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P11309 | PIM1_HUMAN | Serine/threonine-protein kinase pim-1 (PIM1)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4107575 OBDepict CH 3 O F F S N N H O N N H 3 C H O H H 2 N H F Ki = 0.001 nM 495.53 CCOc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c1F Homo sapiens CHEMBL3888384 assay format
CHEMBL4107029 OBDepict O NH N N N F CH 3 H O F F H NH 2 H F OH Ki = 0.001 nM 519.5 Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL4111580 OBDepict CH 3 O F F S N N H O N N H 3 C H O H H 2 N H F Ki = 0.001 nM 481.5 COc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c1F Homo sapiens CHEMBL3888384 assay format
CHEMBL3105022 OBDepict O N H N N N F F F H H 3 C H NH 2 H HO Ki = 0.001 nM 457.46 C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O Homo sapiens CHEMBL3106177 single protein format
CHEMBL3105021 OBDepict O HN N NH 2 N N F F F H H 3 C H H 2 N H HO Ki = 0.001 nM 472.47 C[C@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@@H]1O Homo sapiens CHEMBL3106177 single protein format
CHEMBL4109634 OBDepict Cl F S N N H O N N CH 3 H O H H 2 N H F Ki = 0.002 nM 467.93 Cn1ncc(NC(=O)c2csc(-c3ccc(Cl)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL3934801 OBDepict O N H N H 2 N S N N CH 3 O F F H H H 2 N Ki = 0.002 nM 460.51 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@@]12CC[C@H](N)[C@@H](CC1)O2 Homo sapiens CHEMBL3888384 assay format
CHEMBL4113580 OBDepict O N H N S N N N N CH 3 H O H F H NH 2 Ki = 0.002 nM 455.52 Cn1ncc(NC(=O)c2csc(-n3cc4ccccc4n3)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL3103868 OBDepict O N H N NH 2 N N F F H H 2 N Ki = 0.002 nM 424.46 Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 Homo sapiens CHEMBL3106175 single protein format
CHEMBL3103869 OBDepict O N H N H 2 N N N F F H NH 2 H HO Ki = 0.002 nM 440.45 Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1N1CC[C@@H](O)[C@H](N)C1 Homo sapiens CHEMBL3106177 single protein format
CHEMBL3970782 OBDepict O N H N S N N CH 3 H O F F O H NH 2 H F H O Ki = 0.00224 nM 537.56 Cn1ncc(NC(=O)c2csc(-c3c(F)cc(O[C@H]4CCOC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL4114779 OBDepict HN N H N N CH 3 O N F F NH 2 S H NH 2 F F Ki = 0.003 nM 485.51 C/N=C(C(C=N)NC(=O)c1nc(-c2c(F)cccc2F)sc1N)N1CC[C@@H](N)CC(F)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL4107986 OBDepict O N H N NH 2 S N N CH 3 H O F F F H H 2 N H F Ki = 0.003 nM 484.48 Cn1ncc(NC(=O)c2nc(-c3c(F)ccc(F)c3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL4110368 OBDepict O N H N NH 2 S N N CH 3 H O F F H H 3 C H NH 2 Ki = 0.003 nM 462.53 C[C@@H]1C[C@@H](N)CC[C@H](c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)O1 Homo sapiens CHEMBL3888384 assay format
CHEMBL4110034 OBDepict O N H N S N N CH 3 H O F F O H NH 2 H F H O Ki = 0.003 nM 537.56 Cn1ncc(NC(=O)c2csc(-c3c(F)cc(O[C@@H]4CCOC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL3318855 OBDepict O N H N S N N CH 3 H O F F H NH 2 H H 3 C CH 3 OH Ki = 0.003 nM 463.51 C[C@H]1O[C@@H](c2c(NC(=O)c3csc(-c4c(F)cccc4F)n3)cnn2C)C[C@@H](N)[C@]1(C)O Homo sapiens CHEMBL3373728 single protein format
CHEMBL4107524 OBDepict O HN N S N N CH 3 H O F H H 2 N H F CH 3 O Ki = 0.003 nM 503.58 Cn1ncc(NC(=O)c2csc(-c3ccc(C4(C)COC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL3648851 OBDepict O N H N NH 2 S N N N CH 3 F F F F H 3 C NH 2 Ki = 0.003 nM 497.52 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(C)(N)CC(F)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL4106822 OBDepict CH 3 F F S N N H O N N H 3 C H O H H 2 N H F Ki = 0.003 nM 465.5 Cc1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c(F)c1 Homo sapiens CHEMBL3888384 assay format
CHEMBL2387464 OBDepict O N H N N N N NH H N H F H F N H Ki = 0.003 nM 502.53 O=C(Nc1c[nH]c2ncc(-c3ccccc3F)cc12)c1cnn2ccc(NC[C@H]3CCNC[C@@H]3F)nc12 Homo sapiens CHEMBL2388109 single protein format
CHEMBL4111897 OBDepict O N H N NH 2 S N N CH 3 H O F F H H 2 N H F Ki = 0.00342 nM 466.49 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL3648676 OBDepict NH 2 N F F N N H CH 3 N O N NH 2 S F F Ki = 0.004 nM 483.5 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(N)CC(F)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL3639475 OBDepict F F S N H 2 N N H O N N N H 3 C F F H H 2 N Ki = 0.004 nM 483.5 Cn1ncc(NC(=O)c2nc(-c3cc(F)ccc3F)sc2N)c1N1CC[C@H](N)CC(F)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL3652032 OBDepict H 3 C O NH 2 N N N H H 3 C N O N H 2 N S F F Ki = 0.004 nM 503.58 COC1C(N)CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC12CC2 Homo sapiens CHEMBL3705780 assay format
CHEMBL4109001 OBDepict O N H N H 2 N S N N N H 3 C H O H 3 C H H 2 N H F Ki = 0.004 nM 445.52 Cc1cccnc1-c1nc(C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)c(N)s1 Homo sapiens CHEMBL3888384 assay format
CHEMBL3918462 OBDepict O N H N NH 2 S N N CH 3 H O F F H H 2 N H F Ki = 0.004 nM 466.49 Cn1ncc(NC(=O)c2nc(-c3cccc(F)c3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL3901936 OBDepict O N H N NH 2 S N N CH 3 H O F F F H H 2 N H F Ki = 0.004 nM 484.48 Cn1ncc(NC(=O)c2nc(-c3c(F)ccc(F)c3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL3914022 OBDepict CH 3 N N N N H N N HN Ki = 0.004 nM 385.48 CCc1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)c1 Homo sapiens CHEMBL3887976 assay format
CHEMBL3623150 OBDepict O N H N NH 2 S N N N CH 3 F F F F H NH 2 Ki = 0.005 nM 483.5 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H](N)CC(F)(F)C1 Homo sapiens CHEMBL4316999 single protein format
CHEMBL4110546 OBDepict O N H N NH 2 S N N CH 3 H O F H H 2 N H F Ki = 0.00509 nM 448.5 Cn1ncc(NC(=O)c2nc(-c3ccccc3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL4741714 OBDepict O N H N F H F F H H 3 C H NH 2 IC50 = 0.006 nM 439.48 C[C@@H]1C[C@H](N)C[C@H](c2ccccc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 Homo sapiens CHEMBL4687899 single protein format
CHEMBL3318853 OBDepict O N H N H 2 N S N N CH 3 O F F H H H 2 N Ki = 0.006 nM 460.51 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@]12CC[C@H](N)[C@H](CC1)O2 Homo sapiens CHEMBL3373728 single protein format
CHEMBL3648771 OBDepict OH N F F N N H CH 3 N O N NH 2 S F F Ki = 0.006 nM 484.48 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(O)CC(F)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL3648832 OBDepict CH 3 O F F S N H 2 N N H O N N N H 3 C F F H 2 N Ki = 0.006 nM 513.52 COc1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3N3CCC(N)CC(F)(F)C3)c(N)s2)c(F)c1 Homo sapiens CHEMBL3705780 assay format
CHEMBL3651966 OBDepict O N H N N F H F F H H 3 C H NH 2 Ki = 0.006 nM 440.47 C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 Homo sapiens CHEMBL3750379 single protein format
CHEMBL4108678 OBDepict O N H N N N F CH 3 H O F F H NH 2 H F HO O Ki = 0.006 nM 563.55 Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL4114733 OBDepict HN N H N N CH 3 O N F F NH 2 S H NH 2 F F Ki = 0.006 nM 485.51 C/N=C(C(C=N)NC(=O)c1nc(-c2c(F)cccc2F)sc1N)N1CC[C@H](N)CC(F)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL3938654 OBDepict O N H N H 2 N S N N H 3 C H O N H 3 C N CH 3 H NH 2 H F Ki = 0.007 nM 448.53 Cc1c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@@H](F)CO3)c(N)s2)cnn1C Homo sapiens CHEMBL3888384 assay format
CHEMBL4114315 OBDepict Cl F N F N H O N N H 3 C H O H H 2 N H F Ki = 0.007 nM 479.89 Cn1ncc(NC(=O)c2ccc(F)c(-c3ccc(Cl)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL3648694 OBDepict O NH N H 2 N N N N N H 3 C F F F H H 2 N Ki = 0.007 nM 460.46 Cn1ncc(NC(=O)c2nc(-c3ccccc3F)cnc2N)c1N1CC[C@@H](N)CC(F)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL4107709 OBDepict O N H N NH 2 S N N CH 3 H O F Cl H H 2 N H F Ki = 0.007 nM 482.94 Cn1ncc(NC(=O)c2nc(-c3cccc(Cl)c3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL4114955 OBDepict H 3 C O H O H H 2 N H N N H H 3 C N O N H 2 N S F Cl Ki = 0.007 nM 494.98 CO[C@H]1CO[C@H](c2c(NC(=O)c3nc(-c4cc(Cl)ccc4F)sc3N)cnn2C)CC[C@H]1N Homo sapiens CHEMBL3888384 assay format
CHEMBL4459538 OBDepict CH 3 O H N H NH 2 N N H CH 3 N O N NH 2 S F F Ki = 0.007 nM 477.54 CO[C@H]1C[C@H](N)CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)C1 Homo sapiens CHEMBL4316999 single protein format
CHEMBL3648793 OBDepict CH 3 HN N F F N N H CH 3 N O N NH 2 S F F Ki = 0.007 nM 497.52 CNC1CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC(F)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL2387463 OBDepict O N H N N N N NH H N F HN Ki = 0.007 nM 484.54 O=C(Nc1c[nH]c2ncc(-c3ccccc3F)cc12)c1cnn2ccc(NCC3CCNCC3)nc12 Homo sapiens CHEMBL2388109 single protein format
CHEMBL3922546 OBDepict O N H N H 2 N S N N H 3 C H O H 3 C F H H 2 N H F Ki = 0.007 nM 462.53 Cc1cccc(F)c1-c1nc(C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@@H](F)CO2)c(N)s1 Homo sapiens CHEMBL3888384 assay format
CHEMBL3933850 OBDepict O N H N NH 2 S N N CH 3 H O F H H 2 N H F Ki = 0.007 nM 448.5 Cn1ncc(NC(=O)c2nc(-c3ccccc3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL3648753 OBDepict O N H N H 2 N S N N N F F F F H H 2 N Ki = 0.007 nM 509.53 Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnn(C2CC2)c1N1CC[C@@H](N)CC(F)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL2387465 OBDepict O N H N N N N NH H N H F F H F N H Ki = 0.007 nM 520.52 O=C(Nc1c[nH]c2ncc(-c3c(F)cccc3F)cc12)c1cnn2ccc(NC[C@H]3CCNC[C@@H]3F)nc12 Homo sapiens CHEMBL2388109 single protein format
CHEMBL4110136 OBDepict O N H N S N N CH 3 H O F F H NH 2 H F HO O Ki = 0.00762 nM 537.56 Cn1ncc(NC(=O)c2csc(-c3c(F)cc(C4(O)CCOC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL3919783 OBDepict H N N N N N H N H H H 2 N Ki = 0.0079 nM 385.48 N[C@H]1CCC[C@@H](Nc2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 Homo sapiens CHEMBL3887976 assay format
CHEMBL3954702 OBDepict H 2 N O N NH H 3 C N O N NH 2 S F F Ki = 0.008 nM 460.51 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C12CCC(N)C(CC1)O2 Homo sapiens CHEMBL3888384 assay format
CHEMBL3648719 OBDepict F F S N H 2 N N H O N N N H 3 C F F H H 2 N Ki = 0.008 nM 483.5 Cn1ncc(NC(=O)c2nc(-c3cc(F)ccc3F)sc2N)c1N1CC[C@@H](N)CC(F)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL3958042 OBDepict O N H N S N N CH 3 H O F F H NH 2 H F HO H 3 C H Ki = 0.008 nM 495.53 C[C@H](O)c1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c(F)c1 Homo sapiens CHEMBL3888384 assay format
CHEMBL4107009 OBDepict CH 3 O H O H NH 2 H N N H CH 3 N O N NH 2 S F F Ki = 0.008 nM 478.53 CO[C@H]1CO[C@H](c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC[C@H]1N Homo sapiens CHEMBL3888384 assay format
CHEMBL3648815 OBDepict NH 2 N F F N N H CH 3 N O N NH 2 S F F N Ki = 0.008 nM 484.48 Cn1ncc(NC(=O)c2nc(-c3c(F)cncc3F)sc2N)c1N1CCC(N)CC(F)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL3900009 OBDepict H 3 C N N N H NH 2 N H N N Ki = 0.00806 nM 385.48 Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CCC[C@H](N)C1 Homo sapiens CHEMBL3887976 assay format
CHEMBL3648828 OBDepict O N H N NH 2 S N N N CH 3 F F N F F H NH 2 Ki = 0.009 nM 484.48 Cn1ncc(NC(=O)c2nc(-c3c(F)cncc3F)sc2N)c1N1CC[C@@H](N)CC(F)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL4108945 OBDepict O NH N S N N H 3 C H O F F H NH 2 H F Ki = 0.009 nM 491.54 Cn1ncc(NC(=O)c2csc(-c3c(F)cc(C4CC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL4113383 OBDepict O N H N S N N N CH 3 H O N H H NH 2 H F H 3 C H 3 C Ki = 0.009 nM 487.61 Cn1ncc(NC(=O)c2csc(-c3n[nH]c4c3CCC(C)(C)C4)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL3903009 OBDepict H 3 C N N N N N H N N H H 2 N Ki = 0.009 nM 414.52 Cn1cc(-c2cc3c(-c4ccc(C5CC5)c(N5CCC[C@H](N)C5)n4)n[nH]c3cn2)cn1 Homo sapiens CHEMBL3887976 assay format
CHEMBL3648698 OBDepict H 3 C O H 3 C N NH 2 N N H H 3 C N O N H 2 N S F F Ki = 0.009 nM 491.57 COC1(C)CC(N)CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL2387471 OBDepict O N H N N N N NH H N F F HN Ki = 0.009 nM 502.53 O=C(Nc1c[nH]c2ncc(-c3c(F)cccc3F)cc12)c1cnn2ccc(NCC3CCNCC3)nc12 Homo sapiens CHEMBL2388109 single protein format
CHEMBL3972871 OBDepict H 3 C N N N N N H N N Br H H 2 N Ki = 0.009 nM 453.35 Cn1cc(-c2cc3c(-c4ccc(Br)c(N5CCC[C@H](N)C5)n4)n[nH]c3cn2)cn1 Homo sapiens CHEMBL3887976 assay format
CHEMBL4109141 OBDepict O N H N H 2 N S N N CH 3 O F F H H H 2 N Ki = 0.009 nM 460.51 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@@]12CC[C@@H](N)[C@@H](CC1)O2 Homo sapiens CHEMBL3888384 assay format
CHEMBL3648700 OBDepict NH 2 N H 3 C F N N H CH 3 N O N NH 2 S F F Ki = 0.009 nM 479.53 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(N)CC(C)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL3648723 OBDepict O N H N NH 2 S N N N CH 3 F F F H NH 2 Ki = 0.009 nM 465.51 Cn1ncc(NC(=O)c2nc(-c3ccccc3F)sc2N)c1N1CC[C@@H](N)CC(F)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL3687474 OBDepict N O H H CH 3 H H 2 N H N H N O N NH 2 S F F IC50 = 0.01 nM 512.59 C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1OCCC#N Homo sapiens CHEMBL3705754 single protein format
CHEMBL3687509 OBDepict H 3 C O H H CH 3 H H 2 N H HN N O N F F F O IC50 = 0.01 nM 554.61 CO[C@H]1[C@@H](C)C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4CCOCC4)cc3F)n2)C[C@H]1N Homo sapiens CHEMBL3705754 single protein format
CHEMBL3687493 OBDepict N O H H CH 3 H NH 2 H NH N O N F F F H 3 C IC50 = 0.01 nM 523.56 Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)[C@H](OCCC#N)[C@H](N)C3)ccc2F)c(F)c1 Homo sapiens CHEMBL3705754 single protein format
CHEMBL3648722 OBDepict O N H N NH 2 S N N N CH 3 F F F H NH 2 Ki = 0.01 nM 465.51 Cn1ncc(NC(=O)c2nc(-c3ccccc3F)sc2N)c1N1CC[C@H](N)CC(F)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL4439756 OBDepict F N H 2 N N N H CH 3 N O N NH 2 S F F Ki = 0.01 nM 465.51 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(N)CC(F)C1 Homo sapiens CHEMBL4316999 single protein format
CHEMBL3318854 OBDepict O N H N NH 2 S N N CH 3 H O F F H F H H 2 N Ki = 0.01 nM 466.49 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@@H]1C[C@@H](F)[C@H](N)CCO1 Homo sapiens CHEMBL3373728 single protein format
CHEMBL3648822 OBDepict O N H N NH 2 S N N N CH 3 F N F F H NH 2 Ki = 0.01 nM 466.49 Cn1ncc(NC(=O)c2nc(-c3ccncc3F)sc2N)c1N1CC[C@H](N)CC(F)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL3894581 OBDepict H 3 C CH 2 N N N H NH 2 N H N N Ki = 0.01 nM 411.51 C=C(C)c1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CCC[C@H](N)C1 Homo sapiens CHEMBL3887976 assay format
CHEMBL3648693 OBDepict O NH N H 2 N N N N N H 3 C F F F H H 2 N Ki = 0.01 nM 460.46 Cn1ncc(NC(=O)c2nc(-c3ccccc3F)cnc2N)c1N1CC[C@H](N)CC(F)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL3919573 OBDepict O N H N NH 2 S N N CH 3 H O F H H 2 N H F F F F Ki = 0.01 nM 516.5 Cn1ncc(NC(=O)c2nc(-c3ccc(C(F)(F)F)cc3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL3648682 OBDepict O N H N NH 2 S N N N CH 3 F F H F H NH 2 Ki = 0.01 nM 465.51 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@H](N)C[C@@H](F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL4108653 OBDepict H 3 C O H O H H 2 N H N N H H 3 C N O N H 2 N S F F F Ki = 0.01 nM 496.52 CO[C@H]1CO[C@H](c2c(NC(=O)c3nc(-c4c(F)ccc(F)c4F)sc3N)cnn2C)CC[C@H]1N Homo sapiens CHEMBL3888384 assay format
CHEMBL3972110 OBDepict CH N N N H H 2 N N H N N Ki = 0.01 nM 395.47 C#Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CCC[C@H](N)C1 Homo sapiens CHEMBL3887976 assay format
CHEMBL3648671 OBDepict O N H N H 2 N S N N N H 3 C F F CH 3 H H 2 N Ki = 0.01 nM 461.54 Cc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3N3CCC[C@@H](N)CC3)c(N)s2)c1F Homo sapiens CHEMBL3705780 assay format
CHEMBL3676285 OBDepict O N H N NH 2 S N N F F H H 2 N Ki = 0.01 nM 430.48 Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 Homo sapiens CHEMBL4316999 single protein format
CHEMBL4113050 OBDepict O HN N S N N CH 3 H O F F H H 2 N H F F O Ki = 0.01 nM 525.53 Cn1ncc(NC(=O)c2csc(-c3c(F)cc(C4(F)COC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL3648752 OBDepict O N H N H 2 N S N N N F F F F H H 2 N Ki = 0.01 nM 509.53 Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnn(C2CC2)c1N1CC[C@H](N)CC(F)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL3648717 OBDepict F F N N N N H F F O H H 2 N N NH 2 S F F Ki = 0.01 nM 533.5 Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnn(CC(F)F)c1N1CC[C@H](N)CC(F)(F)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL3634783 OBDepict CH 3 N N N N N H N N HN Ki = 0.01 nM 372.44 Cc1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)n1 Homo sapiens CHEMBL3636740 single protein format
CHEMBL2387479 OBDepict O N H N N N N NH H N H H F N H Ki = 0.011 nM 408.44 O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NC[C@@H]3CCNC[C@H]3F)nc12 Homo sapiens CHEMBL2388109 single protein format
CHEMBL4109372 OBDepict O N H N S N N CH 3 H O F F H NH 2 H F O Ki = 0.011 nM 521.57 Cn1ncc(NC(=O)c2csc(-c3c(F)cc(C4CCOC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL4111174 OBDepict O N H N N N F CH 3 H O F F H NH 2 H F OH H 3 C H 3 C Ki = 0.011 nM 521.52 Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(C(C)(C)O)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL4112826 OBDepict O N H N S N N CH 3 H O F N H H NH 2 H F Ki = 0.011 nM 472.52 Cn1ncc(NC(=O)c2csc(-c3c(F)ccc4[nH]ccc34)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL3902148 OBDepict F N N H O N NH H 3 C O NH H CH 3 H 3 C CH 3 H 3 C IC50 = 0.012 nM 383.43 C[C@H]1NC(=O)c2cc(-c3c(F)ccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 Homo sapiens CHEMBL3888799 single protein format
CHEMBL3648826 OBDepict CH 3 N H 2 N N N H CH 3 N O N NH 2 S F F Ki = 0.012 nM 461.54 CC1CC(N)CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)C1 Homo sapiens CHEMBL3705780 assay format
CHEMBL3959091 OBDepict CH 3 N H 2 N N N N N N N HN Ki = 0.012 nM 401.48 Cc1nc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cnc1N Homo sapiens CHEMBL3889101 assay format
CHEMBL4110434 OBDepict HO F F N F N H O N N CH 3 H O H NH 2 H F Ki = 0.012 nM 479.43 Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(O)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 Homo sapiens CHEMBL3888384 assay format
CHEMBL3895124 OBDepict CH 3 N N NH O CH 3 F N H O NH H CH 3 IC50 = 0.013 nM 395.44 CCn1c(NC2(C)CC2)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)c(F)ccc2c1=O Homo sapiens CHEMBL3888799 single protein format
CHEMBL3634760 OBDepict CH 3 N N N N N H N N H 3 C H H 2 N Ki = 0.013 nM 388.48 Cc1ccc(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)nc1N1CCC[C@H](N)C1 Homo sapiens CHEMBL3636740 single protein format
CHEMBL4115609 OBDepict O N H N H 2 N S N N CH 3 O F N H H H 2 N Ki = 0.013 nM 443.51 Cn1ncc(NC(=O)c2nc(-c3ccncc3F)sc2N)c1[C@@]12CC[C@@H](N)[C@@H](CC1)O2 Homo sapiens CHEMBL3888384 assay format
CHEMBL4113395 OBDepict O N H N S N N H 3 C H O F F CH 3 H H 2 N H F Ki = 0.013 nM 465.5 Cc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c1F Homo sapiens CHEMBL3888384 assay format
CHEMBL3949620 OBDepict CH 3 N N N H H 2 N N H N N N H 3 C Ki = 0.013 nM 416.53 CCc1ccc(-c2n[nH]c3cnc(-c4cnn(CC)c4)cc23)nc1N1CCC[C@H](N)C1 Homo sapiens CHEMBL3887976 assay format
CHEMBL3943948 OBDepict O N H N NH 2 S N N CH 3 H O F F H H 2 N F F Ki = 0.013 nM 484.48 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@@H]1CC[C@@H](N)C(F)(F)CO1 Homo sapiens CHEMBL3888384 assay format