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P05231 | IL6_HUMAN | Interleukin-6 (IL6)

3D structures mapped by conservation among orthologs

[ Domain: "4-helical cytokines" // IL6 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3647441 OBDepict O N H CH 3 N H OH F F F IC50 = 1.1 nM 522.61 Cc1ncccc1NC(=O)c1ccc2c(c1)CC[C@@H]1C[C@@](O)(CCC(F)(F)F)CC[C@@]21Cc1ccccc1 Homo sapiens CHEMBL3705674 single protein format
CHEMBL3647443 OBDepict O N H H 3 C N O H HO F F F IC50 = 1.1 nM 508.54 Cc1ncccc1NC(=O)c1ccc2c(c1)C(=O)C[C@@H]1C[C@@](O)(C(F)(F)F)CC[C@@]21Cc1ccccc1 Homo sapiens CHEMBL3705674 single protein format
CHEMBL3647442 OBDepict O NH N CH 3 H OH F F F IC50 = 1.3 nM 494.56 Cc1ccncc1NC(=O)c1ccc2c(c1)CC[C@@H]1C[C@@](O)(C(F)(F)F)CC[C@@]21Cc1ccccc1 Homo sapiens CHEMBL3705674 single protein format
CHEMBL3647445 OBDepict O N H CH 3 + N _ O H OH F F F IC50 = 2.1 nM 510.56 Cc1c(NC(=O)c2ccc3c(c2)CC[C@@H]2C[C@@](O)(C(F)(F)F)CC[C@@]32Cc2ccccc2)ccc[n+]1[O-] Homo sapiens CHEMBL3705674 single protein format
CHEMBL3647447 OBDepict O NH CH 3 N H OH F F F IC50 = 2.8 nM 492.54 Cc1ncccc1NC(=O)c1ccc2c(c1)C=C[C@@H]1C[C@@](O)(C(F)(F)F)CC[C@@]21Cc1ccccc1 Homo sapiens CHEMBL3705674 single protein format
CHEMBL3647440 OBDepict CH 3 N N CH 3 N H O H HO F F F IC50 = 4.0 nM 509.57 Cc1cnc(NC(=O)c2ccc3c(c2)CC[C@@H]2C[C@@](O)(C(F)(F)F)CC[C@@]32Cc2ccccc2)c(C)n1 Homo sapiens CHEMBL3705674 single protein format
CHEMBL131 OBDepict HO O OH CH 3 H H OH H H CH 3 O IC50 = 4.2 nM 360.45 C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO Homo sapiens CHEMBL3705674 single protein format
CHEMBL3647446 OBDepict O N H CH 3 N H OH F F IC50 = 4.3 nM 476.57 Cc1ncccc1NC(=O)c1ccc2c(c1)CC[C@@H]1C[C@@](O)(C(F)F)CC[C@@]21Cc1ccccc1 Homo sapiens CHEMBL3705674 single protein format
CHEMBL3647444 OBDepict O N H CH 3 N H OH H OH F F F IC50 = 7.0 nM 510.56 Cc1ncccc1NC(=O)c1ccc2c(c1)[C@H](O)C[C@@H]1C[C@@](O)(C(F)(F)F)CC[C@@]21Cc1ccccc1 Homo sapiens CHEMBL3705674 single protein format
CHEMBL3137316 OBDepict O N H H 3 C N H O P F F F O OH HO IC50 = 60.0 nM 574.54 Cc1ncccc1NC(=O)c1ccc2c(c1)CC[C@@H]1C[C@@](OP(=O)(O)O)(C(F)(F)F)CC[C@@]21Cc1ccccc1 Homo sapiens CHEMBL3705674 single protein format
CHEMBL273019 OBDepict H 3 C O HO OH H O O O H H H HO OH H OH IC50 = 208.0 nM 328.27 COc1c(O)cc2c(c1O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1OC2=O Homo sapiens CHEMBL4046839 single protein format
CHEMBL3647448 OBDepict CH 3 N N CH 3 NH O H HO F F F IC50 = 291.0 nM 537.63 Cc1ncc(NC(=O)c2ccc3c(c2)CC[C@@H]2C[C@@](O)(CCC(F)(F)F)CC[C@@]32Cc2ccccc2)c(C)n1 Homo sapiens CHEMBL3705674 single protein format