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P06730 | IF4E_HUMAN | Eukaryotic translation initiation factor 4E (EIF4E)

3D structures mapped by conservation among orthologs

[ Domain: "Translation initiation factor eIF4e and phosphothreonine lyase" // IF4E ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL2046918 OBDepict CH 3 N H N N H N O N O P F F O OH HO Cl IC50 = 16.0 nM 525.84 CNc1nc2nc(-c3ccc(C(F)(F)P(=O)(O)O)cc3)n(CCOc3ccc(Cl)cc3)c2c(=O)[nH]1 Homo sapiens CHEMBL2051182 assay format
CHEMBL1094973 OBDepict H N NH 2 N O + N N H 3 C H O H HO H H HO O P O O _ O P O O OH P O OH HO Ki = 28.0 nM 537.21 C[n+]1cn([C@@H]2O[C@H](COP(=O)([O-])OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c21 Homo sapiens CHEMBL2051182 assay format
CHEMBL2046906 OBDepict Br O + N N O N N H O H H OH H 2 N H H HO O P O HO _ O IC50 = 41.0 nM 562.27 Nc1nc2c(c(=O)[nH]1)[n+](CCOc1ccc(Br)cc1)cn2[C@@H]1O[C@H](COP(=O)([O-])O)[C@@H](O)[C@H]1O Homo sapiens CHEMBL2051182 assay format
CHEMBL2046915 OBDepict Cl O + N N O N N H O H H O H 2 N H H O O H 3 C H 3 C P O HO _ O IC50 = 51.0 nM 557.88 CC1(C)O[C@@H]2[C@@H](COP(=O)([O-])O)O[C@@H](n3c[n+](CCOc4ccc(Cl)cc4)c4c(=O)[nH]c(N)nc43)[C@@H]2O1 Homo sapiens CHEMBL2051182 assay format
CHEMBL2046910 OBDepict F Cl O + N N O N N H O H H OH H 2 N H H HO O P O HO _ O IC50 = 56.0 nM 535.81 Nc1nc2c(c(=O)[nH]1)[n+](CCOc1ccc(Cl)c(F)c1)cn2[C@@H]1O[C@H](COP(=O)([O-])O)[C@@H](O)[C@H]1O Homo sapiens CHEMBL2051182 assay format
CHEMBL2046905 OBDepict Cl O + N N O N N H O H H OH H 2 N H H HO O P O HO _ O IC50 = 59.0 nM 517.82 Nc1nc2c(c(=O)[nH]1)[n+](CCOc1ccc(Cl)cc1)cn2[C@@H]1O[C@H](COP(=O)([O-])O)[C@@H](O)[C@H]1O Homo sapiens CHEMBL2051182 assay format
CHEMBL2046916 OBDepict H 3 C N H N N H N O N O P O OH OH Cl IC50 = 95.0 nM 475.83 CNc1nc2nc(-c3ccc(P(=O)(O)O)cc3)n(CCOc3ccc(Cl)cc3)c2c(=O)[nH]1 Homo sapiens CHEMBL2051182 assay format
CHEMBL2046912 OBDepict Cl O + N N O N N H O H H OH H 2 N H H HO O P O HO _ O IC50 = 117.0 nM 527.81 Nc1nc2c(c(=O)[nH]1)[n+](Cc1cc3cc(Cl)ccc3o1)cn2[C@@H]1O[C@H](COP(=O)([O-])O)[C@@H](O)[C@H]1O Homo sapiens CHEMBL2051182 assay format
CHEMBL2046908 OBDepict N O + N N O N N H O H H OH NH 2 H H HO O P O HO _ O IC50 = 125.0 nM 508.38 N#Cc1ccc(OCC[n+]2cn([C@@H]3O[C@H](COP(=O)([O-])O)[C@@H](O)[C@H]3O)c3nc(N)[nH]c(=O)c32)cc1 Homo sapiens CHEMBL2051182 assay format
CHEMBL2046917 OBDepict CH 3 N H N N H N O N O P O OH HO Cl IC50 = 160.0 nM 489.86 CNc1nc2nc(-c3ccc(CP(=O)(O)O)cc3)n(CCOc3ccc(Cl)cc3)c2c(=O)[nH]1 Homo sapiens CHEMBL2051182 assay format
CHEMBL3659374 OBDepict HO O S N + N O _ O Cl Cl IC50 = 500.0 nM 471.32 O=C(O)c1cc(-c2nc(-c3ccc(Cl)c(Cl)c3)cs2)ccc1-c1ccccc1[N+](=O)[O-] Homo sapiens CHEMBL3705829 assay format
CHEMBL3659444 OBDepict HO O S N Cl O F F F Cl Cl IC50 = 600.0 nM 544.77 O=C(O)c1cc(-c2nc(-c3ccc(Cl)c(Cl)c3)cs2)ccc1-c1cc(OC(F)(F)F)ccc1Cl Homo sapiens CHEMBL3705829 assay format
CHEMBL3663619 OBDepict OH O S N Cl F CH 3 Cl Cl IC50 = 700.0 nM 492.79 Cc1ccc(Cl)c(-c2ccc(-c3nc(-c4ccc(Cl)c(Cl)c4)cs3)cc2C(=O)O)c1F Homo sapiens CHEMBL3705829 assay format
CHEMBL3663603 OBDepict F F F F O OH S N Cl Cl IC50 = 800.0 nM 512.31 O=C(O)c1cc(-c2nc(-c3ccc(Cl)c(Cl)c3)cs2)ccc1-c1ccc(F)cc1C(F)(F)F Homo sapiens CHEMBL3705829 assay format
CHEMBL3659436 OBDepict OH O S N N H O Cl CH 3 Cl IC50 = 970.0 nM 573.5 CC(NC(=O)c1ccc(-c2ccc(-c3nc(-c4ccc(Cl)c(Cl)c4)cs3)cc2C(=O)O)cc1)c1ccccc1 Homo sapiens CHEMBL3705829 assay format