HOME LIGAND hPROTEOME OTHERS DOCUMENT

P09769 | FGR_HUMAN | Tyrosine-protein kinase Fgr (FGR)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3647967 OBDepict CH 2 HN O H H N N N N H 2 N O IC50 = 0.4 nM 454.53 C=CC(=O)N[C@H]1CC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 Homo sapiens CHEMBL3887539 single protein format
CHEMBL364623 OBDepict CH 3 N N H N H 3 C N S N H O H 3 C Cl IC50 = 0.8 nM 373.87 Cc1cc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)nc(C)n1 Homo sapiens CHEMBL910566 single protein format
CHEMBL288441 OBDepict CH 3 O O N N H N N Cl O H 3 C Cl N CH 3 IC50 = 1.1 nM 530.46 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl Homo sapiens CHEMBL1244326 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 1.15 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328423 single protein format
CHEMBL2151321 OBDepict CH 3 O H 3 C N H N N N N NH CH 3 H N F IC50 = 2.2 nM 381.42 CC(C)Oc1cc(-n2cnc3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 Homo sapiens CHEMBL2154704 single protein format
CHEMBL1873475 OBDepict CH 2 N O H N N N N H 2 N O IC50 = 2.3 nM 440.51 C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 Homo sapiens CHEMBL3887539 single protein format
CHEMBL2336005 OBDepict OH NH S N N O IC50 = 3.7 nM 417.53 Oc1cccc(Nc2ccnc3cc(-c4cccc(CN5CCOCC5)c4)sc23)c1 Homo sapiens CHEMBL3707718 cell membrane format
CHEMBL4877846 OBDepict O N H O N N H CH 3 H 3 C CH 3 N N N H CH 3 N H 3 C N H 3 C CH 3 IC50 = 5.36 nM 566.71 Cc1nn(C(C)C)c(C)c1-c1nc2c(-c3ccc4c(c3)CCCC[C@H]4NC(=O)c3nc(C(C)(C)C)no3)ccnc2[nH]1 Homo sapiens CHEMBL4822490 single protein format
CHEMBL3928976 OBDepict Cl O NH 2 N CH 3 H N O O N OH H 3 C H 3 C Cl IC50 = 15.0 nM 587.46 Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)cc2c(Cl)cccn2c1=O Homo sapiens CHEMBL4672812 single protein format
CHEMBL4077588 OBDepict F N HN O N H 2 N N N H N F F F O IC50 = 22.0 nM 583.59 Nc1nccn2c([C@@H]3CCCN(C4CCOCC4)C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 Homo sapiens CHEMBL4057958 single protein format
CHEMBL4749037 OBDepict O O N H H N N N H 2 N HN O N F F F IC50 = 26.0 nM 537.5 Nc1nccn2c([C@@H]3CC[C@H]4COC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 Homo sapiens CHEMBL4727422 single protein format
CHEMBL4525187 OBDepict H 2 N N N N H N O H O IC50 = 28.0 nM 441.54 Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2C[C@H]1CCCN1C[C@@H]1CO1 Homo sapiens CHEMBL4347060 single protein format
CHEMBL4076024 OBDepict CH 3 O N O H N N N H 2 N F N H O N F F F IC50 = 28.0 nM 571.54 COCC(=O)N1CCC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 Homo sapiens CHEMBL4057958 single protein format
CHEMBL3116050 OBDepict F N N N H CH 3 H N N HN N H N N CH 3 IC50 = 33.0 nM 353.37 C[C@H](Nc1nc(Nc2cn(C)cn2)c2cc[nH]c2n1)c1ncc(F)cn1 Homo sapiens CHEMBL3118224 single protein format
CHEMBL4108687 OBDepict O O N H 3 C CH 3 H H N N N H 2 N N H O N F F F IC50 = 34.0 nM 565.56 CC1(C)OC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@H]21 Homo sapiens CHEMBL4727422 single protein format
CHEMBL4103954 OBDepict O N H CH 3 H N N N H 2 N F HN O N F F F IC50 = 37.0 nM 581.57 C[C@H]1CC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)CN1C(=O)C1CC1 Homo sapiens CHEMBL4717041 single protein format
CHEMBL4060757 OBDepict F N NH O N NH 2 N N H O N F F F O IC50 = 39.0 nM 585.56 Nc1nccn2c([C@H]3CN(C4CCOCC4)CCO3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 Homo sapiens CHEMBL4057958 single protein format
CHEMBL4862806 OBDepict CH 3 N N N H 2 N CH 3 NH O F F F F F F IC50 = 41.0 nM 543.47 Cc1ccc(C(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1C#Cc1cc(-c2cnn(C)c2)cnc1N Homo sapiens CHEMBL4839598 single protein format
CHEMBL3586447 OBDepict CH 3 N N N H N NH 2 O NH 2 IC50 = 41.0 nM 318.34 Cc1cc2cn[nH]c2cc1-c1cccc2c(N)c(C(N)=O)nnc12 Homo sapiens CHEMBL3588280 single protein format
CHEMBL386637 OBDepict H 3 C N H 3 C H N N H O F F F F N N H 2 N IC50 = 43.0 nM 526.54 CN(C)[C@H]1CCCN(c2ccc(C(F)(F)F)cc2NC(=O)c2cc(C#Cc3cnc(N)nc3)ccc2F)C1 Homo sapiens CHEMBL910176 single protein format
CHEMBL4799627 OBDepict O N CH 3 O H N N N NH 2 F N H O N F F F IC50 = 55.0 nM 597.57 CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4F)c4c(N)nccn34)C2)COC1 Homo sapiens CHEMBL4717041 single protein format
CHEMBL4114929 OBDepict CH 3 O N N H O N H 2 N N N H N F F F H O IC50 = 64.0 nM 565.56 COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 Homo sapiens CHEMBL4727422 single protein format
CHEMBL3753341 OBDepict NH 2 N N N N N O H 3 C CH 3 IC50 = 65.0 nM 284.32 CC(C)n1nc(-c2cc(C3CC3)on2)c2c(N)ncnc21 Homo sapiens CHEMBL3757135 single protein format
CHEMBL4062498 OBDepict CH 3 O N O O H N N N H 2 N F N H O N F F F IC50 = 69.0 nM 573.51 COCC(=O)N1CCO[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 Homo sapiens CHEMBL4057958 single protein format
CHEMBL2177736 OBDepict NH 2 O N NH N HN H N H H 2 N N N IC50 = 81.0 nM 393.45 NC(=O)c1cnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc(-n2nccn2)c1 Homo sapiens CHEMBL3707994 single protein format
CHEMBL4640601 OBDepict H 3 C O O H 3 C N N N O NH 2 N H 3 C IC50 = 98.0 nM 459.55 COc1ccc(-c2cnn3c(N)c(-c4ccccc4)c(OC4CCN(C)CC4)nc23)cc1OC Homo sapiens CHEMBL4605800 cell-based format
CHEMBL4095253 OBDepict CH 2 S N O O H N N N H 2 N O O IC50 = 133.3 nM 427.49 C=CS(=O)(=O)N1CCC[C@@H]1Cn1cc(-c2ccc3c(c2)OCO3)c2c(N)ncnc21 Homo sapiens CHEMBL4058131 cell-based format
CHEMBL4069387 OBDepict O N CH 3 H 3 C H N N N H 2 N F N H O N F F F IC50 = 203.0 nM 569.56 CC(C)C(=O)N1CCC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 Homo sapiens CHEMBL4057958 single protein format
CHEMBL4107779 OBDepict O N H H N N N H 2 N O N H O N F F F IC50 = 263.0 nM 591.59 Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3OC3CC3)c12 Homo sapiens CHEMBL4727422 single protein format
CHEMBL4075954 OBDepict O N CH 3 H 3 C O H N N N H 2 N F N H O N F F F IC50 = 268.0 nM 571.54 CC(C)C(=O)N1CCO[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 Homo sapiens CHEMBL4057958 single protein format
CHEMBL460472 OBDepict CH 3 O N O N N H O CH 3 N O N OH CH 3 H 3 C IC50 = 328.0 nM 539.59 COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1 Homo sapiens CHEMBL985576 single protein format
CHEMBL272198 OBDepict CH 3 O O H 3 C O N NH O IC50 = 396.0 nM 414.46 COc1cc2nccc(Oc3ccc4c(C(=O)NC5CC5)cccc4c3)c2cc1OC Homo sapiens CHEMBL950239 single protein format
CHEMBL4634073 OBDepict CH 3 O N H O O N NH 2 N N N H 3 C O O H 3 C H 3 C IC50 = 440.0 nM 532.6 COC(=O)Nc1ccc(-c2c(OC3CCN(C)CC3)nc3c(-c4ccc(OC)c(OC)c4)cnn3c2N)cc1 Homo sapiens CHEMBL4605800 cell-based format
CHEMBL4281823 OBDepict CH 3 N N N NH 2 N O O F F F IC50 = 470.0 nM 481.48 CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL4261444 single protein format
CHEMBL4755698 OBDepict H 2 C N O N N N H 2 N O O IC50 = 657.4 nM 405.46 C=CC(=O)N1CCC(Cn2cc(-c3ccc4c(c3)OCO4)c3c(N)ncnc32)CC1 Homo sapiens CHEMBL4720247 single protein format
CHEMBL1922094 OBDepict O N OH CH 3 H N S CH 3 N N N O N N H 2 N IC50 = 697.0 nM 498.61 Cc1c(CN2CCN(C(=O)[C@H](C)O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 Homo sapiens CHEMBL1925484 single protein format