P11586 | C1TC_HUMAN | "C-1-tetrahydrofolate synthase, cytoplasmic" (MTHFD1)
3D structures mapped by conservation among orthologs
[ Domain: "NAD(P)-binding Rossmann-fold domains" // THF_DHG_CYH_C ]
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[ Domain: "Aminoacid dehydrogenase-like, N-terminal domain" // THF_DHG_CYH ]
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[ Domain: pdbs with more than 2 multi-domains ]
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[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
IC50 table
| molecule_chembl_id | structure | assay_type | relation | values | units | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1233930 | IC50 | = | 96.0 | nM | 471.43 | Nc1nc(O)c2c(n1)NC[C@@H]1CN(c3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)C(=O)N21 | Homo sapiens | CHEMBL4434261 | assay format |