH 3 N H O O F F F IC50 = 0.263 nM 522.47 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cn(CC(F)F)c(=O)c(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3936445 OBDepict H 3 C N H N H 3 C N O O O F F F IC50 = 0.265 nM 471.48 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3923479 OBDepict CH 3 N H N CH 3 N O O O S O O H 3 C IC50 = 0.269 nM 481.57 Cc1ccc(NC(=O)c2cccc(S(C)(=O)=O)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3945337 OBDepict H 3 C N N H N CH 3 N O O O F F F IC50 = 0.27 nM 472.47 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cn(C)c(=O)c(N2CCOCC2)n1 Homo sapiens CHEMBL3887885 single protein format
CHEMBL3935549 OBDepict N N H 3 C H O N CH 3 NH O O F F F IC50 = 0.273 nM 510.52 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n([C@@H](C)C#N)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3951205 OBDepict CH 3 N N H N N CH 3 O O O F F IC50 = 0.278 nM 454.48 Cc1ccc(NC(=O)c2cccc(C(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3955103 OBDepict O NH F F F CH 3 N N N N O O IC50 = 0.282 nM 553.59 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CC3CCC(C2)O3)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3933060 OBDepict N CH 3 CH 3 N H O H 3 C N N O O IC50 = 0.285 nM 524.67 Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-c1cc(C2CCOCC2)nc(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL4112070 OBDepict N N H 3 C H O N CH 3 NH O O F F F IC50 = 0.285 nM 510.52 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n([C@H](C)C#N)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3971254 OBDepict HO H O N N CH 3 N H O N H 3 C H 3 C N IC50 = 0.29 nM 471.56 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(N2CCO[C@H](CO)C2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3956383 OBDepict CH 3 O N N O CH 3 N H O F F F IC50 = 0.299 nM 471.48 COc1ncc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)cc1N1CCOCC1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3968350 OBDepict N CH 3 CH 3 N H O H 3 C N N N N O O IC50 = 0.299 nM 526.64 Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3955401 OBDepict O NH N O O N N H IC50 = 0.3 nM 410.43 O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4ccccc4[nH]3)ccnc2N1 Homo sapiens CHEMBL3888086 assay format
CHEMBL4437227 OBDepict H 3 C N N H N N O O H O H F F F F O IC50 = 0.3 nM 560.55 Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(O[C@H]2CCOC[C@H]2F)c(N2CCOCC2)c1 Homo sapiens CHEMBL4342919 single protein format
CHEMBL1197798 OBDepict Cl N H N N H H 3 C N N N N N H Ki = 0.3 nM 478.95 Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1Nc1ncccc1-c1ncnc2[nH]cnc12 Homo sapiens CHEMBL2173453 single protein format
CHEMBL3900045 OBDepict OH O N N N CH 3 N O N H O F F F IC50 = 0.304 nM 503.48 Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(OCCO)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3978705 OBDepict CH 3 O N N O CH 3 N N H O F F F IC50 = 0.31 nM 472.47 COc1ncc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)cnc2C)cc1N1CCOCC1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3896594 OBDepict CH 3 N N H N N O F F F O F F F IC50 = 0.314 nM 510.44 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(C(F)(F)F)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3969555 OBDepict H 3 C NH N N N CH 3 O N H O F F F IC50 = 0.322 nM 471.48 CNc1nc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)cc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3963090 OBDepict OH NH HO N N N CH 3 O N H O F F F IC50 = 0.322 nM 531.54 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(NC(CO)CO)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3913790 OBDepict H 3 C N H N N O CH 3 H 3 C O O F F F IC50 = 0.322 nM 499.53 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C(C)C)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3975759 OBDepict CH 3 N HN N N N O O N O O H 3 C CH 3 H 3 C IC50 = 0.328 nM 506.61 Cc1ccc(NC(=O)c2cc(C(C)(C)C)no2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3919411 OBDepict F NH O N N O F F F IC50 = 0.332 nM 459.44 O=C(Nc1cccc(C(F)(F)F)c1)c1ccc(CF)c(-c2ccnc(N3CCOCC3)c2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3931694 OBDepict OH N O N CH 3 HN O O F F F IC50 = 0.341 nM 501.51 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(CCO)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3894913 OBDepict NH 2 N N N CH 3 O N H O F F F IC50 = 0.344 nM 457.46 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL4110542 OBDepict HO H N O N N N CH 3 O N H O F F F IC50 = 0.347 nM 557.57 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOC[C@H]2CO)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3941872 OBDepict O NH N O O N N H N IC50 = 0.35 nM 437.46 O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc(-c4ccncc4)c[nH]3)ccnc2N1 Homo sapiens CHEMBL3888086 assay format
CHEMBL3932011 OBDepict CH 3 N HN N N N O N O O O H 3 C CH 3 H 3 C IC50 = 0.352 nM 506.61 Cc1ccc(NC(=O)c2cc(C(C)(C)C)on2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3953527 OBDepict H 3 C N N N H N N N O O O F F F IC50 = 0.353 nM 528.54 Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3894928 OBDepict O N H F F F H 3 C N N N N O O IC50 = 0.356 nM 539.56 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CC3(COC3)C2)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3940053 OBDepict N CH 3 CH 3 N N H O H 3 C N N O O IC50 = 0.359 nM 525.65 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(C2CCOCC2)nc(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3890463 OBDepict H 3 C N O N CH 3 N H O O F F F IC50 = 0.361 nM 485.51 CCn1cc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)cc(N2CCOCC2)c1=O Homo sapiens CHEMBL3887884 single protein format
CHEMBL3946717 OBDepict CH 3 N N N H O F F F H 3 C N N O IC50 = 0.362 nM 553.63 CCN1CCN(c2cc(C(=O)Nc3ccc(C)c(-c4ccnc(N5CCOCC5)c4)c3)cc(C(F)(F)F)c2)CC1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3964430 OBDepict H 3 C N H N N O O O F F F IC50 = 0.363 nM 525.57 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(C2CCOCC2)nc(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3917649 OBDepict H 3 C O N N O CH 3 N H O N F F F IC50 = 0.366 nM 486.49 CCOc1ncc(-c2cc(NC(=O)c3ccnc(C(F)(F)F)c3)ccc2C)cc1N1CCOCC1 Homo sapiens CHEMBL3887884 single protein format