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P11166 | GTR1_HUMAN | "Solute carrier family 2, facilitated glucose transporter member 1" (SLC2A1)

3D structures mapped by conservation among orthologs

[ Domain: "Major facilitator superfamily (MFS) general substrate transporter" // MFS_1 ]

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[ Domain: "Major facilitator superfamily (MFS) general substrate transporter" // MFS_1_1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3780239 OBDepict CH 3 O N F N N N N N IC50 = 1.0 nM 404.45 COc1ccc(F)cc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL4448899 OBDepict N N N CH 3 HN F F F O N O NH 2 F IC50 = 2.0 nM 496.42 Cc1c(NC(=O)c2cc(C(N)=O)nc3cc(F)ccc23)c(C(F)(F)F)nn1Cc1ccc(C#N)cc1 Homo sapiens CHEMBL4357107 cell-based format
CHEMBL3781913 OBDepict CH 3 O N N N N N N IC50 = 4.0 nM 400.49 COc1ccccc1N1CCCN(c2ncnc3c2cnn3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL4092369 OBDepict H 3 C CH 3 O H CH 3 H H O CH 3 H HO H H HO HO H HO H 3 C N CH 3 O HO H 3 C O H 3 C IC50 = 4.9 nM 577.72 C/C=C(C)[C@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H](C)/C=C(C)/C=C/C/C(C)=C/Cc1nc(OC)c(OC)c(O)c1C Homo sapiens CHEMBL3992745 cell-based format
CHEMBL3781331 OBDepict CH 3 O N O H 2 N N N N N N IC50 = 5.0 nM 429.48 COc1ccc(C(N)=O)cc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3781149 OBDepict OH N N N N N N IC50 = 7.0 nM 372.43 Oc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3781548 OBDepict CH 3 O N N N N N N F IC50 = 7.0 nM 404.45 COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2F)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3780460 OBDepict CH 3 O N N N N N N F F IC50 = 8.0 nM 422.44 COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2cc(F)cc(F)c2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3780372 OBDepict CH 3 O N N N N N N N IC50 = 9.0 nM 387.45 COc1ccncc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3780972 OBDepict CH 3 O N F N N N N N IC50 = 10.0 nM 404.45 COc1cc(F)ccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3781347 OBDepict CH 3 O N N N N N N H 3 C IC50 = 10.0 nM 400.49 COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2C)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3781308 OBDepict CH 3 O N CH 3 N N N N N IC50 = 14.0 nM 400.49 COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1C Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3781194 OBDepict CH 3 O N N N N N N N IC50 = 17.0 nM 411.47 COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccc(C#N)cc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3781151 OBDepict CH 3 O N N N N N N F IC50 = 17.0 nM 404.45 COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccc(F)cc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3780144 OBDepict N N O H 3 C N N N N N IC50 = 20.0 nM 411.47 COc1ccc(C#N)cc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3781157 OBDepict CH 3 O N N N N N N IC50 = 25.0 nM 386.46 COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3780785 OBDepict CH 3 O N N N N N N IC50 = 27.0 nM 386.46 COc1ccccc1N1CCN(c2ncnc3c2ncn3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3780470 OBDepict CH 3 O N N N N N N O F CH 3 IC50 = 30.0 nM 434.48 COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2cc(F)ccc2OC)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3780765 OBDepict CH 3 O N N N N N N N IC50 = 33.0 nM 411.47 COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2cccc(C#N)c2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3781741 OBDepict CH 3 O N N N N N N F IC50 = 35.0 nM 404.45 COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2cccc(F)c2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL4647311 OBDepict O NH O CH 3 CH 3 H 3 C N N N H O N N H IC50 = 36.0 nM 498.59 CC(C)(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COCC3)c1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL4645691 OBDepict CH 3 N H CH 3 H 3 C O O N N N H O N N H IC50 = 37.0 nM 498.59 CCC(C)(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL3780717 OBDepict N N N N N N N IC50 = 39.0 nM 381.44 N#Cc1cccc(N2CCN(c3ncnc4c3cnn4-c3ccccc3)CC2)c1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3780527 OBDepict CH 3 O N N N N N N IC50 = 40.0 nM 378.48 COc1ccccc1N1CCN(c2ncnc3c2cnn3C2CCCC2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL4634839 OBDepict CH 3 NH CH 3 O O N N N H O N N H IC50 = 48.0 nM 512.61 CCC(CC)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COCC3)c1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL3781384 OBDepict CH 3 O N N N N N N N IC50 = 49.0 nM 387.45 COc1ccccc1N1CCN(c2ncnc3c2nnn3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3780043 OBDepict CH 3 O N N N N N N CH 3 IC50 = 50.0 nM 400.49 COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2cccc(C)c2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3780235 OBDepict CH 3 O N N N N N N O CH 3 IC50 = 50.0 nM 416.49 COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2OC)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3780054 OBDepict CH 3 O N N N N N N H O IC50 = 53.0 nM 402.46 COc1ccccc1N1CCN(c2ncnc3c2[nH]c(=O)n3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3781835 OBDepict CH 3 O N N N N N N N IC50 = 60.0 nM 387.45 COc1cccnc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL4645036 OBDepict O NH O CH 3 N N N H N N N H IC50 = 72.0 nM 535.65 CC1(NC(=O)COc2cccc(-c3nc4c(c(Nc5ccc(-c6cn[nH]c6)cc5)n3)CN(C3CC3)CC4)c2)CC1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL3781535 OBDepict CH 3 O N N N N N N N F IC50 = 80.0 nM 405.44 COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ncccc2F)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3780595 OBDepict CH 3 O N N N N N N N O H 3 C IC50 = 100.0 nM 417.47 COc1ccc(-n2ncc3c(N4CCN(c5ccccc5OC)CC4)ncnc32)cn1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL4634011 OBDepict O HN O N N N H O N N H IC50 = 102.0 nM 496.57 O=C(COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1)NC1CCCC1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL4649311 OBDepict F N CH 3 N N H N O N N N H O H CH 3 H 3 C CH 3 IC50 = 105.0 nM 557.67 CC(CF)N1CCc2nc(-c3cccc(OCC(=O)NC(C)(C)C)c3)nc(Nc3ccc(-c4cn[nH]c4)cc3)c2C1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL3781654 OBDepict CH 3 O N F N N N N N IC50 = 110.0 nM 404.45 COc1cccc(F)c1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3781633 OBDepict CH 3 O N N CH 3 N N N N IC50 = 120.0 nM 400.49 COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)C(C)C1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL4642046 OBDepict H 3 C O N CH 3 N N H N O N N N H O H CH 3 H 3 C CH 3 IC50 = 128.0 nM 569.71 COCC(C)N1CCc2nc(-c3cccc(OCC(=O)NC(C)(C)C)c3)nc(Nc3ccc(-c4cn[nH]c4)cc3)c2C1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL4645662 OBDepict H 3 C HN CH 3 O O N N N H N N N H IC50 = 140.0 nM 523.64 CC(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CN(C2CC2)CC3)c1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL4089982 OBDepict CH 3 O HN O H N H O CH 3 H Br IC50 = 140.0 nM 495.42 COc1ccc(CC(=O)N[C@@H](Cc2ccccc2Br)C(=O)N[C@@H](C)c2ccccc2)cc1 Homo sapiens CHEMBL3992749 cell-based format
CHEMBL4638542 OBDepict H 3 C O N N N H N O N N N H O H CH 3 H 3 C CH 3 IC50 = 143.0 nM 555.68 COCCN1CCc2nc(-c3cccc(OCC(=O)NC(C)(C)C)c3)nc(Nc3ccc(-c4cn[nH]c4)cc3)c2C1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL3781183 OBDepict CH 3 O N N N N N N N IC50 = 150.0 nM 411.47 COc1cc(C#N)ccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL4634012 OBDepict O HN O H 3 C H 3 C CH 3 N N N H N O N N H IC50 = 161.0 nM 567.69 CC(C)(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CN(C2CCOC2)CC3)c1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL4638234 OBDepict O N H O N N N H O N N H IC50 = 179.0 nM 482.54 O=C(COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1)NC1CCC1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL3780764 OBDepict CH 3 O N N N N N N N IC50 = 180.0 nM 387.45 COc1ncccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3781827 OBDepict H 3 C O N N N N N N IC50 = 180.0 nM 386.46 COc1cccc(N2CCN(c3ncnc4c3cnn4-c3ccccc3)CC2)c1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3780772 OBDepict CH 3 O N N N N N N O H 3 C IC50 = 200.0 nM 416.49 COc1cccc(-n2ncc3c(N4CCN(c5ccccc5OC)CC4)ncnc32)c1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL4633651 OBDepict O NH O CH 3 CH 3 H 3 C N N N H NH N N H IC50 = 220.0 nM 497.6 CC(C)(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CNCC3)c1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL3781625 OBDepict CH 3 O N N N N N N O H 3 C IC50 = 230.0 nM 416.49 COc1ccc(-n2ncc3c(N4CCN(c5ccccc5OC)CC4)ncnc32)cc1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3781847 OBDepict CH 3 O N N N N N N N IC50 = 230.0 nM 387.45 COc1cnccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL4647401 OBDepict O N H O H 3 C N N N H N N N H IC50 = 242.0 nM 549.68 CC1(NC(=O)COc2cccc(-c3nc4c(c(Nc5ccc(-c6cn[nH]c6)cc5)n3)CN(C3CCC3)CC4)c2)CC1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL4632395 OBDepict O N H O CH 3 H 3 C CH 3 N N N H N N N H IC50 = 259.0 nM 551.7 CC(C)(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CN(C2CCC2)CC3)c1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL4061928 OBDepict O NH H N H O HO CH 3 H F IC50 = 267.0 nM 420.48 C[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)Cc1cccc(O)c1)c1ccccc1 Homo sapiens CHEMBL3992749 cell-based format
CHEMBL3780459 OBDepict F N N N N N N IC50 = 270.0 nM 374.42 Fc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL4648466 OBDepict CH 3 N H CH 3 O O N N N H O N N H IC50 = 289.0 nM 470.53 CC(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL3781994 OBDepict F N N N N N N IC50 = 290.0 nM 374.42 Fc1cccc(N2CCN(c3ncnc4c3cnn4-c3ccccc3)CC2)c1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3780756 OBDepict CH 3 O N N N N N IC50 = 300.0 nM 385.47 COc1ccccc1N1CCN(c2ccnc3c2cnn3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL4648473 OBDepict O HN O CH 3 H 3 C CH 3 N N N H N CH 3 CH 3 N N H IC50 = 326.0 nM 539.68 CC(C)N1CCc2nc(-c3cccc(OCC(=O)NC(C)(C)C)c3)nc(Nc3ccc(-c4cn[nH]c4)cc3)c2C1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL4635864 OBDepict CH 3 NH H 3 C H 3 C O O N N N H N H 3 C N N H IC50 = 342.0 nM 525.66 CCC(C)(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CN(C)CC3)c1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL4638502 OBDepict CH 3 N N N H N O N N N H O H H 3 C CH 3 H 3 C IC50 = 359.0 nM 511.63 CN1CCc2nc(-c3cccc(OCC(=O)NC(C)(C)C)c3)nc(Nc3ccc(-c4cn[nH]c4)cc3)c2C1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL3780729 OBDepict CH 3 O N N N N N N CH 3 IC50 = 410.0 nM 414.51 COc1ccccc1N1CCN(c2ncnc3c2cnn3C(C)c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL4637134 OBDepict CH 3 NH CH 3 O O N N N H HN N N H IC50 = 441.0 nM 511.63 CCC(CC)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CNCC3)c1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL4632920 OBDepict CH 3 N H O O N N N H O N N H IC50 = 447.0 nM 470.53 CCCNC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL4064730 OBDepict H N N N O N OH H H IC50 = 450.0 nM 242.24 O=c1[nH]cnc2nc([C@@H](O)c3ccccc3)[nH]c12 Homo sapiens CHEMBL3992751 cell-based format
CHEMBL4635564 OBDepict O HN O N N NH HN N N H IC50 = 459.0 nM 509.61 O=C(COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CNCC3)c1)NC1CCCC1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL3781290 OBDepict CH 3 O N N N N N IC50 = 470.0 nM 385.47 COc1ccccc1N1CCC(c2ncnc3c2cnn3-c2ccccc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL3780349 OBDepict CH 3 O N N N N N N N IC50 = 510.0 nM 387.45 COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccn2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL4641999 OBDepict CH 3 N N N H N O N N N H O H CH 3 H 3 C CH 3 IC50 = 552.0 nM 525.66 CCN1CCc2nc(-c3cccc(OCC(=O)NC(C)(C)C)c3)nc(Nc3ccc(-c4cn[nH]c4)cc3)c2C1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL4633530 OBDepict O N H O N N HN N H 3 C N N H IC50 = 559.0 nM 523.64 CN1CCc2nc(-c3cccc(OCC(=O)NC4CCCC4)c3)nc(Nc3ccc(-c4cn[nH]c4)cc3)c2C1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL4635844 OBDepict O NH O F F F N N N H O N N H IC50 = 565.0 nM 510.48 O=C(COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1)NCC(F)(F)F Homo sapiens CHEMBL4605536 cell-based format
CHEMBL4649021 OBDepict O NH O N N NH O N N H IC50 = 666.0 nM 468.52 O=C(COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1)NC1CC1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL3781797 OBDepict CH 3 O N N N N N N N IC50 = 750.0 nM 387.45 COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2cccnc2)CC1 Homo sapiens CHEMBL3782730 cell-based format
CHEMBL4637311 OBDepict O HN O N N N H N CH 3 N N H IC50 = 763.0 nM 509.61 CN1CCc2nc(-c3cccc(OCC(=O)NC4CCC4)c3)nc(Nc3ccc(-c4cn[nH]c4)cc3)c2C1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL4647586 OBDepict CH 3 NH CH 3 O O N N N H N H 3 C N N H IC50 = 789.0 nM 525.66 CCC(CC)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CN(C)CC3)c1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL4649877 OBDepict O HN O N N N H O N N H IC50 = 885.0 nM 504.55 O=C(COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1)Nc1ccccc1 Homo sapiens CHEMBL4605536 cell-based format
CHEMBL4642809 OBDepict CH 3 N H CH 3 O O N N N H N N N H IC50 = 914.0 nM 537.67 CC(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CN(C2CCC2)CC3)c1 Homo sapiens CHEMBL4605536 cell-based format