HOME LIGAND hPROTEOME OTHERS DOCUMENT

P10276 | RARA_HUMAN | Retinoic acid receptor alpha (RARA)

3D structures mapped by conservation among orthologs

[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep_1 ]

download pymol session

[ Domain: "LIM domain-like" // zf-C4 ]

download pymol session



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL38 OBDepict CH 3 CH 3 CH 3 H 3 C CH 3 O OH Ki = 0.1 nM 300.44 CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 Homo sapiens CHEMBL799977 single protein format
CHEMBL134375 OBDepict HO O N H CH 3 H 3 C H 3 C CH 3 IC50 = 0.45 nM 373.5 CC1(C)CCC(C)(C)c2cc(-c3ccc(-c4ccc(C(=O)O)cc4)[nH]3)ccc21 Homo sapiens CHEMBL799791 single protein format
CHEMBL38 OBDepict CH 3 CH 3 CH 3 H 3 C CH 3 O OH IC50 = 0.89 nM 300.44 CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 Homo sapiens CHEMBL799873 single protein format
CHEMBL133725 OBDepict H N N N CH 3 CH 3 O OH H 3 C H 3 C IC50 = 2.2 nM 375.47 CC1(C)CCC(C)(C)c2nc(-c3ccc(-c4ccc(C(=O)O)cc4)[nH]3)cnc21 Homo sapiens CHEMBL799792 single protein format
CHEMBL131850 OBDepict HO O S N N H 3 C H 3 C CH 3 CH 3 IC50 = 2.4 nM 392.52 CC1(C)CCC(C)(C)c2nc(-c3cc(-c4ccc(C(=O)O)cc4)cs3)cnc21 Homo sapiens CHEMBL799792 single protein format
CHEMBL74331 OBDepict OH O CH 3 CH 3 CH 3 H 3 C H 3 C Ki = 3.1 nM 314.47 CC(/C=C/C1CC1/C=C/C1=CC(C)(C)CCC1(C)C)=CC(=O)O Homo sapiens CHEMBL799977 single protein format
CHEMBL36768 OBDepict HO O CH 3 H 3 C H 3 C CH 3 Ki = 5.3 nM 358.48 CC1(C)CCC(C)(C)c2cc3cc(-c4ccc(C(=O)O)cc4)ccc3cc21 Homo sapiens CHEMBL799802 single protein format
CHEMBL705 OBDepict CH 3 CH 3 CH 3 H 3 C CH 3 O OH IC50 = 7.0 nM 300.44 CC1=C(/C=C/C(C)=CC=CC(C)=CC(=O)O)C(C)(C)CCC1 Homo sapiens CHEMBL799871 single protein format
CHEMBL550796 OBDepict CH 3 CH 3 O O O OH CH 3 H 3 C H 3 C CH 3 IC50 = 15.0 nM 380.48 CC(=Cc1coc2cc3c(cc2c1=O)C(C)(C)CCC3(C)C)/C=C(C)C(=O)O Homo sapiens CHEMBL1063213 single protein format
CHEMBL131925 OBDepict HO O O N N H 3 C H 3 C CH 3 CH 3 IC50 = 19.0 nM 376.46 CC1(C)CCC(C)(C)c2nc(-c3cc(-c4ccc(C(=O)O)cc4)co3)cnc21 Homo sapiens CHEMBL799792 single protein format
CHEMBL275311 OBDepict CH 3 H 3 C CH 3 CH 3 H 3 C O OH Ki = 21.0 nM 348.49 C/C(=Cc1ccc(C(=O)O)cc1)c1ccc2c(c1)C(C)(C)CCC2(C)C Homo sapiens CHEMBL799802 single protein format
CHEMBL705 OBDepict CH 3 CH 3 CH 3 H 3 C CH 3 O OH Ki = 22.3 nM 300.44 CC1=C(/C=C/C(C)=CC=CC(C)=CC(=O)O)C(C)(C)CCC1 Homo sapiens CHEMBL877734 single protein format
CHEMBL132033 OBDepict HO O O N N CH 3 H 3 C H 3 C CH 3 IC50 = 32.0 nM 376.46 CC1(C)CCC(C)(C)c2nc(-c3ccc(-c4ccc(C(=O)O)cc4)o3)cnc21 Homo sapiens CHEMBL799792 single protein format
CHEMBL275311 OBDepict CH 3 H 3 C CH 3 CH 3 H 3 C O OH IC50 = 36.0 nM 348.49 C/C(=Cc1ccc(C(=O)O)cc1)c1ccc2c(c1)C(C)(C)CCC2(C)C Homo sapiens CHEMBL799871 single protein format
CHEMBL432592 OBDepict O N H N N H 3 C H 3 C CH 3 CH 3 O OH IC50 = 40.0 nM 353.42 CC1(C)CCC(C)(C)c2nc(C(=O)Nc3ccc(C(=O)O)cc3)cnc21 Homo sapiens CHEMBL799793 single protein format
CHEMBL69367 OBDepict O N H H 3 C H 3 C CH 3 CH 3 O OH IC50 = 41.0 nM 351.45 CC1(C)CCC(C)(C)c2cc(C(=O)Nc3ccc(C(=O)O)cc3)ccc21 Homo sapiens CHEMBL799791 single protein format
CHEMBL42314 OBDepict F F O CH 3 H 3 C H 3 C CH 3 CH 3 CH 3 H 3 C CH 3 O OH Ki = 54.0 nM 420.54 C/C(=C/C=C/C(C)=C/C(=O)O)c1cc(C(C)(C)C)cc(C(C)(C)C)c1OCC(F)F Homo sapiens CHEMBL803373 cell-based format
CHEMBL89241 OBDepict H 3 C CH 3 H 3 C CH 3 CH 3 CH 3 H 3 C H 3 C O HO Ki = 63.5 nM 340.51 CC(/C=C/C=C(C)c1cc(C(C)(C)C)cc(C(C)(C)C)c1)=CC(=O)O Homo sapiens CHEMBL877734 single protein format
CHEMBL25202 OBDepict O N H O OH H 3 C H 3 C CH 3 CH 3 IC50 = 78.0 nM 351.45 CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(C(=O)O)cc3)ccc21 Homo sapiens CHEMBL799791 single protein format
CHEMBL336311 OBDepict HO O S N N N CH 3 H 3 C H 3 C CH 3 IC50 = 83.0 nM 393.51 CC1(C)CCC(C)(C)c2nc(-c3csc(-c4ccc(C(=O)O)cc4)n3)cnc21 Homo sapiens CHEMBL799792 single protein format
CHEMBL62047 OBDepict OH O O CH 3 H 3 C H 3 C CH 3 Ki = 93.0 nM 324.42 CC1(C)CCC(C)(C)c2cc(-c3ccc(/C=C/C(=O)O)o3)ccc21 Homo sapiens CHEMBL799800 single protein format
CHEMBL284937 OBDepict CH 3 CH 3 CH 3 H 3 C H 3 C CH 3 O OH IC50 = 100.0 nM 376.54 CCc1cc2c(cc1/C(C)=C/c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C Homo sapiens CHEMBL799871 single protein format
CHEMBL472172 OBDepict OH O CH 3 CH 3 IC50 = 114.0 nM 404.51 CC1(C)CC=C(C#Cc2ccccc2)c2cc(/C=C/c3ccc(C(=O)O)cc3)ccc21 Homo sapiens CHEMBL3118431 single protein format
CHEMBL131810 OBDepict HO O S N N CH 3 H 3 C H 3 C CH 3 IC50 = 130.0 nM 392.52 CC1(C)CCC(C)(C)c2nc(-c3ccc(-c4ccc(C(=O)O)cc4)s3)cnc21 Homo sapiens CHEMBL799792 single protein format
CHEMBL74826 OBDepict CH 3 O H 3 C H 3 C CH 3 CH 3 O OH Ki = 130.0 nM 324.42 COc1ccc(/C(C)=C/c2ccc(C(=O)O)cc2)cc1C(C)(C)C Homo sapiens CHEMBL799802 single protein format
CHEMBL1023 OBDepict CH 3 CH 2 H 3 C H 3 C CH 3 CH 3 O OH Ki = 180.0 nM 348.49 C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C Homo sapiens CHEMBL799804 single protein format
CHEMBL111589 OBDepict CH 3 O H 3 C CH 3 H 3 C H 3 C CH 3 CH 3 O OH Ki = 306.0 nM 368.52 COc1cc2c(cc1/C(C)=CC=CC(C)=CC(=O)O)C(C)(C)CCC2(C)C Homo sapiens CHEMBL799799 single protein format
CHEMBL356326 OBDepict CH 3 O CH 3 CH 3 O OH Ki = 420.0 nM 364.49 COc1ccc(/C(C)=C/c2ccc(C(=O)O)cc2)cc1C1(C)CCCCC1 Homo sapiens CHEMBL799802 single protein format
CHEMBL146449 OBDepict CH 3 O CH 3 O OH Ki = 460.0 nM 402.53 COc1ccc(/C(C)=C/c2ccc(C(=O)O)cc2)cc1C12CC3CC(CC(C3)C1)C2 Homo sapiens CHEMBL799802 single protein format
CHEMBL75848 OBDepict OH O O H 3 C H 3 C CH 3 CH 3 Ki = 487.0 nM 362.47 CC1(C)CCC(C)(C)c2cc(C3=Cc4ccc(C(=O)O)cc4OC3)ccc21 Homo sapiens CHEMBL799803 single protein format
CHEMBL25361 OBDepict HO O CH 3 H 3 C H 3 C CH 3 Ki = 580.0 nM 358.48 CC1(C)CCC(C)(C)c2cc(-c3ccc4cc(C(=O)O)ccc4c3)ccc21 Homo sapiens CHEMBL799803 single protein format
CHEMBL146646 OBDepict OH O HO Ki = 610.0 nM 374.48 O=C(O)c1ccc(/C=C/c2ccc(O)c(C34CC5CC(CC(C5)C3)C4)c2)cc1 Homo sapiens CHEMBL799802 single protein format
CHEMBL32505 OBDepict CH 3 CH 3 CH 3 CH 3 H 3 C H 3 C O OH IC50 = 638.0 nM 362.51 C/C(=Cc1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C Homo sapiens CHEMBL799871 single protein format
CHEMBL357917 OBDepict HO O OH Ki = 695.0 nM 440.58 O=C(O)c1ccc2cc(-c3ccc(CCCO)c(C45CC6CC(CC(C6)C4)C5)c3)ccc2c1 Homo sapiens CHEMBL799802 single protein format
CHEMBL75732 OBDepict CH 3 O H H H O O HO Ki = 764.0 nM 416.52 COc1ccc(C2=Cc3ccc(C(=O)O)cc3OC2)cc1C12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3 Homo sapiens CHEMBL799803 single protein format
CHEMBL75048 OBDepict OH H H H O O OH Ki = 821.0 nM 402.49 O=C(O)c1ccc2c(c1)OCC(c1ccc(O)c(C34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c1)=C2 Homo sapiens CHEMBL799803 single protein format
CHEMBL348449 OBDepict CH 3 HO H 3 C H 3 C CH 3 O OH Ki = 834.0 nM 310.39 C/C(=Cc1ccc(C(=O)O)cc1)c1ccc(O)c(C(C)(C)C)c1 Homo sapiens CHEMBL799802 single protein format
CHEMBL337859 OBDepict HO O N S CH 3 H 3 C H 3 C CH 3 Ki = 900.0 nM 441.6 CC1(C)CCC(C)(C)c2cc3c(cc21)Sc1ccccc1N=C3c1ccc(C(=O)O)cc1 Homo sapiens CHEMBL799805 single protein format
CHEMBL96184 OBDepict CH 2 H 3 C CH 3 CH 3 H 3 C O HO Ki = 944.0 nM 334.46 C=C(c1ccc(C(=O)O)cc1)c1ccc2c(c1)C(C)(C)CCC2(C)C Homo sapiens CHEMBL802573 single protein format
CHEMBL334534 OBDepict HO O N O CH 3 H 3 C H 3 C CH 3 Ki = 980.0 nM 425.53 CC1(C)CCC(C)(C)c2cc3c(cc21)Oc1ccccc1N=C3c1ccc(C(=O)O)cc1 Homo sapiens CHEMBL799805 single protein format