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P04070 | PROC_HUMAN | Vitamin K-dependent protein C (PROC)

3D structures mapped by conservation among orthologs

[ Domain: "FMN-binding split barrel 2" // Trypsin ]

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[ Domain: "EGF/Laminin" // hEGF ]

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[ Domain: "EGF/Laminin" // FXa_inhibition ]

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[ Domain: "GLA-domain" // Gla ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4638245 OBDepict H 3 C O HN O HN O H H 3 C N H N O F F Cl Ki = 1.9 nM 595.05 COC(=O)Nc1ccc2c(c1)NC(=O)[C@H](C)CCC[C@H](N1CCC(c3c(F)ccc(Cl)c3F)=CC1=O)c1cc-2ccn1 Homo sapiens CHEMBL4618305 single protein format
CHEMBL3115901 OBDepict OH O HN H N H O H HN O NH 2 HN NH 2 Ki = 40.0 nM 522.65 N=C(N)c1ccc(CNC(=O)[C@H](Cc2ccc(N)cc2)NC(=O)[C@@H](CC2CCCCC2)NCC(=O)O)cc1 Homo sapiens CHEMBL3119469 single protein format
CHEMBL3594313 OBDepict H 3 C S O O N H HN O O H NH HN NH 2 Ki = 41.0 nM 533.65 CCS(=O)(=O)c1ccc2cc1CNC(=O)[C@H](Nc1ccc(C(=N)N)cc1)c1ccc(cc1)CCCC(=O)N2 Homo sapiens CHEMBL3595071 single protein format
CHEMBL211973 OBDepict HO O NH H N H O HN O NH NH 2 IC50 = 100.0 nM 519.65 N=C(N)c1ccc(CNC(=O)C2(NC(=O)[C@@H](CC3CCCCC3)NCC(=O)O)Cc3ccccc3C2)cc1 Homo sapiens CHEMBL870370 single protein format
CHEMBL3115900 OBDepict OH O HN H N H O H HN O OH HN NH 2 Ki = 100.0 nM 523.63 N=C(N)c1ccc(CNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CC2CCCCC2)NCC(=O)O)cc1 Homo sapiens CHEMBL3119469 single protein format
CHEMBL3115904 OBDepict NH 2 NH HN N H H N H O O N H H O OH NH H 2 N Ki = 100.0 nM 516.65 N=C(N)NCCC[C@H](NC(=O)[C@@H](CC1CCCCC1)NCC(=O)O)C(=O)NCc1ccc(C(=N)N)cc1 Homo sapiens CHEMBL3119469 single protein format
CHEMBL3115901 OBDepict OH O HN H N H O H HN O NH 2 HN NH 2 IC50 = 130.0 nM 522.65 N=C(N)c1ccc(CNC(=O)[C@H](Cc2ccc(N)cc2)NC(=O)[C@@H](CC2CCCCC2)NCC(=O)O)cc1 Homo sapiens CHEMBL3119480 single protein format
CHEMBL3115897 OBDepict OH O NH H N H O H NH O NH NH 2 Ki = 200.0 nM 507.64 N=C(N)c1ccc(CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CC2CCCCC2)NCC(=O)O)cc1 Homo sapiens CHEMBL3119469 single protein format
CHEMBL3934882 OBDepict O O HN H CH 3 CH 3 N CH 3 O H N H F NH 2 N Ki = 220.0 nM 567.67 Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)ncc(F)c2c1 Homo sapiens CHEMBL3855500 single protein format
CHEMBL215639 OBDepict OH O HN H NH O CH 3 CH 3 N H O NH NH 2 IC50 = 250.0 nM 515.61 CC(C)[C@@H](NCC(=O)O)C(=O)NC1(C(=O)NCc2ccc(C(=N)N)cc2)Cc2ccc3ccccc3c2C1 Homo sapiens CHEMBL870370 single protein format
CHEMBL3115900 OBDepict OH O HN H N H O H HN O OH HN NH 2 IC50 = 260.0 nM 523.63 N=C(N)c1ccc(CNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CC2CCCCC2)NCC(=O)O)cc1 Homo sapiens CHEMBL3119480 single protein format
CHEMBL3115894 OBDepict OH O N H H NH O N H O HN NH NH 2 Ki = 300.0 nM 528.7 N=C(N)c1ccc(CNC(=O)C(CCC2CCNCC2)NC(=O)[C@@H](CC2CCCCC2)NCC(=O)O)cc1 Homo sapiens CHEMBL3119469 single protein format
CHEMBL3115903 OBDepict NH 2 NH HN O O NH H O OH HN NH 2 Ki = 300.0 nM 536.68 N=C(N)c1ccc(CNC(=O)C(Cc2ccc(CN)cc2)NC(=O)[C@@H](CC2CCCCC2)NCC(=O)O)cc1 Homo sapiens CHEMBL3119469 single protein format
CHEMBL3115898 OBDepict OH O N H H NH O H N H O NH NH 2 Ki = 300.0 nM 557.7 N=C(N)c1ccc(CNC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H](CC2CCCCC2)NCC(=O)O)cc1 Homo sapiens CHEMBL3119469 single protein format
CHEMBL3115899 OBDepict OH O N H H NH O H N H O NH NH 2 Ki = 300.0 nM 557.7 N=C(N)c1ccc(CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](CC2CCCCC2)NCC(=O)O)cc1 Homo sapiens CHEMBL3119469 single protein format
CHEMBL425613 OBDepict HO O N H H N H O H 3 C CH 3 H N H O NH H 2 N IC50 = 350.0 nM 479.58 CC(C)[C@@H](NCC(=O)O)C(=O)N[C@H](C(=O)NCc1ccc(C(=N)N)cc1)C1Cc2ccccc2C1 Homo sapiens CHEMBL870370 single protein format
CHEMBL3115893 OBDepict HO O N H H HN O N H O N H HN NH 2 Ki = 400.0 nM 514.67 N=C(N)c1ccc(CNC(=O)C(CC2CCNCC2)NC(=O)[C@@H](CC2CCCCC2)NCC(=O)O)cc1 Homo sapiens CHEMBL3119469 single protein format
CHEMBL215357 OBDepict HO O N H H HN O CH 3 CH 3 N H O NH H 2 N IC50 = 430.0 nM 515.61 CC(C)[C@@H](NCC(=O)O)C(=O)NC1(C(=O)NCc2ccc(C(=N)N)cc2)Cc2cccc3cccc(c23)C1 Homo sapiens CHEMBL870370 single protein format
CHEMBL3115904 OBDepict NH 2 NH HN N H H N H O O N H H O OH NH H 2 N IC50 = 470.0 nM 516.65 N=C(N)NCCC[C@H](NC(=O)[C@@H](CC1CCCCC1)NCC(=O)O)C(=O)NCc1ccc(C(=N)N)cc1 Homo sapiens CHEMBL3119480 single protein format
CHEMBL3115905 OBDepict NH 2 NH HN N H H N H O O NH 2 H NH H 2 N Ki = 500.0 nM 444.58 N=C(N)NCCC[C@H](NC(=O)[C@H](N)C1CCCCC1)C(=O)NCc1ccc(C(=N)N)cc1 Homo sapiens CHEMBL3119469 single protein format
CHEMBL215295 OBDepict HO O N H H HN O N H O NH H 2 N Ki = 500.0 nM 505.62 N=C(N)c1ccc(CNC(=O)C2(NC(=O)[C@H](NCC(=O)O)C3CCCCC3)Cc3ccccc3C2)cc1 Homo sapiens CHEMBL3119469 single protein format
CHEMBL3115897 OBDepict OH O NH H N H O H NH O NH NH 2 IC50 = 670.0 nM 507.64 N=C(N)c1ccc(CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CC2CCCCC2)NCC(=O)O)cc1 Homo sapiens CHEMBL3119480 single protein format
CHEMBL212789 OBDepict OH O N H H NH O H 3 C H 3 C H N H O NH H 2 N IC50 = 710.0 nM 453.54 CC(C)[C@@H](NCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccc(C(=N)N)cc1 Homo sapiens CHEMBL870370 single protein format
CHEMBL380157 OBDepict CH 3 H 3 C N H H NH O O OH N H O NH NH 2 IC50 = 750.0 nM 479.58 CC(C)C[C@@H](NCC(=O)O)C(=O)NC1(C(=O)NCc2ccc(C(=N)N)cc2)Cc2ccccc2C1 Homo sapiens CHEMBL870370 single protein format
CHEMBL426333 OBDepict HO O NH H HN O CH 3 H 3 C N H O NH H 2 N IC50 = 800.0 nM 465.55 CC(C)[C@@H](NCC(=O)O)C(=O)NC1(C(=O)NCc2ccc(C(=N)N)cc2)Cc2ccccc2C1 Homo sapiens CHEMBL870370 single protein format
CHEMBL3115906 OBDepict NH 2 N H NH N H H N H O O N H H O OH HN NH 2 Ki = 800.0 nM 530.67 N=C(N)NCCC[C@H](NC(=O)[C@@H](CC1CCCCC1)NCCC(=O)O)C(=O)NCc1ccc(C(=N)N)cc1 Homo sapiens CHEMBL3119469 single protein format
CHEMBL215295 OBDepict HO O N H H HN O N H O NH H 2 N IC50 = 820.0 nM 505.62 N=C(N)c1ccc(CNC(=O)C2(NC(=O)[C@H](NCC(=O)O)C3CCCCC3)Cc3ccccc3C2)cc1 Homo sapiens CHEMBL870370 single protein format
CHEMBL3594314 OBDepict H 3 C S O O HN N H O O H N H CH 3 H 2 N N Ki = 830.0 nM 571.7 CCS(=O)(=O)c1ccc2cc1CNC(=O)[C@H](Nc1ccc3c(N)nccc3c1)c1ccc(c(C)c1)CCCC(=O)N2 Homo sapiens CHEMBL3595071 single protein format
CHEMBL3115896 OBDepict O N H NH O H 2 N H NH NH H 2 N Ki = 900.0 nM 470.66 N=C(N)c1ccc(CNC(=O)C(CCC2CCNCC2)NC(=O)[C@H](N)CC2CCCCC2)cc1 Homo sapiens CHEMBL3119469 single protein format
CHEMBL3115892 OBDepict OH O NH H N H O H N H O N H HN NH 2 Ki = 900.0 nM 500.64 N=C(N)c1ccc(CNC(=O)[C@@H](NC(=O)[C@@H](CC2CCCCC2)NCC(=O)O)C2CCNCC2)cc1 Homo sapiens CHEMBL3119469 single protein format
CHEMBL3115894 OBDepict OH O N H H NH O N H O HN NH NH 2 IC50 = 920.0 nM 528.7 N=C(N)c1ccc(CNC(=O)C(CCC2CCNCC2)NC(=O)[C@@H](CC2CCCCC2)NCC(=O)O)cc1 Homo sapiens CHEMBL3119480 single protein format
CHEMBL3115899 OBDepict OH O N H H NH O H N H O NH NH 2 IC50 = 980.0 nM 557.7 N=C(N)c1ccc(CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](CC2CCCCC2)NCC(=O)O)cc1 Homo sapiens CHEMBL3119480 single protein format