HOME LIGAND hPROTEOME OTHERS DOCUMENT

P14222 | PERF_HUMAN | Perforin-1 (PRF1)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3754633 OBDepict NH 2 O S O O IC50 = 180.0 nM 335.38 NC(=O)c1ccc(-c2ccc(-c3ccc4c(c3)COC4=O)s2)cc1 Homo sapiens CHEMBL3756437 cell-based format
CHEMBL1934375 OBDepict S N H N H O N S O O IC50 = 340.0 nM 343.39 O=C1NC(=S)N/C1=C/c1csc(-c2ccc3c(c2)COC3=O)n1 Homo sapiens CHEMBL1936847 cell-based format
CHEMBL1934383 OBDepict S NH N H O N H O O IC50 = 360.0 nM 375.41 O=C1NC(=S)N/C1=C/c1cc2ccc(-c3ccc4c(c3)COC4=O)cc2[nH]1 Homo sapiens CHEMBL1936847 cell-based format
CHEMBL1934381 OBDepict S NH N H O S O O IC50 = 360.0 nM 392.46 O=C1NC(=S)N/C1=C/c1cc2ccc(-c3ccc4c(c3)COC4=O)cc2s1 Homo sapiens CHEMBL1936847 cell-based format
CHEMBL1934370 OBDepict S N H N H O N O O IC50 = 370.0 nM 337.36 O=C1NC(=S)N/C1=C/c1ccc(-c2ccc3c(c2)COC3=O)cn1 Homo sapiens CHEMBL1936847 cell-based format
CHEMBL1934397 OBDepict S N H HN O O S O O IC50 = 400.0 nM 370.41 O=C1NC(=S)NC(=O)C1=Cc1ccc(-c2ccc3c(c2)COC3=O)s1 Homo sapiens CHEMBL1936847 cell-based format
CHEMBL3103651 OBDepict O N H N H O S NH O IC50 = 400.0 nM 325.35 O=C1NC(=O)/C(=Cc2ccc(-c3ccc4c(c3)CNC4=O)s2)N1 Homo sapiens CHEMBL3106784 cell-based format
CHEMBL1934386 OBDepict S N H N H O N O O IC50 = 470.0 nM 387.42 O=C1NC(=S)N/C1=C/c1ccc2cc(-c3ccc4c(c3)COC4=O)ccc2n1 Homo sapiens CHEMBL1936847 cell-based format
CHEMBL1934380 OBDepict S N H N H O S O O IC50 = 490.0 nM 392.46 O=C1NC(=S)N/C1=C/c1cc2cc(-c3ccc4c(c3)COC4=O)ccc2s1 Homo sapiens CHEMBL1936847 cell-based format
CHEMBL1934382 OBDepict S N H N H O O O O IC50 = 510.0 nM 376.39 O=C1NC(=S)N/C1=C/c1cc2cc(-c3ccc4c(c3)COC4=O)ccc2o1 Homo sapiens CHEMBL1936847 cell-based format
CHEMBL3103907 OBDepict S HN NH O S N O CH 3 IC50 = 510.0 nM 355.44 CN1Cc2cc(-c3ccc(/C=C4/NC(=S)NC4=O)s3)ccc2C1=O Homo sapiens CHEMBL3106784 cell-based format
CHEMBL3103914 OBDepict HO N O S N H O N H S IC50 = 530.0 nM 399.5 O=C1NC(=S)N/C1=C/c1ccc(-c2ccc3c(c2)CN(CCCO)C3=O)s1 Homo sapiens CHEMBL3106784 cell-based format
CHEMBL3103917 OBDepict CH 3 O N O O S HN O N H S IC50 = 550.0 nM 413.48 CCOC(=O)N1Cc2cc(-c3ccc(/C=C4/NC(=S)NC4=O)s3)ccc2C1=O Homo sapiens CHEMBL3106784 cell-based format
CHEMBL3103908 OBDepict CH 3 N O S NH O HN S IC50 = 600.0 nM 369.47 CCN1Cc2cc(-c3ccc(/C=C4/NC(=S)NC4=O)s3)ccc2C1=O Homo sapiens CHEMBL3106784 cell-based format
CHEMBL3103655 OBDepict S N H N H O N N H O IC50 = 630.0 nM 336.38 O=C1NC(=S)N/C1=C/c1ccc(-c2ccc3c(c2)CNC3=O)cn1 Homo sapiens CHEMBL3106784 cell-based format
CHEMBL3103647 OBDepict S N H N H O S O HN IC50 = 640.0 nM 355.44 O=C1NC(=S)N/C1=C/c1ccc(-c2ccc3c(c2)C(=O)NCC3)s1 Homo sapiens CHEMBL3106784 cell-based format
CHEMBL3754407 OBDepict NH 2 O OH S O O IC50 = 670.0 nM 351.38 NC(=O)c1ccc(-c2ccc(-c3ccc4c(c3)COC4=O)s2)cc1O Homo sapiens CHEMBL3756437 cell-based format
CHEMBL4169732 OBDepict HO O S N H O O N S N O H 3 C IC50 = 750.0 nM 505.58 CN1Cc2cc(-c3ccc(-c4cncc(NS(=O)(=O)c5ccc(C(=O)O)cc5)c4)s3)ccc2C1=O Homo sapiens CHEMBL4130818 cell-based format
CHEMBL4453871 OBDepict CH 3 O N N H S O O F F F S N N O H 3 C IC50 = 780.0 nM 560.58 COc1ncc(-c2ccc(-c3cnc4c(c3)CN(C)C4=O)s2)cc1NS(=O)(=O)c1ccccc1C(F)(F)F Homo sapiens CHEMBL4343116 cell-based format
CHEMBL1934364 OBDepict S N H N H O S O O IC50 = 780.0 nM 342.4 O=C1NC(=S)N/C1=C/c1ccc(-c2ccc3c(c2)COC3=O)s1 Homo sapiens CHEMBL1936847 cell-based format
CHEMBL3103913 OBDepict OH N O S HN O NH S IC50 = 780.0 nM 385.47 O=C1NC(=S)N/C1=C/c1ccc(-c2ccc3c(c2)CN(CCO)C3=O)s1 Homo sapiens CHEMBL3106784 cell-based format
CHEMBL3102870 OBDepict S N H HN O S O H 2 N IC50 = 790.0 nM 329.41 NC(=O)c1cccc(-c2ccc(/C=C3/NC(=S)NC3=O)s2)c1 Homo sapiens CHEMBL3106784 cell-based format
CHEMBL1934396 OBDepict O N H NH O O S O O IC50 = 800.0 nM 354.34 O=C1NC(=O)C(=Cc2ccc(-c3ccc4c(c3)COC4=O)s2)C(=O)N1 Homo sapiens CHEMBL1936847 cell-based format
CHEMBL1934384 OBDepict S N H N H O N H O O IC50 = 820.0 nM 375.41 O=C1NC(=S)N/C1=C/c1cc2cc(-c3ccc4c(c3)COC4=O)ccc2[nH]1 Homo sapiens CHEMBL1936847 cell-based format
CHEMBL3753587 OBDepict HO S O O IC50 = 900.0 nM 322.39 O=C1OCc2cc(-c3ccc(-c4ccc(CO)cc4)s3)ccc21 Homo sapiens CHEMBL3756437 cell-based format
CHEMBL3753271 OBDepict NH 2 O N S O O IC50 = 920.0 nM 336.37 NC(=O)c1ccc(-c2ccc(-c3ccc4c(c3)COC4=O)s2)cn1 Homo sapiens CHEMBL3756437 cell-based format
CHEMBL3103916 OBDepict S NH HN O S N O O CH 3 IC50 = 930.0 nM 383.45 CC(=O)N1Cc2cc(-c3ccc(/C=C4/NC(=S)NC4=O)s3)ccc2C1=O Homo sapiens CHEMBL3106784 cell-based format
CHEMBL463187 OBDepict O O S N H CH 3 S IC50 = 970.0 nM 325.41 Cc1cc2c(c(=S)[nH]1)C(=O)O/C2=Cc1csc2ccccc12 Homo sapiens CHEMBL1000314 cell-based format