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P09871 | C1S_HUMAN | Complement C1s subcomponent (C1S)

3D structures mapped by conservation among orthologs

[ Domain: "Spermadhesin, CUB domain" // CUB ]

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[ Domain: "FMN-binding split barrel 2" // Trypsin_1 ]

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[ Domain: "EGF/Laminin" // EGF_CA ]

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[ Domain: "Complement control module/SCR domain" // Sushi ]

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[ Domain: "Complement control module/SCR domain" // Sushi_3 ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4244141 OBDepict O S O O S S H 3 C NH H 2 N Ki = 6.0 nM 416.55 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2cccc(C=O)c2)c1 Homo sapiens CHEMBL4229691 single protein format
CHEMBL205904 OBDepict CH 3 S S S O O Br N N F F HN NH 2 Ki = 10.0 nM 557.47 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2c(c1)ncn2Cc1cc(F)ccc1F Homo sapiens CHEMBL865639 single protein format
CHEMBL399284 OBDepict H 3 C S S S O O H 3 C HN O S O O CH 3 NH H 2 N Ki = 14.0 nM 565.76 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2c(C)cccc2NC(=O)CCCS(C)(=O)=O)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL377090 OBDepict CH 3 S S S O O Br N N Cl Cl HN NH 2 Ki = 20.0 nM 590.38 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2c(c1)ncn2Cc1c(Cl)cccc1Cl Homo sapiens CHEMBL865639 single protein format
CHEMBL401398 OBDepict CH 3 S S S O O H 3 C NH 2 HN NH 2 Ki = 20.0 nM 417.58 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2c(C)cccc2N)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL403782 OBDepict H 3 C S S S O O HN H 3 C HN O O OH NH H 2 N Ki = 22.0 nM 574.75 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2c(C)cccc2NC(=O)NCCCCCC(=O)O)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL4239924 OBDepict CH 3 S S S N NH H 2 N N H S O O F F Ki = 30.0 nM 522.65 CSc1sc(C(=N)N)cc1-c1nc(-c2cccc(NS(=O)(=O)c3ccc(F)cc3F)c2)cs1 Homo sapiens CHEMBL4229691 single protein format
CHEMBL438807 OBDepict CH 3 S S S O O Br N N HN NH 2 Ki = 30.0 nM 521.49 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2c(c1)ncn2Cc1ccccc1 Homo sapiens CHEMBL865639 single protein format
CHEMBL413993 OBDepict CH 3 S S S O O CH 3 HN NH 2 Ki = 30.0 nM 402.57 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2ccccc2C)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL377281 OBDepict CH 3 S S S O O Br N N F + N O _ O HN NH 2 Ki = 30.0 nM 584.47 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2c(c1)ncn2Cc1cc([N+](=O)[O-])ccc1F Homo sapiens CHEMBL865639 single protein format
CHEMBL382350 OBDepict CH 3 S S S O O Br N N F F HN NH 2 Ki = 40.0 nM 557.47 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2c(c1)ncn2Cc1c(F)cccc1F Homo sapiens CHEMBL865639 single protein format
CHEMBL252998 OBDepict CH 3 S S S O O Cl HN NH 2 Ki = 40.0 nM 422.98 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2ccccc2Cl)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL252004 OBDepict CH 3 S S S O O N CH 3 HN NH 2 Ki = 40.0 nM 403.55 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2cccc(C)n2)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL252203 OBDepict H 3 C S S S O O H 3 C HN O O OH NH H 2 N Ki = 42.0 nM 545.71 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2c(C)cccc2NC(=O)CCCCC(=O)O)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL2220483 OBDepict H 2 N NH S O O S IC50 = 46.0 nM 302.38 N=C(N)c1cc2ccc(OC(=O)c3cccs3)cc2s1 Homo sapiens CHEMBL4229686 assay format
CHEMBL206020 OBDepict CH 3 S S S O O Br N N H 3 C CH 3 HN NH 2 Ki = 50.0 nM 499.48 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2c(c1)ncn2CC=C(C)C Homo sapiens CHEMBL865639 single protein format
CHEMBL253646 OBDepict H 3 C S S S O O H 3 C OH NH H 2 N Ki = 50.0 nM 432.59 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2c(C)cccc2CO)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL319394 OBDepict CH 3 N N N S S S H 3 C HN NH 2 Ki = 60.0 nM 439.64 CCCc1c(-c2csc(-c3cc(C(=N)N)sc3SC)n2)cnn1-c1ccccc1 Homo sapiens CHEMBL666759 single protein format
CHEMBL254283 OBDepict H 3 C S S S O O H 3 C HN HN O N N N N H NH H 2 N Ki = 64.0 nM 556.7 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2c(C)cccc2NC(=O)NCCc2nn[nH]n2)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL317917 OBDepict CH 3 O N N N N S S S CH 3 NH H 2 N Ki = 70.0 nM 456.62 CCCOc1c(-c2csc(-c3cc(C(=N)N)sc3SC)n2)cnn1-c1ccccn1 Homo sapiens CHEMBL666759 single protein format
CHEMBL381771 OBDepict H 2 C N N Br S O O S S H 3 C HN NH 2 Ki = 70.0 nM 471.43 C=CCn1cnc2cc(S(=O)(=O)c3cc(C(=N)N)sc3SC)cc(Br)c21 Homo sapiens CHEMBL865639 single protein format
CHEMBL321341 OBDepict CH 3 O N N N S S S H 3 C HN NH 2 Ki = 90.0 nM 441.61 CCOc1c(-c2csc(-c3cc(C(=N)N)sc3SC)n2)cnn1-c1ccccc1 Homo sapiens CHEMBL666759 single protein format
CHEMBL382443 OBDepict CH 3 S S S O O Cl N N F F HN NH 2 Ki = 100.0 nM 513.02 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Cl)c2c(c1)ncn2Cc1c(F)cccc1F Homo sapiens CHEMBL865639 single protein format
CHEMBL205385 OBDepict H 3 C S S S O O Cl N N F F NH H 2 N Ki = 100.0 nM 513.02 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Cl)c2ncn(Cc3c(F)cccc3F)c2c1 Homo sapiens CHEMBL865639 single protein format
CHEMBL252619 OBDepict H 3 C S S S O O H 3 C HN O S O O CH 3 NH H 2 N Ki = 120.0 nM 537.71 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2c(C)cccc2NC(=O)CS(C)(=O)=O)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL252794 OBDepict H 3 C S S S O O OH NH H 2 N Ki = 120.0 nM 418.57 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2ccccc2CO)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL273264 OBDepict NH 2 HN NH O O NH H 2 N IC50 = 140.0 nM 347.38 N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1 Homo sapiens CHEMBL655973 single protein format
CHEMBL253430 OBDepict CH 3 S S S O O CH 2 HN NH 2 Ki = 140.0 nM 414.58 C=Cc1ccccc1-c1cccc(S(=O)(=O)c2cc(C(=N)N)sc2SC)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL252793 OBDepict CH 3 S S S O O OH HN NH 2 Ki = 150.0 nM 404.54 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2cccc(O)c2)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL400375 OBDepict H 3 C S S S O O H 3 C O OH NH H 2 N Ki = 150.0 nM 446.58 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2c(C)cccc2C(=O)O)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL322834 OBDepict H 3 C S S S N NH H 2 N N N Ki = 150.0 nM 397.55 CSc1sc(C(=N)N)cc1-c1nc(-c2cnn(-c3ccccc3)c2)cs1 Homo sapiens CHEMBL666759 single protein format
CHEMBL426490 OBDepict H 3 C S S S O O Br N N Cl Cl NH H 2 N Ki = 160.0 nM 590.38 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2ncn(Cc3c(Cl)cccc3Cl)c2c1 Homo sapiens CHEMBL865639 single protein format
CHEMBL381097 OBDepict H 3 C S S S O O Br N N F + N O _ O NH H 2 N Ki = 170.0 nM 584.47 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2ncn(Cc3cc([N+](=O)[O-])ccc3F)c2c1 Homo sapiens CHEMBL865639 single protein format
CHEMBL205804 OBDepict H 3 C S S S O O Br N N F F NH H 2 N Ki = 170.0 nM 557.47 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2ncn(Cc3c(F)cccc3F)c2c1 Homo sapiens CHEMBL865639 single protein format
CHEMBL205342 OBDepict H 3 C S S S O O Br N N NH H 2 N Ki = 180.0 nM 507.46 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2ncn(-c3ccccc3)c2c1 Homo sapiens CHEMBL865639 single protein format
CHEMBL400497 OBDepict CH 3 S S S O O HO HN NH 2 Ki = 190.0 nM 404.54 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2ccc(O)cc2)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL106388 OBDepict CH 3 N N H 3 C N S S S CH 3 NH NH 2 Ki = 190.0 nM 377.56 CCCc1nn(C)cc1-c1csc(-c2cc(C(=N)N)sc2SC)n1 Homo sapiens CHEMBL666759 single protein format
CHEMBL380315 OBDepict H 3 C S S S O O Br N N CH 3 CH 3 NH H 2 N Ki = 200.0 nM 499.48 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2ncn(CC=C(C)C)c2c1 Homo sapiens CHEMBL865639 single protein format
CHEMBL377934 OBDepict H 2 C N N S Br O O S S CH 3 NH H 2 N Ki = 210.0 nM 471.43 C=CCn1cnc2c(Br)cc(S(=O)(=O)c3cc(C(=N)N)sc3SC)cc21 Homo sapiens CHEMBL865639 single protein format
CHEMBL438267 OBDepict H 3 C S S S O O Br N N F F NH H 2 N Ki = 240.0 nM 557.47 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2ncn(Cc3cc(F)ccc3F)c2c1 Homo sapiens CHEMBL865639 single protein format
CHEMBL252591 OBDepict CH 3 S S S O O H 3 C HN NH 2 Ki = 250.0 nM 402.57 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2ccc(C)cc2)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL252393 OBDepict CH 3 S S S O O HN NH 2 Ki = 260.0 nM 388.54 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2ccccc2)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL317917 OBDepict CH 3 O N N N N S S S CH 3 NH H 2 N IC50 = 300.0 nM 456.62 CCCOc1c(-c2csc(-c3cc(C(=N)N)sc3SC)n2)cnn1-c1ccccn1 Homo sapiens CHEMBL885071 single protein format
CHEMBL204679 OBDepict CH 3 S S S O O Br N N HN NH 2 Ki = 310.0 nM 507.46 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2c(c1)ncn2-c1ccccc1 Homo sapiens CHEMBL865639 single protein format
CHEMBL205657 OBDepict CH 3 S S S O O Br N N CH 3 HN NH 2 Ki = 330.0 nM 445.39 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2ncn(C)c2c1 Homo sapiens CHEMBL865639 single protein format
CHEMBL205578 OBDepict CH 3 S S S O O Br N N CH 3 H HN NH 2 Ki = 330.0 nM 535.51 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2c(c1)ncn2[C@@H](C)c1ccccc1 Homo sapiens CHEMBL865639 single protein format
CHEMBL318576 OBDepict CH 3 N CH 3 N N S S S H 3 C HN H 2 N Ki = 330.0 nM 377.56 CCCc1c(-c2csc(-c3cc(C(=N)N)sc3SC)n2)cnn1C Homo sapiens CHEMBL666759 single protein format
CHEMBL415092 OBDepict CH 3 O S O O S S CH 3 HN NH 2 Ki = 350.0 nM 418.57 COc1ccc(-c2cccc(S(=O)(=O)c3cc(C(=N)N)sc3SC)c2)cc1 Homo sapiens CHEMBL927223 single protein format
CHEMBL398527 OBDepict CH 3 S S S O O Br HN NH 2 Ki = 360.0 nM 391.34 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(Br)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL205354 OBDepict CH 3 S S S O O Br N N CH 3 H HN NH 2 Ki = 380.0 nM 535.51 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2c(c1)ncn2[C@H](C)c1ccccc1 Homo sapiens CHEMBL865639 single protein format
CHEMBL380325 OBDepict CH 3 S S S O O Br N N H 3 C HN NH 2 Ki = 400.0 nM 445.39 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2c(c1)ncn2C Homo sapiens CHEMBL865639 single protein format
CHEMBL205698 OBDepict CH 3 S S S O O Br N N H HN NH 2 Ki = 400.0 nM 431.36 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2[nH]cnc2c1 Homo sapiens CHEMBL865639 single protein format
CHEMBL204889 OBDepict CH 3 S S S O O N N HN NH 2 Ki = 400.0 nM 442.59 CSc1sc(C(=N)N)cc1S(=O)(=O)c1ccc2c(c1)ncn2Cc1ccccc1 Homo sapiens CHEMBL865639 single protein format
CHEMBL379523 OBDepict H 3 C S S S O O Br N N NH H 2 N Ki = 400.0 nM 521.49 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cc(Br)c2ncn(Cc3ccccc3)c2c1 Homo sapiens CHEMBL865639 single protein format
CHEMBL380318 OBDepict CH 3 S S S O O HN NH 2 Ki = 410.0 nM 362.5 CSc1sc(C(=N)N)cc1S(=O)(=O)c1ccc2ccccc2c1 Homo sapiens CHEMBL865639 single protein format
CHEMBL29304 OBDepict CH 3 S S S N HN NH 2 H 3 C Ki = 420.0 nM 345.52 CSc1sc(C(=N)N)cc1-c1nc(-c2ccc(C)cc2)cs1 Homo sapiens CHEMBL666759 single protein format
CHEMBL204936 OBDepict H 3 C S S S O O N N NH H 2 N Ki = 420.0 nM 442.59 CSc1sc(C(=N)N)cc1S(=O)(=O)c1ccc2ncn(Cc3ccccc3)c2c1 Homo sapiens CHEMBL865639 single protein format
CHEMBL286243 OBDepict CH 3 S S S N HN NH 2 Cl Ki = 436.0 nM 365.94 CSc1sc(C(=N)N)cc1-c1nc(-c2ccc(Cl)cc2)cs1 Homo sapiens CHEMBL666759 single protein format
CHEMBL28875 OBDepict CH 3 S S S N HN NH 2 S Ki = 450.0 nM 387.58 CSc1sc(C(=N)N)cc1-c1nc(-c2csc3ccccc23)cs1 Homo sapiens CHEMBL666759 single protein format
CHEMBL252592 OBDepict CH 3 S S S O O OH HN NH 2 Ki = 460.0 nM 404.54 CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2ccccc2O)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL102417 OBDepict CH 3 S S S N HN NH 2 N N H 3 C Ki = 460.0 nM 335.48 CSc1sc(C(=N)N)cc1-c1nc(-c2cnn(C)c2)cs1 Homo sapiens CHEMBL666759 single protein format
CHEMBL29205 OBDepict CH 3 O N S S S CH 3 HN H 2 N Ki = 470.0 nM 361.52 COc1cccc(-c2csc(-c3cc(C(=N)N)sc3SC)n2)c1 Homo sapiens CHEMBL666759 single protein format
CHEMBL29290 OBDepict CH 3 S S S N HN NH 2 Ki = 490.0 nM 381.55 CSc1sc(C(=N)N)cc1-c1nc(-c2ccc3ccccc3c2)cs1 Homo sapiens CHEMBL666759 single protein format
CHEMBL399262 OBDepict CH 3 O S O O S S CH 3 HN NH 2 Ki = 490.0 nM 418.57 COc1cccc(-c2cccc(S(=O)(=O)c3cc(C(=N)N)sc3SC)c2)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL287292 OBDepict CH 3 S S S N HN NH 2 O Ki = 520.0 nM 361.52 CSc1sc(C(=N)N)cc1-c1nc(COc2ccccc2)cs1 Homo sapiens CHEMBL666759 single protein format
CHEMBL102835 OBDepict H 3 C S S S N NH NH 2 N O N Ki = 530.0 nM 481.67 CSc1sc(C(=N)N)cc1-c1nc(-c2cnn(-c3ccccc3)c2OCC2CCC2)cs1 Homo sapiens CHEMBL666759 single protein format
CHEMBL281899 OBDepict CH 3 S S S N HN NH 2 Ki = 560.0 nM 331.49 CSc1sc(C(=N)N)cc1-c1nc(-c2ccccc2)cs1 Homo sapiens CHEMBL666759 single protein format
CHEMBL382447 OBDepict CH 3 S S S O O N N N HN NH 2 Ki = 580.0 nM 443.58 CSc1sc(C(=N)N)cc1S(=O)(=O)c1ccc2c(c1)ncn2Cc1ccccn1 Homo sapiens CHEMBL865639 single protein format
CHEMBL401087 OBDepict CH 3 S S S O O O CH 3 HN NH 2 Ki = 610.0 nM 418.57 COc1ccccc1-c1cccc(S(=O)(=O)c2cc(C(=N)N)sc2SC)c1 Homo sapiens CHEMBL927223 single protein format
CHEMBL286267 OBDepict CH 3 O O CH 3 N S S S CH 3 HN H 2 N Ki = 640.0 nM 391.54 COc1ccc(-c2csc(-c3cc(C(=N)N)sc3SC)n2)c(OC)c1 Homo sapiens CHEMBL666759 single protein format
CHEMBL31549 OBDepict CH 3 S S S N HN NH 2 S Ki = 700.0 nM 337.52 CSc1sc(C(=N)N)cc1-c1nc(-c2cccs2)cs1 Homo sapiens CHEMBL666759 single protein format
CHEMBL205489 OBDepict CH 3 S S S O O HN NH 2 Ki = 750.0 nM 312.44 CSc1sc(C(=N)N)cc1S(=O)(=O)c1ccccc1 Homo sapiens CHEMBL865639 single protein format
CHEMBL28949 OBDepict CH 3 S S S N HN NH 2 CH 3 Ki = 850.0 nM 345.52 CSc1sc(C(=N)N)cc1-c1nc(-c2ccccc2C)cs1 Homo sapiens CHEMBL666759 single protein format
CHEMBL283080 OBDepict CH 3 S S S N NH H 2 N O H 3 C Ki = 850.0 nM 361.52 COc1ccccc1-c1csc(-c2cc(C(=N)N)sc2SC)n1 Homo sapiens CHEMBL666759 single protein format
CHEMBL413764 OBDepict H 3 C S S S N NH H 2 N + N Cl O _ O Ki = 860.0 nM 410.93 CSc1sc(C(=N)N)cc1-c1nc(-c2ccc(Cl)c([N+](=O)[O-])c2)cs1 Homo sapiens CHEMBL666759 single protein format
CHEMBL28723 OBDepict CH 3 S S S N HN NH 2 N Cl Ki = 870.0 nM 366.92 CSc1sc(C(=N)N)cc1-c1nc(-c2cnccc2Cl)cs1 Homo sapiens CHEMBL666759 single protein format
CHEMBL4247936 OBDepict O N H H N O H 3 C CH 3 Cl Cl N H O S HN NH 2 IC50 = 900.0 nM 536.49 CC(C)[C@@H](NC(=O)Cc1c(Cl)cccc1Cl)C(=O)N1CC=CC1C(=O)NCc1ccc(C(=N)N)s1 Homo sapiens CHEMBL4229690 single protein format
CHEMBL28618 OBDepict CH 3 S S S N NH H 2 N O H 3 C Ki = 900.0 nM 361.52 COc1ccc(-c2csc(-c3cc(C(=N)N)sc3SC)n2)cc1 Homo sapiens CHEMBL666759 single protein format
CHEMBL286498 OBDepict CH 3 S S S N HN NH 2 H 3 C Ki = 960.0 nM 345.52 CSc1sc(C(=N)N)cc1-c1nc(-c2cccc(C)c2)cs1 Homo sapiens CHEMBL666759 single protein format
CHEMBL29006 OBDepict CH 3 S S S N HN NH 2 + N O _ O Ki = 1000.0 nM 376.49 CSc1sc(C(=N)N)cc1-c1nc(-c2ccc([N+](=O)[O-])cc2)cs1 Homo sapiens CHEMBL666759 single protein format