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P08473 | NEP_HUMAN | Neprilysin (MME)

3D structures mapped by conservation among orthologs

[ Domain: "Metalloproteases ("zincins") catalytic domain" // Peptidase_M13 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3677673 OBDepict HO O CH 3 H HN H O N H N O HO Cl IC50 = 0.03 nM 455.9 C[C@H](C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)c1cc(C(=O)O)n[nH]1)C(=O)O Homo sapiens CHEMBL3706201 cell-based format
CHEMBL3677671 OBDepict Cl NH H H 3 C H O O HO O N OH IC50 = 0.04 nM 428.87 C[C@@H](C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)c1cc(O)no1)C(=O)O Homo sapiens CHEMBL3706201 cell-based format
CHEMBL198316 OBDepict O N H SH H H O N H O OH IC50 = 0.08 nM 438.55 O=C(N[C@H]1Cc2ccccc2C2CCC[C@H](C(=O)O)N2C1=O)[C@H](S)Cc1ccccc1 Homo sapiens CHEMBL882907 single protein format
CHEMBL3695448 OBDepict H 3 C O O NH H 3 C H H N H O N N N H N Cl IC50 = 0.09 nM 442.91 CCOC(=O)[C@H](C)N[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)C(=O)Nc1nnn[nH]1 Homo sapiens CHEMBL3705384 cell-based format
CHEMBL3890914 OBDepict OH O HN H O P O OH OH F Cl IC50 = 0.11 nM 443.8 O=C(O)C[C@@H](Cc1ccc(-c2cc(Cl)ccc2F)cc1)NC(=O)CCP(=O)(O)O Homo sapiens CHEMBL3887399 cell-based format
CHEMBL3695454 OBDepict CH 3 NH H O HO H N H O HN N N H NH Cl IC50 = 0.2 nM 430.9 CC[C@H](N[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)C(=O)NC1=NNNN1)C(=O)O Homo sapiens CHEMBL3705384 cell-based format
CHEMBL3695453 OBDepict Cl N H H N H O H N H N O OH HN HN IC50 = 0.2 nM 506.99 O=C(O)[C@H](CCc1ccccc1)N[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)C(=O)NC1=NNNN1 Homo sapiens CHEMBL3705384 cell-based format
CHEMBL1778532 OBDepict H 3 C O NH H O OH N H O H O OH N O IC50 = 0.3 nM 459.5 COCC[C@H](NC1(C(=O)N[C@@H](Cc2ncc(-c3ccccc3)o2)C(=O)O)CCCC1)C(=O)O Homo sapiens CHEMBL1780284 single protein format
CHEMBL3695449 OBDepict O HN NH H N N H 3 C H N H N O O CH 3 H 3 C CH 3 Cl Cl IC50 = 0.3 nM 505.41 C[C@H](N[C@@H](Cc1ccc(-c2cc(Cl)ccc2Cl)cc1)C(=O)Nc1nnn[nH]1)C(=O)OC(C)(C)C Homo sapiens CHEMBL3705384 cell-based format
CHEMBL1778534 OBDepict CH 3 O HN H O HO N H O H O HO N O Cl IC50 = 0.3 nM 493.94 COCC[C@H](NC1(C(=O)N[C@@H](Cc2ncc(-c3ccc(Cl)cc3)o2)C(=O)O)CCCC1)C(=O)O Homo sapiens CHEMBL1780284 single protein format
CHEMBL3677674 OBDepict OH O H 3 C H NH H O O O OH Cl IC50 = 0.3 nM 455.89 C[C@H](C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)c1ccc(C(=O)O)o1)C(=O)O Homo sapiens CHEMBL3706201 cell-based format
CHEMBL3703484 OBDepict O NH H O OH CH 3 H O OH Cl IC50 = 0.3 nM 417.89 C[C@H](C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)CCC(=O)O)C(=O)O Homo sapiens CHEMBL4339144 cell-based format
CHEMBL1829584 OBDepict OH O HN O N H H H O HO IC50 = 0.36 nM 474.56 O=C(O)CCNC(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)N[C@@H](CCc1ccccc1)C(=O)O Homo sapiens CHEMBL1833759 assay format
CHEMBL3676144 OBDepict CH 3 O Cl N H H O O OH O HO IC50 = 0.38 nM 419.86 COc1ccc(Cl)cc1-c1ccc(C[C@H](CC(=O)O)NC(=O)CCC(=O)O)cc1 Homo sapiens CHEMBL4339144 cell-based format
CHEMBL1829585 OBDepict O NH N H H H CH 3 H O HO O OH IC50 = 0.51 nM 488.58 C[C@@H](CNC(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)N[C@@H](CCc1ccccc1)C(=O)O)C(=O)O Homo sapiens CHEMBL1833759 assay format
CHEMBL268473 OBDepict H N N N N N H H P O OH OH O O IC50 = 0.6 nM 493.46 O=P(O)(O)C(Cc1ccc2c(c1)OCO2)N[C@@H](Cc1ccc(-c2ccccc2)cc1)c1nnn[nH]1 Homo sapiens CHEMBL754363 single protein format
CHEMBL42583 OBDepict H 2 N HN H NH O S O O CH 3 H O HO N H O H O OH HO IC50 = 0.6 nM 584.69 CS(=O)(=O)N[C@@H](CCCCN)C(=O)NC[C@H](CC1(C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)O)CCCC1)C(=O)O Homo sapiens CHEMBL1780284 single protein format
CHEMBL1778530 OBDepict CH 3 N H H O OH N H O H O OH N O IC50 = 0.6 nM 443.5 CCC[C@H](NC1(C(=O)N[C@@H](Cc2ncc(-c3ccccc3)o2)C(=O)O)CCCC1)C(=O)O Homo sapiens CHEMBL1780284 single protein format
CHEMBL34541 OBDepict HO O N S N H O H H O OH O IC50 = 0.69 nM 544.63 O=C(O)Cc1csc(NC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)C[C@@H](COc2ccccc2)C(=O)O)n1 Homo sapiens CHEMBL752989 single protein format
CHEMBL51715 OBDepict SH H N H O H 3 C H O HO Ki = 0.7 nM 267.35 C[C@H](NC(=O)[C@@H](CS)Cc1ccccc1)C(=O)O Homo sapiens CHEMBL3365756 single protein format
CHEMBL276690 OBDepict H N N N N N H H P O OH OH O O IC50 = 0.7 nM 493.46 O=P(O)(O)C(Cc1cccc2c1OCO2)N[C@@H](Cc1ccc(-c2ccccc2)cc1)c1nnn[nH]1 Homo sapiens CHEMBL754363 single protein format
CHEMBL2052008 OBDepict SH H H 3 C H N H O CH 3 H O HO Ki = 0.7 nM 281.38 C[C@H](NC(=O)[C@H](CS)[C@@H](C)c1ccccc1)C(=O)O Homo sapiens CHEMBL755097 organism-based format
CHEMBL276872 OBDepict H N N N N N H H P O OH OH IC50 = 0.74 nM 449.45 O=P(O)(O)C(Cc1ccccc1)N[C@@H](Cc1ccc(-c2ccccc2)cc1)c1nnn[nH]1 Homo sapiens CHEMBL754363 single protein format
CHEMBL2204326 OBDepict SH H O NH H N O H H OH O HO IC50 = 0.8 nM 358.46 O=C(O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H]1CCCCCC[C@@H](CS)C(=O)N1 Homo sapiens CHEMBL2208603 single protein format
CHEMBL4443138 OBDepict O NH H O OH CH 3 O OH Cl IC50 = 0.8 nM 417.89 CC(C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)CCC(=O)O)C(=O)O Homo sapiens CHEMBL4339144 cell-based format
CHEMBL150222 OBDepict SH H O HN H O OH IC50 = 0.9 nM 307.42 O=C1N[C@H](C(=O)O)CCCCc2ccccc2C[C@@H]1CS Homo sapiens CHEMBL752993 single protein format
CHEMBL290698 OBDepict H N N N N N H H P O OH OH IC50 = 0.9 nM 359.33 O=P(O)(O)CN[C@@H](Cc1ccc(-c2ccccc2)cc1)c1nn[nH]n1 Homo sapiens CHEMBL754363 single protein format
CHEMBL3677663 OBDepict OH O H 3 C H NH H O N N O HO IC50 = 1.0 nM 433.46 C[C@H](C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)c1cc(C(=O)O)ncn1)C(=O)O Homo sapiens CHEMBL3706201 cell-based format
CHEMBL420321 OBDepict O NH H P H 3 C H O OH O HO H 2 N CH 3 H Ki = 1.2 nM 418.43 C[C@H](NC(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)CP(=O)(O)[C@@H](C)N)C(=O)O Homo sapiens CHEMBL752997 single protein format
CHEMBL273748 OBDepict SH H 3 C HN O O OH IC50 = 1.3 nM 267.35 CC(c1ccccc1)C(CS)C(=O)NCC(=O)O Homo sapiens CHEMBL755096 organism-based format
CHEMBL16779 OBDepict OH NH O NH O O HO IC50 = 1.4 nM 280.28 O=C(O)CNC(=O)C(CC(=O)NO)Cc1ccccc1 Homo sapiens CHEMBL752995 single protein format
CHEMBL268761 OBDepict H N N N N N H H P O OH OH N IC50 = 1.46 nM 500.5 O=P(O)(O)C(Cc1cccc2cccnc12)N[C@@H](Cc1ccc(-c2ccccc2)cc1)c1nnn[nH]1 Homo sapiens CHEMBL754363 single protein format
CHEMBL3676150 OBDepict HO O N H H O O OH Cl IC50 = 1.5 nM 389.83 O=C(O)CCC(=O)N[C@@H](CC(=O)O)Cc1ccc(-c2cccc(Cl)c2)cc1 Homo sapiens CHEMBL4339144 cell-based format
CHEMBL3298934 OBDepict SH H NH O H O OH O HO Ki = 1.5 nM 311.36 O=C(O)C[C@H](NC(=O)[C@@H](CS)Cc1ccccc1)C(=O)O Homo sapiens CHEMBL3365756 single protein format
CHEMBL4557208 OBDepict OH O N H H O O HO CH 3 IC50 = 1.6 nM 369.42 Cc1cccc(-c2ccc(C[C@H](CC(=O)O)NC(=O)CCC(=O)O)cc2)c1 Homo sapiens CHEMBL4339144 cell-based format
CHEMBL2052007 OBDepict SH H CH 3 H NH O H O HO Ki = 1.6 nM 357.48 C[C@@H](c1ccccc1)[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)O Homo sapiens CHEMBL755097 organism-based format
CHEMBL85320 OBDepict OH NH O H N H O CH 3 H O OH Ki = 1.7 nM 294.31 C[C@H](NC(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C(=O)O Homo sapiens CHEMBL752997 single protein format
CHEMBL61512 OBDepict SH H HN O O HO Ki = 1.7 nM 253.32 O=C(O)CNC(=O)[C@H](CS)Cc1ccccc1 Homo sapiens CHEMBL753641 single protein format
CHEMBL1778536 OBDepict CH 3 O N H H O HO N H O H O HO O N N IC50 = 1.9 nM 460.49 COCC[C@H](NC1(C(=O)N[C@@H](Cc2nc(-c3ccccc3)no2)C(=O)O)CCCC1)C(=O)O Homo sapiens CHEMBL1780284 single protein format
CHEMBL4075182 OBDepict HO O H O HS S Ki = 2.0 nM 388.55 O=C(O)[C@H](CC(=O)C1(S)CCCCC1)Cc1ccc(-c2ccsc2)cc1 Homo sapiens CHEMBL4056822 single protein format
CHEMBL442455 OBDepict H 3 C CH 3 N NH O P O HO OH H O OH IC50 = 2.0 nM 408.39 CC(C)CN(CP(=O)(O)O)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)O Homo sapiens CHEMBL930674 single protein format
CHEMBL4442804 OBDepict O NH H O OH CH 3 H O OH Cl IC50 = 2.0 nM 417.89 C[C@@H](C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)CCC(=O)O)C(=O)O Homo sapiens CHEMBL4339144 cell-based format
CHEMBL2051773 OBDepict SH CH 3 N H O H 3 C H O OH IC50 = 2.0 nM 281.38 CC(c1ccccc1)C(CS)C(=O)N[C@@H](C)C(=O)O Homo sapiens CHEMBL755096 organism-based format
CHEMBL90545 OBDepict CH 3 H 3 C H NH H N H O P H O OH HO O OH IC50 = 2.0 nM 448.46 CC[C@@H](C)[C@H](NCP(=O)(O)O)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)O Homo sapiens CHEMBL752990 single protein format
CHEMBL11297 OBDepict SH CH 3 N H O CH 3 O OH F IC50 = 2.0 nM 299.37 CC(NC(=O)C(CS)C(C)c1ccc(F)cc1)C(=O)O Homo sapiens CHEMBL755096 organism-based format
CHEMBL11495 OBDepict SH N H O O HO HO IC50 = 2.0 nM 359.45 O=C(NC(Cc1ccc(O)cc1)C(=O)O)C(CS)Cc1ccccc1 Homo sapiens CHEMBL755096 organism-based format
CHEMBL11620 OBDepict SH CH 3 N H O CH 3 O O OH O IC50 = 2.0 nM 325.39 CC(NC(=O)C(CS)C(C)c1ccc2c(c1)OCO2)C(=O)O Homo sapiens CHEMBL755096 organism-based format
CHEMBL3298935 OBDepict SH NH O H 3 C H S O HO Ki = 2.0 nM 273.38 C[C@H](NC(=O)C(CS)Cc1ccsc1)C(=O)O Homo sapiens CHEMBL3365756 single protein format
CHEMBL1160959 OBDepict H 3 C S NH 2 H S S H N H O O O Ki = 2.0 nM 582.86 CSCC[C@H](N)CSSC[C@@H](Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)OCc1ccccc1 Homo sapiens CHEMBL752997 single protein format
CHEMBL117394 OBDepict O NH H P H 3 C H O OH O HO NH 2 H Ki = 2.0 nM 480.5 C[C@H](NC(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)CP(=O)(O)[C@H](N)c1ccccc1)C(=O)O Homo sapiens CHEMBL752997 single protein format
CHEMBL298827 OBDepict SH H HN O O HO Ki = 2.2 nM 253.32 O=C(O)CNC(=O)[C@@H](CS)Cc1ccccc1 Homo sapiens CHEMBL753641 single protein format
CHEMBL45412 OBDepict HS N H H O O HO Ki = 2.3 nM 253.32 O=C(O)CC(=O)N[C@@H](CS)Cc1ccccc1 Homo sapiens CHEMBL4732978 single protein format
CHEMBL225085 OBDepict H 3 C O H O OH HN O Cl IC50 = 2.3 nM 395.93 COCC[C@H](CC1(C(=O)NCCCc2ccc(Cl)cc2)CCCC1)C(=O)O Homo sapiens CHEMBL914049 single protein format
CHEMBL3695451 OBDepict Cl N H H HN O CH 3 H O O OH N OH IC50 = 2.4 nM 429.86 C[C@H](N[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)C(=O)Nc1cc(O)no1)C(=O)O Homo sapiens CHEMBL3705384 cell-based format
CHEMBL267766 OBDepict SH HN O CH 3 O OH OH IC50 = 2.4 nM 387.5 CCC(c1ccccc1)C(CS)C(=O)NC(Cc1ccc(O)cc1)C(=O)O Homo sapiens CHEMBL755096 organism-based format
CHEMBL3298860 OBDepict HS H N H O H OH H 3 C H O OH Ki = 2.5 nM 297.38 C[C@@H](O)[C@H](NC(=O)[C@@H](CS)Cc1ccccc1)C(=O)O Homo sapiens CHEMBL3365756 single protein format
CHEMBL11616 OBDepict SH CH 3 HN O O OH OH IC50 = 2.5 nM 373.47 CC(c1ccccc1)C(CS)C(=O)NC(Cc1ccc(O)cc1)C(=O)O Homo sapiens CHEMBL755096 organism-based format
CHEMBL273489 OBDepict H N N N N N H H P O OH OH O O IC50 = 2.5 nM 493.46 O=P(O)(O)C(Cc1ccc2c(c1)OCO2)N[C@H](Cc1ccc(-c2ccccc2)cc1)c1nnn[nH]1 Homo sapiens CHEMBL754363 single protein format
CHEMBL3298859 OBDepict SH H N H O H O HO HO Ki = 2.9 nM 283.35 O=C(N[C@@H](CO)C(=O)O)[C@@H](CS)Cc1ccccc1 Homo sapiens CHEMBL3365756 single protein format
CHEMBL342091 OBDepict HS H O NH H O HO IC50 = 3.0 nM 321.44 O=C1N[C@H](C(=O)O)CCCCCc2ccccc2C[C@@H]1CS Homo sapiens CHEMBL752993 single protein format
CHEMBL89563 OBDepict H N H O OH O N H H H 3 C CH 3 P O HO OH IC50 = 3.0 nM 434.43 CC(C)[C@H](NCP(=O)(O)O)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)O Homo sapiens CHEMBL752990 single protein format
CHEMBL11537 OBDepict H 3 C HN O OH O CH 3 SH IC50 = 3.1 nM 323.46 CCCCC(NC(=O)C(CS)C(C)c1ccccc1)C(=O)O Homo sapiens CHEMBL755096 organism-based format
CHEMBL34884 OBDepict OH O N H O H H O OH O IC50 = 3.2 nM 461.51 O=C(O)CNC(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)C[C@@H](COc1ccccc1)C(=O)O Homo sapiens CHEMBL752989 single protein format
CHEMBL34427 OBDepict HO O N S N H O H H O OH O IC50 = 3.3 nM 544.63 O=C(O)Cc1csc(NC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)C[C@H](COc2ccccc2)C(=O)O)n1 Homo sapiens CHEMBL752989 single protein format
CHEMBL3298940 OBDepict SH HN O H O OH O OH Ki = 3.45 nM 275.33 O=C(O)C[C@H](NC(=O)C1(CS)CCCC1)C(=O)O Homo sapiens CHEMBL3365756 single protein format
CHEMBL276008 OBDepict SH H 3 C HN O CH 3 F O OH F IC50 = 3.5 nM 317.36 CC(NC(=O)C(CS)C(C)c1ccc(F)c(F)c1)C(=O)O Homo sapiens CHEMBL755096 organism-based format
CHEMBL273898 OBDepict SH CH 3 N H O O OH CH 3 CH 3 IC50 = 3.5 nM 323.46 CC(C)CC(NC(=O)C(CS)C(C)c1ccccc1)C(=O)O Homo sapiens CHEMBL755096 organism-based format
CHEMBL225084 OBDepict CH 3 O H O HO N H O HO IC50 = 3.7 nM 389.49 COCC[C@H](CC1(C(=O)NC2(CO)Cc3ccccc3C2)CCCC1)C(=O)O Homo sapiens CHEMBL914049 single protein format
CHEMBL357311 OBDepict HS H O N H H O HO IC50 = 4.0 nM 321.44 O=C(O)[C@@H]1CCCCCc2ccccc2C[C@@H](CS)C(=O)N1 Homo sapiens CHEMBL752993 single protein format
CHEMBL357584 OBDepict SH H O N H H O HO IC50 = 4.0 nM 335.47 O=C1N[C@H](C(=O)O)CCCCCCc2cccc(c2)C[C@@H]1CS Homo sapiens CHEMBL752994 single protein format
CHEMBL450935 OBDepict H 3 C CH 3 N NH O OH H H O HO O OH IC50 = 4.0 nM 402.45 CC(C)CN(C[C@H](O)C(=O)O)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)O Homo sapiens CHEMBL930674 single protein format
CHEMBL329894 OBDepict HO NH H O OH O N H H O N H H CH 3 H 3 C P O OH OH IC50 = 4.0 nM 597.61 CC(C)[C@H](NCP(=O)(O)O)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O Homo sapiens CHEMBL752990 single protein format
CHEMBL11236 OBDepict SH CH 3 HN O O OH O IC50 = 4.0 nM 387.5 CC(c1ccccc1)C(CS)C(=O)NC(COCc1ccccc1)C(=O)O Homo sapiens CHEMBL755096 organism-based format
CHEMBL275690 OBDepict SH H 3 C HN O O OH H 3 C IC50 = 4.0 nM 309.43 CCCC(NC(=O)C(CS)C(C)c1ccccc1)C(=O)O Homo sapiens CHEMBL755096 organism-based format
CHEMBL4091227 OBDepict H O OH O SH Ki = 4.2 nM 382.53 O=C(O)[C@H](CC(=O)C1(S)CCCCC1)Cc1ccc(-c2ccccc2)cc1 Homo sapiens CHEMBL4056822 single protein format
CHEMBL442337 OBDepict SH NH O H O OH H 3 C CH 3 IC50 = 4.5 nM 309.43 CC(C)C[C@@H](NC(=O)C(CS)Cc1ccccc1)C(=O)O Homo sapiens CHEMBL752995 single protein format
CHEMBL3676141 OBDepict CH 3 O N H H O O OH O HO IC50 = 4.5 nM 385.42 COc1ccccc1-c1ccc(C[C@H](CC(=O)O)NC(=O)CCC(=O)O)cc1 Homo sapiens CHEMBL4339144 cell-based format
CHEMBL4080935 OBDepict HO O O SH S Ki = 4.6 nM 388.55 O=C(O)C(CC(=O)C1(S)CCCCC1)Cc1ccc(-c2ccsc2)cc1 Homo sapiens CHEMBL4056822 single protein format
CHEMBL224670 OBDepict H 3 C O H O OH HN O F IC50 = 4.6 nM 379.47 COCC[C@H](CC1(C(=O)NCCCc2ccc(F)cc2)CCCC1)C(=O)O Homo sapiens CHEMBL914049 single protein format
CHEMBL10247 OBDepict SH N H O O OH Ki = 4.7 nM 253.32 O=C(O)CNC(=O)C(CS)Cc1ccccc1 Homo sapiens CHEMBL753641 single protein format
CHEMBL10247 OBDepict SH N H O O OH IC50 = 4.8 nM 253.32 O=C(O)CNC(=O)C(CS)Cc1ccccc1 Homo sapiens CHEMBL754363 single protein format
CHEMBL10251 OBDepict H N N N N N H H P O OH OH IC50 = 4.8 nM 499.51 O=P(O)(O)C(Cc1cccc2ccccc12)N[C@@H](Cc1ccc(-c2ccccc2)cc1)c1nnn[nH]1 Homo sapiens CHEMBL754363 single protein format
CHEMBL1778531 OBDepict CH 3 O N H H O HO N H O H O HO O N IC50 = 4.8 nM 459.5 COCC[C@H](NC1(C(=O)N[C@@H](Cc2nc(-c3ccccc3)co2)C(=O)O)CCCC1)C(=O)O Homo sapiens CHEMBL1780284 single protein format
CHEMBL81232 OBDepict HS N H O O HO Ki = 4.9 nM 251.31 O=C(O)CNC(=O)/C(=Cc1ccccc1)CS Homo sapiens CHEMBL753641 single protein format
CHEMBL1778533 OBDepict H 3 C O NH H O OH N H O H O OH O N H 3 C IC50 = 5.0 nM 473.53 COCC[C@H](NC1(C(=O)N[C@@H](Cc2nc(C)c(-c3ccccc3)o2)C(=O)O)CCCC1)C(=O)O Homo sapiens CHEMBL1780284 single protein format
CHEMBL285619 OBDepict H N N N N N H H P O OH OH IC50 = 5.0 nM 513.54 O=P(O)(O)C(CCc1cccc2ccccc12)N[C@@H](Cc1ccc(-c2ccccc2)cc1)c1nnn[nH]1 Homo sapiens CHEMBL751028 single protein format
CHEMBL273142 OBDepict HO O HN H N O OH H CH 3 CH 3 H 3 C O HO IC50 = 5.0 nM 416.47 CC(C)(C)CN(C[C@H](O)C(=O)O)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)O Homo sapiens CHEMBL930674 single protein format
CHEMBL11607 OBDepict SH CH 3 HN O F O OH F OH IC50 = 5.2 nM 409.45 CC(c1ccc(F)c(F)c1)C(CS)C(=O)NC(Cc1ccc(O)cc1)C(=O)O Homo sapiens CHEMBL755096 organism-based format
CHEMBL2051772 OBDepict SH H CH 3 H NH O H O HO Ki = 5.3 nM 357.48 C[C@H](c1ccccc1)[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)O Homo sapiens CHEMBL755097 organism-based format
CHEMBL4518426 OBDepict H 3 C N H H O O HO O OH IC50 = 5.4 nM 383.44 CCc1cccc(-c2ccc(C[C@H](CC(=O)O)NC(=O)CCC(=O)O)cc2)c1 Homo sapiens CHEMBL4339144 cell-based format
CHEMBL37539 OBDepict OH O N H O H H O OH O IC50 = 5.9 nM 461.51 O=C(O)CNC(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)C[C@H](COc1ccccc1)C(=O)O Homo sapiens CHEMBL752989 single protein format
CHEMBL273724 OBDepict SH CH 3 HN O O OH F OH IC50 = 5.9 nM 391.46 CC(c1ccc(F)cc1)C(CS)C(=O)NC(Cc1ccc(O)cc1)C(=O)O Homo sapiens CHEMBL755096 organism-based format
CHEMBL1778535 OBDepict H 3 C O NH H O OH N H O H O OH N O N IC50 = 6.0 nM 460.49 COCC[C@H](NC1(C(=O)N[C@@H](Cc2nnc(-c3ccccc3)o2)C(=O)O)CCCC1)C(=O)O Homo sapiens CHEMBL1780284 single protein format
CHEMBL417007 OBDepict H N H O H 3 C H O OH O HO IC50 = 6.0 nM 383.44 C[C@H](C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)O)C(=O)O Homo sapiens CHEMBL4339144 cell-based format
CHEMBL257251 OBDepict CH 3 H 3 C N HN O P H O OH HO O OH IC50 = 6.0 nM 422.42 CC(C)CN(CCP(=O)(O)O)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)O Homo sapiens CHEMBL930674 single protein format
CHEMBL270576 OBDepict CH 3 CH 3 N NH O HO H H O HO O HO HO IC50 = 6.0 nM 368.39 CC(C)CN(C[C@H](O)C(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O Homo sapiens CHEMBL930674 single protein format
CHEMBL389061 OBDepict CH 3 O H O HO NH O H H O H 3 C IC50 = 6.1 nM 389.49 COCC[C@H](CC1(C(=O)N[C@@H]2C[C@H]2c2ccc(OC)cc2)CCCC1)C(=O)O Homo sapiens CHEMBL914049 single protein format
CHEMBL6915 OBDepict HS CH 3 NH O O OH CH 3 IC50 = 6.3 nM 295.4 CCC(NC(=O)C(CS)C(C)c1ccccc1)C(=O)O Homo sapiens CHEMBL755096 organism-based format
CHEMBL3676140 OBDepict HO O N H H O O OH F IC50 = 6.7 nM 373.38 O=C(O)CCC(=O)N[C@@H](CC(=O)O)Cc1ccc(-c2cccc(F)c2)cc1 Homo sapiens CHEMBL4339144 cell-based format
CHEMBL415967 OBDepict H N N N N N H H P O OH OH IC50 = 6.9 nM 499.51 O=P(O)(O)C(Cc1ccc2ccccc2c1)N[C@@H](Cc1ccc(-c2ccccc2)cc1)c1nnn[nH]1 Homo sapiens CHEMBL754363 single protein format