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P05198 | IF2A_HUMAN | Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

3D structures mapped by conservation among orthologs

[ Domain: "eIF2alpha middle domain" // EIF_2_alpha_N ]

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[ Domain: "Nucleic acid-binding proteins" // S1_1 ]

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[ Domain: "eIF-2-alpha, C-terminal domain" // EIF_2_alpha_C ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4857782 OBDepict H 3 C NH N O HO H H 2 N NH O CH 3 H 3 C F F IC50 = 9.0 nM 468.5 CCc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 Homo sapiens CHEMBL4822226 single protein format
CHEMBL4858308 OBDepict CH 3 HO H HN O CH 3 N NH 2 HN O H 3 C CH 3 IC50 = 18.0 nM 446.55 CCc1cccc([C@@H](O)C(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)c1 Homo sapiens CHEMBL4822226 single protein format
CHEMBL4848143 OBDepict H 3 C N H CH 3 O H 2 N N Cl NH O HO H F F IC50 = 23.0 nM 474.9 CC(C)NC(=O)c1cc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2Cl)cnc1N Homo sapiens CHEMBL4822226 single protein format
CHEMBL4869882 OBDepict F F OH H N H O CH 3 N H 2 N N H O IC50 = 27.0 nM 452.46 Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2CC2)c1 Homo sapiens CHEMBL4822226 single protein format
CHEMBL4862478 OBDepict CH 3 NH H 3 C O NH 2 N CH 3 HN O OH H F F IC50 = 33.0 nM 454.48 Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 Homo sapiens CHEMBL4822226 single protein format
CHEMBL4853221 OBDepict CH 3 NH H 3 C O NH 2 N CH 3 HN O OH H Cl IC50 = 40.0 nM 452.94 Cc1cc(NC(=O)[C@H](O)c2cccc(Cl)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 Homo sapiens CHEMBL4822226 single protein format
CHEMBL4848359 OBDepict CH 3 N H O N NH 2 N CH 3 HN O OH H F F IC50 = 40.0 nM 427.41 CNC(=O)c1nc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2C)cnc1N Homo sapiens CHEMBL4822226 single protein format
CHEMBL4861671 OBDepict CH 3 NH H 3 C O N NH 2 N CH 3 HN O OH H F F IC50 = 42.0 nM 455.47 Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)n1 Homo sapiens CHEMBL4822226 single protein format
CHEMBL4863698 OBDepict H 3 C N H O H 2 N N CH 3 NH O HO H F F IC50 = 45.0 nM 440.45 CCNC(=O)c1cc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2C)cnc1N Homo sapiens CHEMBL4822226 single protein format
CHEMBL4870100 OBDepict CH 3 O H 3 C O NH 2 N CH 3 HN O OH H F F IC50 = 49.0 nM 455.46 Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)OC(C)C)c1 Homo sapiens CHEMBL4822226 single protein format
CHEMBL4870780 OBDepict CH 3 N H CH 3 O NH 2 N CH 3 N H O OH H CH 3 IC50 = 54.0 nM 432.52 Cc1cccc([C@@H](O)C(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)c1 Homo sapiens CHEMBL4822226 single protein format
CHEMBL4875875 OBDepict CH 3 N H O NH 2 N CH 3 HN O OH H F F IC50 = 58.0 nM 426.42 CNC(=O)c1cc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2C)cnc1N Homo sapiens CHEMBL4822226 single protein format
CHEMBL4851480 OBDepict H 3 C N H CH 3 O H 2 N N F NH O HO H F F IC50 = 72.0 nM 458.44 CC(C)NC(=O)c1cc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2F)cnc1N Homo sapiens CHEMBL4822226 single protein format
CHEMBL4876496 OBDepict F F HO H HN O CH 3 N NH 2 HN O CH 3 CH 3 H 3 C IC50 = 114.0 nM 468.5 Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)(C)C)c1 Homo sapiens CHEMBL4822226 single protein format
CHEMBL4854504 OBDepict CH 3 NH H 3 C O N CH 3 HN O OH H F F IC50 = 181.0 nM 439.46 Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cncc(C(=O)NC(C)C)c1 Homo sapiens CHEMBL4822226 single protein format
CHEMBL4852735 OBDepict CH 3 NH H 3 C O NH 2 N CH 3 HN O OH H F F IC50 = 187.0 nM 454.48 Cc1cc(NC(=O)[C@@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 Homo sapiens CHEMBL4822226 single protein format
CHEMBL4870495 OBDepict CH 3 NH H 3 C O NH 2 N CH 3 HN O OH H IC50 = 198.0 nM 418.5 Cc1cc(NC(=O)[C@H](O)c2ccccc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 Homo sapiens CHEMBL4822226 single protein format
CHEMBL4866245 OBDepict H 3 C N H CH 3 O H 2 N N H 3 C N H O IC50 = 307.0 nM 402.5 Cc1cc(NC(=O)Cc2ccccc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 Homo sapiens CHEMBL4822226 single protein format
CHEMBL4846663 OBDepict CH 3 NH H 3 C O NH 2 N HN O OH H F F IC50 = 313.0 nM 440.45 CC(C)NC(=O)c1cc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2)cnc1N Homo sapiens CHEMBL4822226 single protein format
CHEMBL4870565 OBDepict H 3 C O NH N O HO H H 2 N NH O CH 3 H 3 C F F IC50 = 366.0 nM 470.48 COc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 Homo sapiens CHEMBL4822226 single protein format
CHEMBL4849149 OBDepict CH 3 NH H 3 C O CH 3 N CH 3 HN O OH H F F IC50 = 638.0 nM 453.49 Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(C)c(C(=O)NC(C)C)c1 Homo sapiens CHEMBL4822226 single protein format