P10253 | LYAG_HUMAN | Lysosomal alpha-glucosidase (GAA)

3D structures mapped by conservation among orthologs

[ Domain: "Glycosyl hydrolase domain" // Glyco_hydro_31_C ]

download pymol session

[ Domain: "supersandwich" // Gal_mutarotas_2,Trefoil ]

download pymol session

[ Domain: "supersandwich" // Gal_mutarotas_2 ]

download pymol session

[ Domain: "TIM barrels" // Glyco_hydro_31_N ]

download pymol session

[ Domain: "Trefoil/Plexin domain-like" // Trefoil ]

download pymol session

[ Domain: "Putative glucosidase YicI, C-terminal domain" // DUF5110_1 ]

download pymol session

[ Domain: pdbs with more than 2 multi-domains ]

download pymol session

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id	structure	assay_type	relation	values	units	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL86772		IC50	=	10.3	nM	280.28	OCC12OC(Nc3ccccc3)=NC1C(O)C(O)C2O	Homo sapiens	CHEMBL647267	single protein format
CHEMBL476960		IC50	=	70.0	nM	267.28	OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O	Homo sapiens	CHEMBL993579	cell-based format
CHEMBL1029		IC50	=	100.0	nM	219.28	CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO	Homo sapiens	CHEMBL1040324	single protein format
CHEMBL307429		Ki	=	150.0	nM	163.17	OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O	Homo sapiens	CHEMBL649344	single protein format
CHEMBL1561		IC50	=	350.0	nM	207.23	OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO	Homo sapiens	CHEMBL993567	single protein format
CHEMBL574645		IC50	=	400.0	nM	397.56	OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2	Homo sapiens	CHEMBL1040324	single protein format
CHEMBL88413		IC50	=	402.0	nM	179.17	NC1C(O)C(O)C(O)C1(O)CO	Homo sapiens	CHEMBL647267	single protein format
CHEMBL75971		Ki	=	420.0	nM	177.2	CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO	Homo sapiens	CHEMBL649344	single protein format
CHEMBL1088158		IC50	=	500.0	nM	397.56	OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2	Homo sapiens	CHEMBL1099885	single protein format
CHEMBL1603014		IC50	=	940.0	nM	399.47	CC(=O)c1ccc(N2CCN(S(=O)(=O)c3ccc4c(c3)CC(=O)N4)CC2)cc1	Homo sapiens	CHEMBL2183407	single protein format
CHEMBL432221		Ki	=	1000.0	nM	275.42	C[Si](C)(C)/C=C/CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO	Homo sapiens	CHEMBL649344	single protein format
CHEMBL307429		IC50	=	1000.0	nM	163.17	OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O	Homo sapiens	CHEMBL993567	single protein format
CHEMBL501355		IC50	=	1000.0	nM	193.2	OC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O	Homo sapiens	CHEMBL993567	single protein format