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P11802 | CDK4_HUMAN | Cyclin-dependent kinase 4 (CDK4)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL334285 OBDepict O N H N H N O O N H N S N O NH IC50 = 0.007 nM 507.58 O=C(Nc1cccc2c1C(=O)c1c(-c3ccc(C(=O)N4CCNCC4)s3)n[nH]c1-2)NN1CCOCC1 Homo sapiens CHEMBL4407028 single protein format
CHEMBL151546 OBDepict H 2 N NH O O N N H S Cl IC50 = 0.026 nM 344.78 NC(=O)Nc1cccc2c1C(=O)c1c(-c3csc(Cl)c3)n[nH]c1-2 Homo sapiens CHEMBL4407028 single protein format
CHEMBL148580 OBDepict H 3 C O N H N O NH O N N HN H 2 N IC50 = 0.08 nM 459.51 COc1ccc(-c2[nH]nc3c2C(=O)c2c(NC(=O)CN4CCN(C(=N)N)CC4)cccc2-3)cc1 Homo sapiens CHEMBL4407028 single protein format
CHEMBL3698644 OBDepict NH N N N N H N N N N IC50 = 0.13 nM 415.51 c1cc2c3cnc(Nc4cnc(N5CCNCC5)nc4)nc3n(C3CCCC3)c2cn1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL4453997 OBDepict H 3 C O N N H O O IC50 = 0.2 nM 304.31 COc1ccc(-c2n[nH]c3c2C(=O)c2c(C=O)cccc2-3)cc1 Homo sapiens CHEMBL4407028 single protein format
CHEMBL526110 OBDepict _ O + N O NH N N N N N IC50 = 0.3 nM 333.31 O=[N+]([O-])c1cccc(Nc2nccc(-c3cnn4ncccc34)n2)c1 Homo sapiens CHEMBL1002018 single protein format
CHEMBL3698653 OBDepict HN N N H N N N N IC50 = 0.32 nM 421.51 c1ccc(-n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cc4)nc32)cc1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698639 OBDepict NH N N H N N N N IC50 = 0.45 nM 413.53 c1cc2c3cnc(Nc4ccc(N5CCNCC5)cc4)nc3n(C3CCCC3)c2cn1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL4209329 OBDepict F N N N H F N N N CH 3 H 3 C N N H IC50 = 0.6 nM 490.56 CC1(C)CCc2nc3c(F)cc(-c4nc(Nc5ccc(CN6CCNCC6)cn5)ncc4F)cc3n21 Homo sapiens CHEMBL4188521 single protein format
CHEMBL4211828 OBDepict CH 3 N H 3 C N N N H N N F F N N H 3 C IC50 = 0.6 nM 518.62 CC(C)N1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)C(C)CC6)n3)nc2)CC1 Homo sapiens CHEMBL4188521 single protein format
CHEMBL4215702 OBDepict H 3 C N N N N H N N F F N N H 3 C CH 3 IC50 = 0.8 nM 504.59 CN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)C(C)(C)CC6)n3)nc2)CC1 Homo sapiens CHEMBL4188521 single protein format
CHEMBL3698671 OBDepict NH N N H N N N N IC50 = 0.83 nM 413.53 c1cnc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cc3)nc1n2C1CCCC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698641 OBDepict CH 3 N N N H N N HN N N IC50 = 0.91 nM 428.54 Cc1cc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)cnc1N1CCNCC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698659 OBDepict HN N N N H N N N N IC50 = 0.94 nM 440.56 c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CC4CCC3C4)c2cn1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698688 OBDepict CH 3 N CH 3 N N N H N N N N IC50 = 0.97 nM 456.6 CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)cn2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698657 OBDepict NH N N H N N N IC50 = 1.0 nM 426.57 c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cc3)nc1n2C1CCCCC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3702122 OBDepict HO O N N N N H N N N N IC50 = 1.0 nM 486.58 O=C(O)CN1CCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3702060 OBDepict CH 3 N CH 3 N N N H N N N Cl N IC50 = 1.0 nM 491.04 CN(C)C1CCN(c2ccc(Nc3ncc4c5ccnc(Cl)c5n(C5CCCC5)c4n3)nc2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3702053 OBDepict CH 3 N CH 3 N N N N H N N N N IC50 = 1.0 nM 485.64 CCN(CC)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3642037 OBDepict CH 3 N H 3 C H N H HO N N N H N N N N IC50 = 1.0 nM 473.59 CN(C)[C@@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC[C@H]1O Homo sapiens CHEMBL3705960 single protein format
CHEMBL4205645 OBDepict CH 3 N N N N H N N F N N H 3 C CH 3 IC50 = 1.0 nM 500.63 CCN1CCN(Cc2ccc(Nc3nccc(-c4cc(F)c5nc6n(c5c4)C(C)(C)CC6)n3)nc2)CC1 Homo sapiens CHEMBL4188521 single protein format
CHEMBL3698649 OBDepict CH 3 N CH 3 N N N N H N N N N IC50 = 1.0 nM 457.59 CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3691546 OBDepict H 3 C N CH 3 O N N N N H N N O HN IC50 = 1.0 nM 502.62 CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CC4CN5)cn3)nc2n1C1CCCCCC1 Homo sapiens CHEMBL3705853 single protein format
CHEMBL3702046 OBDepict CH 3 N CH 3 N N N H N N N N IC50 = 1.2 nM 456.6 CC(C)N1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL4866341 OBDepict HO NH O NH O NH N N F N N CH 3 H 3 C H 3 C IC50 = 1.2 nM 533.61 Cc1nc2ccc(-c3nc(Nc4ccc(NC(=O)CCCCCC(=O)NO)cc4)ncc3F)cc2n1C(C)C Homo sapiens CHEMBL4819296 single protein format
CHEMBL3237702 OBDepict H 3 C N N N N N H N N HN IC50 = 1.2 nM 442.57 CC1CCC(n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698698 OBDepict H 2 N N N N H N N N N IC50 = 1.3 nM 442.57 NCC1CCCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)C1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3702158 OBDepict NH N N H N N N N IC50 = 1.3 nM 411.51 C1=C(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CCNC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3642002 OBDepict OH OH H N H N N N N H N N N N IC50 = 1.3 nM 503.61 OC[C@H](O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698658 OBDepict NH N N N H N N N IC50 = 1.3 nM 427.56 c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cn3)nc1n2C1CCCCC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3702120 OBDepict OH O N N N N N H N N N N IC50 = 1.39 nM 473.54 O=C(O)CN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3702197 OBDepict OH N H N N N H N N N N IC50 = 1.4 nM 404.48 OCCCNc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698643 OBDepict NH N N N H N N N N IC50 = 1.4 nM 414.52 c1cc2c3cnc(Nc4ccc(N5CCNCC5)nc4)nc3n(C3CCCC3)c2cn1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698706 OBDepict CH 3 NH N N N H N N N N IC50 = 1.4 nM 442.57 CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3702123 OBDepict O N N N H N H N N N N IC50 = 1.4 nM 442.53 O=C(c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1)N1CCNCC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3641998 OBDepict OH N H CH 3 H N N N N H N N N N IC50 = 1.5 nM 487.61 C[C@@H](CO)NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698642 OBDepict NH N N N N H N N N N IC50 = 1.5 nM 415.51 c1cc2c3cnc(Nc4ccc(N5CCNCC5)nn4)nc3n(C3CCCC3)c2cn1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL4208504 OBDepict H 3 C N N N N N H N N F N N H 3 C H 3 C H 3 C IC50 = 1.5 nM 489.6 CCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)cn2)CC1 Homo sapiens CHEMBL4180589 single protein format
CHEMBL3698654 OBDepict H OH N N N N H N N N N IC50 = 1.6 nM 416.49 O[C@@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698683 OBDepict N H N N N H N N N N IC50 = 1.6 nM 428.54 c1cc2c3cnc(Nc4ccc(N5CCCNCC5)cn4)nc3n(C3CCCC3)c2cn1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698661 OBDepict HN N N N H N N N N IC50 = 1.6 nM 480.62 c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C34CC5CC(CC(C5)C3)C4)c2cn1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698744 OBDepict NH 2 N N N N H N N N N IC50 = 1.6 nM 429.53 NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL4218267 OBDepict H 3 C N N N N N H N F F N N H 3 C H 3 C H 3 C IC50 = 1.6 nM 506.61 CCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)c(F)cn3)cn2)CC1 Homo sapiens CHEMBL4180589 single protein format
CHEMBL4202432 OBDepict CH 3 N H 3 C N N N N H N N F N N H 3 C H 3 C H 3 C IC50 = 1.6 nM 503.63 Cc1nc2c(F)cc(-c3cc(Nc4cnc(CN5CCN(C(C)C)CC5)cn4)ncn3)cc2n1C(C)C Homo sapiens CHEMBL4180589 single protein format
CHEMBL3641997 OBDepict H HO CH 3 N H N N N N H N N N N IC50 = 1.7 nM 487.61 C[C@@H](O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3642031 OBDepict CH 3 O O N H N N N N H N N N N IC50 = 1.7 nM 501.6 COC(=O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698692 OBDepict H CH 3 NH N N N H N N N N IC50 = 1.7 nM 428.54 C[C@@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CCN1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL4210028 OBDepict CH 3 N N N N H N N F N N H 3 C CH 3 IC50 = 1.72 nM 500.63 CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4ccc5nc6n(c5c4)C(C)(C)CC6)n3)nc2)CC1 Homo sapiens CHEMBL4188521 single protein format
CHEMBL3702110 OBDepict OH N N N N N H CH 3 H 3 C N N NH IC50 = 1.8 nM 472.6 CC1(C)CCC(n2c3nc(Nc4ccc(N5CCNCC5)cn4)ncc3c3ccnc(O)c32)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3702050 OBDepict H 3 C O N N N N H N N N N IC50 = 1.8 nM 472.6 COCCN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3301610 OBDepict H 3 C N N N N H N N F F N N H 3 C H 3 C H 3 C IC50 = 1.9 nM 506.61 CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 Homo sapiens CHEMBL4180589 single protein format
CHEMBL3642000 OBDepict OH N H CH 3 H N N N N H N N N N IC50 = 1.9 nM 487.61 C[C@H](CO)NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3702091 OBDepict F N N N N HN N N H OH IC50 = 1.9 nM 433.49 O[C@@H]1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)C1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698739 OBDepict H NH 2 N N N N H N N N N IC50 = 1.9 nM 415.51 N[C@@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698693 OBDepict H CH 3 NH N N N H N N N N IC50 = 2.0 nM 428.54 C[C@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CCN1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3702092 OBDepict F N N N N HN N N H OH IC50 = 2.0 nM 433.49 O[C@H]1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)C1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698681 OBDepict NH N N H N N N O IC50 = 2.0 nM 428.54 c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cc3)nc1n2C1CCOCC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3702154 OBDepict CH 3 N CH 3 N N N N H N N N F N IC50 = 2.0 nM 475.58 CN(C)C1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nn2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698682 OBDepict NH N N H N N N IC50 = 2.0 nM 412.54 c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cc3)nc1n2C1CCCC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3237444 OBDepict Cl N N N N N H N N HN IC50 = 2.0 nM 448.96 Clc1nccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c12 Homo sapiens CHEMBL3705960 single protein format
CHEMBL190281 OBDepict Br O N N N N H N HN IC50 = 2.0 nM 469.39 O=c1c(Br)cc2cnc(Nc3ccc(N4CCNCC4)cc3)nc2n1C1CCCC1 Homo sapiens CHEMBL3606997 single protein format
CHEMBL3642019 OBDepict CH 3 NH N N N H N N N N IC50 = 2.0 nM 456.6 CCNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3642033 OBDepict HO O N H N N N N H N N N N IC50 = 2.0 nM 487.57 O=C(O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3702034 OBDepict NH 2 N N N N H N N N O N H IC50 = 2.0 nM 445.53 NC1CCN(c2ccc(Nc3ncc4c5cc[nH]c(=O)c5n(C5CCCC5)c4n3)nn2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL365847 OBDepict CH 3 O CH 3 O N N N N H N HN IC50 = 2.0 nM 446.56 CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cc3)nc2n(C2CCCC2)c1=O Homo sapiens CHEMBL3606997 single protein format
CHEMBL3702236 OBDepict H 3 C N CH 3 H N N N NH N N H HO IC50 = 2.0 nM 403.49 CC[C@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CC[C@@H](O)C4)cn3)nc21 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3237443 OBDepict F N N N N N H N N HN IC50 = 2.0 nM 432.51 Fc1nccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c12 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3702085 OBDepict F N N N N N H N N H H 3 C NH IC50 = 2.0 nM 446.53 C[C@@H]1CNCCN1c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nc1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698746 OBDepict NH 2 N N N N H N N N N IC50 = 2.0 nM 429.53 NC1CCCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3642032 OBDepict HO O N H N N N H N N N N IC50 = 2.0 nM 486.58 O=C(O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698674 OBDepict NH N N N H N N N IC50 = 2.1 nM 441.58 c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cn3)nc1n2C1CCCCCC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL4204030 OBDepict H 3 C N N N N N H N F N N H 3 C H 3 C H 3 C IC50 = 2.1 nM 488.62 CCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ccn3)cn2)CC1 Homo sapiens CHEMBL4180589 single protein format
CHEMBL3698673 OBDepict NH N N N H N N N O IC50 = 2.1 nM 429.53 c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cn3)nc1n2C1CCOCC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3680379 OBDepict H CH 3 H N N N N N H N NH IC50 = 2.1 nM 413.53 C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCNC5)nc32)CC1 Homo sapiens CHEMBL3705969 single protein format
CHEMBL3702049 OBDepict O N N N H N N N N IC50 = 2.2 nM 429.53 c1cc2c3cnc(Nc4ccc(CN5CCOCC5)cn4)nc3n(C3CCCC3)c2cn1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698650 OBDepict HN N N N H N N N N IC50 = 2.2 nM 422.5 c1ccc(-n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)cc1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3642001 OBDepict OH N H OH N N N N H N N N N IC50 = 2.2 nM 503.61 OCC(CO)NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3702167 OBDepict O S O N N H N N N N IC50 = 2.2 nM 460.56 O=S1(=O)CC=C(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL4216534 OBDepict F N N N CH 3 H 3 C CH 3 N HN N N N N IC50 = 2.2 nM 529.67 Cc1nc2c(F)cc(-c3cc(Nc4cnc(CN5CCN(C6CCCC6)CC5)cn4)ncn3)cc2n1C(C)C Homo sapiens CHEMBL4180589 single protein format
CHEMBL3698646 OBDepict CH 3 CH 3 NH N N N N H N N N N IC50 = 2.2 nM 443.56 CC1(C)CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CCN1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL336242 OBDepict Cl H N H N N H N H HN O H N O IC50 = 2.3 nM 476.97 O=C(Nc1cc(CN[C@H]2Cc3ccc(Cl)cc3C2)n[nH]1)Nc1cccc2c1[C@@H]1CCCN1C2=O Homo sapiens CHEMBL910890 single protein format
CHEMBL3698703 OBDepict CH 3 NH N CH 3 N N H N N N N IC50 = 2.3 nM 442.57 CC1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC(C)N1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698745 OBDepict O NH N N N N H N N N N IC50 = 2.3 nM 429.49 O=C1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CCN1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL4207218 OBDepict H 3 C N N N N H N N F N N H 3 C H 3 C H 3 C IC50 = 2.4 nM 488.62 CCN1CCC(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)cn2)CC1 Homo sapiens CHEMBL4180589 single protein format
CHEMBL3680385 OBDepict H H 3 C H N N N N HN N N S O O CH 3 IC50 = 2.4 nM 519.68 CS(=O)(=O)CCN1CCc2nc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)ccc2C1 Homo sapiens CHEMBL3705969 single protein format
CHEMBL3702101 OBDepict HO H HN N N N H N N N F N IC50 = 2.4 nM 462.53 OC[C@H]1CN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CCN1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3702077 OBDepict HO N N N N H N N N F N IC50 = 2.5 nM 476.56 OCCN1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3971812 OBDepict HO N N N N N H N N HN IC50 = 2.5 nM 444.54 OC1CCC(n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698728 OBDepict N H N H N N HN N N N N IC50 = 2.5 nM 429.53 c1cc2c3cnc(Nc4ccc(NCC5CCNC5)nn4)nc3n(C3CCCC3)c2cn1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698684 OBDepict O N N S N H NH N N N N IC50 = 2.5 nM 448.56 O=C(c1csc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)n1)N1CCNCC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3702067 OBDepict CH 3 N CH 3 N N N N H N N N H 3 C CH 3 N IC50 = 2.5 nM 431.55 CC(C)n1c2cnccc2c2cnc(Nc3ccc(N4CCC(N(C)C)CC4)nn3)nc21 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3642030 OBDepict OH N H CH 3 H N N N H N N N N IC50 = 2.6 nM 486.62 C[C@@H](CO)NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698713 OBDepict NH 2 N N N N H N N N N IC50 = 2.6 nM 429.53 NC1CCN(c2cnc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)cn2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3641972 OBDepict H OH CH 3 N N N N NH N N N H HO IC50 = 2.6 nM 406.45 C[C@H](O)Cn1c2cnccc2c2cnc(Nc3ccc(N4CC[C@@H](O)C4)nn3)nc21 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3680381 OBDepict HO N N N H N N N H N H CH 3 IC50 = 2.6 nM 457.58 C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCN(CCO)C5)nc32)CC1 Homo sapiens CHEMBL3705969 single protein format
CHEMBL3702186 OBDepict CH 3 N CH 3 N N N H N N N O N CH 3 IC50 = 2.6 nM 514.68 CCN(CC)C1CCN(c2ccc(Nc3ncc4c5ccnc(OC)c5n(C5CCCC5)c4n3)nc2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3702107 OBDepict CH 3 N CH 3 N N N H N N N N H 3 C CH 3 IC50 = 2.6 nM 498.68 CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCC(C)(C)CC5)c4n3)cn2)CC1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698676 OBDepict N N N N N H N N HN IC50 = 2.7 nM 438.54 N#Cc1ccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c2c1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3698695 OBDepict H HN NH N N H N N N N IC50 = 2.8 nM 414.52 c1cc2c3cnc(Nc4ccc(N[C@H]5CCNC5)cn4)nc3n(C3CCCC3)c2cn1 Homo sapiens CHEMBL3705960 single protein format
CHEMBL3642003 OBDepict O N N N N N H N N N N IC50 = 2.8 nM 499.62 c1cc2c3cnc(Nc4ccc(N5CCC(N6CCOCC6)CC5)nn4)nc3n(C3CCCC3)c2cn1 Homo sapiens CHEMBL3705960 single protein format