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P10398 | ARAF_HUMAN | Serine/threonine-protein kinase A-Raf (ARAF)

3D structures mapped by conservation among orthologs

[ Domain: "Ubiquitin-like" // RBD ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4466555 OBDepict O N H N N CH 3 N N H HN O Cl F F F IC50 = 1.0 nM 514.9 Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]cnc23)CC1 Homo sapiens CHEMBL4331428 single protein format
CHEMBL4207519 OBDepict O NH N O O H H H N N H F F F IC50 = 5.6 nM 478.43 O=C1CCc2c(Oc3ccc4c(c3)[C@@H]3[C@@H](c5nc6ccc(C(F)(F)F)cc6[nH]5)[C@@H]3O4)ccnc2N1 Homo sapiens CHEMBL4194764 single protein format
CHEMBL1336 OBDepict CH 3 NH O N O N H NH O Cl F F F IC50 = 7.1 nM 464.83 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 Homo sapiens CHEMBL4050073 single protein format
CHEMBL4438236 OBDepict O N H N CH 3 N N H HN O Cl F F F IC50 = 8.6 nM 513.91 Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]ccc23)CC1 Homo sapiens CHEMBL4331497 single protein format
CHEMBL3890467 OBDepict N N N O H F F N H S O O N IC50 < 10.0 nM 439.4 N#Cc1ccnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4cccnc4)c3F)c12 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3979361 OBDepict CH 3 S N H O O F F O N H N HN S O O H 3 C IC50 < 10.0 nM 548.59 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(NS(C)(=O)=O)cc4)cc23)c1F Homo sapiens CHEMBL3880148 single protein format
CHEMBL3942381 OBDepict CH 3 S N H O O F F O N H N N N N CH 3 H 3 C IC50 < 10.0 nM 500.53 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4cnc(N(C)C)nc4)cc23)c1F Homo sapiens CHEMBL3880148 single protein format
CHEMBL3899101 OBDepict F F O N H S N O O F H Cl N IC50 < 10.0 nM 465.84 O=C(c1c(F)ccc(NS(=O)(=O)c2ccccc2F)c1F)c1c[nH]c2nccc(Cl)c12 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3909499 OBDepict CH 3 S N H O O F F O N H N N O H 2 N IC50 < 10.0 nM 499.5 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(C(N)=O)nc4)cc23)c1F Homo sapiens CHEMBL3880148 single protein format
CHEMBL3897700 OBDepict H 3 C N N N H O F F N H S O O CH 3 IC50 < 10.0 nM 498.56 CCCc1ccc(-c2cnc3[nH]cc(C(=O)c4c(F)ccc(NS(=O)(=O)CCC)c4F)c3c2)cn1 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3919966 OBDepict CH 3 S N H O O F F O N H N N N IC50 < 10.0 nM 525.58 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(N5CCCC5)nc4)cc23)c1F Homo sapiens CHEMBL3880148 single protein format
CHEMBL3917210 OBDepict CH 3 S N H O O F F O N H N N O N O IC50 < 10.0 nM 585.63 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(OCCN5CCOCC5)nc4)cc23)c1F Homo sapiens CHEMBL3880148 single protein format
CHEMBL3958968 OBDepict CH 3 S N H O O F F O N H N N O N IC50 < 10.0 nM 569.63 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(OCCN5CCCC5)nc4)cc23)c1F Homo sapiens CHEMBL3880148 single protein format
CHEMBL3961672 OBDepict CH 3 S N H O O F F O N H N N HO IC50 < 10.0 nM 472.47 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(O)nc4)cc23)c1F Homo sapiens CHEMBL3880148 single protein format
CHEMBL3941565 OBDepict CH 3 S N H O O F F O N H N N O N IC50 < 10.0 nM 583.66 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(OCCCN5CCCC5)nc4)cc23)c1F Homo sapiens CHEMBL3880148 single protein format
CHEMBL3896039 OBDepict CH 3 S N H O O F F O N H N N O N O IC50 < 10.0 nM 599.66 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(OCCCN5CCOCC5)nc4)cc23)c1F Homo sapiens CHEMBL3880148 single protein format
CHEMBL3945707 OBDepict H 3 C O N N H O F F N H S O O CH 3 IC50 < 10.0 nM 447.46 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(C#CCOC)cc23)c1F Homo sapiens CHEMBL3880148 single protein format
CHEMBL3948349 OBDepict H 3 C S N H O O F F O N H N CH IC50 < 10.0 nM 403.41 C#Cc1cnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)CCC)c3F)c2c1 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3981313 OBDepict F S N H O O F F O N H Cl N IC50 < 10.0 nM 465.84 O=C(c1c(F)ccc(NS(=O)(=O)c2cccc(F)c2)c1F)c1c[nH]c2nccc(Cl)c12 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3896422 OBDepict F S F N H O O F F O N H Cl N IC50 < 10.0 nM 483.83 O=C(c1c(F)ccc(NS(=O)(=O)c2cc(F)ccc2F)c1F)c1c[nH]c2nccc(Cl)c12 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3923610 OBDepict CH 3 S N H O O F O N H N N N N CH 3 H 3 C IC50 < 10.0 nM 482.54 CCCS(=O)(=O)Nc1cccc(C(=O)c2c[nH]c3ncc(-c4cnc(N(C)C)nc4)cc23)c1F Homo sapiens CHEMBL3880148 single protein format
CHEMBL3948750 OBDepict H 3 C N N H O F F N H S O O F IC50 < 10.0 nM 445.42 Cc1cnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4cccc(F)c4)c3F)c2c1 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3986998 OBDepict H 3 C N N H O F F N H S O O F F IC50 < 10.0 nM 463.41 Cc1cnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4cc(F)ccc4F)c3F)c2c1 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3939013 OBDepict H 3 C N N H O F F N H S O O F IC50 < 10.0 nM 445.42 Cc1cnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4ccccc4F)c3F)c2c1 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3941703 OBDepict N N N H O F F N H S O O F IC50 < 10.0 nM 456.4 N#Cc1cnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4ccccc4F)c3F)c2c1 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3957835 OBDepict H 3 C O N N H O F F N H S O O F F IC50 < 10.0 nM 479.41 COc1cnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4cc(F)ccc4F)c3F)c2c1 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3903656 OBDepict H 3 C O N N H O F F N H S O O F IC50 < 10.0 nM 461.42 COc1cnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4ccccc4F)c3F)c2c1 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3918722 OBDepict F S F N H O O F F O N H N Cl IC50 < 10.0 nM 483.83 O=C(c1c(F)ccc(NS(=O)(=O)c2cc(F)ccc2F)c1F)c1c[nH]c2ncc(Cl)cc12 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3917962 OBDepict CH 3 S N H O O F O N H N N N O CH 3 IC50 < 10.0 nM 469.5 CCCS(=O)(=O)Nc1cccc(C(=O)c2c[nH]c3ncc(-c4cnc(OC)nc4)cc23)c1F Homo sapiens CHEMBL3880148 single protein format
CHEMBL3934437 OBDepict N N N O H F F N H S O O F IC50 < 10.0 nM 456.4 N#Cc1ccnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4ccccc4F)c3F)c12 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3926189 OBDepict N N N O H F F N H S O O F F IC50 < 10.0 nM 474.39 N#Cc1ccnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4cc(F)ccc4F)c3F)c12 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3890797 OBDepict N N N O H F F N H S O O F F IC50 < 10.0 nM 474.39 N#Cc1ccnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4c(F)cccc4F)c3F)c12 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3979607 OBDepict N N N O H F F N H S O O F IC50 < 10.0 nM 456.4 N#Cc1ccnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4cccc(F)c4)c3F)c12 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3916725 OBDepict N N N H O F F N H S O O IC50 < 10.0 nM 438.42 N#Cc1cnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4ccccc4)c3F)c2c1 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3931676 OBDepict N N N H O F N H S O O IC50 < 10.0 nM 420.43 N#Cc1cnc2[nH]cc(C(=O)c3cccc(NS(=O)(=O)c4ccccc4)c3F)c2c1 Homo sapiens CHEMBL3880148 single protein format
CHEMBL72365 OBDepict I N H O Br Br HO IC50 = 14.6 nM 520.95 O=C1Nc2ccc(I)cc2/C1=C/c1cc(Br)c(O)c(Br)c1 Homo sapiens CHEMBL4328310 single protein format
CHEMBL4060057 OBDepict CH 3 N H N N N H O CH 3 N H O Cl F F F IC50 = 17.8 nM 503.91 CNc1cc(C2(C(=O)Nc3cc(C(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc3C)CC2)ncn1 Homo sapiens CHEMBL4050073 single protein format
CHEMBL2028663 OBDepict H 2 N N N S N H 3 C H 3 C CH 3 F N H S O O F F IC50 = 26.0 nM 519.57 CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1 Homo sapiens CHEMBL3578906 cell-based format
CHEMBL3891833 OBDepict CH 3 HN N N CH 3 F N H HN O CH 3 CH 3 CH 3 IC50 = 31.0 nM 409.51 CNc1cc2nc(C)c(-c3cc(NC(=O)NCCC(C)(C)C)ccc3F)cc2cn1 Homo sapiens CHEMBL3887602 cell-based format
CHEMBL4087837 OBDepict CH 3 N H 3 C NH N N NH O CH 3 N H O Cl F F F IC50 = 34.1 nM 575.03 Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2cc(NCCCN(C)C)ncn2)CC1 Homo sapiens CHEMBL4050073 single protein format
CHEMBL4080362 OBDepict CH 3 HN N N NH O CH 3 N H O O F F F N H 3 C IC50 = 37.6 nM 596.65 CNc1cc(C2(C(=O)Nc3cc(C(=O)Nc4ccc(OCC5CCN(C)CC5)c(C(F)(F)F)c4)ccc3C)CC2)ncn1 Homo sapiens CHEMBL4050073 single protein format
CHEMBL4066939 OBDepict CH 3 N H N N N H O CH 3 N H O O F F F N CH 3 IC50 = 43.4 nM 582.63 CNc1cc(C2(C(=O)Nc3cc(C(=O)Nc4ccc(OC5CCN(C)CC5)c(C(F)(F)F)c4)ccc3C)CC2)ncn1 Homo sapiens CHEMBL4050073 single protein format
CHEMBL3577124 OBDepict CH 3 N H N N N H 3 C CH 3 NH F N H O H 3 C CH 3 H 3 C IC50 = 44.0 nM 424.52 CNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)c(C)nc2n1 Homo sapiens CHEMBL3578906 cell-based format
CHEMBL4082425 OBDepict O N H N CH 3 N HN N H O N Cl F F F IC50 = 46.9 nM 587.05 Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2cc(NCCN3CCCC3)ncn2)CC1 Homo sapiens CHEMBL4050073 single protein format
CHEMBL4586402 OBDepict H 3 C N O F F F N H O NH CH 3 O N N N H IC50 = 52.4 nM 592.62 Cc1ccc(C(=O)Nc2ccc(OC3CCN(C)CC3)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]ccc23)CC1 Homo sapiens CHEMBL4331497 single protein format
CHEMBL3968167 OBDepict Cl N N H O F F N H S O O N IC50 < 100.0 nM 448.84 O=C(c1c(F)ccc(NS(=O)(=O)c2cccnc2)c1F)c1c[nH]c2ncc(Cl)cc12 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3977421 OBDepict H 3 C N N H O F F N H S O O N IC50 < 100.0 nM 428.42 Cc1cnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4cccnc4)c3F)c2c1 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3949599 OBDepict CH 3 O N N O H F F N H S O O F F IC50 < 100.0 nM 479.41 COc1ccnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4cc(F)ccc4F)c3F)c12 Homo sapiens CHEMBL3880148 single protein format
CHEMBL3963155 OBDepict CH 3 NH N N H 3 C CH 3 N H F NH O F H 3 C H 3 C IC50 = 120.0 nM 427.5 CNc1cc2nc(C)c(-c3cc(NC(=O)NCCC(C)(C)F)c(F)cc3C)cc2cn1 Homo sapiens CHEMBL3887602 cell-based format
CHEMBL4542639 OBDepict CH 3 HN O H 2 N O N H O Cl F F F IC50 = 183.0 nM 463.84 CNC(=O)c1cc(Oc2ccc(NC(=O)c3ccc(Cl)c(C(F)(F)F)c3)cc2)ccc1N Homo sapiens CHEMBL4392745 single protein format
CHEMBL4101882 OBDepict CH 3 HN N N N H O CH 3 N H O Cl F F F IC50 = 194.0 nM 503.91 CNc1nccc(C2(C(=O)Nc3cc(C(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc3C)CC2)n1 Homo sapiens CHEMBL4050073 single protein format
CHEMBL4447617 OBDepict CH 3 O NH O O H 2 N N H O H 3 C IC50 = 211.0 nM 391.43 CNC(=O)c1cc(Oc2ccc(NC(=O)c3ccc(OC)cc3)cc2)ccc1N Homo sapiens CHEMBL4392745 single protein format
CHEMBL1229517 OBDepict CH 3 S N H O O F F O N H N Cl IC50 = 950.0 nM 489.93 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F Homo sapiens CHEMBL3578906 cell-based format