P14679 | TYRO_HUMAN | Tyrosinase (TYR)
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
IC50 table
Ki table
| molecule_chembl_id | structure | assay_type | relation | values | units | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL463145 | IC50 | = | 23.0 | nM | 286.24 | O=c1cc(-c2ccc(O)cc2O)oc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL4136573 | single protein format | |
| CHEMBL24152 | IC50 | = | 60.0 | nM | 457.39 | O=C(N[C@@H](Cc1ccccc1)C(=O)OCc1cc(=O)c(O)co1)OCc1cc(=O)c(O)co1 | Homo sapiens | CHEMBL813551 | single protein format | |
| CHEMBL394855 | IC50 | = | 70.0 | nM | 272.26 | O=C(/C=C/c1ccc(O)cc1O)c1ccc(O)cc1O | Homo sapiens | CHEMBL4411347 | single protein format | |
| CHEMBL465880 | IC50 | = | 80.0 | nM | 340.38 | CC(C)=CCc1c(O)ccc(C(=O)/C=C/c2ccc(O)cc2O)c1O | Homo sapiens | CHEMBL4411347 | single protein format | |
| CHEMBL480477 | IC50 | = | 90.0 | nM | 324.38 | CC1(C)C=Cc2c(ccc3c2OC[C@@H](c2ccc(O)cc2O)C3)O1 | Homo sapiens | CHEMBL4053414 | single protein format | |
| CHEMBL43065 | IC50 | = | 90.0 | nM | 244.25 | Oc1cc(O)cc(/C=C/c2ccc(O)cc2O)c1 | Homo sapiens | CHEMBL4723116 | cell-based format | |
| CHEMBL1563332 | IC50 | = | 154.0 | nM | 370.45 | COc1cc2c(c(OC)c1CC=C(C)C)C[C@H](c1ccc(O)cc1O)CO2 | Homo sapiens | CHEMBL3810649 | single protein format | |
| CHEMBL4239110 | IC50 | = | 170.0 | nM | 356.37 | C/C(=CCc1c(O)ccc(C(=O)/C=C/c2ccc(O)cc2O)c1O)CO | Homo sapiens | CHEMBL4411347 | single protein format | |
| CHEMBL1630857 | IC50 | = | 177.0 | nM | 356.42 | COc1c(CC=C(C)C)c(O)cc2c1C[C@H](c1ccc(O)cc1O)CO2 | Homo sapiens | CHEMBL3810649 | single protein format | |
| CHEMBL4743159 | Ki | = | 250.0 | nM | 278.33 | CC(C)C(=O)Nc1nc(-c2ccc(O)cc2O)cs1 | Homo sapiens | CHEMBL4723093 | cell-based format | |
| CHEMBL3978212 | Ki | = | 350.0 | nM | 271.23 | O=C1/C(=C/c2ccc(=O)n(O)c2)Oc2cc(O)ccc21 | Homo sapiens | CHEMBL3871139 | cell-based format | |
| CHEMBL499124 | IC50 | = | 370.0 | nM | 246.26 | Oc1ccc(CCc2ccc(O)cc2O)c(O)c1 | Homo sapiens | CHEMBL1764166 | single protein format | |
| CHEMBL491410 | IC50 | = | 430.0 | nM | 378.38 | Oc1ccc(CCc2ccc(O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)cc2O)c(O)c1 | Homo sapiens | CHEMBL1764166 | single protein format | |
| CHEMBL443605 | IC50 | = | 560.0 | nM | 194.27 | CCCCCCc1ccc(O)cc1O | Homo sapiens | CHEMBL3619576 | single protein format | |
| CHEMBL1760463 | IC50 | = | 680.0 | nM | 570.54 | OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO)O[C@@H](Oc3ccc(CCc4ccc(O)cc4O)c(O)c3)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O | Homo sapiens | CHEMBL1764166 | single protein format | |
| CHEMBL1794031 | IC50 | = | 700.0 | nM | 423.37 | CC[C@H](C)[C@H](NC(=O)OCc1cc(=O)c(O)co1)C(=O)OCc1cc(=O)c(O)co1 | Homo sapiens | CHEMBL813551 | single protein format | |
| CHEMBL489989 | IC50 | = | 730.0 | nM | 510.49 | Oc1ccc(CCc2ccc(O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)cc2O[C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)c(O)c1 | Homo sapiens | CHEMBL1764166 | single protein format | |
| CHEMBL1760462 | IC50 | = | 770.0 | nM | 408.4 | OC[C@H]1O[C@@H](Oc2ccc(CCc3ccc(O)cc3O)c(O)c2)[C@H](O)[C@@H](O)[C@@H]1O | Homo sapiens | CHEMBL1764166 | single protein format | |
| CHEMBL1760464 | IC50 | = | 830.0 | nM | 570.54 | OC[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](Oc3ccc(CCc4ccc(O)cc4O)c(O)c3)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O | Homo sapiens | CHEMBL1764166 | single protein format | |
| CHEMBL458395 | IC50 | = | 980.0 | nM | 288.25 | O=C1C[C@@H](c2ccc(O)cc2O)Oc2cc(O)cc(O)c21 | Homo sapiens | CHEMBL4411347 | single protein format | |
| CHEMBL218924 | IC50 | = | 1000.0 | nM | 340.5 | CCCCCCCCCCCCC/C=C1C(=O)O[C@@](C)(OC)[C@@H]1O | Homo sapiens | CHEMBL4723094 | cell-based format | |
| CHEMBL150 | IC50 | = | 1000.0 | nM | 286.24 | O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL3810649 | single protein format | |
| CHEMBL4473314 | IC50 | = | 1000.0 | nM | 308.46 | C=C1OC(=O)/C(=CCCCCCCCCCCCCC)[C@H]1O | Homo sapiens | CHEMBL4723094 | cell-based format |